CCKBR | ENSG00000110148 | NCBI 887

Details for: CCKBR

Gene ID: 887

Symbol: CCKBR

Ensembl ID: ENSG00000110148

Description: cholecystokinin B receptor

Associated with

Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
G alpha (q) signalling events
(R-HSA-416476)
Gastrin-creb signalling pathway via pkc and mapk
(R-HSA-881907)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Peptide ligand-binding receptors
(R-HSA-375276)
Signaling by gpcr
(R-HSA-372790)
Signal transduction
(R-HSA-162582)
1-phosphatidylinositol-3-kinase regulator activity
(GO:0046935)
Cell surface receptor signaling pathway
(GO:0007166)
Cholecystokinin receptor activity
(GO:0004951)
Cholecystokinin signaling pathway
(GO:0038188)
Digestive tract development
(GO:0048565)
Gastric acid secretion
(GO:0001696)
Gastrin receptor activity
(GO:0015054)
Gland development
(GO:0048732)
Intracellular membrane-bounded organelle
(GO:0043231)
Peptide hormone binding
(GO:0017046)
Phospholipase c-activating g protein-coupled receptor signaling pathway
(GO:0007200)
Ph reduction
(GO:0045851)
Plasma membrane
(GO:0005886)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Protein binding
(GO:0005515)
Type b gastrin/cholecystokinin receptor binding
(GO:0031741)

Other Information

Proteins

GASR_HUMAN
E9PIC8_HUMAN

Genular Protein ID: 2577243348

Symbol: GASR_HUMAN

Name: N/A

UniProtKB Accession Codes:

P32239 A8K7P9 O75824 Q16144 Q92492 Q96LC6 Q9NYK7 Q9UBV1

Database IDs:

Citations:

PubMed ID: 1280419

Title: Molecular cloning of the human brain and gastric cholecystokinin receptor: structure, functional expression and chromosomal localization.

PubMed ID: 1280419

DOI: 10.1016/0006-291x(92)91557-7

PubMed ID: 7681836

Title: The human brain cholecystokinin-B/gastrin receptor. Cloning and characterization.

PubMed ID: 7681836

DOI: 10.1016/s0021-9258(18)53076-3

PubMed ID: 8349705

Title: Functional characterization of a human brain cholecystokinin-B receptor. A trophic effect of cholecystokinin and gastrin.

PubMed ID: 8349705

DOI: 10.1016/s0021-9258(17)46844-x

PubMed ID: 8415658

Title: The human gastrin/cholecystokinin type B receptor gene: alternative splice donor site in exon 4 generates two variant mRNAs.

PubMed ID: 8415658

DOI: 10.1073/pnas.90.19.9085

PubMed ID: 8185170

Title: Cholecystokinin stimulates Ca2+ mobilization and clonal growth in small cell lung cancer through CCKA and CCKB/gastrin receptors.

PubMed ID: 8185170

DOI: 10.1111/j.1749-6632.1994.tb44076.x

PubMed ID: 7848914

Title: Functional characterization of two cholecystokinin-B/gastrin receptor isoforms: a preferential splice donor site in the human receptor gene.

PubMed ID: 7848914

PubMed ID: 7887934

Title: A truncated isoform of human CCK-B/gastrin receptor generated by alternative usage of a novel exon.

PubMed ID: 7887934

DOI: 10.1006/bbrc.1995.1328

PubMed ID: 10913157

Title: Human colorectal cancers express a constitutively active cholecystokinin-B/gastrin receptor that stimulates cell growth.

PubMed ID: 10913157

DOI: 10.1074/jbc.m005754200

PubMed ID: 11495676

Title: Identification of CCK-B/gastrin receptor splice variants in human peripheral blood mononuclear cells.

PubMed ID: 11495676

DOI: 10.1016/s0167-0115(01)00281-6

PubMed ID: 12429993

Title: Characterization of the CCK-C (cancer) receptor in human pancreatic cancer.

PubMed ID: 12429993

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9872672

Title: An 84-kilobase physical map and repeat polymorphisms of the gastrin/cholecystokinin brain receptor region at the junction of chromosome segments 11p15.4 and 15.5.

PubMed ID: 9872672

DOI: 10.1023/a:1009289625352

PubMed ID: 8221657

Title: CCKA and CCKB receptors are expressed in small cell lung cancer lines and mediate Ca2+ mobilization and clonal growth.

PubMed ID: 8221657

PubMed ID: 8222757

Title: Localization of the human cholecystokinin-B/gastrin receptor gene (CCKBR) to chromosome 11p15.5-->p15.4 by fluorescence in situ hybridization.

PubMed ID: 8222757

DOI: 10.1159/000133628

PubMed ID: 11926817

Title: Intermolecular interactions between cholecystokinin-8 and the third extracellular loop of the cholecystokinin-2 receptor.

PubMed ID: 11926817

DOI: 10.1021/bi0160009

Sequence Information:

Length: 447
Mass: 48419
Checksum: BAEEFAD4C1F85915
Sequence:

MELLKLNRSV QGTGPGPGAS LCRPGAPLLN SSSVGNLSCE PPRIRGAGTR ELELAIRITL 
YAVIFLMSVG GNMLIIVVLG LSRRLRTVTN AFLLSLAVSD LLLAVACMPF TLLPNLMGTF 
IFGTVICKAV SYLMGVSVSV STLSLVAIAL ERYSAICRPL QARVWQTRSH AARVIVATWL 
LSGLLMVPYP VYTVVQPVGP RVLQCVHRWP SARVRQTWSV LLLLLLFFIP GVVMAVAYGL 
ISRELYLGLR FDGDSDSDSQ SRVRNQGGLP GAVHQNGRCR PETGAVGEDS DGCYVQLPRS 
RPALELTALT APGPGSGSRP TQAKLLAKKR VVRMLLVIVV LFFLCWLPVY SANTWRAFDG 
PGAHRALSGA PISFIHLLSY ASACVNPLVY CFMHRRFRQA CLETCARCCP RPPRARPRAL 
PDEDPPTPSI ASLSRLSYTT ISTLGPG

Genular Protein ID: 3781845939

Symbol: E9PIC8_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PIC8

Database IDs:

Citations:

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

Length: 363
Mass: 39286
Checksum: 872A069F630A64E6
Sequence:

MELLKLNRSV QGTGPGPGAS LCRPGAPLLN SSSVGNLSCE PPRIRGAGTR GVSVSVSTLS 
LVAIALERYS AICRPLQARV WQTRSHAARV IVATWLLSGL LMVPYPVYTV VQPVGPRVLQ 
CVHRWPSARV RQTWSVLLLL LLFFIPGVVM AVAYGLISRE LYLGLRFDGD SDSDSQSRVR 
NQGGLPGAVH QNGRCRPETG AVGEDSDGCY VQLPRSRPAL ELTALTAPGP GSGSRPTQAK 
LLAKKRVVRM LLVIVVLFFL CWLPVYSANT WRAFDGPGAH RALSGAPISF IHLLSYASAC 
VNPLVYCFMH RRFRQACLET CARCCPRPPR ARPRALPDED PPTPSIASLS RLSYTTISTL 
GPG

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CCKBR

Associated with

Other Information

Molecular cloning of the human brain and gastric cholecystokinin receptor: structure, functional expression and chromosomal localization. PubMed ID: 1280419

The human brain cholecystokinin-B/gastrin receptor. Cloning and characterization. PubMed ID: 7681836

Functional characterization of a human brain cholecystokinin-B receptor. A trophic effect of cholecystokinin and gastrin. PubMed ID: 8349705

The human gastrin/cholecystokinin type B receptor gene: alternative splice donor site in exon 4 generates two variant mRNAs. PubMed ID: 8415658

Cholecystokinin stimulates Ca2+ mobilization and clonal growth in small cell lung cancer through CCKA and CCKB/gastrin receptors. PubMed ID: 8185170

Functional characterization of two cholecystokinin-B/gastrin receptor isoforms: a preferential splice donor site in the human receptor gene. PubMed ID: 7848914

A truncated isoform of human CCK-B/gastrin receptor generated by alternative usage of a novel exon. PubMed ID: 7887934

Human colorectal cancers express a constitutively active cholecystokinin-B/gastrin receptor that stimulates cell growth. PubMed ID: 10913157

Identification of CCK-B/gastrin receptor splice variants in human peripheral blood mononuclear cells. PubMed ID: 11495676

Characterization of the CCK-C (cancer) receptor in human pancreatic cancer. PubMed ID: 12429993

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

An 84-kilobase physical map and repeat polymorphisms of the gastrin/cholecystokinin brain receptor region at the junction of chromosome segments 11p15.4 and 15.5. PubMed ID: 9872672

CCKA and CCKB receptors are expressed in small cell lung cancer lines and mediate Ca2+ mobilization and clonal growth. PubMed ID: 8221657

Localization of the human cholecystokinin-B/gastrin receptor gene (CCKBR) to chromosome 11p15.5--&gt;p15.4 by fluorescence in situ hybridization. PubMed ID: 8222757

Intermolecular interactions between cholecystokinin-8 and the third extracellular loop of the cholecystokinin-2 receptor. PubMed ID: 11926817

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811