Details for: KRIT1
Associated with
Other Information
Genular Protein ID: 2603428829
Symbol: KRIT1_HUMAN
Name: Krev interaction trapped protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9285558
Title: Association of Krev-1/rap1a with Krit1, a novel ankyrin repeat-containing protein encoded by a gene mapping to 7q21-22.
PubMed ID: 9285558
PubMed ID: 11161791
Title: Cloning of the murine Krit1 cDNA reveals novel mammalian 5' coding exons.
PubMed ID: 11161791
PubMed ID: 11161805
Title: Computational and experimental analyses reveal previously undetected coding exons of the KRIT1 (CCM1) gene.
PubMed ID: 11161805
PubMed ID: 12172908
Title: Mutation and expression analysis of the KRIT1 gene associated with cerebral cavernous malformations (CCM1).
PubMed ID: 12172908
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 12853948
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11342228
Title: Identification of eight novel 5`-exons in cerebral capillary malformation gene-1 (CCM1) encoding KRIT1.
PubMed ID: 11342228
PubMed ID: 11741838
Title: Interaction between krit1 and icap1alpha infers perturbation of integrin beta1-mediated angiogenesis in the pathogenesis of cerebral cavernous malformation.
PubMed ID: 11741838
PubMed ID: 11854171
Title: KRIT1 association with the integrin-binding protein ICAP-1: a new direction in the elucidation of cerebral cavernous malformations (CCM1) pathogenesis.
PubMed ID: 11854171
DOI: 10.1093/hmg/11.4.389
PubMed ID: 17916086
Title: Krit 1 interactions with microtubules and membranes are regulated by Rap1 and integrin cytoplasmic domain associated protein-1.
PubMed ID: 17916086
PubMed ID: 20332120
Title: CCM1 regulates vascular-lumen organization by inducing endothelial polarity.
PubMed ID: 20332120
DOI: 10.1242/jcs.059329
PubMed ID: 20668652
Title: KRIT1 regulates the homeostasis of intracellular reactive oxygen species.
PubMed ID: 20668652
PubMed ID: 20616044
Title: Cerebral cavernous malformation protein CCM1 inhibits sprouting angiogenesis by activating DELTA-NOTCH signaling.
PubMed ID: 20616044
PubMed ID: 21633110
Title: A mechanism of Rap1-induced stabilization of endothelial cell--cell junctions.
PubMed ID: 21633110
PubMed ID: 26417067
Title: Defective autophagy is a key feature of cerebral cavernous malformations.
PubMed ID: 26417067
PubMed ID: 22577140
Title: Structural basis for small G protein effector interaction of Ras-related protein 1 (Rap1) and adaptor protein Krev interaction trapped 1 (KRIT1).
PubMed ID: 22577140
PubMed ID: 23007647
Title: Structural basis of the junctional anchorage of the cerebral cavernous malformations complex.
PubMed ID: 23007647
PubMed ID: 23317506
Title: Mechanism for KRIT1 release of ICAP1-mediated suppression of integrin activation.
PubMed ID: 23317506
PubMed ID: 26458359
Title: Structural analysis of the KRIT1 ankyrin repeat and FERM domains reveals a conformationally stable ARD-FERM interface.
PubMed ID: 26458359
Sequence Information:
- Length: 736
- Mass: 84348
- Checksum: D11F75ED629E85AC
- Sequence:
MGNPENIEDA YVAVIRPKNT ASLNSREYRA KSYEILLHEV PIEGQKKKRK KVLLETKLQG NSEITQGILD YVVETTKPIS PANQGIRGKR VVLMKKFPLD GEKMGREASL FIVPSVVKDN TKYTYTPGCP IFYCLQDIMR VCSESSTHFA TLTARMLIAL DKWLDERHAQ SHFIPALFRP SPLERIKTNV INPAYATESG QTENSLHMGY SALEIKSKML ALEKADTCIY NPLFGSDLQY TNRVDKVVIN PYFGLGAPDY SKIQIPKQEK WQRSMSSVTE DKERQWVDDF PLHRSACEGD SELLSRLLSE RFSVNQLDSD HWAPIHYACW YGKVEATRIL LEKGKCNPNL LNGQLSSPLH FAAGGGHAEI VQILLNHPET DRHITDQQGR SPLNICEENK QNNWEEAAKL LKEAINKPYE KVRIYRMDGS YRSVELKHGN NTTVQQIMEG MRLSQETQQY FTIWICSENL SLQLKPYHKP LQHVRDWPEI LAELTNLDPQ RETPQLFLRR DVRLPLEVEK QIEDPLAILI LFDEARYNLL KGFYTAPDAK LITLASLLLQ IVYGNYESKK HKQGFLNEEN LKSIVPVTKL KSKAPHWTNR ILHEYKNLST SEGVSKEMHH LQRMFLQNCW EIPTYGAAFF TGQIFTKASP SNHKVIPVYV GVNIKGLHLL NMETKALLIS LKYGCFMWQL GDTDTCFQIH SMENKMSFIV HTKQAGLVVK LLMKLNGQLM PTERNS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.