SPHK1 | ENSG00000176170 | NCBI 8877

Details for: SPHK1

Gene ID: 8877

Symbol: SPHK1

Ensembl ID: ENSG00000176170

Description: sphingosine kinase 1

Associated with

Antiviral mechanism by ifn-stimulated genes
(R-HSA-1169410)
Association of tric/cct with target proteins during biosynthesis
(R-HSA-390471)
Chaperonin-mediated protein folding
(R-HSA-390466)
Cytokine signaling in immune system
(R-HSA-1280215)
Esr-mediated signaling
(R-HSA-8939211)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
Immune system
(R-HSA-168256)
Interferon signaling
(R-HSA-913531)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Metabolism of proteins
(R-HSA-392499)
Pkr-mediated signaling
(R-HSA-9833482)
Protein folding
(R-HSA-391251)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by vegf
(R-HSA-194138)
Signal transduction
(R-HSA-162582)
Sphingolipid de novo biosynthesis
(R-HSA-1660661)
Sphingolipid metabolism
(R-HSA-428157)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Vegfr2 mediated cell proliferation
(R-HSA-5218921)
Acetyltransferase activity
(GO:0016407)
Atp binding
(GO:0005524)
Blood vessel development
(GO:0001568)
Brain development
(GO:0007420)
Calcium-mediated signaling
(GO:0019722)
Calmodulin binding
(GO:0005516)
Cell population proliferation
(GO:0008283)
Cellular response to growth factor stimulus
(GO:0071363)
Cellular response to hydrogen peroxide
(GO:0070301)
Cellular response to vascular endothelial growth factor stimulus
(GO:0035924)
Clathrin-coated pit
(GO:0005905)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
D-erythro-sphingosine kinase activity
(GO:0017050)
Dna binding
(GO:0003677)
Dna biosynthetic process
(GO:0071897)
Early endosome membrane
(GO:0031901)
Endocytic vesicle
(GO:0030139)
Inflammatory response
(GO:0006954)
Intracellular membrane-bounded organelle
(GO:0043231)
Intracellular signal transduction
(GO:0035556)
Lipid binding
(GO:0008289)
Magnesium ion binding
(GO:0000287)
Membrane
(GO:0016020)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of ceramide biosynthetic process
(GO:1900060)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Phosphorylation
(GO:0016310)
Plasma membrane
(GO:0005886)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of cell growth
(GO:0030307)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of interleukin-17 production
(GO:0032740)
Positive regulation of mitotic cell cycle
(GO:0045931)
Positive regulation of mitotic nuclear division
(GO:0045840)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of non-canonical nf-kappab signal transduction
(GO:1901224)
Positive regulation of p38mapk cascade
(GO:1900745)
Positive regulation of peptidyl-threonine phosphorylation
(GO:0010800)
Positive regulation of protein ubiquitination
(GO:0031398)
Positive regulation of smooth muscle contraction
(GO:0045987)
Presynapse
(GO:0098793)
Protein acetylation
(GO:0006473)
Protein binding
(GO:0005515)
Protein phosphatase 2a binding
(GO:0051721)
Regulation of endocytosis
(GO:0030100)
Regulation of endosomal vesicle fusion
(GO:1905364)
Regulation of interleukin-1 beta production
(GO:0032651)
Regulation of microglial cell activation
(GO:1903978)
Regulation of neuroinflammatory response
(GO:0150077)
Regulation of phagocytosis
(GO:0050764)
Regulation of tumor necrosis factor-mediated signaling pathway
(GO:0010803)
Response to tumor necrosis factor
(GO:0034612)
Sphinganine kinase activity
(GO:0008481)
Sphingoid catabolic process
(GO:0046521)
Sphingolipid biosynthetic process
(GO:0030148)
Sphingosine-1-phosphate receptor activity
(GO:0038036)
Sphingosine-1-phosphate receptor signaling pathway
(GO:0003376)
Sphingosine biosynthetic process
(GO:0046512)
Sphingosine metabolic process
(GO:0006670)

Other Information

Proteins

Acetyltransferase SPHK1

Genular Protein ID: 4010330774

Symbol: SPHK1_HUMAN

Name: Acetyltransferase SPHK1

UniProtKB Accession Codes:

Q9NYA1 Q8N632 Q96GK1 Q9HD92 Q9NY70 Q9NYL3

Database IDs:

Citations:

PubMed ID: 10863092

Title: Human sphingosine kinase: molecular cloning, functional characterization and tissue distribution.

PubMed ID: 10863092

DOI: 10.1016/s0378-1119(00)00205-5

PubMed ID: 10802064

Title: Functional characterization of human sphingosine kinase-1.

PubMed ID: 10802064

DOI: 10.1016/s0014-5793(00)01510-6

PubMed ID: 10947957

Title: Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes.

PubMed ID: 10947957

DOI: 10.1042/bj3500429

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11923095

Title: 1-O-Hexadecyl-2-desoxy-2-amino-sn-glycerol, a substrate for human sphingosine kinase.

PubMed ID: 11923095

DOI: 10.1016/s1388-1981(01)00166-4

PubMed ID: 12080051

Title: Cloning and characterization of a protein kinase A anchoring protein (AKAP)-related protein that interacts with and regulates sphingosine kinase 1 activity.

PubMed ID: 12080051

DOI: 10.1074/jbc.m202841200

PubMed ID: 14575709

Title: Identification of functional nuclear export sequences in human sphingosine kinase 1.

PubMed ID: 14575709

DOI: 10.1016/j.bbrc.2003.09.194

PubMed ID: 16118219

Title: SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism.

PubMed ID: 16118219

DOI: 10.1074/jbc.m502207200

PubMed ID: 18263879

Title: Eukaryotic elongation factor 1A interacts with sphingosine kinase and directly enhances its catalytic activity.

PubMed ID: 18263879

DOI: 10.1074/jbc.m708782200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19854831

Title: Translocation of sphingosine kinase 1 to the plasma membrane is mediated by calcium- and integrin-binding protein 1.

PubMed ID: 19854831

DOI: 10.1074/jbc.m109.068395

PubMed ID: 20577214

Title: Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2.

PubMed ID: 20577214

DOI: 10.1038/nature09128

PubMed ID: 23935096

Title: Sphingosine kinase 1 regulates tumor necrosis factor-mediated RANTES induction through p38 mitogen-activated protein kinase but independently of nuclear factor kappaB activation.

PubMed ID: 23935096

DOI: 10.1074/jbc.m113.489443

PubMed ID: 24929359

Title: Coupling between endocytosis and sphingosine kinase 1 recruitment.

PubMed ID: 24929359

DOI: 10.1038/ncb2987

PubMed ID: 25417698

Title: Pathological roles of the VEGF/SphK pathway in Niemann-Pick type C neurons.

PubMed ID: 25417698

DOI: 10.1038/ncomms6514

PubMed ID: 28049734

Title: Sphingosine and Sphingosine Kinase 1 Involvement in Endocytic Membrane Trafficking.

PubMed ID: 28049734

DOI: 10.1074/jbc.m116.762377

PubMed ID: 29662056

Title: Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease.

PubMed ID: 29662056

DOI: 10.1038/s41467-018-03674-2

PubMed ID: 23602659

Title: Molecular basis of sphingosine kinase 1 substrate recognition and catalysis.

PubMed ID: 23602659

DOI: 10.1016/j.str.2013.02.025

Sequence Information:

Length: 384
Mass: 42518
Checksum: EB04A7F2034C2DB0
Sequence:

MDPAGGPRGV LPRPCRVLVL LNPRGGKGKA LQLFRSHVQP LLAEAEISFT LMLTERRNHA 
RELVRSEELG RWDALVVMSG DGLMHEVVNG LMERPDWETA IQKPLCSLPA GSGNALAASL 
NHYAGYEQVT NEDLLTNCTL LLCRRLLSPM NLLSLHTASG LRLFSVLSLA WGFIADVDLE 
SEKYRRLGEM RFTLGTFLRL AALRTYRGRL AYLPVGRVGS KTPASPVVVQ QGPVDAHLVP 
LEEPVPSHWT VVPDEDFVLV LALLHSHLGS EMFAAPMGRC AAGVMHLFYV RAGVSRAMLL 
RLFLAMEKGR HMEYECPYLV YVPVVAFRLE PKDGKGVFAV DGELMVSEAV QGQVHPNYFW 
MVSGCVEPPP SWKPQQMPPP EEPL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SPHK1

Associated with

Other Information

Human sphingosine kinase: molecular cloning, functional characterization and tissue distribution. PubMed ID: 10863092

Functional characterization of human sphingosine kinase-1. PubMed ID: 10802064

Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes. PubMed ID: 10947957

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. PubMed ID: 16625196

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

1-O-Hexadecyl-2-desoxy-2-amino-sn-glycerol, a substrate for human sphingosine kinase. PubMed ID: 11923095

Cloning and characterization of a protein kinase A anchoring protein (AKAP)-related protein that interacts with and regulates sphingosine kinase 1 activity. PubMed ID: 12080051

Identification of functional nuclear export sequences in human sphingosine kinase 1. PubMed ID: 14575709

SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism. PubMed ID: 16118219

Eukaryotic elongation factor 1A interacts with sphingosine kinase and directly enhances its catalytic activity. PubMed ID: 18263879

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Translocation of sphingosine kinase 1 to the plasma membrane is mediated by calcium- and integrin-binding protein 1. PubMed ID: 19854831

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2. PubMed ID: 20577214

Sphingosine kinase 1 regulates tumor necrosis factor-mediated RANTES induction through p38 mitogen-activated protein kinase but independently of nuclear factor kappaB activation. PubMed ID: 23935096

Coupling between endocytosis and sphingosine kinase 1 recruitment. PubMed ID: 24929359

Pathological roles of the VEGF/SphK pathway in Niemann-Pick type C neurons. PubMed ID: 25417698

Sphingosine and Sphingosine Kinase 1 Involvement in Endocytic Membrane Trafficking. PubMed ID: 28049734

Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease. PubMed ID: 29662056

Molecular basis of sphingosine kinase 1 substrate recognition and catalysis. PubMed ID: 23602659