NR1I2 | ENSG00000144852 | NCBI 8856

Details for: NR1I2

Gene ID: 8856

Symbol: NR1I2

Ensembl ID: ENSG00000144852

Description: nuclear receptor subfamily 1 group I member 2

Associated with

Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Metabolism of proteins
(R-HSA-392499)
Nuclear receptor transcription pathway
(R-HSA-383280)
Post-translational protein modification
(R-HSA-597592)
Rna polymerase ii transcription
(R-HSA-73857)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Sumoylation of intracellular receptors
(R-HSA-4090294)
Cell differentiation
(GO:0030154)
Chromatin
(GO:0000785)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Intermediate filament cytoskeleton
(GO:0045111)
Intracellular receptor signaling pathway
(GO:0030522)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nuclear body
(GO:0016604)
Nuclear receptor activity
(GO:0004879)
Nuclear receptor binding
(GO:0016922)
Nucleoplasm
(GO:0005654)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of dna-templated transcription
(GO:0006355)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific double-stranded dna binding
(GO:1990837)
Signal transduction
(GO:0007165)
Steroid metabolic process
(GO:0008202)
Transcription regulator complex
(GO:0005667)
Xenobiotic catabolic process
(GO:0042178)
Xenobiotic metabolic process
(GO:0006805)
Xenobiotic transport
(GO:0042908)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Nuclear receptor subfamily 1 group I member 2
F1D8P9_HUMAN

Genular Protein ID: 767322038

Symbol: NR1I2_HUMAN

Name: Nuclear receptor subfamily 1 group I member 2

UniProtKB Accession Codes:

O75469 Q006P5 Q008C8 Q96AC7 Q9UJ22 Q9UJ23 Q9UJ24 Q9UJ25 Q9UJ26 Q9UJ27 Q9UNW4

Database IDs:

Citations:

PubMed ID: 9784494

Title: SXR, a novel steroid and xenobiotic-sensing nuclear receptor.

PubMed ID: 9784494

DOI: 10.1101/gad.12.20.3195

PubMed ID: 9727070

Title: The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

PubMed ID: 9727070

DOI: 10.1172/jci3703

PubMed ID: 9770465

Title: Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction.

PubMed ID: 9770465

DOI: 10.1073/pnas.95.21.12208

PubMed ID: 11668216

Title: The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants.

PubMed ID: 11668216

DOI: 10.1097/00008571-200110000-00003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11297522

Title: Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin.

PubMed ID: 11297522

DOI: 10.1074/jbc.m010173200

PubMed ID: 12606758

Title: Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR.

PubMed ID: 12606758

DOI: 10.1124/mol.63.3.524

PubMed ID: 19297428

Title: Human CYP3A4 and murine Cyp3A11 are regulated by equol and genistein via the pregnane X receptor in a species-specific manner.

PubMed ID: 19297428

DOI: 10.3945/jn.108.103572

PubMed ID: 11408620

Title: The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity.

PubMed ID: 11408620

DOI: 10.1126/science.1060762

PubMed ID: 12578355

Title: 2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin.

PubMed ID: 12578355

DOI: 10.1021/bi0268753

PubMed ID: 12909012

Title: Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor.

PubMed ID: 12909012

DOI: 10.1016/s0022-2836(03)00795-2

PubMed ID: 15705662

Title: Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin.

PubMed ID: 15705662

DOI: 10.1210/me.2004-0346

PubMed ID: 17215127

Title: Crystal structure of the PXR-T1317 complex provides a scaffold to examine the potential for receptor antagonism.

PubMed ID: 17215127

DOI: 10.1016/j.bmc.2006.12.026

PubMed ID: 18768384

Title: Structural basis of human pregnane X receptor activation by the hops constituent colupulone.

PubMed ID: 18768384

DOI: 10.1124/mol.108.050732

PubMed ID: 15618712

Title: Eleven novel single nucleotide polymorphisms in the NR1I2 (PXR) gene, four of which induce non-synonymous amino acid alterations.

PubMed ID: 15618712

DOI: 10.2133/dmpk.17.561

Sequence Information:

Length: 434
Mass: 49762
Checksum: 1DF6A2AE3109C4DA
Sequence:

MEVRPKESWN HADFVHCEDT ESVPGKPSVN ADEEVGGPQI CRVCGDKATG YHFNVMTCEG 
CKGFFRRAMK RNARLRCPFR KGACEITRKT RRQCQACRLR KCLESGMKKE MIMSDEAVEE 
RRALIKRKKS ERTGTQPLGV QGLTEEQRMM IRELMDAQMK TFDTTFSHFK NFRLPGVLSS 
GCELPESLQA PSREEAAKWS QVRKDLCSLK VSLQLRGEDG SVWNYKPPAD SGGKEIFSLL 
PHMADMSTYM FKGIISFAKV ISYFRDLPIE DQISLLKGAA FELCQLRFNT VFNAETGTWE 
CGRLSYCLED TAGGFQQLLL EPMLKFHYML KKLQLHEEEY VLMQAISLFS PDRPGVLQHR 
VVDQLQEQFA ITLKSYIECN RPQPAHRFLF LKIMAMLTEL RSINAQHTQR LLRIQDIHPF 
ATPLMQELFG ITGS

Genular Protein ID: 3256046602

Symbol: F1D8P9_HUMAN

Name: N/A

UniProtKB Accession Codes:

F1D8P9

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

Length: 473
Mass: 53899
Checksum: 3049D23C9B903016
Sequence:

MTVTRTHHFK EGSLRAPAIP LHSAAAELAS NHPRGPEANL EVRPKESWNH ADFVHCEDTE 
SVPGKPSVNA DEEVGGPQIC RVCGDKATGY HFNVMTCEGC KGFFRRAMKR NARLRCPFRK 
GACEITRKTR RQCQACRLRK CLESGMKKEM IMSDEAVEER RALIKRKKSE RTGTQPLGVQ 
GLTEEQRMMI RELMDAQMKT FDTTFSHFKN FRLPGVLSSG CELPESLQAP SREEAAKWSQ 
VRKDLCSLKV SLQLRGEDGS VWNYKPPADS GGKEIFSLLP HMADMSTYMF KGIISFAKVI 
SYFRDLPIED QISLLKGAAF ELCQLRFNTV FNAETGTWEC GRLSYCLEDT AGGFQQLLLE 
PMLKFHYMLK KLQLHEEEYV LMQAISLFSP DRPGVLQHRV VDQLQEQFAI TLKSYIECNR 
PQPAHRFLFL KIMAMLTELR SINAQHTQRL LRIQDIHPFA TPLMQELFGI TGS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: NR1I2

Associated with

Other Information

SXR, a novel steroid and xenobiotic-sensing nuclear receptor. PubMed ID: 9784494

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. PubMed ID: 9727070

Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. PubMed ID: 9770465

The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants. PubMed ID: 11668216

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. PubMed ID: 11297522

Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR. PubMed ID: 12606758

Human CYP3A4 and murine Cyp3A11 are regulated by equol and genistein via the pregnane X receptor in a species-specific manner. PubMed ID: 19297428

The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity. PubMed ID: 11408620

2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin. PubMed ID: 12578355

Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor. PubMed ID: 12909012

Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin. PubMed ID: 15705662

Crystal structure of the PXR-T1317 complex provides a scaffold to examine the potential for receptor antagonism. PubMed ID: 17215127

Structural basis of human pregnane X receptor activation by the hops constituent colupulone. PubMed ID: 18768384

Eleven novel single nucleotide polymorphisms in the NR1I2 (PXR) gene, four of which induce non-synonymous amino acid alterations. PubMed ID: 15618712

The sequence of the human genome. PubMed ID: 11181995