Details for: MTMR3
Gene ID: 8897
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: MTMR3
Ensembl ID: ENSG00000100330
Description: myotubularin related protein 3
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 18.85rCSI 33.88%PRS 46.52
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CSI 15.89rCSI 26.67%PRS 36.13
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CSI 14.22rCSI 51.16%PRS 34.77
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CSI 12.45rCSI 33.05%PRS 66.22
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CSI 11.53rCSI 11.8%PRS 70
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CSI 10.33rCSI 20.51%PRS 51.41
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CSI 10.21rCSI 24.81%PRS 34.9
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CSI 9.42rCSI 21.47%PRS 50.68
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CSI 9.22rCSI 26.72%PRS 43.66
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CSI 8.88rCSI 14.12%PRS 45.78
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CSI 8.8rCSI 11.29%PRS 51.08
-
CSI 8.78rCSI 14%PRS 46.58
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CSI 8.71rCSI 12.09%PRS 52.56
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CSI 8.46rCSI 19.35%PRS 52.72
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CSI 7.61rCSI 11.59%PRS 49.78
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CSI 7.02rCSI 28.32%PRS 51.65
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CSI 6.72rCSI 7.76%PRS 47.17
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CSI 6.65rCSI 8.03%PRS 61.7
-
CSI 6.64rCSI 10.68%PRS 38.25
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CSI 6.43rCSI 4.62%PRS 67.31
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CSI 6.29rCSI 8.61%PRS 47.95
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CSI 6.04rCSI 4.7%PRS 71.25
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CSI 5.64rCSI 17.64%PRS 37.5
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CSI 5.33rCSI 7.8%PRS 56.97
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CSI 5.32rCSI 5.57%PRS 50.09
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CSI 5rCSI 18.89%PRS 36.9
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CSI 4.98rCSI 7.15%PRS 43.57
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CSI 4.96rCSI 28.05%PRS 38.84
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CSI 4.88rCSI 6.03%PRS 49.22
-
CSI 4.84rCSI 10.66%PRS 57.28
-
CSI 4.6rCSI 33.79%PRS 40.49
-
CSI 4.37rCSI 3.75%PRS 60.78
-
CSI 4.31rCSI 16.66%PRS 69.34
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CSI 4.1rCSI 7.67%PRS 42.19
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CSI 3.98rCSI 6.09%PRS 62.71
-
CSI 3.98rCSI 5.11%PRS 47.11
-
CSI 3.85rCSI 11.41%PRS 63.73
-
CSI 3.66rCSI 2.89%PRS 40.46
-
CSI 3.6rCSI 21.2%PRS 37.55
-
CSI 3.6rCSI 5.79%PRS 43.39
-
CSI 3.59rCSI 3.58%PRS 47.01
-
CSI 3.42rCSI 6.04%PRS 35.12
-
CSI 3.42rCSI 3.15%PRS 54.45
-
CSI 3.37rCSI 6.84%PRS 34.01
-
CSI 3.29rCSI 4.09%PRS 64.36
-
CSI 3.26rCSI 7.31%PRS 36.89
-
CSI 3.25rCSI 5.27%PRS 50.82
-
CSI 3.2rCSI 2.59%PRS 63.09
-
CSI 3.18rCSI 12.37%PRS 73.95
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CSI 3.16rCSI 5.21%PRS 58.77
-
CSI 3.15rCSI 2.55%PRS 54.54
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CSI 3.15rCSI 3.91%PRS 55.42
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CSI 3.14rCSI 5.51%PRS 45.36
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CSI 3.14rCSI 3.68%PRS 69.48
-
CSI 3.13rCSI 3.9%PRS 34.36
-
CSI 3.07rCSI 9.59%PRS 39.99
-
CSI 3.01rCSI 2.09%PRS 63.49
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CSI 2.99rCSI 17.24%PRS 53.54
-
CSI 2.82rCSI 7.45%PRS 61.67
-
CSI 2.8rCSI 5.82%PRS 50.57
-
CSI 2.8rCSI 4.12%PRS 47.53
-
CSI 2.8rCSI 4.42%PRS 54.74
-
CSI 2.77rCSI 2.72%PRS 55.87
-
CSI 2.76rCSI 2.04%PRS 46.04
-
CSI 2.75rCSI 2.12%PRS 52.85
-
CSI 2.74rCSI 10.26%PRS 45.56
-
CSI 2.7rCSI 9.06%PRS 39.69
-
CSI 2.7rCSI 64.55%PRS 35.51
-
CSI 2.7rCSI 2.89%PRS 51.81
-
CSI 2.67rCSI 4.62%PRS 43.49
-
CSI 2.64rCSI 63.77%PRS 36.48
-
CSI 2.61rCSI 6.79%PRS 57.55
-
CSI 2.6rCSI 5.94%PRS 45.69
-
CSI 2.57rCSI 5.93%PRS 43.38
-
CSI 2.55rCSI 2.64%PRS 59.05
-
CSI 2.54rCSI 6.06%PRS 54.63
-
CSI 2.51rCSI 1.69%PRS 65.51
-
CSI 2.5rCSI 8.14%PRS 54.48
-
CSI 2.48rCSI 2.6%PRS 56.6
-
CSI 2.46rCSI 9.61%PRS 29.79
-
CSI 2.45rCSI 3.79%PRS 61.81
-
CSI 2.37rCSI 2.47%PRS 53.66
-
CSI 2.36rCSI 3.87%PRS 43.08
-
CSI 2.32rCSI 6.64%PRS 68.3
-
CSI 2.27rCSI 2.92%PRS 37.18
-
CSI 2.25rCSI 11.54%PRS 57.37
-
CSI 2.24rCSI 1.97%PRS 63.54
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CSI 2.18rCSI 2.03%PRS 53.05
-
CSI 2.17rCSI 5.61%PRS 48.65
-
CSI 2.15rCSI 5.33%PRS 51.24
-
CSI 2.14rCSI 1.66%PRS 54.32
-
CSI 2.14rCSI 4.3%PRS 42.64
-
CSI 2.14rCSI 2.74%PRS 58.19
-
CSI 2.1rCSI 2.56%PRS 61.16
-
CSI 2.08rCSI 1.91%PRS 61.76
-
CSI 2.02rCSI 8.59%PRS 48.06
-
CSI 1.95rCSI 2.33%PRS 35.94
-
CSI 1.94rCSI 4.4%PRS 58.4
-
CSI 1.94rCSI 4.97%PRS 53.96
-
CSI 1.93rCSI 3.45%PRS 51.92
-
CSI 0.2rCSI 1.4%PRS 82.2%
-
CSI 0.2rCSI 4.7%PRS 46.0%
-
CSI 0.2rCSI 2.5%PRS 52.7%
-
CSI 0.3rCSI 5.0%PRS 44.7%
-
CSI 0.3rCSI 4.1%PRS 44.8%
-
CSI 0.3rCSI 1.5%PRS 65.6%
-
CSI 0.4rCSI 1.5%PRS 43.2%
-
CSI 0.5rCSI 1.8%PRS 45.1%
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CSI 0.5rCSI 4.1%PRS 50.1%
-
CSI 0.5rCSI 3.4%PRS 45.3%
-
CSI 0.6rCSI 1.3%PRS 41.4%
-
CSI 0.6rCSI 2.3%PRS 70.2%
-
CSI 0.6rCSI 2.8%PRS 51.8%
-
CSI 0.6rCSI 2.6%PRS 52.4%
-
CSI 0.6rCSI 4.0%PRS 49.9%
-
CSI 0.6rCSI 2.6%PRS 45.1%
-
CSI 0.6rCSI 5.3%PRS 40.3%
-
CSI 0.7rCSI 3.6%PRS 65.2%
-
CSI 0.7rCSI 3.7%PRS 60.0%
-
CSI 0.7rCSI 3.5%PRS 64.8%
-
CSI 0.7rCSI 2.0%PRS 61.4%
-
CSI 0.7rCSI 4.7%PRS 56.6%
-
CSI 0.8rCSI 2.5%PRS 41.1%
-
CSI 0.8rCSI 1.3%PRS 62.8%
-
CSI 0.8rCSI 3.4%PRS 38.0%
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CSI 0.8rCSI 2.6%PRS 52.1%
-
CSI 0.8rCSI 1.6%PRS 55.8%
-
CSI 0.9rCSI 2.4%PRS 51.3%
-
CSI 0.9rCSI 4.0%PRS 73.7%
-
CSI 0.9rCSI 5.7%PRS 51.0%
-
CSI 0.9rCSI 3.6%PRS 64.9%
-
CSI 0.9rCSI 6.8%PRS 47.6%
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CSI 1.0rCSI 2.1%PRS 60.6%
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CSI 1.0rCSI 2.1%PRS 62.1%
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CSI 1.0rCSI 2.9%PRS 72.7%
-
CSI 1.0rCSI 0.9%PRS 41.7%
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CSI 1.1rCSI 4.7%PRS 50.6%
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CSI 1.1rCSI 1.7%PRS 53.9%
-
CSI 1.1rCSI 1.8%PRS 51.3%
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CSI 1.2rCSI 1.9%PRS 64.4%
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CSI 1.3rCSI 1.8%PRS 63.1%
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CSI 1.3rCSI 1.8%PRS 69.6%
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CSI 1.3rCSI 1.0%PRS 57.9%
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CSI 1.3rCSI 2.3%PRS 61.7%
-
CSI 1.3rCSI 1.3%PRS 43.9%
-
CSI 1.4rCSI 3.9%PRS 51.8%
-
CSI 1.4rCSI 3.8%PRS 49.2%
-
CSI 1.4rCSI 3.0%PRS 66.9%
-
CSI 1.4rCSI 3.5%PRS 61.8%
-
CSI 1.4rCSI 3.5%PRS 43.0%
-
CSI 1.4rCSI 3.8%PRS 43.8%
-
CSI 1.4rCSI 3.8%PRS 45.0%
-
CSI 1.4rCSI 2.0%PRS 65.6%
-
CSI 1.4rCSI 1.3%PRS 67.8%
-
CSI 1.5rCSI 2.7%PRS 63.8%
-
CSI 1.5rCSI 1.6%PRS 57.0%
-
CSI 1.5rCSI 3.6%PRS 58.1%
-
CSI 1.5rCSI 3.7%PRS 47.7%
-
CSI 1.5rCSI 1.3%PRS 55.0%
-
CSI 1.5rCSI 2.1%PRS 54.4%
-
CSI 1.6rCSI 1.8%PRS 62.4%
-
CSI 1.6rCSI 3.2%PRS 45.2%
-
CSI 1.6rCSI 5.1%PRS 50.3%
-
CSI 1.6rCSI 2.3%PRS 58.7%
-
CSI 1.6rCSI 3.4%PRS 42.3%
-
CSI 1.6rCSI 3.5%PRS 40.4%
-
CSI 1.6rCSI 9.2%PRS 62.5%
-
CSI 1.7rCSI 3.0%PRS 46.0%
-
CSI 1.7rCSI 2.6%PRS 56.4%
-
CSI 1.7rCSI 15.1%PRS 40.5%
-
CSI 1.7rCSI 8.3%PRS 52.8%
-
CSI 1.7rCSI 2.5%PRS 49.7%
-
CSI 1.8rCSI 3.9%PRS 51.0%
-
CSI 1.8rCSI 8.5%PRS 52.6%
-
CSI 1.8rCSI 2.1%PRS 43.2%
-
CSI 1.8rCSI 1.7%PRS 53.5%
-
CSI 1.9rCSI 4.8%PRS 52.5%
-
CSI 1.9rCSI 3.3%PRS 50.8%
-
CSI 1.9rCSI 3.0%PRS 57.1%
-
CSI 1.9rCSI 2.9%PRS 57.9%
-
CSI 1.9rCSI 15.5%PRS 46.8%
-
CSI 1.9rCSI 3.5%PRS 51.9%
-
CSI 1.9rCSI 5.0%PRS 54.0%
-
CSI 1.9rCSI 4.4%PRS 58.4%
-
CSI 2.0rCSI 2.3%PRS 35.9%
-
CSI 2.0rCSI 8.6%PRS 48.1%
-
CSI 2.1rCSI 1.9%PRS 61.8%
-
CSI 2.1rCSI 2.6%PRS 61.2%
-
CSI 2.1rCSI 2.7%PRS 58.2%
-
CSI 2.1rCSI 4.3%PRS 42.6%
-
CSI 2.1rCSI 1.7%PRS 54.3%
-
CSI 2.2rCSI 5.3%PRS 51.2%
-
CSI 2.2rCSI 5.6%PRS 48.7%
-
CSI 2.2rCSI 2.0%PRS 53.1%
-
CSI 2.2rCSI 2.0%PRS 63.5%
-
CSI 2.3rCSI 11.5%PRS 57.4%
-
CSI 2.3rCSI 2.9%PRS 37.2%
-
CSI 2.3rCSI 6.6%PRS 68.3%
-
CSI 2.4rCSI 3.9%PRS 43.1%
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CSI 2.4rCSI 2.5%PRS 53.7%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1831685636
Symbol: MTMR3_HUMAN
Name: Zinc finger FYVE domain-containing protein 10
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10733931
Title: FYVE-DSP1, a dual-specificity protein phosphatase containing an FYVE domain.
PubMed ID: 10733931
PubMed ID: 9205841
Title: Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
PubMed ID: 9205841
PubMed ID: 15461802
Title: A genome annotation-driven approach to cloning the human ORFeome.
PubMed ID: 15461802
PubMed ID: 10591208
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9736772
Title: Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human.
PubMed ID: 9736772
PubMed ID: 8640223
Title: A gene mutated in X-linked myotubular myopathy defines a new putative tyrosine phosphatase family conserved in yeast.
PubMed ID: 8640223
DOI: 10.1038/ng0696-175
PubMed ID: 11302699
Title: FYVE-DSP2, a FYVE domain-containing dual specificity protein phosphatase that dephosphorylates phosphatidylinositol 3-phosphate.
PubMed ID: 11302699
PubMed ID: 11676921
Title: Characterization of MTMR3. an inositol lipid 3-phosphatase with novel substrate specificity.
PubMed ID: 11676921
PubMed ID: 12646134
Title: Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatases.
PubMed ID: 12646134
PubMed ID: 18220336
Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
PubMed ID: 18220336
DOI: 10.1021/pr0705441
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
PubMed ID: 32690950
Title: STEEP mediates STING ER exit and activation of signaling.
PubMed ID: 32690950
PubMed ID: 32929276
PubMed ID: 25659891
Title: Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission.
PubMed ID: 25659891
Sequence Information:
- Length: 1198
- Mass: 133619
- Checksum: FE6F4B165074D5F8
- Sequence:
MDEETRHSLE CIQANQIFPR KQLIREDENL QVPFLELHGE STEFVGRAED AIIALSNYRL HIKFKESLVN VPLQLIESVE CRDIFQLHLT CKDCKVIRCQ FSTFEQCQEW LKRLNNAIRP PAKIEDLFSF AYHAWCMEVY ASEKEQHGDL CRPGEHVTSR FKNEVERMGF DMNNAWRISN INEKYKLCGS YPQELIVPAW ITDKELESVS SFRSWKRIPA VIYRHQSNGA VIARCGQPEV SWWGWRNADD EHLVQSVAKA CASDSRSSGS KLSTRNTSRD FPNGGDLSDV EFDSSLSNAS GAESLAIQPQ KLLILDARSY AAAVANRAKG GGCECPEYYP NCEVVFMGMA NIHSIRRSFQ SLRLLCTQMP DPGNWLSALE STKWLHHLSV LLKSALLVVH AVDQDQRPVL VHCSDGWDRT PQIVALAKLL LDPYYRTIEG FQVLVEMEWL DFGHKFADRC GHGENSDDLN ERCPVFLQWL DCVHQLQRQF PCSFEFNEAF LVKLVQHTYS CLFGTFLCNN AKERGEKHTQ ERTCSVWSLL RAGNKAFKNL LYSSQSEAVL YPVCHVRNLM LWSAVYLPCP SPTTPVDDSC APYPAPGTSP DDPPLSRLPK TRSYDNLTTA CDNTVPLASR RCSDPSLNEK WQEHRRSLEL SSLAGPGEDP LSADSLGKPT RVPGGAELSV AAGVAEGQME NILQEATKEE SGVEEPAHRA GIEIQEGKED PLLEKESRRK TPEASAIGLH QDPELGDAAL RSHLDMSWPL FSQGISEQQS GLSVLLSSLQ VPPRGEDSLE VPVEQFRIEE IAEGREEAVL PIPVDAKVGY GTSQSCSLLP SQVPFETRGP NVDSSTDMLV EDKVKSVSGP QGHHRSCLVN SGKDRLPQTM EPSPSETSLV ERPQVGSVVH RTSLGSTLSL TRSPCALPLA ECKEGLVCNG APETENRASE QPPGLSTLQM YPTPNGHCAN GEAGRSKDSL SRQLSAMSCS SAHLHSRNLH HKWLHSHSGR PSATSSPDQP SRSHLDDDGM SVYTDTIQQR LRQIESGHQQ EVETLKKQVQ ELKSRLESQY LTSSLHFNGD FGDEVTSIPD SESNLDQNCL SRCSTEIFSE ASWEQVDKQD TEMTRWLPDH LAAHCYACDS AFWLASRKHH CRNCGNVFCS SCCNQKVPVP SQQLFEPSRV CKSCYSSLHP TSSSIDLELD KPIAATSN