Details for: AKAP4

Gene ID: 8852

Symbol: AKAP4

Ensembl ID: ENSG00000147081

Description: A-kinase anchoring protein 4

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.39
    Marker Score: 7,904
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 4.72
    Marker Score: 30,408
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.55
    Marker Score: 6,470
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.38
    Marker Score: 2,391
  • Cell Name: T cell (CL0000084)
    Fold Change: 2.22
    Marker Score: 3,821
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 2
    Marker Score: 502
  • Cell Name: pericyte (CL0000669)
    Fold Change: 2
    Marker Score: 1,169
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.97
    Marker Score: 2,204
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 1.93
    Marker Score: 500
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.52
    Marker Score: 489
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.47
    Marker Score: 461
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.42
    Marker Score: 449
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.38
    Marker Score: 500
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.35
    Marker Score: 500
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.26
    Marker Score: 1,203
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 1.25
    Marker Score: 501
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.2
    Marker Score: 501
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.19
    Marker Score: 545
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,691
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 1.07
    Marker Score: 490
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 1
    Marker Score: 443
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 0.99
    Marker Score: 71,347
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,572
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,389
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.96
    Marker Score: 552
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.94
    Marker Score: 494
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5,239
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,740
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.9
    Marker Score: 473
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,290
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.87
    Marker Score: 502
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.82
    Marker Score: 1,556
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.81
    Marker Score: 555
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.79
    Marker Score: 495
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.79
    Marker Score: 377
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.79
    Marker Score: 436
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 406
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 714
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,269
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.75
    Marker Score: 1,200
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.75
    Marker Score: 491
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.74
    Marker Score: 419
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.73
    Marker Score: 703
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.69
    Marker Score: 552
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.66
    Marker Score: 503
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.61
    Marker Score: 470
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.54
    Marker Score: 1,106
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.53
    Marker Score: 621
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.51
    Marker Score: 304
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.49
    Marker Score: 527
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.48
    Marker Score: 503
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.48
    Marker Score: 286
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.47
    Marker Score: 503
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.47
    Marker Score: 501
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.44
    Marker Score: 390
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.43
    Marker Score: 479
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.41
    Marker Score: 659
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.39
    Marker Score: 391
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.37
    Marker Score: 480
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.35
    Marker Score: 501
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.33
    Marker Score: 5,162
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.33
    Marker Score: 460
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.32
    Marker Score: 1,893
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.3
    Marker Score: 628
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.3
    Marker Score: 459
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.27
    Marker Score: 376
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.26
    Marker Score: 501
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.25
    Marker Score: 448
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.23
    Marker Score: 724
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.23
    Marker Score: 608
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.21
    Marker Score: 503
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.16
    Marker Score: 382
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.16
    Marker Score: 503
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.14
    Marker Score: 494
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.14
    Marker Score: 555
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.12
    Marker Score: 502
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.12
    Marker Score: 1,224
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.11
    Marker Score: 551
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.1
    Marker Score: 515
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.06
    Marker Score: 525
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.04
    Marker Score: 503
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.04
    Marker Score: 502
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.01
    Marker Score: 500
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.01
    Marker Score: 497
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.01
    Marker Score: 503
  • Cell Name: mural cell (CL0008034)
    Fold Change: 0
    Marker Score: 502

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** AKAP4 belongs to the A-Kinase Anchoring Protein (AKAP) family, which consists of proteins that anchor protein kinase A (PKA) to specific subcellular locations. AKAP4 is specifically expressed in various cell types, including oligodendrocyte precursor cells, progenitor cells, microglial cells, and blood vessel endothelial cells. Its expression is also observed in immune cells, such as T cells and mononuclear cells. **Pathways and Functions:** AKAP4 interacts with PKA, a key regulator of cellular signaling pathways, and modulates its activity by anchoring it to specific subcellular locations. This interaction influences various cellular processes, including: 1. **Signal transduction:** AKAP4 regulates the activity of PKA, which in turn modulates the activity of downstream signaling pathways involved in cell growth, differentiation, and survival. 2. **Protein localization:** AKAP4 anchors PKA to specific subcellular locations, such as the nucleus, perinuclear region of cytoplasm, and cytoskeleton, thereby regulating its activity and localization. 3. **Cytoskeletal organization:** AKAP4 interacts with cytoskeletal proteins, such as actin and tubulin, to regulate the organization and dynamics of the cytoskeleton. 4. **Cell motility:** AKAP4 is involved in the regulation of cell motility, particularly in sperm cells, where it influences flagellated sperm motility and flagellum assembly. **Clinical Significance:** AKAP4 has been implicated in various disease states, including: 1. **Neurological disorders:** AKAP4 has been linked to neurological disorders, such as multiple sclerosis, where it plays a role in the regulation of oligodendrocyte precursor cell function and myelin formation. 2. **Cancer:** AKAP4 has been overexpressed in various types of cancer, including breast cancer and colon cancer, where it regulates cell growth, invasion, and metastasis. 3. **Immune system disorders:** AKAP4 has been implicated in immune system disorders, such as rheumatoid arthritis, where it regulates T cell function and activation. 4. **Sperm-related disorders:** AKAP4 has been linked to sperm-related disorders, such as infertility, where it regulates sperm motility and flagellum assembly. In conclusion, AKAP4 is a multifunctional protein that plays a crucial role in various cellular processes, including signal transduction, protein localization, and cytoskeletal organization. Its dysregulation has been implicated in various disease states, highlighting the importance of further research into the mechanisms of AKAP4 and its role in human health and disease.

Genular Protein ID: 4127602565

Symbol: AKAP4_HUMAN

Name: A-kinase anchor protein 4

UniProtKB Accession Codes:

Q5JQC9 A0AV85 O60904 O95246 Q5JQD1 Q5JQD2 Q5JQD3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 21 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9514854

Title: Molecular cloning of human testis mRNA specifically expressed in haploid germ cells, having structural homology with the A-kinase anchoring proteins.

PubMed ID: 9514854

DOI: 10.1006/bbrc.1998.8079

PubMed ID: 9822690

Title: An X-linked gene encodes a major human sperm fibrous sheath protein, hAKAP82. Genomic organization, protein kinase A-RII binding, and distribution of the precursor in the sperm tail.

PubMed ID: 9822690

DOI: 10.1074/jbc.273.48.32135

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12509440

Title: Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation.

PubMed ID: 12509440

DOI: 10.1074/jbc.m202325200

Sequence Information:

  • Length: 854
  • Mass: 94477
  • Checksum: E440CBE8AB9394F4
  • Sequence:
    • MMAYSDTTMM SDDIDWLRSH RGVCKVDLYN PEGQQDQDRK VICFVDVSTL NVEDKDYKDA 
ASSSSEGNLN LGSLEEKEII VIKDTEKKDQ SKTEGSVCLF KQAPSDPVSV LNWLLSDLQK 
YALGFQHALS PSTSTCKHKV GDTEGEYHRA SSENCYSVYA DQVNIDYLMN RPQNLRLEMT 
AAKNTNNNQS PSAPPAKPPS TQRAVISPDG ECSIDDLSFY VNRLSSLVIQ MAHKEIKEKL 
EGKSKCLHHS ICPSPGNKER ISPRTPASKI ASEMAYEAVE LTAAEMRGTG EESREGGQKS 
FLYSELSNKS KSGDKQMSQR ESKEFADSIS KGLMVYANQV ASDMMVSLMK TLKVHSSGKP 
IPASVVLKRV LLRHTKEIVS DLIDSCMKNL HNITGVLMTD SDFVSAVKRN LFNQWKQNAT 
DIMEAMLKRL VSALIGEEKE TKSQSLSYAS LKAGSHDPKC RNQSLEFSTM KAEMKERDKG 
KMKSDPCKSL TSAEKVGEHI LKEGLTIWNQ KQGNSCKVAT KACSNKDEKG EKINASTDSL 
AKDLIVSALK LIQYHLTQQT KGKDTCEEDC PGSTMGYMAQ STQYEKCGGG QSAKALSVKQ 
LESHRAPGPS TCQKENQHLD SQKMDMSNIV LMLIQKLLNE NPFKCEDPCE GENKCSEPRA 
SKAASMSNRS DKAEEQCQEH QELDCTSGMK QANGQFIDKL VESVMKLCLI MAKYSNDGAA 
LAELEEQAAS ANKPNFRGTR CIHSGAMPQN YQDSLGHEVI VNNQCSTNSL QKQLQAVLQW 
IAASQFNVPM LYFMGDKDGQ LEKLPQVSAK AAEKGYSVGG LLQEVMKFAK ERQPDEAVGK 
VARKQLLDWL LANL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.