Details for: MCM3AP
Gene ID: 8888
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: MCM3AP
Ensembl ID: ENSG00000160294
Description: minichromosome maintenance complex component 3 associated protein
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 13.63rCSI 12.68%PRS 39.61
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CSI 10.34rCSI 7.22%PRS 41.47
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CSI 8.59rCSI 13.57%PRS 40.73
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CSI 6.27rCSI 9.46%PRS 41.35
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CSI 5.32rCSI 6.68%PRS 48.89
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CSI 4.93rCSI 30.8%PRS 33.22
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CSI 4.75rCSI 5.49%PRS 30.84
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CSI 4.57rCSI 10.2%PRS 45.76
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CSI 4.37rCSI 17.62%PRS 38.52
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CSI 3.34rCSI 10.44%PRS 29
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CSI 3.1rCSI 2.61%PRS 56.49
-
CSI 2.93rCSI 2.57%PRS 30.09
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CSI 2.81rCSI 6.31%PRS 26.46
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CSI 2.8rCSI 2.75%PRS 54.53
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CSI 2.76rCSI 1.92%PRS 47.58
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CSI 2.74rCSI 4.21%PRS 46.16
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CSI 2.58rCSI 2.26%PRS 49.17
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CSI 2.57rCSI 3.12%PRS 46.96
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CSI 2.55rCSI 2.73%PRS 37.68
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CSI 2.52rCSI 5.93%PRS 49.26
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CSI 2.51rCSI 4.33%PRS 31.43
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CSI 2.45rCSI 2.56%PRS 39.6
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CSI 2.37rCSI 1.8%PRS 50.29
-
CSI 2.32rCSI 17.07%PRS 29.01
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CSI 2.29rCSI 1.35%PRS 53.6
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CSI 2.26rCSI 5.9%PRS 38.96
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CSI 2.25rCSI 5.05%PRS 60.21
-
CSI 2.16rCSI 5.15%PRS 42.39
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CSI 2.15rCSI 8.07%PRS 33.92
-
CSI 2.15rCSI 1.54%PRS 51.9
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CSI 2.13rCSI 1.68%PRS 28.76
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CSI 2.13rCSI 3.25%PRS 36.91
-
CSI 2.12rCSI 2.69%PRS 44.66
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CSI 2.11rCSI 1.71%PRS 40.26
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CSI 2.11rCSI 2.2%PRS 40.34
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CSI 2.1rCSI 4.81%PRS 39.27
-
CSI 2.08rCSI 9.98%PRS 38.13
-
CSI 2.08rCSI 1.85%PRS 38.99
-
CSI 2.07rCSI 3.39%PRS 31.55
-
CSI 2.03rCSI 4.63%PRS 34.2
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CSI 2.02rCSI 2.41%PRS 25.84
-
CSI 2rCSI 3.58%PRS 38.28
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CSI 2rCSI 2.4%PRS 38
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CSI 1.97rCSI 1.33%PRS 49.16
-
CSI 1.96rCSI 1.46%PRS 34.17
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CSI 1.96rCSI 5.07%PRS 36.43
-
CSI 1.9rCSI 3.56%PRS 30.74
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CSI 1.9rCSI 3.81%PRS 30.79
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CSI 1.88rCSI 2.2%PRS 54.47
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CSI 1.88rCSI 1.31%PRS 52.03
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CSI 1.86rCSI 2.49%PRS 47.7
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CSI 1.83rCSI 4.35%PRS 45.45
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CSI 1.82rCSI 1.72%PRS 40.93
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CSI 1.71rCSI 5.75%PRS 29.72
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CSI 1.7rCSI 4.16%PRS 36.52
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CSI 1.69rCSI 3.51%PRS 38.13
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CSI 1.68rCSI 3.83%PRS 38.76
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CSI 1.67rCSI 1.5%PRS 36.57
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CSI 1.64rCSI 1.68%PRS 58.24
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CSI 1.63rCSI 2.65%PRS 38.62
-
CSI 1.61rCSI 1.92%PRS 59.56
-
CSI 1.61rCSI 3.26%PRS 24.27
-
CSI 1.57rCSI 3.63%PRS 32.73
-
CSI 1.55rCSI 1.21%PRS 39.93
-
CSI 1.54rCSI 4.94%PRS 36.98
-
CSI 1.53rCSI 36.74%PRS 25.34
-
CSI 1.53rCSI 2.69%PRS 32.88
-
CSI 1.53rCSI 2.7%PRS 38.68
-
CSI 1.49rCSI 1.24%PRS 38.3
-
CSI 1.49rCSI 1.12%PRS 42.77
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CSI 1.48rCSI 35.73%PRS 26.2
-
CSI 1.47rCSI 2.16%PRS 56.79
-
CSI 1.46rCSI 1.88%PRS 26.77
-
CSI 1.46rCSI 2.06%PRS 37.18
-
CSI 1.44rCSI 2.05%PRS 42.51
-
CSI 1.42rCSI 4.45%PRS 26.95
-
CSI 1.41rCSI 4.02%PRS 39.97
-
CSI 1.39rCSI 3.08%PRS 37.1
-
CSI 1.37rCSI 2.18%PRS 33.78
-
CSI 1.37rCSI 1.7%PRS 24.5
-
CSI 1.3rCSI 1.88%PRS 49.72
-
CSI 1.27rCSI 1.88%PRS 44.33
-
CSI 1.26rCSI 3.01%PRS 50.85
-
CSI 1.25rCSI 1.27%PRS 51.94
-
CSI 1.21rCSI 0.94%PRS 55.72
-
CSI 1.15rCSI 1.43%PRS 35.86
-
CSI 1.12rCSI 0.97%PRS 43.54
-
CSI 1.09rCSI 2.41%PRS 29.54
-
CSI 1.09rCSI 1.76%PRS 27.89
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CSI 1.09rCSI 2.69%PRS 37.93
-
CSI 1.08rCSI 1.84%PRS 60.49
-
CSI 1.07rCSI 2.13%PRS 39.57
-
CSI 1.06rCSI 1.25%PRS 43.53
-
CSI 1.02rCSI 2.7%PRS 46.71
-
CSI 1.01rCSI 1.01%PRS 34.48
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CSI 0.99rCSI 0.76%PRS 38.35
-
CSI 0.98rCSI 1.13%PRS 50.46
-
CSI 0.95rCSI 1.59%PRS 25.89
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CSI 0.92rCSI 2.24%PRS 25.1
-
CSI 0.89rCSI 1.57%PRS 24.96
-
CSI 0.1rCSI 0.7%PRS 50.1%
-
CSI 0.3rCSI 2.3%PRS 28.3%
-
CSI 0.3rCSI 5.0%PRS 43.2%
-
CSI 0.3rCSI 1.0%PRS 32.3%
-
CSI 0.4rCSI 1.0%PRS 31.4%
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CSI 0.4rCSI 2.4%PRS 27.1%
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CSI 0.5rCSI 2.9%PRS 27.6%
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CSI 0.5rCSI 2.1%PRS 26.8%
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CSI 0.6rCSI 2.1%PRS 34.5%
-
CSI 0.6rCSI 2.1%PRS 24.8%
-
CSI 0.6rCSI 1.6%PRS 33.7%
-
CSI 0.7rCSI 2.9%PRS 34.5%
-
CSI 0.8rCSI 2.2%PRS 56.4%
-
CSI 0.8rCSI 1.2%PRS 32.2%
-
CSI 0.9rCSI 1.6%PRS 25.0%
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CSI 0.9rCSI 2.2%PRS 25.1%
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CSI 1.0rCSI 1.6%PRS 25.9%
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CSI 1.0rCSI 1.1%PRS 50.5%
-
CSI 1.0rCSI 0.8%PRS 38.4%
-
CSI 1.0rCSI 1.0%PRS 34.5%
-
CSI 1.0rCSI 2.7%PRS 46.7%
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CSI 1.1rCSI 1.3%PRS 43.5%
-
CSI 1.1rCSI 2.1%PRS 39.6%
-
CSI 1.1rCSI 1.8%PRS 60.5%
-
CSI 1.1rCSI 2.7%PRS 37.9%
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CSI 1.1rCSI 1.8%PRS 27.9%
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CSI 1.1rCSI 2.4%PRS 29.5%
-
CSI 1.1rCSI 1.0%PRS 43.5%
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CSI 1.2rCSI 1.4%PRS 35.9%
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CSI 1.2rCSI 0.9%PRS 55.7%
-
CSI 1.3rCSI 1.3%PRS 51.9%
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CSI 1.3rCSI 3.0%PRS 50.9%
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CSI 1.3rCSI 1.9%PRS 44.3%
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CSI 1.3rCSI 1.9%PRS 49.7%
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CSI 1.4rCSI 1.7%PRS 24.5%
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CSI 1.4rCSI 2.2%PRS 33.8%
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CSI 1.4rCSI 3.1%PRS 37.1%
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CSI 1.4rCSI 4.0%PRS 40.0%
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CSI 1.4rCSI 4.5%PRS 27.0%
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CSI 1.4rCSI 2.1%PRS 42.5%
-
CSI 1.5rCSI 2.1%PRS 37.2%
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CSI 1.5rCSI 1.9%PRS 26.8%
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CSI 1.5rCSI 2.2%PRS 56.8%
-
CSI 1.5rCSI 35.7%PRS 26.2%
-
CSI 1.5rCSI 1.1%PRS 42.8%
-
CSI 1.5rCSI 1.2%PRS 38.3%
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CSI 1.5rCSI 2.7%PRS 38.7%
-
CSI 1.5rCSI 2.7%PRS 32.9%
-
CSI 1.5rCSI 36.7%PRS 25.3%
-
CSI 1.5rCSI 4.9%PRS 37.0%
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CSI 1.6rCSI 1.2%PRS 39.9%
-
CSI 1.6rCSI 3.6%PRS 32.7%
-
CSI 1.6rCSI 3.3%PRS 24.3%
-
CSI 1.6rCSI 1.9%PRS 59.6%
-
CSI 1.6rCSI 2.7%PRS 38.6%
-
CSI 1.6rCSI 1.7%PRS 58.2%
-
CSI 1.7rCSI 1.5%PRS 36.6%
-
CSI 1.7rCSI 3.8%PRS 38.8%
-
CSI 1.7rCSI 3.5%PRS 38.1%
-
CSI 1.7rCSI 4.2%PRS 36.5%
-
CSI 1.7rCSI 5.8%PRS 29.7%
-
CSI 1.8rCSI 1.7%PRS 40.9%
-
CSI 1.8rCSI 4.4%PRS 45.5%
-
CSI 1.9rCSI 2.5%PRS 47.7%
-
CSI 1.9rCSI 1.3%PRS 52.0%
-
CSI 1.9rCSI 2.2%PRS 54.5%
-
CSI 1.9rCSI 3.8%PRS 30.8%
-
CSI 1.9rCSI 3.6%PRS 30.7%
-
CSI 2.0rCSI 5.1%PRS 36.4%
-
CSI 2.0rCSI 1.5%PRS 34.2%
-
CSI 2.0rCSI 1.3%PRS 49.2%
-
CSI 2.0rCSI 2.4%PRS 38.0%
-
CSI 2.0rCSI 3.6%PRS 38.3%
-
CSI 2.0rCSI 2.4%PRS 25.8%
-
CSI 2.0rCSI 4.6%PRS 34.2%
-
CSI 2.1rCSI 3.4%PRS 31.6%
-
CSI 2.1rCSI 1.9%PRS 39.0%
-
CSI 2.1rCSI 10.0%PRS 38.1%
-
CSI 2.1rCSI 4.8%PRS 39.3%
-
CSI 2.1rCSI 2.2%PRS 40.3%
-
CSI 2.1rCSI 1.7%PRS 40.3%
-
CSI 2.1rCSI 2.7%PRS 44.7%
-
CSI 2.1rCSI 3.3%PRS 36.9%
-
CSI 2.1rCSI 1.7%PRS 28.8%
-
CSI 2.2rCSI 1.5%PRS 51.9%
-
CSI 2.2rCSI 8.1%PRS 33.9%
-
CSI 2.2rCSI 5.2%PRS 42.4%
-
CSI 2.3rCSI 5.1%PRS 60.2%
-
CSI 2.3rCSI 5.9%PRS 39.0%
-
CSI 2.3rCSI 1.4%PRS 53.6%
-
CSI 2.3rCSI 17.1%PRS 29.0%
-
CSI 2.4rCSI 1.8%PRS 50.3%
-
CSI 2.5rCSI 2.6%PRS 39.6%
-
CSI 2.5rCSI 4.3%PRS 31.4%
-
CSI 2.5rCSI 5.9%PRS 49.3%
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CSI 2.6rCSI 2.7%PRS 37.7%
-
CSI 2.6rCSI 3.1%PRS 47.0%
-
CSI 2.6rCSI 2.3%PRS 49.2%
-
CSI 2.7rCSI 4.2%PRS 46.2%
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CSI 2.8rCSI 1.9%PRS 47.6%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3148048654
Symbol: GANP_HUMAN
Name: Germinal-center associated nuclear protein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11024281
Title: Structure, expression, and chromosomal localization of the human gene encoding a germinal center-associated nuclear protein (GANP) that associates with MCM3 involved in the initiation of DNA replication.
PubMed ID: 11024281
PubMed ID: 10830953
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9628581
Title: Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
PubMed ID: 9628581
PubMed ID: 9712829
Title: Identification of a novel MCM3-associated protein that facilitates MCM3 nuclear localization.
PubMed ID: 9712829
PubMed ID: 11258703
Title: MCM3AP, a novel acetyltransferase that acetylates replication protein MCM3.
PubMed ID: 11258703
PubMed ID: 12226073
Title: The MCM3 acetylase MCM3AP inhibits initiation, but not elongation, of DNA replication via interaction with MCM3.
PubMed ID: 12226073
PubMed ID: 16914116
Title: Functional interaction between the glucocorticoid receptor and GANP/MCM3AP.
PubMed ID: 16914116
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20005110
Title: mRNA export from mammalian cell nuclei is dependent on GANP.
PubMed ID: 20005110
PubMed ID: 20384790
Title: Germinal center-associated nuclear protein (GANP) is involved in mRNA export of Shugoshin-1 required for centromere cohesion and in sister-chromatid exchange.
PubMed ID: 20384790
PubMed ID: 20507984
Title: GANP-mediated recruitment of activation-induced cytidine deaminase to cell nuclei and to immunoglobulin variable region DNA.
PubMed ID: 20507984
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21195085
Title: MCM3AP is transcribed from a promoter within an intron of the overlapping gene for GANP.
PubMed ID: 21195085
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23591820
Title: The human TREX-2 complex is stably associated with the nuclear pore basket.
PubMed ID: 23591820
DOI: 10.1242/jcs.118000
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23652018
Title: GANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and nucleosome occupancy.
PubMed ID: 23652018
DOI: 10.1038/ncomms2823
PubMed ID: 22307388
Title: Functional and structural characterization of the mammalian TREX-2 complex that links transcription with nuclear messenger RNA export.
PubMed ID: 22307388
DOI: 10.1093/nar/gks059
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
PubMed ID: 24123876
Title: Identification of pathogenic gene variants in small families with intellectually disabled siblings by exome sequencing.
PubMed ID: 24123876
PubMed ID: 28633435
Title: MCM3AP in recessive Charcot-Marie-Tooth neuropathy and mild intellectual disability.
PubMed ID: 28633435
DOI: 10.1093/brain/awx138
PubMed ID: 28969388
Title: Biallelic MCM3AP mutations cause Charcot-Marie-Tooth neuropathy with variable clinical presentation.
PubMed ID: 28969388
DOI: 10.1093/brain/awx222
PubMed ID: 29982295
Title: A novel MCM3AP mutation in a Lebanese family with recessive Charcot-Marie-Tooth neuropathy.
PubMed ID: 29982295
DOI: 10.1093/brain/awy184
Sequence Information:
- Length: 1980
- Mass: 218405
- Checksum: 503D192686FC38A8
- Sequence:
MNPTNPFSGQ QPSAFSASSS NVGTLPSKPP FRFGQPSLFG QNSTLSGKSS GFSQVSSFPA SSGVSHSSSV QTLGFTQTSS VGPFSGLEHT STFVATSGPS SSSVLGNTGF SFKSPTSVGA FPSTSAFGQE AGEIVNSGFG KTEFSFKPLE NAVFKPILGA ESEPEKTQSQ IASGFFTFSH PISSAPGGLA PFSFPQVTSS SATTSNFTFS KPVSSNNSLS AFTPALSNQN VEEEKRGPKS IFGSSNNSFS SFPVSSAVLG EPFQASKAGV RQGCEEAVSQ VEPLPSLMKG LKRKEDQDRS PRRHGHEPAE DSDPLSRGDH PPDKRPVRLN RPRGGTLFGR TIQDVFKSNK EVGRLGNKEA KKETGFVESA ESDHMAIPGG NQSVLAPSRI PGVNKEEETE SREKKEDSLR GTPARQSNRS ESTDSLGGLS PSEVTAIQCK NIPDYLNDRT ILENHFGKIA KVQRIFTRRS KKLAVVHFFD HASAALARKK GKSLHKDMAI FWHRKKISPN KKPFSLKEKK PGDGEVSPST EDAPFQHSPL GKAAGRTGAS SLLNKSSPVK KPSLLKAHQF EGDSFDSASE GSEGLGPCVL SLSTLIGTVA ETSKEKYRLL DQRDRIMRQA RVKRTDLDKA RTFVGTCLDM CPEKERYMRE TRSQLSVFEV VPGTDQVDHA AAVKEYSRSS ADQEEPLPHE LRPLPVLSRT MDYLVTQIMD QKEGSLRDWY DFVWNRTRGI RKDITQQHLC DPLTVSLIEK CTRFHIHCAH FMCEEPMSSF DAKINNENMT KCLQSLKEMY QDLRNKGVFC ASEAEFQGYN VLLSLNKGDI LREVQQFHPA VRNSSEVKFA VQAFAALNSN NFVRFFKLVQ SASYLNACLL HCYFSQIRKD ALRALNFAYT VSTQRSTIFP LDGVVRMLLF RDCEEATDFL TCHGLTVSDG CVELNRSAFL EPEGLSKTRK SVFITRKLTV SVGEIVNGGP LPPVPRHTPV CSFNSQNKYI GESLAAELPV STQRPGSDTV GGGRGEECGV EPDAPLSSLP QSLPAPAPSP VPLPPVLALT PSVAPSLFQL SVQPEPPPPE PVPMYSDEDL AQVVDELIQE ALQRDCEEVG SAGAAYAAAA LGVSNAAMED LLTAATTGIL RHIAAEEVSK ERERREQERQ RAEEERLKQE RELVLSELSQ GLAVELMERV MMEFVRETCS QELKNAVETD QRVRVARCCE DVCAHLVDLF LVEEIFQTAK ETLQELQCFC KYLQRWREAV TARKKLRRQM RAFPAAPCCV DVSDRLRALA PSAECPIAEE NLARGLLDLG HAGRLGISCT RLRRLRNKTA HQMKVQHFYQ QLLSDVAWAS LDLPSLVAEH LPGRQEHVFW KLVLVLPDVE EQSPESCGRI LANWLKVKFM GDEGSVDDTS SDAGGIQTLS LFNSLSSKGD QMISVNVCIK VAHGALSDGA IDAVETQKDL LGASGLMLLL PPKMKSEDMA EEDVYWLSAL LQLKQLLQAK PFQPALPLVV LVPSPGGDAV EKEVEDGLML QDLVSAKLIS DYTVTEIPDT INDLQGSTKV LQAVQWLVSH CPHSLDLCCQ TLIQYVEDGI GHEFSGRFFH DRRERRLGGL ASQEPGAIIE LFNSVLQFLA SVVSSEQLCD LSWPVTEFAE AGGSRLLPHL HWNAPEHLAW LKQAVLGFQL PQMDLPPLGA PWLPVCSMVV QYASQIPSSR QTQPVLQSQV ENLLHRTYCR WKSKSPSPVH GAGPSVMEIP WDDLIALCIN HKLRDWTPPR LPVTSEALSE DGQICVYFFK NDLKKYDVPL SWEQARLQTQ KELQLREGRL AIKPFHPSAN NFPIPLLHMH RNWKRSTECA QEGRIPSTED LMRGASAEEL LAQCLSSSLL LEKEENKRFE DQLQQWLSED SGAFTDLTSL PLYLPQTLVS LSHTIEPVMK TSVTTSPQSD MMREQLQLSE ATGTCLGERL KHLERLIRSS REEEVASELH LSALLDMVDI