Gene CCNB1 - ENSG00000134057 | NCBI Gene ID: 891

Details for: CCNB1

Gene ID: 891

Symbol: CCNB1

Ensembl ID: ENSG00000134057

Description: cyclin B1

Associated with

Activation of apc/c and apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176814)
Activation of nima kinases nek9, nek6, nek7
(R-HSA-2980767)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apc/c:cdc20 mediated degradation of cyclin b
(R-HSA-174048)
Apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176409)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Chk1/chk2(cds1) mediated inactivation of cyclin b:cdk1 complex
(R-HSA-75035)
Condensation of prometaphase chromosomes
(R-HSA-2514853)
Condensation of prophase chromosomes
(R-HSA-2299718)
Cyclin a/b1/b2 associated events during g2/m transition
(R-HSA-69273)
Depolymerization of the nuclear lamina
(R-HSA-4419969)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
E2f-enabled inhibition of pre-replication complex formation
(R-HSA-113507)
E2f mediated regulation of dna replication
(R-HSA-113510)
G1/s transition
(R-HSA-69206)
G2/m checkpoints
(R-HSA-69481)
G2/m dna damage checkpoint
(R-HSA-69473)
G2/m dna replication checkpoint
(R-HSA-69478)
G2/m transition
(R-HSA-69275)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Golgi cisternae pericentriolar stack reorganization
(R-HSA-162658)
Initiation of nuclear envelope (ne) reformation
(R-HSA-2995383)
Mastl facilitates mitotic progression
(R-HSA-2465910)
Mitotic anaphase
(R-HSA-68882)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic prometaphase
(R-HSA-68877)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Nuclear envelope (ne) reassembly
(R-HSA-2995410)
Nuclear envelope breakdown
(R-HSA-2980766)
Nuclear events stimulated by alk signaling in cancer
(R-HSA-9725371)
Nuclear pore complex (npc) disassembly
(R-HSA-3301854)
Phosphorylation of emi1
(R-HSA-176417)
Phosphorylation of the apc/c
(R-HSA-176412)
Polo-like kinase mediated events
(R-HSA-156711)
Regulation of apc/c activators between g1/s and early anaphase
(R-HSA-176408)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of plk1 activity at g2/m transition
(R-HSA-2565942)
Resolution of sister chromatid cohesion
(R-HSA-2500257)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by alk fusions and activated point mutants
(R-HSA-9725370)
Signaling by alk in cancer
(R-HSA-9700206)
The role of gtse1 in g2/m progression after g2 checkpoint
(R-HSA-8852276)
Tp53 regulates transcription of cell cycle genes
(R-HSA-6791312)
Tp53 regulates transcription of genes involved in g2 cell cycle arrest
(R-HSA-6804114)
Transcriptional regulation by runx2
(R-HSA-8878166)
Transcriptional regulation by tp53
(R-HSA-3700989)
Cell division
(GO:0051301)
Centrosome
(GO:0005813)
Cyclin-dependent protein serine/threonine kinase activator activity
(GO:0061575)
Cyclin-dependent protein serine/threonine kinase regulator activity
(GO:0016538)
Cyclin b1-cdk1 complex
(GO:0097125)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
G2/m transition of mitotic cell cycle
(GO:0000086)
In utero embryonic development
(GO:0001701)
Membrane
(GO:0016020)
Mitochondrial matrix
(GO:0005759)
Mitotic cell cycle phase transition
(GO:0044772)
Mitotic metaphase chromosome alignment
(GO:0007080)
Mitotic spindle organization
(GO:0007052)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Outer kinetochore
(GO:0000940)
Patched binding
(GO:0005113)
Positive regulation of attachment of spindle microtubules to kinetochore
(GO:0051987)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of g2/m transition of mitotic cell cycle
(GO:0010971)
Positive regulation of mitochondrial atp synthesis coupled electron transport
(GO:1905448)
Positive regulation of mitotic cell cycle
(GO:0045931)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0000079)
Regulation of mitotic cell cycle spindle assembly checkpoint
(GO:0090266)
Spindle pole
(GO:0000922)
Ubiquitin-like protein ligase binding
(GO:0044389)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 2.54
Marker Score: 2648
Cell Name: oogonial cell (CL0000024)
Fold Change: 1.91
Marker Score: 2746
Cell Name: male germ cell (CL0000015)
Fold Change: 1.69
Marker Score: 486
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 1.68
Marker Score: 539
Cell Name: proerythroblast (CL0000547)
Fold Change: 1.43
Marker Score: 968
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 1.38
Marker Score: 1294
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.19
Marker Score: 3541
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.15
Marker Score: 4510
Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.13
Marker Score: 1420
Cell Name: plasmablast (CL0000980)
Fold Change: 1.06
Marker Score: 1414
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 1.05
Marker Score: 2861
Cell Name: oocyte (CL0000023)
Fold Change: 1.03
Marker Score: 254
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71797
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48021
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30405
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.96
Marker Score: 494
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.95
Marker Score: 448
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2409
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5322
Cell Name: neural crest cell (CL0011012)
Fold Change: 0.93
Marker Score: 996
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.92
Marker Score: 691
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 0.92
Marker Score: 302
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2728
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.89
Marker Score: 1843
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5294
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.87
Marker Score: 313
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.86
Marker Score: 1458.5
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.85
Marker Score: 1770
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.81
Marker Score: 511
Cell Name: osteoclast (CL0000092)
Fold Change: 0.8
Marker Score: 399
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1268
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.75
Marker Score: 26037
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.74
Marker Score: 383
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.74
Marker Score: 2012
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.73
Marker Score: 561
Cell Name: brush cell (CL0002204)
Fold Change: 0.73
Marker Score: 668
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.73
Marker Score: 293
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.72
Marker Score: 725
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.67
Marker Score: 171
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.66
Marker Score: 210
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.65
Marker Score: 2733
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.64
Marker Score: 352
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.62
Marker Score: 2306
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.6
Marker Score: 1135
Cell Name: type I NK T cell (CL0000921)
Fold Change: 0.59
Marker Score: 466
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.59
Marker Score: 9284
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.59
Marker Score: 2290
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.59
Marker Score: 2395
Cell Name: stem cell (CL0000034)
Fold Change: 0.57
Marker Score: 1346
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 442
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.55
Marker Score: 580
Cell Name: enteric neuron (CL0007011)
Fold Change: 0.54
Marker Score: 288
Cell Name: B-2 B cell (CL0000822)
Fold Change: 0.53
Marker Score: 657
Cell Name: kidney cell (CL1000497)
Fold Change: 0.53
Marker Score: 352
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.52
Marker Score: 121
Cell Name: radial glial cell (CL0000681)
Fold Change: 0.51
Marker Score: 188
Cell Name: erythroblast (CL0000765)
Fold Change: 0.51
Marker Score: 318
Cell Name: Unknown (CL0000548)
Fold Change: 0.51
Marker Score: 370
Cell Name: promyelocyte (CL0000836)
Fold Change: 0.5
Marker Score: 246
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.49
Marker Score: 272
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.47
Marker Score: 1111
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.47
Marker Score: 125
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.46
Marker Score: 1082
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 0.46
Marker Score: 224
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.45
Marker Score: 270
Cell Name: neural cell (CL0002319)
Fold Change: 0.45
Marker Score: 216
Cell Name: pre-conventional dendritic cell (CL0002010)
Fold Change: 0.44
Marker Score: 131
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.44
Marker Score: 282
Cell Name: preosteoblast (CL0007010)
Fold Change: 0.43
Marker Score: 123
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.42
Marker Score: 136
Cell Name: Unknown (CL0002371)
Fold Change: 0.42
Marker Score: 448
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.42
Marker Score: 173
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.41
Marker Score: 4115
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.41
Marker Score: 831
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.41
Marker Score: 5351
Cell Name: Leydig cell (CL0000178)
Fold Change: 0.39
Marker Score: 425
Cell Name: mesangial cell (CL0000650)
Fold Change: 0.39
Marker Score: 471
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.39
Marker Score: 245
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.38
Marker Score: 368
Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.38
Marker Score: 2252.5
Cell Name: ventricular cardiac muscle cell (CL2000046)
Fold Change: 0.38
Marker Score: 157
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: 0.38
Marker Score: 188
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.37
Marker Score: 171
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.37
Marker Score: 350
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.37
Marker Score: 116
Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 0.37
Marker Score: 127
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.36
Marker Score: 361
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.36
Marker Score: 152
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.36
Marker Score: 256
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.36
Marker Score: 3097
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.36
Marker Score: 184
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.36
Marker Score: 70
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 0.35
Marker Score: 97
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.34
Marker Score: 274
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.33
Marker Score: 220
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.33
Marker Score: 173
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.32
Marker Score: 285
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 0.32
Marker Score: 102
Cell Name: centroblast (CL0009112)
Fold Change: 0.32
Marker Score: 156
Cell Name: malignant cell (CL0001064)
Fold Change: 0.32
Marker Score: 4244

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## Summary CCNB1 is a cell cycle-regulated protein that plays a crucial role in controlling the cell cycle. It is a key component of the G1/S transition and plays a critical role in the regulation of cell cycle progression. CCNB1 is also involved in the regulation of cell cycle checkpoints and the maintenance of genomic integrity. ## Key characteristics * CCNB1 is a protein of the Cyclin-B1 family of cell cycle regulators. * It is a highly conserved protein with a conserved structure and function across different species. * CCNB1 is a key regulator of the G1/S transition and is essential for the progression of the cell cycle from G1 to S phase. * It is also involved in the regulation of cell cycle checkpoints and the maintenance of genomic integrity. * CCNB1 is a target for various anti-cancer drugs. ## Pathways and functions * CCNB1 is involved in the regulation of the cell cycle through its interaction with the CDK-cyclin complex. * It acts as a negative regulator of the cell cycle by inhibiting the activation of cyclin-dependent kinases (CDKs). * In the G1 phase, CCNB1 binds to the CDK-cyclin complex and prevents its interaction with cyclin, thereby inhibiting the activation of CDK and the subsequent progression of the cell cycle into the S phase. * In the G2/M phase, CCNB1 dissociates from the CDK-cyclin complex and allows the activation of CDK, leading to the progression of the cell cycle into the M phase. * CCNB1 also plays a role in the regulation of cell cycle checkpoints. It is involved in the detection of DNA damage and the activation of DNA repair mechanisms. * In addition to its role in cell cycle regulation, CCNB1 is also involved in the regulation of cell fate decisions. It is expressed in a variety of cell types, including embryonic stem cells, germ cells, and cancer cells. ## Clinical significance CCNB1 is a key target for cancer therapy. Mutations in CCNB1 have been linked to the development of a number of human cancers, including breast cancer, ovarian cancer, and leukemia. Inhibition of CCNB1 has been shown to be effective in inhibiting cancer cell growth and proliferation.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

G2/mitotic-specific cyclin-B1

Genular Protein ID: 4253425813

Symbol: CCNB1_HUMAN

Name: G2/mitotic-specific cyclin-B1

UniProtKB Accession Codes:

P14635 A8K066 Q5TZP9

Database IDs:

Citations:

PubMed ID: 2570636

Title: Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2.

PubMed ID: 2570636

DOI: 10.1016/0092-8674(89)90936-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7843284

Title: Structure and growth-dependent regulation of the human cyclin B1 promoter.

PubMed ID: 7843284

DOI: 10.1006/excr.1995.1050

PubMed ID: 10716937

Title: Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction.

PubMed ID: 10716937

DOI: 10.1093/emboj/19.6.1378

PubMed ID: 12447691

Title: Cooperative phosphorylation including the activity of polo-like kinase 1 regulates the subcellular localization of cyclin B1.

PubMed ID: 12447691

DOI: 10.1038/sj.onc.1206011

PubMed ID: 12775724

Title: RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis.

PubMed ID: 12775724

DOI: 10.1074/jbc.m302191200

PubMed ID: 12612082

Title: A novel RING finger protein, human enhancer of invasion 10, alters mitotic progression through regulation of cyclin B levels.

PubMed ID: 12612082

DOI: 10.1128/mcb.23.6.2109-2122.2003

PubMed ID: 12524548

Title: Active cyclin B1-Cdk1 first appears on centrosomes in prophase.

PubMed ID: 12524548

DOI: 10.1038/ncb918

PubMed ID: 16009132

Title: NIPA defines an SCF-type mammalian E3 ligase that regulates mitotic entry.

PubMed ID: 16009132

DOI: 10.1016/j.cell.2005.04.034

PubMed ID: 15181148

Title: p21-mediated nuclear retention of cyclin B1-Cdk1 in response to genotoxic stress.

PubMed ID: 15181148

DOI: 10.1091/mbc.e03-12-0871

PubMed ID: 15790566

Title: Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint.

PubMed ID: 15790566

DOI: 10.1074/jbc.m413431200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21540187

Title: Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling.

PubMed ID: 21540187

DOI: 10.1074/jbc.m110.203471

PubMed ID: 17495531

Title: Cyclin B and cyclin A confer different substrate recognition properties on CDK2.

PubMed ID: 17495531

DOI: 10.4161/cc.6.11.4278

PubMed ID: 17495533

Title: The crystal structure of human cyclin B.

PubMed ID: 17495533

DOI: 10.4161/cc.6.11.4297

Sequence Information:

Length: 433
Mass: 48337
Checksum: E2C4767AE8A11EC0
Sequence:

MALRVTRNSK INAENKAKIN MAGAKRVPTA PAATSKPGLR PRTALGDIGN KVSEQLQAKM 
PMKKEAKPSA TGKVIDKKLP KPLEKVPMLV PVPVSEPVPE PEPEPEPEPV KEEKLSPEPI 
LVDTASPSPM ETSGCAPAEE DLCQAFSDVI LAVNDVDAED GADPNLCSEY VKDIYAYLRQ 
LEEEQAVRPK YLLGREVTGN MRAILIDWLV QVQMKFRLLQ ETMYMTVSII DRFMQNNCVP 
KKMLQLVGVT AMFIASKYEE MYPPEIGDFA FVTDNTYTKH QIRQMEMKIL RALNFGLGRP 
LPLHFLRRAS KIGEVDVEQH TLAKYLMELT MLDYDMVHFP PSQIAAGAFC LALKILDNGE 
WTPTLQHYLS YTEESLLPVM QHLAKNVVMV NQGLTKHMTV KNKYATSKHA KISTLPQLNS 
ALVQDLAKAV AKV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: CCNB1

Associated with

Cells (max top 100)

Other Information

Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2. PubMed ID: 2570636

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 5. PubMed ID: 15372022

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Structure and growth-dependent regulation of the human cyclin B1 promoter. PubMed ID: 7843284

Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction. PubMed ID: 10716937

Cooperative phosphorylation including the activity of polo-like kinase 1 regulates the subcellular localization of cyclin B1. PubMed ID: 12447691

RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis. PubMed ID: 12775724

A novel RING finger protein, human enhancer of invasion 10, alters mitotic progression through regulation of cyclin B levels. PubMed ID: 12612082

Active cyclin B1-Cdk1 first appears on centrosomes in prophase. PubMed ID: 12524548

NIPA defines an SCF-type mammalian E3 ligase that regulates mitotic entry. PubMed ID: 16009132

p21-mediated nuclear retention of cyclin B1-Cdk1 in response to genotoxic stress. PubMed ID: 15181148

Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint. PubMed ID: 15790566

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling. PubMed ID: 21540187

Cyclin B and cyclin A confer different substrate recognition properties on CDK2. PubMed ID: 17495531

The crystal structure of human cyclin B. PubMed ID: 17495533