Details for: KRIT1

Gene ID: 889

Symbol: KRIT1

Ensembl ID: ENSG00000001631

Description: KRIT1 ankyrin repeat containing

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 234.8192
    Cell Significance Index: -36.5300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 146.6626
    Cell Significance Index: -37.2000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 83.7918
    Cell Significance Index: -39.5600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 81.6724
    Cell Significance Index: -33.1800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 75.2938
    Cell Significance Index: -38.7300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 34.9204
    Cell Significance Index: -33.3400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 32.4870
    Cell Significance Index: -40.0600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.2523
    Cell Significance Index: -38.1800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.6080
    Cell Significance Index: -38.7300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.0299
    Cell Significance Index: -24.1400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.3648
    Cell Significance Index: -40.9000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 8.6667
    Cell Significance Index: 142.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.5204
    Cell Significance Index: 725.2100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.1942
    Cell Significance Index: 356.8700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7714
    Cell Significance Index: 355.3400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.7418
    Cell Significance Index: 29.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.5105
    Cell Significance Index: 299.7700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.4439
    Cell Significance Index: 28.1800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2831
    Cell Significance Index: 139.5700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.2788
    Cell Significance Index: 458.6900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.2640
    Cell Significance Index: 70.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.0551
    Cell Significance Index: 80.9700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0049
    Cell Significance Index: 60.3300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.9159
    Cell Significance Index: 11.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.8844
    Cell Significance Index: 54.3600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.8004
    Cell Significance Index: 19.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7816
    Cell Significance Index: 107.3300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7811
    Cell Significance Index: 21.8300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.7321
    Cell Significance Index: 18.3000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.6412
    Cell Significance Index: 24.2800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.6408
    Cell Significance Index: 28.3500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5980
    Cell Significance Index: 73.5300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5621
    Cell Significance Index: 101.3300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5617
    Cell Significance Index: 29.2600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4859
    Cell Significance Index: 14.0000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4183
    Cell Significance Index: 377.7000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4124
    Cell Significance Index: 225.2400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4027
    Cell Significance Index: 178.0300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3413
    Cell Significance Index: 23.6000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3364
    Cell Significance Index: 15.2500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2600
    Cell Significance Index: 33.3400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2495
    Cell Significance Index: 6.6900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2057
    Cell Significance Index: 20.3500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1711
    Cell Significance Index: 2.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1679
    Cell Significance Index: 7.8300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.1525
    Cell Significance Index: 2.1900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1319
    Cell Significance Index: 25.1100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1298
    Cell Significance Index: 9.1800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1286
    Cell Significance Index: 15.1600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1280
    Cell Significance Index: 6.7200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1250
    Cell Significance Index: 8.0700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1009
    Cell Significance Index: 2.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0877
    Cell Significance Index: 3.0800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0804
    Cell Significance Index: 3.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0432
    Cell Significance Index: 7.3800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0278
    Cell Significance Index: 0.4100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0086
    Cell Significance Index: 0.2300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0064
    Cell Significance Index: 4.7000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0039
    Cell Significance Index: 2.8900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0120
    Cell Significance Index: -7.5200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0152
    Cell Significance Index: -28.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0156
    Cell Significance Index: -29.2900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0186
    Cell Significance Index: -28.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0201
    Cell Significance Index: -15.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0285
    Cell Significance Index: -38.8000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0337
    Cell Significance Index: -18.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0462
    Cell Significance Index: -2.4000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0515
    Cell Significance Index: -1.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0525
    Cell Significance Index: -33.3700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0589
    Cell Significance Index: -6.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0780
    Cell Significance Index: -35.4000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0795
    Cell Significance Index: -2.0900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0861
    Cell Significance Index: -18.1500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0902
    Cell Significance Index: -1.9200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0988
    Cell Significance Index: -2.6900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1046
    Cell Significance Index: -1.7500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1265
    Cell Significance Index: -4.4000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1295
    Cell Significance Index: -16.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1354
    Cell Significance Index: -15.7900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1640
    Cell Significance Index: -3.7900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1641
    Cell Significance Index: -18.8000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2015
    Cell Significance Index: -12.7000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2376
    Cell Significance Index: -34.5400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2460
    Cell Significance Index: -28.0800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2499
    Cell Significance Index: -3.4100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2654
    Cell Significance Index: -19.7800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2799
    Cell Significance Index: -6.8300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2921
    Cell Significance Index: -4.9200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3612
    Cell Significance Index: -11.5700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3778
    Cell Significance Index: -29.9200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3933
    Cell Significance Index: -40.9500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4376
    Cell Significance Index: -12.5500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4394
    Cell Significance Index: -26.9400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4860
    Cell Significance Index: -6.9900
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.5053
    Cell Significance Index: -4.4900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.5088
    Cell Significance Index: -7.5100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5343
    Cell Significance Index: -11.3400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.5349
    Cell Significance Index: -6.6700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.5623
    Cell Significance Index: -3.8100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5636
    Cell Significance Index: -17.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Ankyrin Repeat Domain**: KRIT1 contains an ankyrin repeat domain, which is crucial for its interactions with other proteins and regulation of cellular processes. 2. **Negative Regulation of Angiogenesis**: KRIT1 acts as a negative regulator of angiogenesis, a process essential for tumor growth and metastasis. Its suppression of angiogenesis prevents excessive tissue growth and maintains tissue homeostasis. 3. **Cell-Cell Junctions**: KRIT1 is involved in regulating cell-cell junctions, which are essential for maintaining tissue integrity and preventing excessive cell migration. 4. **Cytoskeleton Dynamics**: KRIT1 regulates cytoskeleton dynamics, which is critical for cell migration, proliferation, and differentiation. **Pathways and Functions:** 1. **Angiogenesis**: KRIT1 negatively regulates angiogenesis by inhibiting the activation of pro-angiogenic signaling pathways. 2. **Cell-Cell Junctions**: KRIT1 regulates cell-cell junctions by interacting with proteins involved in adhesion and signaling. 3. **Cytoskeleton Dynamics**: KRIT1 regulates cytoskeleton dynamics by interacting with microtubules and other cytoskeletal components. 4. **Protein Binding**: KRIT1 interacts with various proteins, including GTPases, phosphatidylinositol-4,5-bisphosphate, and integrins, to regulate cellular processes. **Clinical Significance:** KRIT1's role in regulating angiogenesis and cell-cell junctions makes it an attractive target for the treatment of various diseases, including cancer, cardiovascular disease, and neurological disorders. Aberrant expression of KRIT1 has been observed in several cancers, including glioblastoma and breast cancer, suggesting its potential as a diagnostic biomarker and therapeutic target. Additionally, KRIT1's involvement in neuronal function and development highlights its potential as a therapeutic target for neurological disorders, such as Alzheimer's disease and Parkinson's disease. **Implications:** Further research is necessary to fully elucidate the mechanisms by which KRIT1 regulates cellular processes and its role in various diseases. However, its identification as a negatively regulated protein with potential therapeutic applications underscores the importance of KRIT1 in maintaining tissue homeostasis and preventing disease.

Genular Protein ID: 2603428829

Symbol: KRIT1_HUMAN

Name: Krev interaction trapped protein 1

UniProtKB Accession Codes:

O00522 A6NNU0 O43894 Q506L6 Q6U276 Q75N19 Q9H180 Q9H264 Q9HAX5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 12 Ensembl 19 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 4 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 14 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 28 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9285558

Title: Association of Krev-1/rap1a with Krit1, a novel ankyrin repeat-containing protein encoded by a gene mapping to 7q21-22.

PubMed ID: 9285558

DOI: 10.1038/sj.onc.1201268

PubMed ID: 11161791

Title: Cloning of the murine Krit1 cDNA reveals novel mammalian 5' coding exons.

PubMed ID: 11161791

DOI: 10.1006/geno.2000.6410

PubMed ID: 11161805

Title: Computational and experimental analyses reveal previously undetected coding exons of the KRIT1 (CCM1) gene.

PubMed ID: 11161805

DOI: 10.1006/geno.2000.6426

PubMed ID: 12172908

Title: Mutation and expression analysis of the KRIT1 gene associated with cerebral cavernous malformations (CCM1).

PubMed ID: 12172908

DOI: 10.1007/s00401-002-0552-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11342228

Title: Identification of eight novel 5`-exons in cerebral capillary malformation gene-1 (CCM1) encoding KRIT1.

PubMed ID: 11342228

DOI: 10.1016/s0167-4781(00)00303-1

PubMed ID: 11741838

Title: Interaction between krit1 and icap1alpha infers perturbation of integrin beta1-mediated angiogenesis in the pathogenesis of cerebral cavernous malformation.

PubMed ID: 11741838

DOI: 10.1093/hmg/10.25.2953

PubMed ID: 11854171

Title: KRIT1 association with the integrin-binding protein ICAP-1: a new direction in the elucidation of cerebral cavernous malformations (CCM1) pathogenesis.

PubMed ID: 11854171

DOI: 10.1093/hmg/11.4.389

PubMed ID: 17916086

Title: Krit 1 interactions with microtubules and membranes are regulated by Rap1 and integrin cytoplasmic domain associated protein-1.

PubMed ID: 17916086

DOI: 10.1111/j.1742-4658.2007.06068.x

PubMed ID: 20332120

Title: CCM1 regulates vascular-lumen organization by inducing endothelial polarity.

PubMed ID: 20332120

DOI: 10.1242/jcs.059329

PubMed ID: 20668652

Title: KRIT1 regulates the homeostasis of intracellular reactive oxygen species.

PubMed ID: 20668652

DOI: 10.1371/journal.pone.0011786

PubMed ID: 20616044

Title: Cerebral cavernous malformation protein CCM1 inhibits sprouting angiogenesis by activating DELTA-NOTCH signaling.

PubMed ID: 20616044

DOI: 10.1073/pnas.1000132107

PubMed ID: 21633110

Title: A mechanism of Rap1-induced stabilization of endothelial cell--cell junctions.

PubMed ID: 21633110

DOI: 10.1091/mbc.e11-02-0157

PubMed ID: 26417067

Title: Defective autophagy is a key feature of cerebral cavernous malformations.

PubMed ID: 26417067

DOI: 10.15252/emmm.201505316

PubMed ID: 22577140

Title: Structural basis for small G protein effector interaction of Ras-related protein 1 (Rap1) and adaptor protein Krev interaction trapped 1 (KRIT1).

PubMed ID: 22577140

DOI: 10.1074/jbc.m112.361295

PubMed ID: 23007647

Title: Structural basis of the junctional anchorage of the cerebral cavernous malformations complex.

PubMed ID: 23007647

DOI: 10.1083/jcb.201205109

PubMed ID: 23317506

Title: Mechanism for KRIT1 release of ICAP1-mediated suppression of integrin activation.

PubMed ID: 23317506

DOI: 10.1016/j.molcel.2012.12.005

PubMed ID: 26458359

Title: Structural analysis of the KRIT1 ankyrin repeat and FERM domains reveals a conformationally stable ARD-FERM interface.

PubMed ID: 26458359

DOI: 10.1016/j.jsb.2015.10.006

Sequence Information:

  • Length: 736
  • Mass: 84348
  • Checksum: D11F75ED629E85AC
  • Sequence:
    • MGNPENIEDA YVAVIRPKNT ASLNSREYRA KSYEILLHEV PIEGQKKKRK KVLLETKLQG 
NSEITQGILD YVVETTKPIS PANQGIRGKR VVLMKKFPLD GEKMGREASL FIVPSVVKDN 
TKYTYTPGCP IFYCLQDIMR VCSESSTHFA TLTARMLIAL DKWLDERHAQ SHFIPALFRP 
SPLERIKTNV INPAYATESG QTENSLHMGY SALEIKSKML ALEKADTCIY NPLFGSDLQY 
TNRVDKVVIN PYFGLGAPDY SKIQIPKQEK WQRSMSSVTE DKERQWVDDF PLHRSACEGD 
SELLSRLLSE RFSVNQLDSD HWAPIHYACW YGKVEATRIL LEKGKCNPNL LNGQLSSPLH 
FAAGGGHAEI VQILLNHPET DRHITDQQGR SPLNICEENK QNNWEEAAKL LKEAINKPYE 
KVRIYRMDGS YRSVELKHGN NTTVQQIMEG MRLSQETQQY FTIWICSENL SLQLKPYHKP 
LQHVRDWPEI LAELTNLDPQ RETPQLFLRR DVRLPLEVEK QIEDPLAILI LFDEARYNLL 
KGFYTAPDAK LITLASLLLQ IVYGNYESKK HKQGFLNEEN LKSIVPVTKL KSKAPHWTNR 
ILHEYKNLST SEGVSKEMHH LQRMFLQNCW EIPTYGAAFF TGQIFTKASP SNHKVIPVYV 
GVNIKGLHLL NMETKALLIS LKYGCFMWQL GDTDTCFQIH SMENKMSFIV HTKQAGLVVK 
LLMKLNGQLM PTERNS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.