Details for: CCKAR

Gene ID: 886

Symbol: CCKAR

Ensembl ID: ENSG00000163394

Description: cholecystokinin A receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 4.5037
    Cell Significance Index: 112.3100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.8786
    Cell Significance Index: 14.2300
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.6764
    Cell Significance Index: 5.1500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.3630
    Cell Significance Index: 6.2100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.2261
    Cell Significance Index: 3.1000
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.1944
    Cell Significance Index: 2.3500
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.1177
    Cell Significance Index: 1.4900
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.0988
    Cell Significance Index: 0.7600
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.0689
    Cell Significance Index: 0.7100
  • Cell Name: duodenum glandular cell (CL1001589)
    Fold Change: 0.0684
    Cell Significance Index: 0.4900
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.0615
    Cell Significance Index: 0.5900
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.0612
    Cell Significance Index: 0.6500
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0470
    Cell Significance Index: 0.5900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.0152
    Cell Significance Index: 1.5800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0149
    Cell Significance Index: 27.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0086
    Cell Significance Index: 4.8400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0084
    Cell Significance Index: 0.3900
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.0080
    Cell Significance Index: 0.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0024
    Cell Significance Index: 4.4500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0024
    Cell Significance Index: 3.6600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0002
    Cell Significance Index: 0.3000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0002
    Cell Significance Index: -0.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0005
    Cell Significance Index: -0.1500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0008
    Cell Significance Index: -0.6000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0009
    Cell Significance Index: -0.5400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0013
    Cell Significance Index: -0.5800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0014
    Cell Significance Index: -0.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0015
    Cell Significance Index: -0.3000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0021
    Cell Significance Index: -0.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0028
    Cell Significance Index: -0.4800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0030
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0036
    Cell Significance Index: -0.7500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0052
    Cell Significance Index: -0.9400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0052
    Cell Significance Index: -0.7100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0061
    Cell Significance Index: -0.8900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0063
    Cell Significance Index: -0.0900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0064
    Cell Significance Index: -0.2600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0068
    Cell Significance Index: -0.3400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0069
    Cell Significance Index: -0.1800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0077
    Cell Significance Index: -0.1000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0104
    Cell Significance Index: -0.4700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0109
    Cell Significance Index: -0.6700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0110
    Cell Significance Index: -0.3600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0115
    Cell Significance Index: -0.7700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0116
    Cell Significance Index: -0.6500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0117
    Cell Significance Index: -0.3700
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0137
    Cell Significance Index: -0.1500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0138
    Cell Significance Index: -0.6100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0161
    Cell Significance Index: -0.6100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0163
    Cell Significance Index: -0.5700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0168
    Cell Significance Index: -0.4200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0176
    Cell Significance Index: -0.2600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0205
    Cell Significance Index: -0.5500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0207
    Cell Significance Index: -0.6600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0223
    Cell Significance Index: -0.6400
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0233
    Cell Significance Index: -0.2400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0234
    Cell Significance Index: -0.6300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0239
    Cell Significance Index: -0.5000
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0241
    Cell Significance Index: -0.3100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0254
    Cell Significance Index: -0.6200
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.0259
    Cell Significance Index: -0.2300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0266
    Cell Significance Index: -0.3500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0270
    Cell Significance Index: -0.7700
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: -0.0273
    Cell Significance Index: -0.2900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0291
    Cell Significance Index: -0.3800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0296
    Cell Significance Index: -0.5900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0297
    Cell Significance Index: -0.7200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0303
    Cell Significance Index: -0.4300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0310
    Cell Significance Index: -0.4300
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0312
    Cell Significance Index: -0.3600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0312
    Cell Significance Index: -0.3800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0328
    Cell Significance Index: -0.4300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0329
    Cell Significance Index: -0.6600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0334
    Cell Significance Index: -0.9900
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.0335
    Cell Significance Index: -0.4700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0343
    Cell Significance Index: -0.7400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0353
    Cell Significance Index: -0.6900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0354
    Cell Significance Index: -0.8500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0358
    Cell Significance Index: -0.7600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0359
    Cell Significance Index: -0.3400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0370
    Cell Significance Index: -0.6100
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.0370
    Cell Significance Index: -0.4200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0374
    Cell Significance Index: -0.8200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0374
    Cell Significance Index: -0.7800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0382
    Cell Significance Index: -0.6400
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0384
    Cell Significance Index: -0.6200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0391
    Cell Significance Index: -0.7700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0391
    Cell Significance Index: -0.5700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0394
    Cell Significance Index: -0.4600
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0406
    Cell Significance Index: -0.4900
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0410
    Cell Significance Index: -0.5200
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0413
    Cell Significance Index: -0.4800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0440
    Cell Significance Index: -0.6500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0440
    Cell Significance Index: -0.7600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0441
    Cell Significance Index: -0.6700
  • Cell Name: ON parasol ganglion cell (CL4033052)
    Fold Change: -0.0442
    Cell Significance Index: -0.5500
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0445
    Cell Significance Index: -0.5700
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0451
    Cell Significance Index: -0.4100
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0452
    Cell Significance Index: -0.4800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0468
    Cell Significance Index: -0.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CCKAR is a member of the GPCR family, characterized by its unique structure and ligand-binding properties. It is activated by the binding of CCK, a peptide hormone that plays a crucial role in regulating various physiological processes. CCKAR is expressed in a wide range of cells, including progenitor cells, blood vessel endothelial cells, pericytes, goblet cells, and various types of neurons and immune cells. Its expression is also observed in the intestinal crypt stem cells of the colon and the cardiac endothelial cells. **Pathways and Functions:** CCKAR is involved in several signaling pathways, including: 1. **Gαq signaling events**: Upon activation by CCK, CCKAR triggers the activation of the Gαq protein, which in turn activates phospholipase C (PLC) and leads to the production of inositol trisphosphate (IP3) and diacylglycerol (DAG). 2. **Cholecystokinin signaling pathway**: CCKAR is a key component of the cholecystokinin signaling pathway, which regulates various physiological processes, including digestion, satiety, and immune responses. 3. **Phospholipase C-activating GPCR signaling pathway**: CCKAR is also involved in the phospholipase C-activating GPCR signaling pathway, which is essential for regulating various cellular processes, including cell proliferation and differentiation. CCKAR's functional significance extends beyond its role in regulating physiological processes. It has been implicated in modulating immune responses, including: 1. **Inflammation**: CCKAR has been shown to regulate inflammatory responses by modulating the production of pro-inflammatory cytokines. 2. **Immune cell function**: CCKAR has been implicated in the regulation of immune cell function, including the activation of T cells and the production of cytokines. **Clinical Significance:** CCKAR's dysregulation has been implicated in various diseases, including: 1. **Gastrointestinal disorders**: CCKAR's dysregulation has been linked to gastrointestinal disorders, such as irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). 2. **Immune-mediated diseases**: CCKAR's dysregulation has been implicated in immune-mediated diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Neurological disorders**: CCKAR's dysregulation has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, CCKAR is a multifunctional GPCR with widespread implications in immunology and beyond. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the molecular mechanisms underlying CCKAR's functional significance.

Genular Protein ID: 1312318225

Symbol: CCKAR_HUMAN

Name: Cholecystokinin receptor type A

UniProtKB Accession Codes:

P32238 B2R9Z5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 DrugCentral 1 EMBL 11 EMDB 9 Ensembl 1 EvolutionaryTrace 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 14 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8503909

Title: Molecular cloning and functional expression of the human gallbladder cholecystokinin A receptor.

PubMed ID: 8503909

DOI: 10.1006/bbrc.1993.1610

PubMed ID: 8343165

Title: Molecular cloning, functional expression and chromosomal localization of the human cholecystokinin type A receptor.

PubMed ID: 8343165

DOI: 10.1006/bbrc.1993.1894

PubMed ID: 7557108

Title: Abnormal processing of the human cholecystokinin receptor gene in association with gallstones and obesity.

PubMed ID: 7557108

DOI: 10.1016/0016-5085(95)90601-0

PubMed ID: 10682840

Title: Gene structure of human cholecystokinin (CCK) type-A receptor: body fat content is related to CCK type-A receptor gene promoter polymorphism.

PubMed ID: 10682840

DOI: 10.1016/s0014-5793(00)01080-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10555959

Title: Molecular complex of cholecystokinin-8 and N-terminus of the cholecystokinin A receptor by NMR spectroscopy.

PubMed ID: 10555959

DOI: 10.1021/bi991272l

PubMed ID: 11300760

Title: Intermolecular interactions between cholecystokinin-8 and the third extracellular loop of the cholecystokinin A receptor.

PubMed ID: 11300760

DOI: 10.1021/bi002659n

Sequence Information:

  • Length: 428
  • Mass: 47841
  • Checksum: A6E8FABDA805E610
  • Sequence:
    • MDVVDSLLVN GSNITPPCEL GLENETLFCL DQPRPSKEWQ PAVQILLYSL IFLLSVLGNT 
LVITVLIRNK RMRTVTNIFL LSLAVSDLML CLFCMPFNLI PNLLKDFIFG SAVCKTTTYF 
MGTSVSVSTF NLVAISLERY GAICKPLQSR VWQTKSHALK VIAATWCLSF TIMTPYPIYS 
NLVPFTKNNN QTANMCRFLL PNDVMQQSWH TFLLLILFLI PGIVMMVAYG LISLELYQGI 
KFEASQKKSA KERKPSTTSS GKYEDSDGCY LQKTRPPRKL ELRQLSTGSS SRANRIRSNS 
SAANLMAKKR VIRMLIVIVV LFFLCWMPIF SANAWRAYDT ASAERRLSGT PISFILLLSY 
TSSCVNPIIY CFMNKRFRLG FMATFPCCPN PGPPGARGEV GEEEEGGTTG ASLSRFSYSH 
MSASVPPQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.