CCNA1 | ENSG00000133101 | NCBI 8900

Details for: CCNA1

Gene ID: 8900

Symbol: CCNA1

Ensembl ID: ENSG00000133101

Description: cyclin A1

Associated with

Activation of apc/c and apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176814)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176409)
Apc:cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
(R-HSA-179419)
Cdc20:phospho-apc/c mediated degradation of cyclin a
(R-HSA-174184)
Cdk-mediated phosphorylation and removal of cdc6
(R-HSA-69017)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromosome maintenance
(R-HSA-73886)
Cyclin a/b1/b2 associated events during g2/m transition
(R-HSA-69273)
Cyclin a:cdk2-associated events at s phase entry
(R-HSA-69656)
Cyclin e associated events during g1/s transition
(R-HSA-69202)
Deubiquitination
(R-HSA-5688426)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Dna double-strand break repair
(R-HSA-5693532)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Extension of telomeres
(R-HSA-180786)
G0 and early g1
(R-HSA-1538133)
G1/s-specific transcription
(R-HSA-69205)
G1/s dna damage checkpoints
(R-HSA-69615)
G1/s transition
(R-HSA-69206)
G2 phase
(R-HSA-68911)
G2/m transition
(R-HSA-69275)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-HSA-5693567)
Homology directed repair
(R-HSA-5693538)
Metabolism of proteins
(R-HSA-392499)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Orc1 removal from chromatin
(R-HSA-68949)
P53-dependent g1 dna damage response
(R-HSA-69563)
P53-dependent g1/s dna damage checkpoint
(R-HSA-69580)
Phosphorylation of proteins involved in the g2/m transition by cyclin a:cdc2 complexes
(R-HSA-170145)
Post-translational protein modification
(R-HSA-597592)
Processing of dna double-strand break ends
(R-HSA-5693607)
Regulation of apc/c activators between g1/s and early anaphase
(R-HSA-176408)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of tp53 activity
(R-HSA-5633007)
Regulation of tp53 activity through phosphorylation
(R-HSA-6804756)
Regulation of tp53 degradation
(R-HSA-6804757)
Regulation of tp53 expression and degradation
(R-HSA-6806003)
Rna polymerase ii transcription
(R-HSA-73857)
Scf(skp2)-mediated degradation of p27/p21
(R-HSA-187577)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
S phase
(R-HSA-69242)
Switching of origins to a post-replicative state
(R-HSA-69052)
Synthesis of dna
(R-HSA-69239)
Telomere extension by telomerase
(R-HSA-171319)
Telomere maintenance
(R-HSA-157579)
Tp53 regulates transcription of cell cycle genes
(R-HSA-6791312)
Tp53 regulates transcription of genes involved in g1 cell cycle arrest
(R-HSA-6804116)
Transcriptional regulation by tp53
(R-HSA-3700989)
Ub-specific processing proteases
(R-HSA-5689880)
Cell division
(GO:0051301)
Centrosome
(GO:0005813)
Cyclin-dependent protein serine/threonine kinase regulator activity
(GO:0016538)
Cyclin a1-cdk2 complex
(GO:0097123)
Cyclin a2-cdk2 complex
(GO:0097124)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Male meiosis i
(GO:0007141)
Microtubule cytoskeleton
(GO:0015630)
Mitotic cell cycle phase transition
(GO:0044772)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0000079)
Spermatogenesis
(GO:0007283)

Other Information

Proteins

Cyclin-A1
A0A140VJG0_HUMAN

Genular Protein ID: 2878528041

Symbol: CCNA1_HUMAN

Name: Cyclin-A1

UniProtKB Accession Codes:

P78396 B7Z7E3 Q5T3V0 Q5U0G2 Q8IY91

Database IDs:

Citations:

PubMed ID: 9041194

Title: Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines.

PubMed ID: 9041194

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10022926

Title: Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins.

PubMed ID: 10022926

DOI: 10.1128/mcb.19.3.2400

PubMed ID: 15159402

Title: Identification of interaction partners and substrates of the cyclin A1-CDK2 complex.

PubMed ID: 15159402

DOI: 10.1074/jbc.m401708200

PubMed ID: 21540187

Title: Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling.

PubMed ID: 21540187

DOI: 10.1074/jbc.m110.203471

PubMed ID: 21596315

Title: Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry.

PubMed ID: 21596315

DOI: 10.1016/j.molcel.2011.03.027

Sequence Information:

Length: 465
Mass: 52358
Checksum: C9C023EEA1CF036D
Sequence:

METGFPAIMY PGSFIGGWGE EYLSWEGPGL PDFVFQQQPV ESEAMHCSNP KSGVVLATVA 
RGPDACQILT RAPLGQDPPQ RTVLGLLTAN GQYRRTCGQG ITRIRCYSGS ENAFPPAGKK 
ALPDCGVQEP PKQGFDIYMD ELEQGDRDSC SVREGMAFED VYEVDTGTLK SDLHFLLDFN 
TVSPMLVDSS LLSQSEDISS LGTDVINVTE YAEEIYQYLR EAEIRHRPKA HYMKKQPDIT 
EGMRTILVDW LVEVGEEYKL RAETLYLAVN FLDRFLSCMS VLRGKLQLVG TAAMLLASKY 
EEIYPPEVDE FVYITDDTYT KRQLLKMEHL LLKVLAFDLT VPTTNQFLLQ YLRRQGVCVR 
TENLAKYVAE LSLLEADPFL KYLPSLIAAA AFCLANYTVN KHFWPETLAA FTGYSLSEIV 
PCLSELHKAY LDIPHRPQQA IREKYKASKY LCVSLMEPPA VLLLQ

Genular Protein ID: 1364890181

Symbol: A0A140VJG0_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A140VJG0

Database IDs:

Sequence Information:

Length: 464
Mass: 52230
Checksum: E67C6E6D741B7D73
Sequence:

METGFPAIMY PGSFIGGWGE EYLSWEGPGL PDFVFQQPVE SEAMHCSNPK SGVVLATVAR 
GPDACQILTR APLGQDPPQR TVLGLLTANG QYRRTCGQGI TRIRCYSGSE NAFPPAGKKA 
LPDCGVQEPP KQGFDIYMDE LEQGDRDSCS VREGMAFEDV YEVDTGTLKS DLHFLLDFNT 
VSPMLVDSSL LSQSEDISSL GTDVINVTEY AEEIYQYLRE AEIRHRPKAH YMKKQPDITE 
GMRTILVDWL VEVGEEYKLR AETLYLAVNF LDRFLSCMSV LRGKLQLVGT AAMLLASKYE 
EIYPPEVDEF VYITDDTYTK RQLLKMEHLL LKVLAFDLTV PTTNQFLLQY LRRQGVCVRT 
ENLAKYVAEL SLLEADPFLK YLPSLIAAAA FCLANYTVNK HFWPETLAAF TGYSLSEIVP 
CLSELHKAYL DIPHRPQQAI REKYKASKYL CVSLMEPPAV LLLQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CCNA1

Associated with

Other Information

Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines. PubMed ID: 9041194

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 13. PubMed ID: 15057823

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins. PubMed ID: 10022926

Identification of interaction partners and substrates of the cyclin A1-CDK2 complex. PubMed ID: 15159402

Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling. PubMed ID: 21540187

Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry. PubMed ID: 21596315