Details for: CACNA1G
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: mesangial cell (CL0000650)
Fold Change: 2.25
Marker Score: 2,712 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 2.06
Marker Score: 69,723 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.61
Marker Score: 1,172 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.48
Marker Score: 2,801 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.38
Marker Score: 873 - Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 1.34
Marker Score: 2,776 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.18
Marker Score: 489 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.18
Marker Score: 12,160 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4,816 - Cell Name: goblet cell (CL0000160)
Fold Change: 1.1
Marker Score: 7,304 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.09
Marker Score: 16,999 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.09
Marker Score: 8,324 - Cell Name: neuron (CL0000540)
Fold Change: 1.08
Marker Score: 4,387 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.06
Marker Score: 21,179 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.05
Marker Score: 800 - Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 1.03
Marker Score: 374 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.03
Marker Score: 37,959 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.01
Marker Score: 687 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.01
Marker Score: 2,055 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,827 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,051 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 511 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.99
Marker Score: 3,828 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.99
Marker Score: 521 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 464 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,408 - Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.96
Marker Score: 305 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.95
Marker Score: 2,249 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,413 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5,352 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.94
Marker Score: 375 - Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 0.93
Marker Score: 940 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.93
Marker Score: 428 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2,741 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.91
Marker Score: 327 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,288 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1,264 - Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 710 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 398 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.76
Marker Score: 291 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.75
Marker Score: 234 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.73
Marker Score: 27,885 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.73
Marker Score: 464 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7
Marker Score: 180 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.67
Marker Score: 2,773 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.66
Marker Score: 5,698 - Cell Name: renal principal cell (CL0005009)
Fold Change: 0.66
Marker Score: 510 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.65
Marker Score: 1,311 - Cell Name: precursor B cell (CL0000817)
Fold Change: 0.64
Marker Score: 426 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.63
Marker Score: 299 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.59
Marker Score: 189 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.58
Marker Score: 460 - Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.56
Marker Score: 149 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.56
Marker Score: 234 - Cell Name: Unknown (CL0002371)
Fold Change: 0.56
Marker Score: 592 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.55
Marker Score: 33,926 - Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 0.55
Marker Score: 519 - Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.53
Marker Score: 380 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.53
Marker Score: 642 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.52
Marker Score: 17,736 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.52
Marker Score: 310 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.49
Marker Score: 5,483 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.43
Marker Score: 6,373 - Cell Name: stellate neuron (CL0000122)
Fold Change: 0.4
Marker Score: 2,141 - Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.39
Marker Score: 101 - Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.38
Marker Score: 167 - Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.37
Marker Score: 373 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.37
Marker Score: 117 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.36
Marker Score: 613 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 0.35
Marker Score: 1,623 - Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 0.34
Marker Score: 191 - Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 0.33
Marker Score: 194 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.32
Marker Score: 3,067 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.32
Marker Score: 497 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 0.32
Marker Score: 1,120 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.29
Marker Score: 1,873 - Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 0.27
Marker Score: 802 - Cell Name: meningeal macrophage (CL0000879)
Fold Change: 0.27
Marker Score: 76 - Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 0.26
Marker Score: 77 - Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 0.26
Marker Score: 262 - Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.25
Marker Score: 3,344 - Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.25
Marker Score: 312 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.23
Marker Score: 139 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.23
Marker Score: 65 - Cell Name: muscle cell (CL0000187)
Fold Change: 0.23
Marker Score: 64 - Cell Name: macroglial cell (CL0000126)
Fold Change: 0.22
Marker Score: 513 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: 0.22
Marker Score: 929 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 75 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.22
Marker Score: 92 - Cell Name: CNS interneuron (CL0000402)
Fold Change: 0.21
Marker Score: 102 - Cell Name: reticular cell (CL0000432)
Fold Change: 0.21
Marker Score: 76 - Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 0.2
Marker Score: 65 - Cell Name: podocyte (CL0000653)
Fold Change: 0.2
Marker Score: 75 - Cell Name: fibroblast (CL0000057)
Fold Change: 0.2
Marker Score: 195 - Cell Name: neuroendocrine cell (CL0000165)
Fold Change: 0.2
Marker Score: 78 - Cell Name: pro-B cell (CL0000826)
Fold Change: 0.2
Marker Score: 193 - Cell Name: mast cell (CL0000097)
Fold Change: 0.19
Marker Score: 112 - Cell Name: rod bipolar cell (CL0000751)
Fold Change: 0.19
Marker Score: 99 - Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 0.19
Marker Score: 65 - Cell Name: astrocyte (CL0000127)
Fold Change: 0.19
Marker Score: 161
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 701312072
Symbol: CAC1G_HUMAN
Name: Voltage-dependent T-type calcium channel subunit alpha-1G
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10493502
Title: Inactivation of CACNA1G, a T-type calcium channel gene, by aberrant methylation of its 5' CpG island in human tumors.
PubMed ID: 10493502
PubMed ID: 10548410
Title: Structure and alternative splicing of the gene encoding alpha1G, a human brain T calcium channel alpha1 subunit.
PubMed ID: 10548410
PubMed ID: 10648811
Title: Molecular cloning and functional expression of ca(v)3.1c, a T-type calcium channel from human brain.
PubMed ID: 10648811
PubMed ID: 10692398
Title: Molecular and functional properties of the human alpha1G subunit that forms T-type calcium channels.
PubMed ID: 10692398
PubMed ID: 16671074
Title: Profiling the array of Ca(v)3.1 variants from the human T-type calcium channel gene CACNA1G: alternative structures, developmental expression, and biophysical variations.
PubMed ID: 16671074
DOI: 10.1002/prot.20877
PubMed ID: 16625196
Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
PubMed ID: 16625196
DOI: 10.1038/nature04689
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10574461
Title: Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.
PubMed ID: 10574461
PubMed ID: 12168954
Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.
PubMed ID: 12168954
PubMed ID: 9495342
Title: Molecular characterization of a neuronal low-voltage-activated T-type calcium channel.
PubMed ID: 9495342
DOI: 10.1038/36110
PubMed ID: 26456284
Title: A recurrent mutation in CACNA1G alters Cav3.1 T-type calcium-channel conduction and causes autosomal-dominant cerebellar ataxia.
PubMed ID: 26456284
PubMed ID: 26715324
Title: A mutation in the low voltage-gated calcium channel CACNA1G alters the physiological properties of the channel, causing spinocerebellar ataxia.
PubMed ID: 26715324
PubMed ID: 29878067
Title: De novo mutation screening in childhood-onset cerebellar atrophy identifies gain-of-function mutations in the CACNA1G calcium channel gene.
PubMed ID: 29878067
DOI: 10.1093/brain/awy145
Sequence Information:
- Length: 2377
- Mass: 262472
- Checksum: 1C9F7C557D9D32DF
- Sequence:
MDEEEDGAGA EESGQPRSFM RLNDLSGAGG RPGPGSAEKD PGSADSEAEG LPYPALAPVV FFYLSQDSRP RSWCLRTVCN PWFERISMLV ILLNCVTLGM FRPCEDIACD SQRCRILQAF DDFIFAFFAV EMVVKMVALG IFGKKCYLGD TWNRLDFFIV IAGMLEYSLD LQNVSFSAVR TVRVLRPLRA INRVPSMRIL VTLLLDTLPM LGNVLLLCFF VFFIFGIVGV QLWAGLLRNR CFLPENFSLP LSVDLERYYQ TENEDESPFI CSQPRENGMR SCRSVPTLRG DGGGGPPCGL DYEAYNSSSN TTCVNWNQYY TNCSAGEHNP FKGAINFDNI GYAWIAIFQV ITLEGWVDIM YFVMDAHSFY NFIYFILLII VGSFFMINLC LVVIATQFSE TKQRESQLMR EQRVRFLSNA STLASFSEPG SCYEELLKYL VYILRKAARR LAQVSRAAGV RVGLLSSPAP LGGQETQPSS SCSRSHRRLS VHHLVHHHHH HHHHYHLGNG TLRAPRASPE IQDRDANGSR RLMLPPPSTP ALSGAPPGGA ESVHSFYHAD CHLEPVRCQA PPPRSPSEAS GRTVGSGKVY PTVHTSPPPE TLKEKALVEV AASSGPPTLT SLNIPPGPYS SMHKLLETQS TGACQSSCKI SSPCLKADSG ACGPDSCPYC ARAGAGEVEL ADREMPDSDS EAVYEFTQDA QHSDLRDPHS RRQRSLGPDA EPSSVLAFWR LICDTFRKIV DSKYFGRGIM IAILVNTLSM GIEYHEQPEE LTNALEISNI VFTSLFALEM LLKLLVYGPF GYIKNPYNIF DGVIVVISVW EIVGQQGGGL SVLRTFRLMR VLKLVRFLPA LQRQLVVLMK TMDNVATFCM LLMLFIFIFS ILGMHLFGCK FASERDGDTL PDRKNFDSLL WAIVTVFQIL TQEDWNKVLY NGMASTSSWA ALYFIALMTF GNYVLFNLLV AILVEGFQAE EISKREDASG QLSCIQLPVD SQGGDANKSE SEPDFFSPSL DGDGDRKKCL ALVSLGEHPE LRKSLLPPLI IHTAATPMSL PKSTSTGLGE ALGPASRRTS SSGSAEPGAA HEMKSPPSAR SSPHSPWSAA SSWTSRRSSR NSLGRAPSLK RRSPSGERRS LLSGEGQESQ DEEESSEEER ASPAGSDHRH RGSLEREAKS SFDLPDTLQV PGLHRTASGR GSASEHQDCN GKSASGRLAR ALRPDDPPLD GDDADDEGNL SKGERVRAWI RARLPACCLE RDSWSAYIFP PQSRFRLLCH RIITHKMFDH VVLVIIFLNC ITIAMERPKI DPHSAERIFL TLSNYIFTAV FLAEMTVKVV ALGWCFGEQA YLRSSWNVLD GLLVLISVID ILVSMVSDSG TKILGMLRVL RLLRTLRPLR VISRAQGLKL VVETLMSSLK PIGNIVVICC AFFIIFGILG VQLFKGKFFV CQGEDTRNIT NKSDCAEASY RWVRHKYNFD NLGQALMSLF VLASKDGWVD IMYDGLDAVG VDQQPIMNHN PWMLLYFISF LLIVAFFVLN MFVGVVVENF HKCRQHQEEE EARRREEKRL RRLEKKRRNL MLDDVIASGS SASAASEAQC KPYYSDYSRF RLLVHHLCTS HYLDLFITGV IGLNVVTMAM EHYQQPQILD EALKICNYIF TVIFVLESVF KLVAFGFRRF FQDRWNQLDL AIVLLSIMGI TLEEIEVNAS LPINPTIIRI MRVLRIARVL KLLKMAVGMR ALLDTVMQAL PQVGNLGLLF MLLFFIFAAL GVELFGDLEC DETHPCEGLG RHATFRNFGM AFLTLFRVST GDNWNGIMKD TLRDCDQEST CYNTVISPIY FVSFVLTAQF VLVNVVIAVL MKHLEESNKE AKEEAELEAE LELEMKTLSP QPHSPLGSPF LWPGVEGPDS PDSPKPGALH PAAHARSASH FSLEHPTDRQ LFDTISLLIQ GSLEWELKLM DELAGPGGQP SAFPSAPSLG GSDPQIPLAE MEALSLTSEI VSEPSCSLAL TDDSLPDDMH TLLLSALESN MQPHPTELPG PDLLTVRKSG VSRTHSLPND SYMCRHGSTA EGPLGHRGWG LPKAQSGSVL SVHSQPADTS YILQLPKDAP HLLQPHSAPT WGTIPKLPPP GRSPLAQRPL RRQAAIRTDS LDVQGLGSRE DLLAEVSGPS PPLARAYSFW GQSSTQAQQH SRSHSKISKH MTPPAPCPGP EPNWGKGPPE TRSSLELDTE LSWISGDLLP PGGQEEPPSP RDLKKCYSVE AQSCQRRPTS WLDEQRRHSI AVSCLDSGSQ PHLGTDPSNL GGQPLGGPGS RPKKKLSPPS ITIDPPESQG PRTPPSPGIC LRRRAPSSDS KDPLASGPPD SMAASPSPKK DVLSLSGLSS DPADLDP
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.