Details for: SQSTM1
Associated with
Other Information
Genular Protein ID: 3275693537
Symbol: SQSTM_HUMAN
Name: Sequestosome-1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8551575
Title: A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes.
PubMed ID: 8551575
PubMed ID: 8650207
Title: Molecular cloning of a phosphotyrosine-independent ligand of the p56lck SH2 domain.
PubMed ID: 8650207
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15372022
Title: The DNA sequence and comparative analysis of human chromosome 5.
PubMed ID: 15372022
DOI: 10.1038/nature02919
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9762895
Title: Genomic structure and promoter analysis of the p62 gene encoding a non-proteasomal multiubiquitin chain binding protein.
PubMed ID: 9762895
PubMed ID: 10362795
Title: Analysis of intracytoplasmic hyaline bodies in a hepatocellular carcinoma. Demonstration of p62 as major constituent.
PubMed ID: 10362795
PubMed ID: 8618896
Title: Phosphotyrosine-independent binding of a 62-kDa protein to the src homology 2 (SH2) domain of p56lck and its regulation by phosphorylation of Ser-59 in the lck unique N-terminal region.
PubMed ID: 8618896
PubMed ID: 8702753
Title: p62, a phosphotyrosine-independent ligand of the SH2 domain of p56lck, belongs to a new class of ubiquitin-binding proteins.
PubMed ID: 8702753
PubMed ID: 8910285
Title: A p56(lck) ligand serves as a coactivator of an orphan nuclear hormone receptor.
PubMed ID: 8910285
PubMed ID: 9566925
Title: Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62.
PubMed ID: 9566925
PubMed ID: 10356400
Title: The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation.
PubMed ID: 10356400
PubMed ID: 10708586
PubMed ID: 10747026
Title: The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway.
PubMed ID: 10747026
PubMed ID: 11244088
Title: The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor.
PubMed ID: 11244088
PubMed ID: 11786419
Title: p62 Is a common component of cytoplasmic inclusions in protein aggregation diseases.
PubMed ID: 11786419
PubMed ID: 11755531
Title: p62 forms a ternary complex with PKCzeta and PAR-4 and antagonizes PAR-4-induced PKCzeta inhibition.
PubMed ID: 11755531
PubMed ID: 11981755
Title: Mallory body -- a disease-associated type of sequestosome.
PubMed ID: 11981755
PubMed ID: 12471037
Title: Association of the atypical protein kinase C-interacting protein p62/ZIP with nerve growth factor receptor TrkA regulates receptor trafficking and Erk5 signaling.
PubMed ID: 12471037
PubMed ID: 12813044
Title: Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins.
PubMed ID: 12813044
PubMed ID: 12887891
Title: PB1 domain-mediated heterodimerization in NADPH oxidase and signaling complexes of atypical protein kinase C with Par6 and p62.
PubMed ID: 12887891
PubMed ID: 12700667
Title: p62 overexpression in breast tumors and regulation by prostate-derived Ets factor in breast cancer cells.
PubMed ID: 12700667
PubMed ID: 15158159
Title: Transcriptional activation of p62/A170/ZIP during the formation of the aggregates: possible mechanisms and the role in Lewy body formation in Parkinson's disease.
PubMed ID: 15158159
PubMed ID: 15340068
Title: Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation.
PubMed ID: 15340068
PubMed ID: 16079148
Title: The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination.
PubMed ID: 16079148
PubMed ID: 16286508
Title: p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death.
PubMed ID: 16286508
PubMed ID: 15953362
Title: Sequestosome 1/p62 shuttles polyubiquitinated tau for proteasomal degradation.
PubMed ID: 15953362
PubMed ID: 15870274
Title: The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex.
PubMed ID: 15870274
PubMed ID: 15911346
Title: Inhibition of sequestosome 1/p62 up-regulation prevents aggregation of ubiquitinated proteins induced by prostaglandin J2 without reducing its neurotoxicity.
PubMed ID: 15911346
PubMed ID: 15592455
Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
PubMed ID: 15592455
DOI: 10.1038/nbt1046
PubMed ID: 15802564
Title: The kinase domain of titin controls muscle gene expression and protein turnover.
PubMed ID: 15802564
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 17580304
Title: p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy.
PubMed ID: 17580304
PubMed ID: 24331465
Title: The globally disseminated M1T1 clone of group A Streptococcus evades autophagy for intracellular replication.
PubMed ID: 24331465
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20168092
Title: p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy.
PubMed ID: 20168092
PubMed ID: 20495340
Title: Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy.
PubMed ID: 20495340
PubMed ID: 20452972
Title: p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription.
PubMed ID: 20452972
PubMed ID: 21149568
Title: Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance.
PubMed ID: 21149568
PubMed ID: 20357094
Title: p62/sequestosome-1 associates with and sustains the expression of retroviral restriction factor TRIM5alpha.
PubMed ID: 20357094
DOI: 10.1128/jvi.02412-09
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 22084127
Title: SQSTM1 mutations in familial and sporadic amyotrophic lateral sclerosis.
PubMed ID: 22084127
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21923101
Title: Independent interactions of ubiquitin-binding domains in a ubiquitin-mediated ternary complex.
PubMed ID: 21923101
DOI: 10.1021/bi201137e
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22622177
Title: The deubiquitinating enzyme USP36 controls selective autophagy activation by ubiquitinated proteins.
PubMed ID: 22622177
DOI: 10.4161/auto.19381
PubMed ID: 22178386
Title: TRIM13 regulates ER stress induced autophagy and clonogenic ability of the cells.
PubMed ID: 22178386
PubMed ID: 22421968
Title: TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death.
PubMed ID: 22421968
DOI: 10.1038/cdd.2012.30
PubMed ID: 22792322
Title: The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome.
PubMed ID: 22792322
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 24128730
Title: TRAF6 mediates ubiquitination of KIF23/MKLP1 and is required for midbody ring degradation by selective autophagy.
PubMed ID: 24128730
DOI: 10.4161/auto.26085
PubMed ID: 23274085
Title: Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage.
PubMed ID: 23274085
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24042580
Title: SQSTM1 mutations in French patients with frontotemporal dementia or frontotemporal dementia with amyotrophic lateral sclerosis.
PubMed ID: 24042580
PubMed ID: 23908376
PubMed ID: 24089205
Title: Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites.
PubMed ID: 24089205
DOI: 10.1038/nature12606
PubMed ID: 25101860
Title: Regulation of C1-Ten protein tyrosine phosphatase by p62/SQSTM1-mediated sequestration and degradation.
PubMed ID: 25101860
PubMed ID: 25127057
Title: TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition.
PubMed ID: 25127057
PubMed ID: 25040165
Title: Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1.
PubMed ID: 25040165
DOI: 10.1111/febs.12905
PubMed ID: 24668264
Title: Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures.
PubMed ID: 24668264
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25422469
Title: Disruption of FAT10-MAD2 binding inhibits tumor progression.
PubMed ID: 25422469
PubMed ID: 20851865
Title: SQSTM1-NUP214: a new gene fusion in adult T-cell acute lymphoblastic leukemia.
PubMed ID: 20851865
PubMed ID: 25114083
Title: A phenotype of atypical apraxia of speech in a family carrying SQSTM1 mutation.
PubMed ID: 25114083
DOI: 10.3233/jad-141512
PubMed ID: 26344566
Title: ATM functions at the peroxisome to induce pexophagy in response to ROS.
PubMed ID: 26344566
DOI: 10.1038/ncb3230
PubMed ID: 26208961
Title: SQSTM1 splice site mutation in distal myopathy with rimmed vacuoles.
PubMed ID: 26208961
PubMed ID: 27545679
Title: Absence of the autophagy adaptor SQSTM1/p62 causes childhood-onset neurodegeneration with ataxia, dystonia, and gaze palsy.
PubMed ID: 27545679
PubMed ID: 27368102
Title: An ER-associated pathway defines endosomal architecture for controlled cargo transport.
PubMed ID: 27368102
PubMed ID: 27498865
Title: TRIM11 suppresses AIM2 inflammasome by degrading AIM2 via p62-dependent selective autophagy.
PubMed ID: 27498865
PubMed ID: 27880896
Title: RNF166 Determines Recruitment of Adaptor Proteins during Antibacterial Autophagy.
PubMed ID: 27880896
PubMed ID: 28380357
Title: Keap1/cullin3 modulates p62/SQSTM1 activity via UBA domain ubiquitination.
PubMed ID: 28380357
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 30143514
Title: TRIM16 controls assembly and degradation of protein aggregates by modulating the p62-NRF2 axis and autophagy.
PubMed ID: 30143514
PubMed ID: 29288164
Title: LRRC25 inhibits type I IFN signaling by targeting ISG15-associated RIG-I for autophagic degradation.
PubMed ID: 29288164
PubMed ID: 28404643
Title: The BEACH-containing protein WDR81 coordinates p62 and LC3C to promote aggrephagy.
PubMed ID: 28404643
PubMed ID: 28871090
Title: TRIM23 mediates virus-induced autophagy via activation of TBK1.
PubMed ID: 28871090
PubMed ID: 29496741
Title: Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1.
PubMed ID: 29496741
PubMed ID: 31281713
Title: p62 Negatively Regulates TLR4 Signaling via Functional Regulation of the TRAF6-ECSIT Complex.
PubMed ID: 31281713
PubMed ID: 32185393
Title: CYLD is a causative gene for frontotemporal dementia - amyotrophic lateral sclerosis.
PubMed ID: 32185393
PubMed ID: 33393215
Title: MOAP-1-mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling.
PubMed ID: 33393215
PubMed ID: 33472082
Title: The ER-embedded UBE2J1/RNF26 ubiquitylation complex exerts spatiotemporal control over the endolysosomal pathway.
PubMed ID: 33472082
PubMed ID: 33509017
Title: The Epstein-Barr virus deubiquitinase BPLF1 targets SQSTM1/p62 to inhibit selective autophagy.
PubMed ID: 33509017
PubMed ID: 34471133
Title: Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and autophagy initiation.
PubMed ID: 34471133
PubMed ID: 12857745
Title: Structure of the ubiquitin-associated domain of p62 (SQSTM1) and implications for mutations that cause Paget's disease of bone.
PubMed ID: 12857745
PubMed ID: 18083707
Title: Ubiquitin recognition by the ubiquitin-associated domain of p62 involves a novel conformational switch.
PubMed ID: 18083707
PubMed ID: 17932931
Title: Conformation and dynamics of the three-helix bundle UBA domain of p62 from experiment and simulation.
PubMed ID: 17932931
DOI: 10.1002/prot.21692
PubMed ID: 19931284
Title: Dimerisation of the UBA domain of p62 inhibits ubiquitin binding and regulates NF-kappaB signalling.
PubMed ID: 19931284
PubMed ID: 11992264
Title: Recurrent mutation of the gene encoding sequestosome 1 (SQSTM1/p62) in Paget disease of bone.
PubMed ID: 11992264
DOI: 10.1086/340731
PubMed ID: 12374763
Title: Domain-specific mutations in sequestosome 1 (SQSTM1) cause familial and sporadic Paget's disease.
PubMed ID: 12374763
PubMed ID: 14584883
Title: Three novel mutations in SQSTM1 identified in familial Paget's disease of bone.
PubMed ID: 14584883
PubMed ID: 15146436
Title: Familial Paget's disease in The Netherlands: occurrence, identification of new mutations in the sequestosome 1 gene, and their clinical associations.
PubMed ID: 15146436
DOI: 10.1002/art.20224
PubMed ID: 15207768
Title: Identification of SQSTM1 mutations in familial Paget's disease in Australian pedigrees.
PubMed ID: 15207768
PubMed ID: 15125799
Title: Two novel mutations at exon 8 of the Sequestosome 1 (SQSTM1) gene in an Italian series of patients affected by Paget's disease of bone (PDB).
PubMed ID: 15125799
DOI: 10.1359/jbmr.040203
PubMed ID: 15176995
Title: Novel UBA domain mutations of SQSTM1 in Paget's disease of bone: genotype phenotype correlation, functional analysis, and structural consequences.
PubMed ID: 15176995
DOI: 10.1359/jbmr.0403015
PubMed ID: 17488105
Title: Detection and validation of non-synonymous coding SNPs from orthogonal analysis of shotgun proteomics data.
PubMed ID: 17488105
DOI: 10.1021/pr0700908
Sequence Information:
- Length: 440
- Mass: 47687
- Checksum: 462D94C171F337CD
- Sequence:
MASLTVKAYL LGKEDAAREI RRFSFCCSPE PEAEAEAAAG PGPCERLLSR VAALFPALRP GGFQAHYRDE DGDLVAFSSD EELTMAMSYV KDDIFRIYIK EKKECRRDHR PPCAQEAPRN MVHPNVICDG CNGPVVGTRY KCSVCPDYDL CSVCEGKGLH RGHTKLAFPS PFGHLSEGFS HSRWLRKVKH GHFGWPGWEM GPPGNWSPRP PRAGEARPGP TAESASGPSE DPSVNFLKNV GESVAAALSP LGIEVDIDVE HGGKRSRLTP VSPESSSTEE KSSSQPSSCC SDPSKPGGNV EGATQSLAEQ MRKIALESEG RPEEQMESDN CSGGDDDWTH LSSKEVDPST GELQSLQMPE SEGPSSLDPS QEGPTGLKEA ALYPHLPPEA DPRLIESLSQ MLSMGFSDEG GWLTRLLQTK NYDIGAALDT IQYSKHPPPL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.