Details for: PROZ

Gene ID: 8858

Symbol: PROZ

Ensembl ID: ENSG00000126231

Description: protein Z, vitamin K dependent plasma glycoprotein

Associated with

Other Information

Genular Protein ID: 1865841570

Symbol: PROZ_HUMAN

Name: Vitamin K-dependent protein Z

UniProtKB Accession Codes:

P22891 A6NMB4 Q15213 Q5JVF5 Q5JVF6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTAC 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 2 EvolutionaryTrace 1 GO 8 Gene3D 3 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 7 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2244898

Title: Amino acid sequence of human protein Z, a vitamin K-dependent plasma glycoprotein.

PubMed ID: 2244898

DOI: 10.1016/0006-291x(90)91566-b

PubMed ID: 9578570

Title: The gene for human protein Z is localized to chromosome 13 at band q34 and is coded by eight regular exons and one alternative exon.

PubMed ID: 9578570

DOI: 10.1021/bi972002a

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2403355

Title: Primary structure of vitamin K-dependent human protein Z.

PubMed ID: 2403355

DOI: 10.1016/0006-291x(90)91197-z

PubMed ID: 2511201

Title: Identification of a disaccharide (Xyl-Glc) and a trisaccharide (Xyl2-Glc) O-glycosidically linked to a serine residue in the first epidermal growth factor-like domain of human factors VII and IX and protein Z and bovine protein Z.

PubMed ID: 2511201

DOI: 10.1016/s0021-9258(19)47065-8

PubMed ID: 2129367

Title: A new trisaccharide sugar chain linked to a serine residue in the first EGF-like domain of clotting factors VII and IX and protein Z.

PubMed ID: 2129367

DOI: 10.1007/978-1-4615-3806-6_12

PubMed ID: 19528533

Title: Crystal structure of protein Z-dependent inhibitor complex shows how protein Z functions as a cofactor in the membrane inhibition of factor X.

PubMed ID: 19528533

DOI: 10.1182/blood-2009-04-210021

PubMed ID: 20427285

Title: Basis for the specificity and activation of the serpin protein Z-dependent proteinase inhibitor (ZPI) as an inhibitor of membrane-associated factor Xa.

PubMed ID: 20427285

DOI: 10.1074/jbc.m110.112748

Sequence Information:

  • Length: 400
  • Mass: 44744
  • Checksum: 7EBD2DCC48860268
  • Sequence:
    • MAGCVPLLQG LVLVLALHRV EPSVFLPASK ANDVLVRWKR AGSYLLEELF EGNLEKECYE 
EICVYEEARE VFENEVVTDE FWRRYKGGSP CISQPCLHNG SCQDSIWGYT CTCSPGYEGS 
NCELAKNECH PERTDGCQHF CLPGQESYTC SCAQGYRLGE DHKQCVPHDQ CACGVLTSEK 
RAPDLQDLPW QVKLTNSEGK DFCGGVIIRE NFVLTTAKCS LLHRNITVKT YFNRTSQDPL 
MIKITHVHVH MRYDADAGEN DLSLLELEWP IQCPGAGLPV CTPEKDFAEH LLIPRTRGLL 
SGWARNGTDL GNSLTTRPVT LVEGEECGQV LNVTVTTRTY CERSSVAAMH WMDGSVVTRE 
HRGSWFLTGV LGSQPVGGQA HMVLVTKVSR YSLWFKQIMN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.