CCNA2 | ENSG00000145386 | NCBI 890

Details for: CCNA2

Gene ID: 890

Symbol: CCNA2

Ensembl ID: ENSG00000145386

Description: cyclin A2

Associated with

Activation of apc/c and apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176814)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176409)
Apc:cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
(R-HSA-179419)
Cdc20:phospho-apc/c mediated degradation of cyclin a
(R-HSA-174184)
Cdk-mediated phosphorylation and removal of cdc6
(R-HSA-69017)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromosome maintenance
(R-HSA-73886)
Cyclin a/b1/b2 associated events during g2/m transition
(R-HSA-69273)
Cyclin a:cdk2-associated events at s phase entry
(R-HSA-69656)
Cyclin e associated events during g1/s transition
(R-HSA-69202)
Deubiquitination
(R-HSA-5688426)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Dna double-strand break repair
(R-HSA-5693532)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Extension of telomeres
(R-HSA-180786)
G0 and early g1
(R-HSA-1538133)
G1/s dna damage checkpoints
(R-HSA-69615)
G1/s transition
(R-HSA-69206)
G2 phase
(R-HSA-68911)
G2/m transition
(R-HSA-69275)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-HSA-5693567)
Homology directed repair
(R-HSA-5693538)
Metabolism of proteins
(R-HSA-392499)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Orc1 removal from chromatin
(R-HSA-68949)
P53-dependent g1 dna damage response
(R-HSA-69563)
P53-dependent g1/s dna damage checkpoint
(R-HSA-69580)
Phosphorylation of proteins involved in the g2/m transition by cyclin a:cdc2 complexes
(R-HSA-170145)
Processing of dna double-strand break ends
(R-HSA-5693607)
Regulation of apc/c activators between g1/s and early anaphase
(R-HSA-176408)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of tp53 activity
(R-HSA-5633007)
Regulation of tp53 activity through phosphorylation
(R-HSA-6804756)
Regulation of tp53 degradation
(R-HSA-6804757)
Regulation of tp53 expression and degradation
(R-HSA-6806003)
Rna polymerase ii transcription
(R-HSA-73857)
Scf(skp2)-mediated degradation of p27/p21
(R-HSA-187577)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
S phase
(R-HSA-69242)
Switching of origins to a post-replicative state
(R-HSA-69052)
Synthesis of dna
(R-HSA-69239)
Telomere extension by telomerase
(R-HSA-171319)
Telomere maintenance
(R-HSA-157579)
Tp53 regulates transcription of cell cycle genes
(R-HSA-6791312)
Tp53 regulates transcription of genes involved in g1 cell cycle arrest
(R-HSA-6804116)
Transcriptional regulation by tp53
(R-HSA-3700989)
Transcription of e2f targets under negative control by p107 (rbl1) and p130 (rbl2) in complex with hdac1
(R-HSA-1362300)
Ub-specific processing proteases
(R-HSA-5689880)
Animal organ regeneration
(GO:0031100)
Cell cycle g1/s phase transition
(GO:0044843)
Cell division
(GO:0051301)
Cellular response to cocaine
(GO:0071314)
Cellular response to estradiol stimulus
(GO:0071392)
Cellular response to hypoxia
(GO:0071456)
Cellular response to insulin-like growth factor stimulus
(GO:1990314)
Cellular response to leptin stimulus
(GO:0044320)
Cellular response to luteinizing hormone stimulus
(GO:0071373)
Cellular response to nitric oxide
(GO:0071732)
Cellular response to platelet-derived growth factor stimulus
(GO:0036120)
Cochlea development
(GO:0090102)
Cyclin-dependent protein kinase holoenzyme complex
(GO:0000307)
Cyclin-dependent protein serine/threonine kinase regulator activity
(GO:0016538)
Cyclin a2-cdk1 complex
(GO:0097122)
Cyclin a2-cdk2 complex
(GO:0097124)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna-templated transcription
(GO:0006351)
Female pronucleus
(GO:0001939)
G1/s transition of mitotic cell cycle
(GO:0000082)
G2/m transition of mitotic cell cycle
(GO:0000086)
Male pronucleus
(GO:0001940)
Microtubule organizing center
(GO:0005815)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of dna biosynthetic process
(GO:2000573)
Positive regulation of fibroblast proliferation
(GO:0048146)
Post-translational protein modification
(GO:0043687)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein kinase binding
(GO:0019901)
Ras protein signal transduction
(GO:0007265)
Regulation of dna replication
(GO:0006275)
Response to glucagon
(GO:0033762)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 34.4578
Cell Significance Index: -8.7400
Cell Name: basophilic erythroblast (CL0000549)
Fold Change: 24.8569
Cell Significance Index: 11.3200
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 22.4981
Cell Significance Index: -9.1400
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 10.3874
Cell Significance Index: 171.1700
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 9.5733
Cell Significance Index: -9.1400
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 6.1640
Cell Significance Index: -7.6000
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 2.2656
Cell Significance Index: -8.9400
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 1.6778
Cell Significance Index: 18.2400
Cell Name: colon endothelial cell (CL1001572)
Fold Change: 1.3495
Cell Significance Index: 1.0300
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.0293
Cell Significance Index: 121.3900
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.8936
Cell Significance Index: 145.3400
Cell Name: sensory neuron (CL0000101)
Fold Change: 0.8814
Cell Significance Index: 5.0100
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.7310
Cell Significance Index: 79.5200
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.7119
Cell Significance Index: 22.8000
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.6027
Cell Significance Index: 59.6300
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.5958
Cell Significance Index: 113.3900
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.5862
Cell Significance Index: 12.2700
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.5633
Cell Significance Index: 19.5800
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4253
Cell Significance Index: 384.0400
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.3922
Cell Significance Index: 45.7100
Cell Name: salivary gland cell (CL0009005)
Fold Change: 0.3302
Cell Significance Index: 4.1000
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2852
Cell Significance Index: 19.7200
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.2760
Cell Significance Index: 3.2900
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.2753
Cell Significance Index: 17.3500
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.2747
Cell Significance Index: 54.5100
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.2634
Cell Significance Index: 6.7300
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1708
Cell Significance Index: 8.8700
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1665
Cell Significance Index: 90.9400
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.1403
Cell Significance Index: 3.7600
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1390
Cell Significance Index: 96.1500
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.1256
Cell Significance Index: 7.0500
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.1252
Cell Significance Index: 25.1100
Cell Name: epidermal cell (CL0000362)
Fold Change: 0.1065
Cell Significance Index: 0.2400
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0966
Cell Significance Index: 2.7000
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0871
Cell Significance Index: 2.5100
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0812
Cell Significance Index: 2.0300
Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
Fold Change: 0.0781
Cell Significance Index: 0.7100
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.0760
Cell Significance Index: 4.5600
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0706
Cell Significance Index: 44.0700
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0522
Cell Significance Index: 23.0600
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0498
Cell Significance Index: 17.8700
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0471
Cell Significance Index: 1.0200
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0442
Cell Significance Index: 1.1800
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0272
Cell Significance Index: 0.5800
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0245
Cell Significance Index: 0.8600
Cell Name: germ cell (CL0000586)
Fold Change: 0.0172
Cell Significance Index: 0.1300
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0033
Cell Significance Index: 0.0500
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.0023
Cell Significance Index: 0.0500
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0022
Cell Significance Index: 0.1000
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0011
Cell Significance Index: -2.0000
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0012
Cell Significance Index: -0.1700
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0039
Cell Significance Index: -2.8900
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0041
Cell Significance Index: -7.6400
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: -0.0058
Cell Significance Index: -0.0500
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0059
Cell Significance Index: -9.1500
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0084
Cell Significance Index: -4.7400
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0089
Cell Significance Index: -12.1000
Cell Name: hepatoblast (CL0005026)
Fold Change: -0.0125
Cell Significance Index: -0.2100
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0125
Cell Significance Index: -9.4800
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0135
Cell Significance Index: -8.6000
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0141
Cell Significance Index: -10.3300
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.0150
Cell Significance Index: -0.1600
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0178
Cell Significance Index: -0.4800
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0196
Cell Significance Index: -8.9000
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0204
Cell Significance Index: -4.3000
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0207
Cell Significance Index: -2.6500
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0211
Cell Significance Index: -3.0600
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0239
Cell Significance Index: -4.0800
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0240
Cell Significance Index: -6.9100
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0340
Cell Significance Index: -1.7700
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0358
Cell Significance Index: -6.4500
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0365
Cell Significance Index: -3.7300
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0367
Cell Significance Index: -2.2500
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0369
Cell Significance Index: -4.5400
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.0498
Cell Significance Index: -0.7700
Cell Name: late promyelocyte (CL0002151)
Fold Change: -0.0573
Cell Significance Index: -0.3800
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0660
Cell Significance Index: -4.6700
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0672
Cell Significance Index: -7.6700
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0691
Cell Significance Index: -7.9200
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0800
Cell Significance Index: -10.3400
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0839
Cell Significance Index: -8.7400
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0874
Cell Significance Index: -5.3700
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1060
Cell Significance Index: -6.8400
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1061
Cell Significance Index: -8.1500
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1112
Cell Significance Index: -7.4800
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1236
Cell Significance Index: -2.5700
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.1342
Cell Significance Index: -3.9400
Cell Name: proerythroblast (CL0000547)
Fold Change: -0.1361
Cell Significance Index: -1.9500
Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.1397
Cell Significance Index: -1.9600
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1408
Cell Significance Index: -7.3900
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.1468
Cell Significance Index: -4.3300
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1479
Cell Significance Index: -11.0200
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1506
Cell Significance Index: -3.8700
Cell Name: muscle fibroblast (CL1001609)
Fold Change: -0.1592
Cell Significance Index: -0.9800
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.1731
Cell Significance Index: -2.4300
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1768
Cell Significance Index: -7.8200
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.1772
Cell Significance Index: -2.6700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1862
Cell Significance Index: -8.6800
Cell Name: radial glial cell (CL0000681)
Fold Change: -0.1871
Cell Significance Index: -1.1100
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1900
Cell Significance Index: -8.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** Cyclin A2 is a member of the cyclin family, which are regulatory proteins that bind to CDKs to drive the cell cycle forward. Cyclin A2 is specifically expressed during the G2/M phase of the cell cycle and is involved in the regulation of the APC/CDK pathway. Key characteristics of cyclin A2 include: * High expression in erythroid progenitor cells, respiratory basal cells, and neural crest cells * Significant involvement in the regulation of the APC/CDK pathway * Essential role in the progression of the cell cycle, particularly during the G2/M phase * Phosphorylation-dependent regulation of the APC/CDK pathway * Interaction with other proteins, including CDK2, CDC20, and TP53 **Pathways and Functions** Cyclin A2 plays a critical role in the regulation of the cell cycle, particularly during the G2/M phase. The key pathways and functions of cyclin A2 include: * APC/CDK pathway regulation: Cyclin A2 binds to CDK2 and CDC20 to regulate the APC/CDK pathway, which is essential for the proper separation of chromosomes during mitosis. * Cell cycle progression: Cyclin A2 is involved in the regulation of the G2/M phase transition, which is critical for the progression of the cell cycle. * DNA replication and repair: Cyclin A2 is involved in the regulation of DNA replication and repair, particularly during the G2/M phase. * Response to stress: Cyclin A2 is involved in the response to cellular stress, including DNA damage and telomere stress. * Protein degradation: Cyclin A2 is involved in the regulation of protein degradation, particularly through the SCF(SKP2)-mediated degradation of p27/p21. **Clinical Significance** Dysregulation of cyclin A2 has been implicated in various diseases, including: * Cancer: Cyclin A2 overexpression has been observed in various types of cancer, including breast, lung, and colon cancer. * Neurodegenerative diseases: Cyclin A2 has been implicated in the regulation of neurodegenerative diseases, including Alzheimer's and Parkinson's disease. * Immune system disorders: Cyclin A2 has been implicated in the regulation of the immune system, particularly in the response to infections and autoimmune diseases. * Telomere maintenance: Cyclin A2 is involved in the regulation of telomere maintenance, which is critical for the prevention of telomere shortening and aging. In conclusion, cyclin A2 is a critical regulatory protein involved in the regulation of the cell cycle, particularly during the G2/M phase. Dysregulation of cyclin A2 has been implicated in various diseases, highlighting the importance of this gene in maintaining cellular homeostasis and preventing disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

CCNA2_HUMAN

Genular Protein ID: 3647368137

Symbol: CCNA2_HUMAN

Name: N/A

UniProtKB Accession Codes:

P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8

Database IDs:

Citations:

PubMed ID: 1967822

Title: Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma.

PubMed ID: 1967822

DOI: 10.1038/343555a0

PubMed ID: 8202514

Title: Structure and cell cycle-regulated transcription of the human cyclin A gene.

PubMed ID: 8202514

DOI: 10.1073/pnas.91.12.5490

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1312467

Title: Cyclin A is required at two points in the human cell cycle.

PubMed ID: 1312467

DOI: 10.1002/j.1460-2075.1992.tb05135.x

PubMed ID: 17698606

Title: SCAPER, a novel cyclin A-interacting protein that regulates cell cycle progression.

PubMed ID: 17698606

DOI: 10.1083/jcb.200701166

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21540187

Title: Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling.

PubMed ID: 21540187

DOI: 10.1074/jbc.m110.203471

PubMed ID: 21596315

Title: Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry.

PubMed ID: 21596315

DOI: 10.1016/j.molcel.2011.03.027

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24101496

Title: Human cytomegalovirus tegument protein pp150 acts as a cyclin A2-CDK-dependent sensor of the host cell cycle and differentiation state.

PubMed ID: 24101496

DOI: 10.1073/pnas.1312235110

PubMed ID: 7630397

Title: Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex.

PubMed ID: 7630397

DOI: 10.1038/376313a0

PubMed ID: 8684460

Title: Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex.

PubMed ID: 8684460

DOI: 10.1038/382325a0

PubMed ID: 8756328

Title: Structural basis of cyclin-dependent kinase activation by phosphorylation.

PubMed ID: 8756328

DOI: 10.1038/nsb0896-696

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

Sequence Information:

Length: 432
Mass: 48551
Checksum: 97763A2897DD35F4
Sequence:

MLGNSAPGPA TREAGSALLA LQQTALQEDQ ENINPEKAAP VQQPRTRAAL AVLKSGNPRG 
LAQQQRPKTR RVAPLKDLPV NDEHVTVPPW KANSKQPAFT IHVDEAEKEA QKKPAESQKI 
EREDALAFNS AISLPGPRKP LVPLDYPMDG SFESPHTMDM SIILEDEKPV SVNEVPDYHE 
DIHTYLREME VKCKPKVGYM KKQPDITNSM RAILVDWLVE VGEEYKLQNE TLHLAVNYID 
RFLSSMSVLR GKLQLVGTAA MLLASKFEEI YPPEVAEFVY ITDDTYTKKQ VLRMEHLVLK 
VLTFDLAAPT VNQFLTQYFL HQQPANCKVE SLAMFLGELS LIDADPYLKY LPSVIAGAAF 
HLALYTVTGQ SWPESLIRKT GYTLESLKPC LMDLHQTYLK APQHAQQSIR EKYKNSKYHG 
VSLLNPPETL NL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CCNA2

Associated with

Cells (max top 100)

Other Information

Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma. PubMed ID: 1967822

Structure and cell cycle-regulated transcription of the human cyclin A gene. PubMed ID: 8202514

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cyclin A is required at two points in the human cell cycle. PubMed ID: 1312467

SCAPER, a novel cyclin A-interacting protein that regulates cell cycle progression. PubMed ID: 17698606

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Initial characterization of the human central proteome. PubMed ID: 21269460

Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling. PubMed ID: 21540187

Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry. PubMed ID: 21596315

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Human cytomegalovirus tegument protein pp150 acts as a cyclin A2-CDK-dependent sensor of the host cell cycle and differentiation state. PubMed ID: 24101496

Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex. PubMed ID: 7630397

Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex. PubMed ID: 8684460

Structural basis of cyclin-dependent kinase activation by phosphorylation. PubMed ID: 8756328

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976