Details for: TIMELESS
Associated with
Other Information
Genular Protein ID: 2850546286
Symbol: TIM_HUMAN
Name: Protein timeless homolog
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9891984
Title: Identification of the mammalian homologues of the Drosophila timeless gene, Timeless1.
PubMed ID: 9891984
PubMed ID: 9856465
Title: Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-ARTNL/BMAL1-induced transcription.
PubMed ID: 9856465
PubMed ID: 16541075
Title: The finished DNA sequence of human chromosome 12.
PubMed ID: 16541075
DOI: 10.1038/nature04569
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15798197
Title: Coupling of human circadian and cell cycles by the timeless protein.
PubMed ID: 15798197
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 17116885
Title: Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function.
PubMed ID: 17116885
PubMed ID: 17102137
Title: Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint.
PubMed ID: 17102137
PubMed ID: 17141802
Title: Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors.
PubMed ID: 17141802
PubMed ID: 17296725
Title: The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement.
PubMed ID: 17296725
DOI: 10.1128/mcb.02190-06
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20139726
Title: The many facets of the Tim-Tipin protein families' roles in chromosome biology.
PubMed ID: 20139726
DOI: 10.4161/cc.9.4.10676
PubMed ID: 20124417
Title: Human Timeless and Tipin stabilize replication forks and facilitate sister-chromatid cohesion.
PubMed ID: 20124417
DOI: 10.1242/jcs.057984
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21670590
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23418588
Title: Mammalian TIMELESS is involved in period determination and DNA damage-dependent phase advancing of the circadian clock.
PubMed ID: 23418588
PubMed ID: 23359676
Title: Human Tim-Tipin complex affects the biochemical properties of the replicative DNA helicase and DNA polymerases.
PubMed ID: 23359676
PubMed ID: 26503245
Title: Tim/Timeless, a member of the replication fork protection complex, operates with the Warsaw breakage syndrome DNA helicase DDX11 in the same fork recovery pathway.
PubMed ID: 26503245
DOI: 10.1093/nar/gkv1112
PubMed ID: 30356214
Title: Nuclear cGAS suppresses DNA repair and promotes tumorigenesis.
PubMed ID: 30356214
PubMed ID: 35585232
Title: Fast and efficient DNA replication with purified human proteins.
PubMed ID: 35585232
PubMed ID: 31138685
Title: TIMELESS mutation alters phase responsiveness and causes advanced sleep phase.
PubMed ID: 31138685
PubMed ID: 26344098
Title: Timeless interacts with PARP-1 to promote homologous recombination repair.
PubMed ID: 26344098
PubMed ID: 28334766
Title: Crystal structure of the N-terminal domain of human Timeless and its interaction with Tipin.
PubMed ID: 28334766
DOI: 10.1093/nar/gkx139
PubMed ID: 32705708
Title: Timeless couples G-quadruplex detection with processing by DDX11 helicase during DNA replication.
PubMed ID: 32705708
PubMed ID: 34694004
Title: Structure of a human replisome shows the organisation and interactions of a DNA replication machine.
PubMed ID: 34694004
PubMed ID: 34700328
Title: A conserved mechanism for regulating replisome disassembly in eukaryotes.
PubMed ID: 34700328
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
Sequence Information:
- Length: 1208
- Mass: 138658
- Checksum: 16C6C07DDC6D2701
- Sequence:
MDLHMMNCEL LATCSALGYL EGDTYHKEPD CLESVKDLIR YLRHEDETRD VRQQLGAAQI LQSDLLPILT QHHQDKPLFD AVIRLMVNLT QPALLCFGNL PKEPSFRHHF LQVLTYLQAY KEAFASEKAF GVLSETLYEL LQLGWEERQE EDNLLIERIL LLVRNILHVP ADLDQEKKID DDASAHDQLL WAIHLSGLDD LLLFLASSSA EEQWSLHVLE IVSLMFRDQN PEQLAGVGQG RLAQERSADF AELEVLRQRE MAEKKTRALQ RGNRHSRFGG SYIVQGLKSI GERDLIFHKG LHNLRNYSSD LGKQPKKVPK RRQAARELSI QRRSALNVRL FLRDFCSEFL ENCYNRLMGS VKDHLLREKA QQHDETYYMW ALAFFMAFNR AASFRPGLVS ETLSVRTFHF IEQNLTNYYE MMLTDRKEAA SWARRMHLAL KAYQELLATV NEMDISPDEA VRESSRIIKN NIFYVMEYRE LFLALFRKFD ERCQPRSFLR DLVETTHLFL KMLERFCRSR GNLVVQNKQK KRRKKKKKVL DQAIVSGNVP SSPEEVEAVW PALAEQLQCC AQNSELSMDS VVPFDAASEV PVEEQRAEAM VRIQDCLLAG QAPQALTLLR SAREVWPEGD VFGSQDISPE EEIQLLKQIL SAPLPRQQGP EERGAEEEEE EEEEEEEELQ VVQVSEKEFN FLDYLKRFAC STVVRAYVLL LRSYQQNSAH TNHCIVKMLH RLAHDLKMEA LLFQLSVFCL FNRLLSDPAA GAYKELVTFA KYILGKFFAL AAVNQKAFVE LLFWKNTAVV REMTEGYGSL DDRSSSRRAP TWSPEEEAHL RELYLANKDV EGQDVVEAIL AHLNTVPRTR KQIIHHLVQM GLADSVKDFQ RKGTHIVLWT GDQELELQRL FEEFRDSDDV LGHIMKNITA KRSRARIVDK LLALGLVAER RELYKKRQKK LASSILPNGA ESLKDFCQED LEEEENLPEE DSEEEEEGGS EAEQVQGSLV LSNENLGQSL HQEGFSIPLL WLQNCLIRAA DDREEDGCSQ AVPLVPLTEE NEEAMENEQF QQLLRKLGVR PPASGQETFW RIPAKLSPTQ LRRAAASLSQ PEEEQKLQPE LQPKVPGEQG SDEEHCKEHR AQALRALLLA HKKKAGLASP EEEDAVGKEP LKAAPKKRQL LDSDEEQEED EGRNRAPELG APGIQKKKRY QIEDDEDD
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.