Gene CCNA2 - ENSG00000145386 | NCBI Gene ID: 890

Details for: CCNA2

Gene ID: 890

Symbol: CCNA2

Ensembl ID: ENSG00000145386

Description: cyclin A2

Associated with

Activation of apc/c and apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176814)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176409)
Apc:cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
(R-HSA-179419)
Cdc20:phospho-apc/c mediated degradation of cyclin a
(R-HSA-174184)
Cdk-mediated phosphorylation and removal of cdc6
(R-HSA-69017)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromosome maintenance
(R-HSA-73886)
Cyclin a/b1/b2 associated events during g2/m transition
(R-HSA-69273)
Cyclin a:cdk2-associated events at s phase entry
(R-HSA-69656)
Cyclin e associated events during g1/s transition
(R-HSA-69202)
Deubiquitination
(R-HSA-5688426)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Dna double-strand break repair
(R-HSA-5693532)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Extension of telomeres
(R-HSA-180786)
G0 and early g1
(R-HSA-1538133)
G1/s dna damage checkpoints
(R-HSA-69615)
G1/s transition
(R-HSA-69206)
G2 phase
(R-HSA-68911)
G2/m transition
(R-HSA-69275)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-HSA-5693567)
Homology directed repair
(R-HSA-5693538)
Metabolism of proteins
(R-HSA-392499)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Orc1 removal from chromatin
(R-HSA-68949)
P53-dependent g1 dna damage response
(R-HSA-69563)
P53-dependent g1/s dna damage checkpoint
(R-HSA-69580)
Phosphorylation of proteins involved in the g2/m transition by cyclin a:cdc2 complexes
(R-HSA-170145)
Processing of dna double-strand break ends
(R-HSA-5693607)
Regulation of apc/c activators between g1/s and early anaphase
(R-HSA-176408)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of tp53 activity
(R-HSA-5633007)
Regulation of tp53 activity through phosphorylation
(R-HSA-6804756)
Regulation of tp53 degradation
(R-HSA-6804757)
Regulation of tp53 expression and degradation
(R-HSA-6806003)
Rna polymerase ii transcription
(R-HSA-73857)
Scf(skp2)-mediated degradation of p27/p21
(R-HSA-187577)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
S phase
(R-HSA-69242)
Switching of origins to a post-replicative state
(R-HSA-69052)
Synthesis of dna
(R-HSA-69239)
Telomere extension by telomerase
(R-HSA-171319)
Telomere maintenance
(R-HSA-157579)
Tp53 regulates transcription of cell cycle genes
(R-HSA-6791312)
Tp53 regulates transcription of genes involved in g1 cell cycle arrest
(R-HSA-6804116)
Transcriptional regulation by tp53
(R-HSA-3700989)
Transcription of e2f targets under negative control by p107 (rbl1) and p130 (rbl2) in complex with hdac1
(R-HSA-1362300)
Ub-specific processing proteases
(R-HSA-5689880)
Animal organ regeneration
(GO:0031100)
Cell cycle g1/s phase transition
(GO:0044843)
Cell division
(GO:0051301)
Cellular response to cocaine
(GO:0071314)
Cellular response to estradiol stimulus
(GO:0071392)
Cellular response to hypoxia
(GO:0071456)
Cellular response to insulin-like growth factor stimulus
(GO:1990314)
Cellular response to leptin stimulus
(GO:0044320)
Cellular response to luteinizing hormone stimulus
(GO:0071373)
Cellular response to nitric oxide
(GO:0071732)
Cellular response to platelet-derived growth factor stimulus
(GO:0036120)
Centrosome
(GO:0005813)
Cochlea development
(GO:0090102)
Cyclin-dependent protein kinase holoenzyme complex
(GO:0000307)
Cyclin-dependent protein serine/threonine kinase regulator activity
(GO:0016538)
Cyclin a2-cdk1 complex
(GO:0097122)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna-templated transcription
(GO:0006351)
Female pronucleus
(GO:0001939)
G1/s transition of mitotic cell cycle
(GO:0000082)
G2/m transition of mitotic cell cycle
(GO:0000086)
Male pronucleus
(GO:0001940)
Mitotic cell cycle phase transition
(GO:0044772)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of dna biosynthetic process
(GO:2000573)
Positive regulation of fibroblast proliferation
(GO:0048146)
Post-translational protein modification
(GO:0043687)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein kinase binding
(GO:0019901)
Ras protein signal transduction
(GO:0007265)
Regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0000079)
Regulation of dna replication
(GO:0006275)
Response to glucagon
(GO:0033762)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 2
Marker Score: 2089
Cell Name: respiratory basal cell (CL0002633)
Fold Change: 1.79
Marker Score: 2564
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 1.65
Marker Score: 4477.5
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 1.59
Marker Score: 1496
Cell Name: erythroblast (CL0000765)
Fold Change: 1.56
Marker Score: 976
Cell Name: proerythroblast (CL0000547)
Fold Change: 1.48
Marker Score: 1002
Cell Name: plasmablast (CL0000980)
Fold Change: 1.17
Marker Score: 1562
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 1.16
Marker Score: 866.5
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.15
Marker Score: 3398
Cell Name: neural crest cell (CL0011012)
Fold Change: 1.05
Marker Score: 1125
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71816
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48040
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 502
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.96
Marker Score: 455
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2410
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5327
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2735
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.89
Marker Score: 320
Cell Name: gut endothelial cell (CL0000131)
Fold Change: 0.88
Marker Score: 314
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5280
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 0.85
Marker Score: 279
Cell Name: Unknown (CL0000548)
Fold Change: 0.85
Marker Score: 617
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.79
Marker Score: 601
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.78
Marker Score: 1333
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1268
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.76
Marker Score: 476
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.75
Marker Score: 390
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.75
Marker Score: 300
Cell Name: brush cell (CL0002204)
Fold Change: 0.75
Marker Score: 681
Cell Name: promyelocyte (CL0000836)
Fold Change: 0.73
Marker Score: 361
Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.72
Marker Score: 906
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.71
Marker Score: 714
Cell Name: osteoclast (CL0000092)
Fold Change: 0.7
Marker Score: 351
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 176
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.68
Marker Score: 2858
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.65
Marker Score: 1355
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 0.6
Marker Score: 166
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 0.6
Marker Score: 431
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.59
Marker Score: 2317
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.54
Marker Score: 170
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.53
Marker Score: 8221
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.52
Marker Score: 2021
Cell Name: pre-conventional dendritic cell (CL0002010)
Fold Change: 0.52
Marker Score: 154
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.51
Marker Score: 539
Cell Name: thymocyte (CL0000893)
Fold Change: 0.51
Marker Score: 531
Cell Name: enteric neuron (CL0007011)
Fold Change: 0.5
Marker Score: 264
Cell Name: oogonial cell (CL0000024)
Fold Change: 0.48
Marker Score: 688
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.45
Marker Score: 1065
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.45
Marker Score: 119
Cell Name: exhausted T cell (CL0011025)
Fold Change: 0.44
Marker Score: 255
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.44
Marker Score: 1191
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 0.44
Marker Score: 214
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.43
Marker Score: 820.5
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.42
Marker Score: 150
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.41
Marker Score: 388
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.4
Marker Score: 256
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.39
Marker Score: 378
Cell Name: stem cell (CL0000034)
Fold Change: 0.39
Marker Score: 921
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.38
Marker Score: 906
Cell Name: mesangial cell (CL0000650)
Fold Change: 0.37
Marker Score: 444
Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.37
Marker Score: 92
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.36
Marker Score: 303
Cell Name: preosteoblast (CL0007010)
Fold Change: 0.36
Marker Score: 102
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.36
Marker Score: 4727
Cell Name: neural cell (CL0002319)
Fold Change: 0.35
Marker Score: 171
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: 0.35
Marker Score: 176
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.35
Marker Score: 111
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.35
Marker Score: 209
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.34
Marker Score: 158
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.34
Marker Score: 139
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 0.34
Marker Score: 108
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.34
Marker Score: 1381
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.34
Marker Score: 685
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 0.33
Marker Score: 88
Cell Name: male germ cell (CL0000015)
Fold Change: 0.33
Marker Score: 96
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 0.33
Marker Score: 135
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.32
Marker Score: 177
Cell Name: malignant cell (CL0001064)
Fold Change: 0.32
Marker Score: 4318
Cell Name: T-helper 17 cell (CL0000899)
Fold Change: 0.32
Marker Score: 209
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.32
Marker Score: 132
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.32
Marker Score: 102
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.29
Marker Score: 92
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.29
Marker Score: 444
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.29
Marker Score: 263
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.29
Marker Score: 158
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.28
Marker Score: 119
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.28
Marker Score: 2897
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.28
Marker Score: 1679
Cell Name: myelocyte (CL0002193)
Fold Change: 0.28
Marker Score: 119
Cell Name: germinal center B cell (CL0000844)
Fold Change: 0.27
Marker Score: 167
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.27
Marker Score: 192
Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 0.26
Marker Score: 91
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 0.26
Marker Score: 372
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 0.26
Marker Score: 92
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.26
Marker Score: 114
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0.26
Marker Score: 512
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.26
Marker Score: 2242
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.25
Marker Score: 87

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**Key characteristics:** - CCNA2 is a cyclin-dependent kinase inhibitor (CDK inhibitor). - It is expressed in a wide range of cell types, including embryonic and adult cells. - It forms heterodimers with other cyclin-dependent kinases (CDKs) to form a complex that is essential for the activation of downstream targets. - It is involved in the regulation of cell cycle checkpoints, ensuring that cells enter the next phase of the cell cycle only when they are properly prepared. - CCNA2 is also involved in DNA repair and maintenance, as it is a key component of the DNA damage checkpoint. **Pathways and functions:** - CCNA2 is involved in the regulation of the G1/S transition, ensuring that cells enter the S phase only when they have completed DNA replication. - It is also involved in the regulation of the G2/M transition, ensuring that cells enter the mitosis phase only when the DNA damage checkpoint has been triggered. - CCNA2 is a key regulator of cell cycle checkpoints, ensuring that cells do not progress through the cell cycle in the presence of DNA damage. - It is involved in DNA repair and maintenance by participating in the repair of DNA double-strand breaks (DSBs). - CCNA2 also plays a role in the regulation of cellular senescence, apoptosis, and tumor suppression. **Clinical significance:** - Mutations in CCNA2 have been linked to a number of human cancers, including breast cancer, lung cancer, and colorectal cancer. - Targeting CCNA2 has been investigated as a therapeutic strategy for cancer. - CCNA2 inhibitors are currently being tested in clinical trials for the treatment of cancer and other diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

CCNA2_HUMAN

Genular Protein ID: 3647368137

Symbol: CCNA2_HUMAN

Name: N/A

UniProtKB Accession Codes:

P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8

Database IDs:

Citations:

PubMed ID: 1967822

Title: Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma.

PubMed ID: 1967822

DOI: 10.1038/343555a0

PubMed ID: 8202514

Title: Structure and cell cycle-regulated transcription of the human cyclin A gene.

PubMed ID: 8202514

DOI: 10.1073/pnas.91.12.5490

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1312467

Title: Cyclin A is required at two points in the human cell cycle.

PubMed ID: 1312467

DOI: 10.1002/j.1460-2075.1992.tb05135.x

PubMed ID: 17698606

Title: SCAPER, a novel cyclin A-interacting protein that regulates cell cycle progression.

PubMed ID: 17698606

DOI: 10.1083/jcb.200701166

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21540187

Title: Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling.

PubMed ID: 21540187

DOI: 10.1074/jbc.m110.203471

PubMed ID: 21596315

Title: Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry.

PubMed ID: 21596315

DOI: 10.1016/j.molcel.2011.03.027

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24101496

Title: Human cytomegalovirus tegument protein pp150 acts as a cyclin A2-CDK-dependent sensor of the host cell cycle and differentiation state.

PubMed ID: 24101496

DOI: 10.1073/pnas.1312235110

PubMed ID: 7630397

Title: Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex.

PubMed ID: 7630397

DOI: 10.1038/376313a0

PubMed ID: 8684460

Title: Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex.

PubMed ID: 8684460

DOI: 10.1038/382325a0

PubMed ID: 8756328

Title: Structural basis of cyclin-dependent kinase activation by phosphorylation.

PubMed ID: 8756328

DOI: 10.1038/nsb0896-696

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

Sequence Information:

Length: 432
Mass: 48551
Checksum: 97763A2897DD35F4
Sequence:

MLGNSAPGPA TREAGSALLA LQQTALQEDQ ENINPEKAAP VQQPRTRAAL AVLKSGNPRG 
LAQQQRPKTR RVAPLKDLPV NDEHVTVPPW KANSKQPAFT IHVDEAEKEA QKKPAESQKI 
EREDALAFNS AISLPGPRKP LVPLDYPMDG SFESPHTMDM SIILEDEKPV SVNEVPDYHE 
DIHTYLREME VKCKPKVGYM KKQPDITNSM RAILVDWLVE VGEEYKLQNE TLHLAVNYID 
RFLSSMSVLR GKLQLVGTAA MLLASKFEEI YPPEVAEFVY ITDDTYTKKQ VLRMEHLVLK 
VLTFDLAAPT VNQFLTQYFL HQQPANCKVE SLAMFLGELS LIDADPYLKY LPSVIAGAAF 
HLALYTVTGQ SWPESLIRKT GYTLESLKPC LMDLHQTYLK APQHAQQSIR EKYKNSKYHG 
VSLLNPPETL NL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: CCNA2

Associated with

Cells (max top 100)

Other Information

Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma. PubMed ID: 1967822

Structure and cell cycle-regulated transcription of the human cyclin A gene. PubMed ID: 8202514

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cyclin A is required at two points in the human cell cycle. PubMed ID: 1312467

SCAPER, a novel cyclin A-interacting protein that regulates cell cycle progression. PubMed ID: 17698606

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Initial characterization of the human central proteome. PubMed ID: 21269460

Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling. PubMed ID: 21540187

Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry. PubMed ID: 21596315

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Human cytomegalovirus tegument protein pp150 acts as a cyclin A2-CDK-dependent sensor of the host cell cycle and differentiation state. PubMed ID: 24101496

Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex. PubMed ID: 7630397

Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex. PubMed ID: 8684460

Structural basis of cyclin-dependent kinase activation by phosphorylation. PubMed ID: 8756328

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976