CCNB1 | ENSG00000134057 | NCBI 891

Details for: CCNB1

Gene ID: 891

Symbol: CCNB1

Ensembl ID: ENSG00000134057

Description: cyclin B1

Associated with

Activation of apc/c and apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176814)
Activation of nima kinases nek9, nek6, nek7
(R-HSA-2980767)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apc/c:cdc20 mediated degradation of cyclin b
(R-HSA-174048)
Apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176409)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Chk1/chk2(cds1) mediated inactivation of cyclin b:cdk1 complex
(R-HSA-75035)
Condensation of prometaphase chromosomes
(R-HSA-2514853)
Condensation of prophase chromosomes
(R-HSA-2299718)
Cyclin a/b1/b2 associated events during g2/m transition
(R-HSA-69273)
Depolymerization of the nuclear lamina
(R-HSA-4419969)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
E2f-enabled inhibition of pre-replication complex formation
(R-HSA-113507)
E2f mediated regulation of dna replication
(R-HSA-113510)
G1/s transition
(R-HSA-69206)
G2/m checkpoints
(R-HSA-69481)
G2/m dna damage checkpoint
(R-HSA-69473)
G2/m dna replication checkpoint
(R-HSA-69478)
G2/m transition
(R-HSA-69275)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Golgi cisternae pericentriolar stack reorganization
(R-HSA-162658)
Initiation of nuclear envelope (ne) reformation
(R-HSA-2995383)
Mastl facilitates mitotic progression
(R-HSA-2465910)
Mitotic anaphase
(R-HSA-68882)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic prometaphase
(R-HSA-68877)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Nuclear envelope (ne) reassembly
(R-HSA-2995410)
Nuclear envelope breakdown
(R-HSA-2980766)
Nuclear events stimulated by alk signaling in cancer
(R-HSA-9725371)
Nuclear pore complex (npc) disassembly
(R-HSA-3301854)
Phosphorylation of emi1
(R-HSA-176417)
Phosphorylation of the apc/c
(R-HSA-176412)
Polo-like kinase mediated events
(R-HSA-156711)
Regulation of apc/c activators between g1/s and early anaphase
(R-HSA-176408)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of plk1 activity at g2/m transition
(R-HSA-2565942)
Resolution of sister chromatid cohesion
(R-HSA-2500257)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by alk fusions and activated point mutants
(R-HSA-9725370)
Signaling by alk in cancer
(R-HSA-9700206)
The role of gtse1 in g2/m progression after g2 checkpoint
(R-HSA-8852276)
Tp53 regulates transcription of cell cycle genes
(R-HSA-6791312)
Tp53 regulates transcription of genes involved in g2 cell cycle arrest
(R-HSA-6804114)
Transcriptional regulation by runx2
(R-HSA-8878166)
Transcriptional regulation by tp53
(R-HSA-3700989)
Cell division
(GO:0051301)
Centrosome
(GO:0005813)
Cyclin-dependent protein serine/threonine kinase activator activity
(GO:0061575)
Cyclin-dependent protein serine/threonine kinase regulator activity
(GO:0016538)
Cyclin b1-cdk1 complex
(GO:0097125)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
G2/m transition of mitotic cell cycle
(GO:0000086)
In utero embryonic development
(GO:0001701)
Membrane
(GO:0016020)
Mitochondrial matrix
(GO:0005759)
Mitotic cell cycle phase transition
(GO:0044772)
Mitotic metaphase chromosome alignment
(GO:0007080)
Mitotic spindle organization
(GO:0007052)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Outer kinetochore
(GO:0000940)
Patched binding
(GO:0005113)
Positive regulation of attachment of spindle microtubules to kinetochore
(GO:0051987)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of g2/m transition of mitotic cell cycle
(GO:0010971)
Positive regulation of mitochondrial atp synthesis coupled electron transport
(GO:1905448)
Positive regulation of mitotic cell cycle
(GO:0045931)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0000079)
Regulation of mitotic cell cycle spindle assembly checkpoint
(GO:0090266)
Spindle pole
(GO:0000922)
Ubiquitin-like protein ligase binding
(GO:0044389)

Other Information

Proteins

G2/mitotic-specific cyclin-B1

Genular Protein ID: 4253425813

Symbol: CCNB1_HUMAN

Name: G2/mitotic-specific cyclin-B1

UniProtKB Accession Codes:

P14635 A8K066 Q5TZP9

Database IDs:

Citations:

PubMed ID: 2570636

Title: Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2.

PubMed ID: 2570636

DOI: 10.1016/0092-8674(89)90936-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7843284

Title: Structure and growth-dependent regulation of the human cyclin B1 promoter.

PubMed ID: 7843284

DOI: 10.1006/excr.1995.1050

PubMed ID: 10716937

Title: Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction.

PubMed ID: 10716937

DOI: 10.1093/emboj/19.6.1378

PubMed ID: 12447691

Title: Cooperative phosphorylation including the activity of polo-like kinase 1 regulates the subcellular localization of cyclin B1.

PubMed ID: 12447691

DOI: 10.1038/sj.onc.1206011

PubMed ID: 12775724

Title: RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis.

PubMed ID: 12775724

DOI: 10.1074/jbc.m302191200

PubMed ID: 12612082

Title: A novel RING finger protein, human enhancer of invasion 10, alters mitotic progression through regulation of cyclin B levels.

PubMed ID: 12612082

DOI: 10.1128/mcb.23.6.2109-2122.2003

PubMed ID: 12524548

Title: Active cyclin B1-Cdk1 first appears on centrosomes in prophase.

PubMed ID: 12524548

DOI: 10.1038/ncb918

PubMed ID: 16009132

Title: NIPA defines an SCF-type mammalian E3 ligase that regulates mitotic entry.

PubMed ID: 16009132

DOI: 10.1016/j.cell.2005.04.034

PubMed ID: 15181148

Title: p21-mediated nuclear retention of cyclin B1-Cdk1 in response to genotoxic stress.

PubMed ID: 15181148

DOI: 10.1091/mbc.e03-12-0871

PubMed ID: 15790566

Title: Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint.

PubMed ID: 15790566

DOI: 10.1074/jbc.m413431200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21540187

Title: Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling.

PubMed ID: 21540187

DOI: 10.1074/jbc.m110.203471

PubMed ID: 17495531

Title: Cyclin B and cyclin A confer different substrate recognition properties on CDK2.

PubMed ID: 17495531

DOI: 10.4161/cc.6.11.4278

PubMed ID: 17495533

Title: The crystal structure of human cyclin B.

PubMed ID: 17495533

DOI: 10.4161/cc.6.11.4297

Sequence Information:

Length: 433
Mass: 48337
Checksum: E2C4767AE8A11EC0
Sequence:

MALRVTRNSK INAENKAKIN MAGAKRVPTA PAATSKPGLR PRTALGDIGN KVSEQLQAKM 
PMKKEAKPSA TGKVIDKKLP KPLEKVPMLV PVPVSEPVPE PEPEPEPEPV KEEKLSPEPI 
LVDTASPSPM ETSGCAPAEE DLCQAFSDVI LAVNDVDAED GADPNLCSEY VKDIYAYLRQ 
LEEEQAVRPK YLLGREVTGN MRAILIDWLV QVQMKFRLLQ ETMYMTVSII DRFMQNNCVP 
KKMLQLVGVT AMFIASKYEE MYPPEIGDFA FVTDNTYTKH QIRQMEMKIL RALNFGLGRP 
LPLHFLRRAS KIGEVDVEQH TLAKYLMELT MLDYDMVHFP PSQIAAGAFC LALKILDNGE 
WTPTLQHYLS YTEESLLPVM QHLAKNVVMV NQGLTKHMTV KNKYATSKHA KISTLPQLNS 
ALVQDLAKAV AKV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CCNB1

Associated with

Other Information

Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2. PubMed ID: 2570636

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 5. PubMed ID: 15372022

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Structure and growth-dependent regulation of the human cyclin B1 promoter. PubMed ID: 7843284

Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction. PubMed ID: 10716937

Cooperative phosphorylation including the activity of polo-like kinase 1 regulates the subcellular localization of cyclin B1. PubMed ID: 12447691

RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis. PubMed ID: 12775724

A novel RING finger protein, human enhancer of invasion 10, alters mitotic progression through regulation of cyclin B levels. PubMed ID: 12612082

Active cyclin B1-Cdk1 first appears on centrosomes in prophase. PubMed ID: 12524548

NIPA defines an SCF-type mammalian E3 ligase that regulates mitotic entry. PubMed ID: 16009132

p21-mediated nuclear retention of cyclin B1-Cdk1 in response to genotoxic stress. PubMed ID: 15181148

Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint. PubMed ID: 15790566

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling. PubMed ID: 21540187

Cyclin B and cyclin A confer different substrate recognition properties on CDK2. PubMed ID: 17495531

The crystal structure of human cyclin B. PubMed ID: 17495533