Details for: CCKBR

Gene ID: 887

Symbol: CCKBR

Ensembl ID: ENSG00000110148

Description: cholecystokinin B receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: 5.5423
    Cell Significance Index: 4.2300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 3.6200
    Cell Significance Index: 61.8800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.3376
    Cell Significance Index: 38.5400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.0457
    Cell Significance Index: 26.1400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4755
    Cell Significance Index: 21.5600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4160
    Cell Significance Index: 41.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4097
    Cell Significance Index: 82.1900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2944
    Cell Significance Index: 56.0400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2481
    Cell Significance Index: 223.9800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2161
    Cell Significance Index: 35.1500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1708
    Cell Significance Index: 4.4900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1599
    Cell Significance Index: 2.2900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1330
    Cell Significance Index: 47.7200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0922
    Cell Significance Index: 10.0300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0503
    Cell Significance Index: 34.7900
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.0503
    Cell Significance Index: 0.6500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0306
    Cell Significance Index: 13.5200
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0127
    Cell Significance Index: 0.1600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0092
    Cell Significance Index: 0.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0049
    Cell Significance Index: 0.8400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0032
    Cell Significance Index: 0.0700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0020
    Cell Significance Index: -0.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0048
    Cell Significance Index: -9.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0065
    Cell Significance Index: -8.7900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0068
    Cell Significance Index: -12.5800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0080
    Cell Significance Index: -12.2400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0102
    Cell Significance Index: -7.5600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0107
    Cell Significance Index: -0.2600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0123
    Cell Significance Index: -8.9900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0138
    Cell Significance Index: -0.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0142
    Cell Significance Index: -9.0400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0146
    Cell Significance Index: -0.2500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0157
    Cell Significance Index: -8.8600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0157
    Cell Significance Index: -8.5700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0166
    Cell Significance Index: -1.0200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0199
    Cell Significance Index: -12.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0217
    Cell Significance Index: -9.8400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0269
    Cell Significance Index: -7.7300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0303
    Cell Significance Index: -0.6500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0336
    Cell Significance Index: -0.9400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0352
    Cell Significance Index: -0.7300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0400
    Cell Significance Index: -2.6900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0424
    Cell Significance Index: -6.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0461
    Cell Significance Index: -9.1400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0466
    Cell Significance Index: -8.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0492
    Cell Significance Index: -10.3600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0505
    Cell Significance Index: -5.8900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0605
    Cell Significance Index: -3.7200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0644
    Cell Significance Index: -4.4600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0720
    Cell Significance Index: -8.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0720
    Cell Significance Index: -9.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0735
    Cell Significance Index: -9.0400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0765
    Cell Significance Index: -2.4500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0913
    Cell Significance Index: -9.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0928
    Cell Significance Index: -9.4800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0964
    Cell Significance Index: -1.3700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1009
    Cell Significance Index: -2.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1022
    Cell Significance Index: -4.5200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1081
    Cell Significance Index: -2.7800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1086
    Cell Significance Index: -3.4600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.1124
    Cell Significance Index: -1.5000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1142
    Cell Significance Index: -3.0600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1240
    Cell Significance Index: -3.3800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1284
    Cell Significance Index: -8.0900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1326
    Cell Significance Index: -5.0200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1346
    Cell Significance Index: -10.3300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1369
    Cell Significance Index: -8.2200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1456
    Cell Significance Index: -5.1000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1542
    Cell Significance Index: -5.0500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1546
    Cell Significance Index: -3.2400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1631
    Cell Significance Index: -1.8500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1674
    Cell Significance Index: -8.7900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1687
    Cell Significance Index: -3.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1691
    Cell Significance Index: -9.4900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1739
    Cell Significance Index: -9.0600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1825
    Cell Significance Index: -1.7300
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.2015
    Cell Significance Index: -2.7400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2048
    Cell Significance Index: -1.3900
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.2076
    Cell Significance Index: -1.8500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2147
    Cell Significance Index: -10.0900
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.2151
    Cell Significance Index: -3.0600
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.2206
    Cell Significance Index: -3.0500
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.2298
    Cell Significance Index: -3.0100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2329
    Cell Significance Index: -11.7700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2342
    Cell Significance Index: -4.5700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2402
    Cell Significance Index: -5.1900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2437
    Cell Significance Index: -6.2100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2498
    Cell Significance Index: -4.9400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2598
    Cell Significance Index: -2.8300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2760
    Cell Significance Index: -4.4700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2969
    Cell Significance Index: -7.1200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3003
    Cell Significance Index: -7.4900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3038
    Cell Significance Index: -6.3400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3073
    Cell Significance Index: -9.0500
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.3084
    Cell Significance Index: -3.4500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3146
    Cell Significance Index: -3.4200
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.3170
    Cell Significance Index: -1.6600
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.3179
    Cell Significance Index: -3.4700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3193
    Cell Significance Index: -10.1000
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: -0.3200
    Cell Significance Index: -3.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **G Protein-Coupled Receptor (GPCR)**: CCKBR belongs to the class of GPCRs, which are the largest family of membrane receptors and play a vital role in cell signaling. 2. **Cholecystokinin (CCK) and Gastrin Binding**: CCKBR specifically binds to cholecystokinin and gastrin, two peptides that regulate digestive processes and immune responses. 3. **Signaling Pathways**: CCKBR activates various signaling pathways, including phospholipase C-activating G protein-coupled receptor signaling, phosphoinositide-3-kinase regulator activity, and mitogen-activated protein kinase (MAPK) signaling. 4. **Cellular Expression**: CCKBR is expressed in various cell types, including hematopoietic stem cells, megakaryocytes, endothelial cells, and colon goblet cells, highlighting its involvement in immune regulation and digestive processes. **Pathways and Functions:** 1. **Immune Regulation**: CCKBR modulates immune responses by regulating the production of cytokines, chemokines, and other immune-related molecules. 2. **Digestive Tract Development**: CCKBR plays a crucial role in the development and function of the digestive tract, particularly in the regulation of gastric acid secretion and gland development. 3. **Cell Proliferation**: CCKBR promotes cell proliferation by activating signaling pathways that regulate cell cycle progression and DNA synthesis. 4. **Intracellular Calcium Signaling**: CCKBR regulates intracellular calcium ion concentration, which is essential for various cellular processes, including cell signaling and immune response. **Clinical Significance:** 1. **Gastrointestinal Disorders**: Abnormalities in CCKBR function have been implicated in various gastrointestinal disorders, including gastrinomas, Zollinger-Ellison syndrome, and gastric cancer. 2. **Immune-Related Disorders**: CCKBR dysregulation has been linked to immune-related disorders, such as inflammatory bowel disease (IBD) and autoimmune hepatitis. 3. **Cancer Therapy**: CCKBR may serve as a target for cancer therapy, particularly in the treatment of gastric cancer and other gastrointestinal malignancies. 4. **Neurological Disorders**: CCKBR has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease, highlighting its potential role in neurodegenerative processes. In conclusion, the cholecystokinin B receptor plays a multifaceted role in immune regulation and digestive processes, making it an essential target for the development of novel therapeutic strategies for various diseases. Further research is needed to fully elucidate the mechanisms of CCKBR function and its clinical significance.

Genular Protein ID: 2577243348

Symbol: GASR_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1280419

Title: Molecular cloning of the human brain and gastric cholecystokinin receptor: structure, functional expression and chromosomal localization.

PubMed ID: 1280419

DOI: 10.1016/0006-291x(92)91557-7

PubMed ID: 7681836

Title: The human brain cholecystokinin-B/gastrin receptor. Cloning and characterization.

PubMed ID: 7681836

DOI: 10.1016/s0021-9258(18)53076-3

PubMed ID: 8349705

Title: Functional characterization of a human brain cholecystokinin-B receptor. A trophic effect of cholecystokinin and gastrin.

PubMed ID: 8349705

DOI: 10.1016/s0021-9258(17)46844-x

PubMed ID: 8415658

Title: The human gastrin/cholecystokinin type B receptor gene: alternative splice donor site in exon 4 generates two variant mRNAs.

PubMed ID: 8415658

DOI: 10.1073/pnas.90.19.9085

PubMed ID: 8185170

Title: Cholecystokinin stimulates Ca2+ mobilization and clonal growth in small cell lung cancer through CCKA and CCKB/gastrin receptors.

PubMed ID: 8185170

DOI: 10.1111/j.1749-6632.1994.tb44076.x

PubMed ID: 7848914

Title: Functional characterization of two cholecystokinin-B/gastrin receptor isoforms: a preferential splice donor site in the human receptor gene.

PubMed ID: 7848914

PubMed ID: 7887934

Title: A truncated isoform of human CCK-B/gastrin receptor generated by alternative usage of a novel exon.

PubMed ID: 7887934

DOI: 10.1006/bbrc.1995.1328

PubMed ID: 10913157

Title: Human colorectal cancers express a constitutively active cholecystokinin-B/gastrin receptor that stimulates cell growth.

PubMed ID: 10913157

DOI: 10.1074/jbc.m005754200

PubMed ID: 11495676

Title: Identification of CCK-B/gastrin receptor splice variants in human peripheral blood mononuclear cells.

PubMed ID: 11495676

DOI: 10.1016/s0167-0115(01)00281-6

PubMed ID: 12429993

Title: Characterization of the CCK-C (cancer) receptor in human pancreatic cancer.

PubMed ID: 12429993

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9872672

Title: An 84-kilobase physical map and repeat polymorphisms of the gastrin/cholecystokinin brain receptor region at the junction of chromosome segments 11p15.4 and 15.5.

PubMed ID: 9872672

DOI: 10.1023/a:1009289625352

PubMed ID: 8221657

Title: CCKA and CCKB receptors are expressed in small cell lung cancer lines and mediate Ca2+ mobilization and clonal growth.

PubMed ID: 8221657

PubMed ID: 8222757

Title: Localization of the human cholecystokinin-B/gastrin receptor gene (CCKBR) to chromosome 11p15.5-->p15.4 by fluorescence in situ hybridization.

PubMed ID: 8222757

DOI: 10.1159/000133628

PubMed ID: 11926817

Title: Intermolecular interactions between cholecystokinin-8 and the third extracellular loop of the cholecystokinin-2 receptor.

PubMed ID: 11926817

DOI: 10.1021/bi0160009

Sequence Information:

  • Length: 447
  • Mass: 48419
  • Checksum: BAEEFAD4C1F85915
  • Sequence:
  • MELLKLNRSV QGTGPGPGAS LCRPGAPLLN SSSVGNLSCE PPRIRGAGTR ELELAIRITL 
    YAVIFLMSVG GNMLIIVVLG LSRRLRTVTN AFLLSLAVSD LLLAVACMPF TLLPNLMGTF 
    IFGTVICKAV SYLMGVSVSV STLSLVAIAL ERYSAICRPL QARVWQTRSH AARVIVATWL 
    LSGLLMVPYP VYTVVQPVGP RVLQCVHRWP SARVRQTWSV LLLLLLFFIP GVVMAVAYGL 
    ISRELYLGLR FDGDSDSDSQ SRVRNQGGLP GAVHQNGRCR PETGAVGEDS DGCYVQLPRS 
    RPALELTALT APGPGSGSRP TQAKLLAKKR VVRMLLVIVV LFFLCWLPVY SANTWRAFDG 
    PGAHRALSGA PISFIHLLSY ASACVNPLVY CFMHRRFRQA CLETCARCCP RPPRARPRAL 
    PDEDPPTPSI ASLSRLSYTT ISTLGPG

Genular Protein ID: 3781845939

Symbol: E9PIC8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

  • Length: 363
  • Mass: 39286
  • Checksum: 872A069F630A64E6
  • Sequence:
  • MELLKLNRSV QGTGPGPGAS LCRPGAPLLN SSSVGNLSCE PPRIRGAGTR GVSVSVSTLS 
    LVAIALERYS AICRPLQARV WQTRSHAARV IVATWLLSGL LMVPYPVYTV VQPVGPRVLQ 
    CVHRWPSARV RQTWSVLLLL LLFFIPGVVM AVAYGLISRE LYLGLRFDGD SDSDSQSRVR 
    NQGGLPGAVH QNGRCRPETG AVGEDSDGCY VQLPRSRPAL ELTALTAPGP GSGSRPTQAK 
    LLAKKRVVRM LLVIVVLFFL CWLPVYSANT WRAFDGPGAH RALSGAPISF IHLLSYASAC 
    VNPLVYCFMH RRFRQACLET CARCCPRPPR ARPRALPDED PPTPSIASLS RLSYTTISTL 
    GPG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.