EIF2B5 | ENSG00000145191 | NCBI 8893

Details for: EIF2B5

Gene ID: 8893

Symbol: EIF2B5

Ensembl ID: ENSG00000145191

Description: eukaryotic translation initiation factor 2B subunit epsilon

Associated with

Cap-dependent translation initiation
(R-HSA-72737)
Eukaryotic translation initiation
(R-HSA-72613)
Metabolism of proteins
(R-HSA-392499)
Recycling of eif2:gdp
(R-HSA-72731)
Translation
(R-HSA-72766)
Astrocyte development
(GO:0014002)
Astrocyte differentiation
(GO:0048708)
Cytoplasm
(GO:0005737)
Cytoplasmic translational initiation
(GO:0002183)
Cytosol
(GO:0005829)
Eukaryotic translation initiation factor 2b complex
(GO:0005851)
Guanyl-nucleotide exchange factor activity
(GO:0005085)
Hippocampus development
(GO:0021766)
Myelination
(GO:0042552)
Nucleus
(GO:0005634)
Oligodendrocyte development
(GO:0014003)
Ovarian follicle development
(GO:0001541)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of translational initiation
(GO:0045948)
Protein binding
(GO:0005515)
Response to endoplasmic reticulum stress
(GO:0034976)
Response to glucose
(GO:0009749)
Response to heat
(GO:0009408)
Response to peptide hormone
(GO:0043434)
T cell receptor signaling pathway
(GO:0050852)
Translational initiation
(GO:0006413)
Translation initiation factor activity
(GO:0003743)
Translation initiation factor binding
(GO:0031369)

Other Information

Proteins

Translation initiation factor eIF2B subunit epsilon

Genular Protein ID: 2036258265

Symbol: EI2BE_HUMAN

Name: Translation initiation factor eIF2B subunit epsilon

UniProtKB Accession Codes:

Q13144 Q541Z1 Q96D04

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8688466

Title: Cloning and characterization of cDNAs encoding the epsilon-subunit of eukaryotic initiation factor-2B from rabbit and human.

PubMed ID: 8688466

DOI: 10.1016/0167-4781(96)00054-1

PubMed ID: 8397507

Title: Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B.

PubMed ID: 8397507

DOI: 10.1042/bj2940625

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19736320

Title: Translational control by RGS2.

PubMed ID: 19736320

DOI: 10.1083/jcb.200811058

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25858979

Title: Stress responses. Mutations in a translation initiation factor identify the target of a memory-enhancing compound.

PubMed ID: 25858979

DOI: 10.1126/science.aaa6986

PubMed ID: 27023709

Title: Expression, purification, and crystallization of Schizosaccharomyces pombe eIF2B.

PubMed ID: 27023709

DOI: 10.1007/s10969-016-9203-3

PubMed ID: 31048492

Title: Structural basis for eIF2B inhibition in integrated stress response.

PubMed ID: 31048492

DOI: 10.1126/science.aaw4104

PubMed ID: 11704758

Title: Subunits of the translation initiation factor eIF2B are mutant in leukoencephalopathy with vanishing white matter.

PubMed ID: 11704758

DOI: 10.1038/ng764

PubMed ID: 12325082

Title: Cree leukoencephalopathy and CACH/VWM disease are allelic at the EIF2B5 locus.

PubMed ID: 12325082

DOI: 10.1002/ana.10339

PubMed ID: 12707859

Title: Ovarian failure related to eukaryotic initiation factor 2B mutations.

PubMed ID: 12707859

DOI: 10.1086/375404

PubMed ID: 15776425

Title: Identification of ten novel mutations in patients with eIF2B-related disorders.

PubMed ID: 15776425

DOI: 10.1002/humu.9325

PubMed ID: 19158808

Title: Identification of novel EIF2B mutations in Chinese patients with vanishing white matter disease.

PubMed ID: 19158808

DOI: 10.1038/jhg.2008.10

PubMed ID: 21484434

Title: Adult-onset leukoencephalopathies with vanishing white matter with novel missense mutations in EIF2B2, EIF2B3, and EIF2B5.

PubMed ID: 21484434

DOI: 10.1007/s10048-011-0284-7

Sequence Information:

Length: 721
Mass: 80380
Checksum: 08B39D3A5EE7D905
Sequence:

MAAPVVAPPG VVVSRANKRS GAGPGGSGGG GARGAEEEPP PPLQAVLVAD SFDRRFFPIS 
KDQPRVLLPL ANVALIDYTL EFLTATGVQE TFVFCCWKAA QIKEHLLKSK WCRPTSLNVV 
RIITSELYRS LGDVLRDVDA KALVRSDFLL VYGDVISNIN ITRALEEHRL RRKLEKNVSV 
MTMIFKESSP SHPTRCHEDN VVVAVDSTTN RVLHFQKTQG LRRFAFPLSL FQGSSDGVEV 
RYDLLDCHIS ICSPQVAQLF TDNFDYQTRD DFVRGLLVNE EILGNQIHMH VTAKEYGARV 
SNLHMYSAVC ADVIRRWVYP LTPEANFTDS TTQSCTHSRH NIYRGPEVSL GHGSILEENV 
LLGSGTVIGS NCFITNSVIG PGCHIGDNVV LDQTYLWQGV RVAAGAQIHQ SLLCDNAEVK 
ERVTLKPRSV LTSQVVVGPN ITLPEGSVIS LHPPDAEEDE DDGEFSDDSG ADQEKDKVKM 
KGYNPAEVGA AGKGYLWKAA GMNMEEEEEL QQNLWGLKIN MEEESESESE QSMDSEEPDS 
RGGSPQMDDI KVFQNEVLGT LQRGKEENIS CDNLVLEINS LKYAYNISLK EVMQVLSHVV 
LEFPLQQMDS PLDSSRYCAL LLPLLKAWSP VFRNYIKRAA DHLEALAAIE DFFLEHEALG 
ISMAKVLMAF YQLEILAEET ILSWFSQRDT TDKGQQLRKN QQLQRFIQWL KEAEEESSED 
D

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: EIF2B5

Associated with

Other Information

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cloning and characterization of cDNAs encoding the epsilon-subunit of eukaryotic initiation factor-2B from rabbit and human. PubMed ID: 8688466

Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B. PubMed ID: 8397507

Phosphoproteome of resting human platelets. PubMed ID: 18088087

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Translational control by RGS2. PubMed ID: 19736320

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Stress responses. Mutations in a translation initiation factor identify the target of a memory-enhancing compound. PubMed ID: 25858979

Expression, purification, and crystallization of Schizosaccharomyces pombe eIF2B. PubMed ID: 27023709

Structural basis for eIF2B inhibition in integrated stress response. PubMed ID: 31048492

Subunits of the translation initiation factor eIF2B are mutant in leukoencephalopathy with vanishing white matter. PubMed ID: 11704758

Cree leukoencephalopathy and CACH/VWM disease are allelic at the EIF2B5 locus. PubMed ID: 12325082

Ovarian failure related to eukaryotic initiation factor 2B mutations. PubMed ID: 12707859

Identification of ten novel mutations in patients with eIF2B-related disorders. PubMed ID: 15776425

Identification of novel EIF2B mutations in Chinese patients with vanishing white matter disease. PubMed ID: 19158808

Adult-onset leukoencephalopathies with vanishing white matter with novel missense mutations in EIF2B2, EIF2B3, and EIF2B5. PubMed ID: 21484434