Details for: BCL10

Gene ID: 8915

Symbol: BCL10

Ensembl ID: ENSG00000142867

Description: BCL10 immune signaling adaptor

Associated with

Other Information

Genular Protein ID: 2804160206

Symbol: BCL10_HUMAN

Name: B-cell lymphoma/leukemia 10

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9989495

Title: Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types.

PubMed ID: 9989495

DOI: 10.1016/s0092-8674(00)80957-5

PubMed ID: 10187770

Title: CIPER, a novel NF kappaB-activating protein containing a caspase recruitment domain with homology to Herpesvirus-2 protein E10.

PubMed ID: 10187770

DOI: 10.1074/jbc.274.15.9955

PubMed ID: 10187771

Title: Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinase.

PubMed ID: 10187771

DOI: 10.1074/jbc.274.15.9962

PubMed ID: 10187815

Title: mE10, a novel caspase recruitment domain-containing proapoptotic molecule.

PubMed ID: 10187815

DOI: 10.1074/jbc.274.15.10287

PubMed ID: 10364242

Title: CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-kappaB activation and apoptosis.

PubMed ID: 10364242

DOI: 10.1074/jbc.274.25.17946

PubMed ID: 10400625

Title: c-E10 is a caspase-recruiting domain-containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor-kappaB.

PubMed ID: 10400625

DOI: 10.1074/jbc.274.29.20127

PubMed ID: 10319863

Title: Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32).

PubMed ID: 10319863

DOI: 10.1038/8767

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11466612

Title: Interchangeable binding of Bcl10 to TRAF2 and cIAPs regulates apoptosis signaling.

PubMed ID: 11466612

DOI: 10.1038/sj.onc.1204576

PubMed ID: 17287217

Title: Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1.

PubMed ID: 17287217

DOI: 10.1074/jbc.m609157200

PubMed ID: 17213322

Title: Negative feedback loop in T cell activation through IkappaB kinase-induced phosphorylation and degradation of Bcl10.

PubMed ID: 17213322

DOI: 10.1073/pnas.0606982104

PubMed ID: 18264101

Title: The proteolytic activity of the paracaspase MALT1 is key in T cell activation.

PubMed ID: 18264101

DOI: 10.1038/ni1568

PubMed ID: 18287044

Title: NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-kappaB activation.

PubMed ID: 18287044

DOI: 10.1073/pnas.0712313105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 25365219

Title: Inherited BCL10 deficiency impairs hematopoietic and nonhematopoietic immunity.

PubMed ID: 25365219

DOI: 10.1172/jci77493

PubMed ID: 26488816

Title: Ubiquitin ligase TRIM62 regulates CARD9-mediated anti-fungal immunity and intestinal inflammation.

PubMed ID: 26488816

DOI: 10.1016/j.immuni.2015.10.005

PubMed ID: 27113748

Title: The paracaspase MALT1 mediates CARD14-induced signaling in keratinocytes.

PubMed ID: 27113748

DOI: 10.15252/embr.201642109

PubMed ID: 27777308

Title: Molecular determinants of scaffold-induced linear ubiquitinylation of B Cell Lymphoma/Leukemia 10 (Bcl10) during T cell receptor and oncogenic caspase recruitment domain-containing protein 11 (CARD11) signaling.

PubMed ID: 27777308

DOI: 10.1074/jbc.m116.754028

PubMed ID: 28628108

Title: Germline hypomorphic CARD11 mutations in severe atopic disease.

PubMed ID: 28628108

DOI: 10.1038/ng.3898

PubMed ID: 31296852

Title: Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation.

PubMed ID: 31296852

DOI: 10.1038/s41467-019-10953-z

PubMed ID: 24074955

Title: Structural architecture of the CARMA1/Bcl10/MALT1 signalosome: nucleation-induced filamentous assembly.

PubMed ID: 24074955

DOI: 10.1016/j.molcel.2013.08.032

PubMed ID: 10582682

Title: Point mutations and deletions of the Bcl10 gene in solid tumors and malignant lymphomas.

PubMed ID: 10582682

PubMed ID: 10380921

Title: Absence of BCL10 mutations in human malignant mesothelioma.

PubMed ID: 10380921

DOI: 10.1016/s0092-8674(02)09765-9

Sequence Information:

  • Length: 233
  • Mass: 26252
  • Checksum: F87C97F2B784BA4B
  • Sequence:
  • MEPTAPSLTE EDLTEVKKDA LENLRVYLCE KIIAERHFDH LRAKKILSRE DTEEISCRTS 
    SRKRAGKLLD YLQENPKGLD TLVESIRREK TQNFLIQKIT DEVLKLRNIK LEHLKGLKCS 
    SCEPFPDGAT NNLSRSNSDE SNFSEKLRAS TVMYHPEGES STTPFFSTNS SLNLPVLEVG 
    RTENTIFSST TLPRPGDPGA PPLPPDLQLE EEGTCANSSE MFLPLRSRTV SRQ

Genular Protein ID: 3341740496

Symbol: A0A087WWW9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

Sequence Information:

  • Length: 222
  • Mass: 25102
  • Checksum: 82781C1DB8C2414E
  • Sequence:
  • MEPTAPSLTE EDLTEVKKDA LENLRVYLCE KIIAERHFDH LRAKKILSRE DTEEISCRTS 
    SRKRAGKLLD YLQENPKGLD TLVESIRREK TQNFLIQKIT DEVLKLRNIK LEHLKDGATN 
    NLSRSNSDES NFSEKLRAST VMYHPEGESS TTPFFSTNSS LNLPVLEVGR TENTIFSSTT 
    LPRPGDPGAP PLPPDLQLEE EGTCANSSEM FLPLRSRTVS RQ

Genular Protein ID: 3337727856

Symbol: A2TDT2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 23661444

Title: Significance of Bcl10 gene mutations in the clinical diagnosis of MALT-type ocular adnexal lymphoma in the Chinese population.

PubMed ID: 23661444

DOI: 10.4238/2013.April.12.6

Sequence Information:

  • Length: 157
  • Mass: 18221
  • Checksum: CD0AE33364933B1F
  • Sequence:
  • MEPTAPSLTE EDLTEVKKDA LENLRVYLCE KIIAERHFDH LRAKKILSRE DTEEISCRTS 
    SRKRAGKLLD YLQENPKGLD TLVESIRREK TQNFLIQKIT DEVLKLRNIK LEHLKDGATN 
    NLSRSNSDES NFSEKLRAST VMYHPEGESS TTPFFFY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.