CCNA2 | ENSG00000145386 | NCBI 890

Details for: CCNA2

Gene ID: 890

Symbol: CCNA2

Ensembl ID: ENSG00000145386

Description: cyclin A2

Associated with

Activation of apc/c and apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176814)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176409)
Apc:cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
(R-HSA-179419)
Cdc20:phospho-apc/c mediated degradation of cyclin a
(R-HSA-174184)
Cdk-mediated phosphorylation and removal of cdc6
(R-HSA-69017)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromosome maintenance
(R-HSA-73886)
Cyclin a/b1/b2 associated events during g2/m transition
(R-HSA-69273)
Cyclin a:cdk2-associated events at s phase entry
(R-HSA-69656)
Cyclin e associated events during g1/s transition
(R-HSA-69202)
Deubiquitination
(R-HSA-5688426)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Dna double-strand break repair
(R-HSA-5693532)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Extension of telomeres
(R-HSA-180786)
G0 and early g1
(R-HSA-1538133)
G1/s dna damage checkpoints
(R-HSA-69615)
G1/s transition
(R-HSA-69206)
G2 phase
(R-HSA-68911)
G2/m transition
(R-HSA-69275)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-HSA-5693567)
Homology directed repair
(R-HSA-5693538)
Metabolism of proteins
(R-HSA-392499)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Orc1 removal from chromatin
(R-HSA-68949)
P53-dependent g1 dna damage response
(R-HSA-69563)
P53-dependent g1/s dna damage checkpoint
(R-HSA-69580)
Phosphorylation of proteins involved in the g2/m transition by cyclin a:cdc2 complexes
(R-HSA-170145)
Processing of dna double-strand break ends
(R-HSA-5693607)
Regulation of apc/c activators between g1/s and early anaphase
(R-HSA-176408)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of tp53 activity
(R-HSA-5633007)
Regulation of tp53 activity through phosphorylation
(R-HSA-6804756)
Regulation of tp53 degradation
(R-HSA-6804757)
Regulation of tp53 expression and degradation
(R-HSA-6806003)
Rna polymerase ii transcription
(R-HSA-73857)
Scf(skp2)-mediated degradation of p27/p21
(R-HSA-187577)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
S phase
(R-HSA-69242)
Switching of origins to a post-replicative state
(R-HSA-69052)
Synthesis of dna
(R-HSA-69239)
Telomere extension by telomerase
(R-HSA-171319)
Telomere maintenance
(R-HSA-157579)
Tp53 regulates transcription of cell cycle genes
(R-HSA-6791312)
Tp53 regulates transcription of genes involved in g1 cell cycle arrest
(R-HSA-6804116)
Transcriptional regulation by tp53
(R-HSA-3700989)
Transcription of e2f targets under negative control by p107 (rbl1) and p130 (rbl2) in complex with hdac1
(R-HSA-1362300)
Ub-specific processing proteases
(R-HSA-5689880)
Animal organ regeneration
(GO:0031100)
Cell cycle g1/s phase transition
(GO:0044843)
Cell division
(GO:0051301)
Cellular response to cocaine
(GO:0071314)
Cellular response to estradiol stimulus
(GO:0071392)
Cellular response to hypoxia
(GO:0071456)
Cellular response to insulin-like growth factor stimulus
(GO:1990314)
Cellular response to leptin stimulus
(GO:0044320)
Cellular response to luteinizing hormone stimulus
(GO:0071373)
Cellular response to nitric oxide
(GO:0071732)
Cellular response to platelet-derived growth factor stimulus
(GO:0036120)
Centrosome
(GO:0005813)
Cochlea development
(GO:0090102)
Cyclin-dependent protein kinase holoenzyme complex
(GO:0000307)
Cyclin-dependent protein serine/threonine kinase regulator activity
(GO:0016538)
Cyclin a2-cdk1 complex
(GO:0097122)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna-templated transcription
(GO:0006351)
Female pronucleus
(GO:0001939)
G1/s transition of mitotic cell cycle
(GO:0000082)
G2/m transition of mitotic cell cycle
(GO:0000086)
Male pronucleus
(GO:0001940)
Mitotic cell cycle phase transition
(GO:0044772)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of dna biosynthetic process
(GO:2000573)
Positive regulation of fibroblast proliferation
(GO:0048146)
Post-translational protein modification
(GO:0043687)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein kinase binding
(GO:0019901)
Ras protein signal transduction
(GO:0007265)
Regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0000079)
Regulation of dna replication
(GO:0006275)
Response to glucagon
(GO:0033762)

Other Information

Proteins

CCNA2_HUMAN

Genular Protein ID: 3647368137

Symbol: CCNA2_HUMAN

Name: N/A

UniProtKB Accession Codes:

P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8

Database IDs:

Citations:

PubMed ID: 1967822

Title: Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma.

PubMed ID: 1967822

DOI: 10.1038/343555a0

PubMed ID: 8202514

Title: Structure and cell cycle-regulated transcription of the human cyclin A gene.

PubMed ID: 8202514

DOI: 10.1073/pnas.91.12.5490

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1312467

Title: Cyclin A is required at two points in the human cell cycle.

PubMed ID: 1312467

DOI: 10.1002/j.1460-2075.1992.tb05135.x

PubMed ID: 17698606

Title: SCAPER, a novel cyclin A-interacting protein that regulates cell cycle progression.

PubMed ID: 17698606

DOI: 10.1083/jcb.200701166

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21540187

Title: Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling.

PubMed ID: 21540187

DOI: 10.1074/jbc.m110.203471

PubMed ID: 21596315

Title: Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry.

PubMed ID: 21596315

DOI: 10.1016/j.molcel.2011.03.027

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24101496

Title: Human cytomegalovirus tegument protein pp150 acts as a cyclin A2-CDK-dependent sensor of the host cell cycle and differentiation state.

PubMed ID: 24101496

DOI: 10.1073/pnas.1312235110

PubMed ID: 7630397

Title: Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex.

PubMed ID: 7630397

DOI: 10.1038/376313a0

PubMed ID: 8684460

Title: Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex.

PubMed ID: 8684460

DOI: 10.1038/382325a0

PubMed ID: 8756328

Title: Structural basis of cyclin-dependent kinase activation by phosphorylation.

PubMed ID: 8756328

DOI: 10.1038/nsb0896-696

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

Sequence Information:

Length: 432
Mass: 48551
Checksum: 97763A2897DD35F4
Sequence:

MLGNSAPGPA TREAGSALLA LQQTALQEDQ ENINPEKAAP VQQPRTRAAL AVLKSGNPRG 
LAQQQRPKTR RVAPLKDLPV NDEHVTVPPW KANSKQPAFT IHVDEAEKEA QKKPAESQKI 
EREDALAFNS AISLPGPRKP LVPLDYPMDG SFESPHTMDM SIILEDEKPV SVNEVPDYHE 
DIHTYLREME VKCKPKVGYM KKQPDITNSM RAILVDWLVE VGEEYKLQNE TLHLAVNYID 
RFLSSMSVLR GKLQLVGTAA MLLASKFEEI YPPEVAEFVY ITDDTYTKKQ VLRMEHLVLK 
VLTFDLAAPT VNQFLTQYFL HQQPANCKVE SLAMFLGELS LIDADPYLKY LPSVIAGAAF 
HLALYTVTGQ SWPESLIRKT GYTLESLKPC LMDLHQTYLK APQHAQQSIR EKYKNSKYHG 
VSLLNPPETL NL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CCNA2

Associated with

Other Information

Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma. PubMed ID: 1967822

Structure and cell cycle-regulated transcription of the human cyclin A gene. PubMed ID: 8202514

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cyclin A is required at two points in the human cell cycle. PubMed ID: 1312467

SCAPER, a novel cyclin A-interacting protein that regulates cell cycle progression. PubMed ID: 17698606

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Initial characterization of the human central proteome. PubMed ID: 21269460

Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling. PubMed ID: 21540187

Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry. PubMed ID: 21596315

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Human cytomegalovirus tegument protein pp150 acts as a cyclin A2-CDK-dependent sensor of the host cell cycle and differentiation state. PubMed ID: 24101496

Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex. PubMed ID: 7630397

Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex. PubMed ID: 8684460

Structural basis of cyclin-dependent kinase activation by phosphorylation. PubMed ID: 8756328

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976