CCNB1 | ENSG00000134057 | NCBI 891

Details for: CCNB1

Gene ID: 891

Symbol: CCNB1

Ensembl ID: ENSG00000134057

Description: cyclin B1

Associated with

Activation of apc/c and apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176814)
Activation of nima kinases nek9, nek6, nek7
(R-HSA-2980767)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apc/c:cdc20 mediated degradation of cyclin b
(R-HSA-174048)
Apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176409)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Chk1/chk2(cds1) mediated inactivation of cyclin b:cdk1 complex
(R-HSA-75035)
Condensation of prometaphase chromosomes
(R-HSA-2514853)
Condensation of prophase chromosomes
(R-HSA-2299718)
Cyclin a/b1/b2 associated events during g2/m transition
(R-HSA-69273)
Depolymerization of the nuclear lamina
(R-HSA-4419969)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
E2f-enabled inhibition of pre-replication complex formation
(R-HSA-113507)
E2f mediated regulation of dna replication
(R-HSA-113510)
G1/s transition
(R-HSA-69206)
G2/m checkpoints
(R-HSA-69481)
G2/m dna damage checkpoint
(R-HSA-69473)
G2/m dna replication checkpoint
(R-HSA-69478)
G2/m transition
(R-HSA-69275)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Golgi cisternae pericentriolar stack reorganization
(R-HSA-162658)
Initiation of nuclear envelope (ne) reformation
(R-HSA-2995383)
Mastl facilitates mitotic progression
(R-HSA-2465910)
Mitf-m-dependent gene expression
(R-HSA-9856651)
Mitf-m-regulated melanocyte development
(R-HSA-9730414)
Mitotic anaphase
(R-HSA-68882)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic prometaphase
(R-HSA-68877)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Nuclear envelope (ne) reassembly
(R-HSA-2995410)
Nuclear envelope breakdown
(R-HSA-2980766)
Nuclear events stimulated by alk signaling in cancer
(R-HSA-9725371)
Nuclear pore complex (npc) disassembly
(R-HSA-3301854)
Phosphorylation of emi1
(R-HSA-176417)
Phosphorylation of the apc/c
(R-HSA-176412)
Polo-like kinase mediated events
(R-HSA-156711)
Regulation of apc/c activators between g1/s and early anaphase
(R-HSA-176408)
Regulation of mitf-m-dependent genes involved in cell cycle and proliferation
(R-HSA-9825892)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of plk1 activity at g2/m transition
(R-HSA-2565942)
Resolution of sister chromatid cohesion
(R-HSA-2500257)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by alk fusions and activated point mutants
(R-HSA-9725370)
Signaling by alk in cancer
(R-HSA-9700206)
The role of gtse1 in g2/m progression after g2 checkpoint
(R-HSA-8852276)
Tp53 regulates transcription of cell cycle genes
(R-HSA-6791312)
Tp53 regulates transcription of genes involved in g2 cell cycle arrest
(R-HSA-6804114)
Transcriptional regulation by runx2
(R-HSA-8878166)
Transcriptional regulation by tp53
(R-HSA-3700989)
Cell division
(GO:0051301)
Centrosome
(GO:0005813)
Cyclin-dependent protein serine/threonine kinase activator activity
(GO:0061575)
Cyclin-dependent protein serine/threonine kinase regulator activity
(GO:0016538)
Cyclin b1-cdk1 complex
(GO:0097125)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
G1/s transition of mitotic cell cycle
(GO:0000082)
G2/m transition of mitotic cell cycle
(GO:0000086)
In utero embryonic development
(GO:0001701)
Membrane
(GO:0016020)
Microtubule organizing center
(GO:0005815)
Mitochondrial matrix
(GO:0005759)
Mitotic metaphase chromosome alignment
(GO:0007080)
Mitotic spindle organization
(GO:0007052)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Outer kinetochore
(GO:0000940)
Patched binding
(GO:0005113)
Positive regulation of attachment of spindle microtubules to kinetochore
(GO:0051987)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of g2/m transition of mitotic cell cycle
(GO:0010971)
Positive regulation of mitochondrial atp synthesis coupled electron transport
(GO:1905448)
Positive regulation of mitotic cell cycle
(GO:0045931)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Regulation of mitotic cell cycle spindle assembly checkpoint
(GO:0090266)
Spindle pole
(GO:0000922)
Ubiquitin-like protein ligase binding
(GO:0044389)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 41.2784
Cell Significance Index: -10.4700
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 31.3025
Cell Significance Index: -12.9000
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 26.6334
Cell Significance Index: -10.8200
Cell Name: basophilic erythroblast (CL0000549)
Fold Change: 23.6931
Cell Significance Index: 10.7900
Cell Name: colon endothelial cell (CL1001572)
Fold Change: 16.4042
Cell Significance Index: 12.5200
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 11.4795
Cell Significance Index: -10.9600
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 8.5161
Cell Significance Index: -10.5000
Cell Name: germ cell (CL0000586)
Fold Change: 4.7274
Cell Significance Index: 35.7000
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 4.6027
Cell Significance Index: -12.3300
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 3.1044
Cell Significance Index: -12.2500
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 2.1865
Cell Significance Index: 416.1000
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 1.8678
Cell Significance Index: 16.0500
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 1.6274
Cell Significance Index: 189.6500
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 1.6272
Cell Significance Index: 17.6900
Cell Name: sensory neuron (CL0000101)
Fold Change: 1.4919
Cell Significance Index: 8.4800
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.2423
Cell Significance Index: 146.5100
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.1706
Cell Significance Index: 190.3900
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.9789
Cell Significance Index: 106.4800
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.9223
Cell Significance Index: 832.8000
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.9097
Cell Significance Index: 31.6100
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.8392
Cell Significance Index: 21.4400
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.7927
Cell Significance Index: 78.4200
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.7041
Cell Significance Index: 22.5500
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.6418
Cell Significance Index: 33.3400
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.6395
Cell Significance Index: 3.1100
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.6094
Cell Significance Index: 332.8200
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.5934
Cell Significance Index: 12.4200
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.5476
Cell Significance Index: 14.4000
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.5215
Cell Significance Index: 103.4900
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.5067
Cell Significance Index: 13.5300
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.4958
Cell Significance Index: 34.2900
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 0.4661
Cell Significance Index: -1.0200
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 0.4471
Cell Significance Index: 4.7500
Cell Name: salivary gland cell (CL0009005)
Fold Change: 0.3978
Cell Significance Index: 4.9400
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.2623
Cell Significance Index: 7.3300
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2544
Cell Significance Index: 11.5300
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.2500
Cell Significance Index: 6.7000
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.2228
Cell Significance Index: 12.5000
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1728
Cell Significance Index: 4.9800
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.1492
Cell Significance Index: 3.7300
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1326
Cell Significance Index: 58.6200
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.1160
Cell Significance Index: 0.7700
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0993
Cell Significance Index: 6.2600
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0974
Cell Significance Index: 19.5300
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.0966
Cell Significance Index: 0.6000
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0873
Cell Significance Index: 11.9900
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0835
Cell Significance Index: 1.8100
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0695
Cell Significance Index: 1.4800
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0653
Cell Significance Index: 8.3700
Cell Name: ventricular cardiac muscle cell (CL2000046)
Fold Change: 0.0565
Cell Significance Index: 0.2500
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.0505
Cell Significance Index: 3.0300
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.0469
Cell Significance Index: 0.4900
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0396
Cell Significance Index: 14.2100
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0377
Cell Significance Index: 4.6400
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0339
Cell Significance Index: 1.1900
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0300
Cell Significance Index: 5.4000
Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
Fold Change: 0.0132
Cell Significance Index: 0.1200
Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.0036
Cell Significance Index: 0.0500
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0021
Cell Significance Index: 0.0400
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0029
Cell Significance Index: -5.4700
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0055
Cell Significance Index: -3.4400
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0061
Cell Significance Index: -0.4300
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0073
Cell Significance Index: -13.4700
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0076
Cell Significance Index: -5.6000
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0085
Cell Significance Index: -13.0400
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0091
Cell Significance Index: -5.1600
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0101
Cell Significance Index: -13.7700
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0114
Cell Significance Index: -1.9400
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0121
Cell Significance Index: -9.1600
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0130
Cell Significance Index: -9.5600
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0166
Cell Significance Index: -10.5400
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0172
Cell Significance Index: -2.2200
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0195
Cell Significance Index: -5.6100
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0232
Cell Significance Index: -2.3700
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0271
Cell Significance Index: -12.3100
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0275
Cell Significance Index: -5.7900
Cell Name: kidney cell (CL1000497)
Fold Change: -0.0438
Cell Significance Index: -0.3500
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0454
Cell Significance Index: -5.2000
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0547
Cell Significance Index: -2.5700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0686
Cell Significance Index: -3.2000
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0726
Cell Significance Index: -10.5500
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0750
Cell Significance Index: -5.5900
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0796
Cell Significance Index: -9.0900
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0890
Cell Significance Index: -5.7400
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0942
Cell Significance Index: -1.0700
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0997
Cell Significance Index: -6.1100
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1014
Cell Significance Index: -6.2300
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1017
Cell Significance Index: -5.3400
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: -0.1047
Cell Significance Index: -0.3000
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1172
Cell Significance Index: -12.2000
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1396
Cell Significance Index: -7.2700
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1467
Cell Significance Index: -11.6200
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1477
Cell Significance Index: -9.9300
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.1522
Cell Significance Index: -4.4700
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: -0.1571
Cell Significance Index: -2.1800
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1626
Cell Significance Index: -12.4800
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.1718
Cell Significance Index: -5.0600
Cell Name: mesodermal cell (CL0000222)
Fold Change: -0.1821
Cell Significance Index: -1.1400
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.1979
Cell Significance Index: -2.7000
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.2123
Cell Significance Index: -5.6800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** * CCNB1 is a G2/mitotic-specific cyclin, meaning it is only expressed during the G2 phase of the cell cycle and is essential for mitotic entry. * It is a member of the cyclin family, which regulates the activity of CDKs. * CCNB1 binds to CDK1 (Cdc2) and CDK2, forming a complex that drives the cell cycle forward. * It is involved in the regulation of the spindle checkpoint, ensuring that chromosomes are properly aligned and attached to the spindle microtubules. * CCNB1 has been shown to interact with various proteins, including APC, Cdc20, and Emi1, to regulate the activity of the CDK complex. **Pathways and Functions** * **Cell Cycle Regulation**: CCNB1 plays a central role in regulating the G2/M phase transition, ensuring that cells enter mitosis in a coordinated and accurate manner. * **Spindle Checkpoint**: CCNB1 is involved in the regulation of the spindle checkpoint, ensuring that chromosomes are properly aligned and attached to the spindle microtubules. * **DNA Replication**: CCNB1 regulates the progression of DNA replication and repair, ensuring that DNA is accurately replicated and repaired. * **Mitotic Entry**: CCNB1 is essential for mitotic entry, driving the cell cycle forward and promoting chromosome condensation. * **Cancer**: Dysregulation of CCNB1 has been implicated in various cancers, including breast, lung, and colon cancer, where it can contribute to uncontrolled cell proliferation and tumorigenesis. **Clinical Significance** * **Cancer**: CCNB1 overexpression has been associated with poor prognosis and increased risk of cancer relapse. * **Reproductive Cancers**: CCNB1 has been implicated in the development of reproductive cancers, including ovarian and testicular cancer. * **Neurological Disorders**: CCNB1 dysregulation has been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease. * **Infectious Diseases**: CCNB1 has been implicated in the progression of infectious diseases, including HIV and hepatitis. In conclusion, CCNB1 is a critical regulator of the cell cycle, particularly during the G2/M phase. Its dysregulation has been implicated in various diseases, including cancer, reproductive cancers, neurological disorders, and infectious diseases. Further research is needed to fully understand the mechanisms by which CCNB1 regulates the cell cycle and to identify potential therapeutic targets for its dysregulation.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

G2/mitotic-specific cyclin-B1

Genular Protein ID: 4253425813

Symbol: CCNB1_HUMAN

Name: G2/mitotic-specific cyclin-B1

UniProtKB Accession Codes:

P14635 A8K066 Q5TZP9

Database IDs:

Citations:

PubMed ID: 2570636

Title: Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2.

PubMed ID: 2570636

DOI: 10.1016/0092-8674(89)90936-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7843284

Title: Structure and growth-dependent regulation of the human cyclin B1 promoter.

PubMed ID: 7843284

DOI: 10.1006/excr.1995.1050

PubMed ID: 10716937

Title: Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction.

PubMed ID: 10716937

DOI: 10.1093/emboj/19.6.1378

PubMed ID: 12447691

Title: Cooperative phosphorylation including the activity of polo-like kinase 1 regulates the subcellular localization of cyclin B1.

PubMed ID: 12447691

DOI: 10.1038/sj.onc.1206011

PubMed ID: 12775724

Title: RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis.

PubMed ID: 12775724

DOI: 10.1074/jbc.m302191200

PubMed ID: 12612082

Title: A novel RING finger protein, human enhancer of invasion 10, alters mitotic progression through regulation of cyclin B levels.

PubMed ID: 12612082

DOI: 10.1128/mcb.23.6.2109-2122.2003

PubMed ID: 12524548

Title: Active cyclin B1-Cdk1 first appears on centrosomes in prophase.

PubMed ID: 12524548

DOI: 10.1038/ncb918

PubMed ID: 16009132

Title: NIPA defines an SCF-type mammalian E3 ligase that regulates mitotic entry.

PubMed ID: 16009132

DOI: 10.1016/j.cell.2005.04.034

PubMed ID: 15181148

Title: p21-mediated nuclear retention of cyclin B1-Cdk1 in response to genotoxic stress.

PubMed ID: 15181148

DOI: 10.1091/mbc.e03-12-0871

PubMed ID: 15790566

Title: Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint.

PubMed ID: 15790566

DOI: 10.1074/jbc.m413431200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21540187

Title: Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling.

PubMed ID: 21540187

DOI: 10.1074/jbc.m110.203471

PubMed ID: 27030811

Title: Ubiquitin-specific protease 22 is a deubiquitinase of CCNB1.

PubMed ID: 27030811

DOI: 10.1038/celldisc.2015.28

PubMed ID: 17495531

Title: Cyclin B and cyclin A confer different substrate recognition properties on CDK2.

PubMed ID: 17495531

DOI: 10.4161/cc.6.11.4278

PubMed ID: 17495533

Title: The crystal structure of human cyclin B.

PubMed ID: 17495533

DOI: 10.4161/cc.6.11.4297

Sequence Information:

Length: 433
Mass: 48337
Checksum: E2C4767AE8A11EC0
Sequence:

MALRVTRNSK INAENKAKIN MAGAKRVPTA PAATSKPGLR PRTALGDIGN KVSEQLQAKM 
PMKKEAKPSA TGKVIDKKLP KPLEKVPMLV PVPVSEPVPE PEPEPEPEPV KEEKLSPEPI 
LVDTASPSPM ETSGCAPAEE DLCQAFSDVI LAVNDVDAED GADPNLCSEY VKDIYAYLRQ 
LEEEQAVRPK YLLGREVTGN MRAILIDWLV QVQMKFRLLQ ETMYMTVSII DRFMQNNCVP 
KKMLQLVGVT AMFIASKYEE MYPPEIGDFA FVTDNTYTKH QIRQMEMKIL RALNFGLGRP 
LPLHFLRRAS KIGEVDVEQH TLAKYLMELT MLDYDMVHFP PSQIAAGAFC LALKILDNGE 
WTPTLQHYLS YTEESLLPVM QHLAKNVVMV NQGLTKHMTV KNKYATSKHA KISTLPQLNS 
ALVQDLAKAV AKV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CCNB1

Associated with

Cells (max top 100)

Other Information

Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2. PubMed ID: 2570636

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 5. PubMed ID: 15372022

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Structure and growth-dependent regulation of the human cyclin B1 promoter. PubMed ID: 7843284

Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction. PubMed ID: 10716937

Cooperative phosphorylation including the activity of polo-like kinase 1 regulates the subcellular localization of cyclin B1. PubMed ID: 12447691

RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis. PubMed ID: 12775724

A novel RING finger protein, human enhancer of invasion 10, alters mitotic progression through regulation of cyclin B levels. PubMed ID: 12612082

Active cyclin B1-Cdk1 first appears on centrosomes in prophase. PubMed ID: 12524548

NIPA defines an SCF-type mammalian E3 ligase that regulates mitotic entry. PubMed ID: 16009132

p21-mediated nuclear retention of cyclin B1-Cdk1 in response to genotoxic stress. PubMed ID: 15181148

Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint. PubMed ID: 15790566

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling. PubMed ID: 21540187

Ubiquitin-specific protease 22 is a deubiquitinase of CCNB1. PubMed ID: 27030811

Cyclin B and cyclin A confer different substrate recognition properties on CDK2. PubMed ID: 17495531

The crystal structure of human cyclin B. PubMed ID: 17495533