Details for: CCNC

Gene ID: 892

Symbol: CCNC

Ensembl ID: ENSG00000112237

Description: cyclin C

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 280.8186
    Cell Significance Index: -43.6800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 166.4936
    Cell Significance Index: -42.2300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 117.8548
    Cell Significance Index: -48.5500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 105.3963
    Cell Significance Index: -49.7600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 101.6351
    Cell Significance Index: -41.2900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 92.4210
    Cell Significance Index: -47.5400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 43.5196
    Cell Significance Index: -41.5500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 38.5517
    Cell Significance Index: -47.5300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.3726
    Cell Significance Index: -43.8600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.2806
    Cell Significance Index: -48.4600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.6134
    Cell Significance Index: -35.6700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.3537
    Cell Significance Index: -22.6600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.1343
    Cell Significance Index: 99.5100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.1149
    Cell Significance Index: 56.4700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.6834
    Cell Significance Index: 183.1100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.6438
    Cell Significance Index: 326.2200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5137
    Cell Significance Index: 303.6500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2060
    Cell Significance Index: 1088.9100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1643
    Cell Significance Index: 31.6900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.1142
    Cell Significance Index: 83.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0802
    Cell Significance Index: 589.9200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.0050
    Cell Significance Index: 9.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9498
    Cell Significance Index: 171.2300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.9460
    Cell Significance Index: 122.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9049
    Cell Significance Index: 111.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8977
    Cell Significance Index: 42.1900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8062
    Cell Significance Index: 41.8800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7457
    Cell Significance Index: 329.6700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7157
    Cell Significance Index: 54.9200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7008
    Cell Significance Index: 49.5600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6901
    Cell Significance Index: 14.9500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6650
    Cell Significance Index: 238.5200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.6174
    Cell Significance Index: 32.4200
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.6019
    Cell Significance Index: 6.4000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5877
    Cell Significance Index: 80.7100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.5080
    Cell Significance Index: 86.7500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5023
    Cell Significance Index: 59.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4646
    Cell Significance Index: 26.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4496
    Cell Significance Index: 12.9600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4378
    Cell Significance Index: 30.2800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4230
    Cell Significance Index: 292.5400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3799
    Cell Significance Index: 23.3500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3147
    Cell Significance Index: 13.9200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2909
    Cell Significance Index: 18.7700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2878
    Cell Significance Index: 10.9000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2695
    Cell Significance Index: 5.2600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2338
    Cell Significance Index: 15.7200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1772
    Cell Significance Index: 333.7000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1678
    Cell Significance Index: 258.3600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1440
    Cell Significance Index: 265.5800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1421
    Cell Significance Index: 18.2100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1112
    Cell Significance Index: 11.0100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1093
    Cell Significance Index: 6.8900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1060
    Cell Significance Index: 3.6900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1045
    Cell Significance Index: 1.7900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0984
    Cell Significance Index: 62.4900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0883
    Cell Significance Index: 120.0600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0748
    Cell Significance Index: 2.6300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0504
    Cell Significance Index: 22.8600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0267
    Cell Significance Index: 1.3900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0260
    Cell Significance Index: 19.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0233
    Cell Significance Index: 4.4400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0073
    Cell Significance Index: -0.3300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0165
    Cell Significance Index: -12.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0174
    Cell Significance Index: -12.8600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0301
    Cell Significance Index: -18.7800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0397
    Cell Significance Index: -1.0700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0475
    Cell Significance Index: -26.8000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0676
    Cell Significance Index: -1.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0809
    Cell Significance Index: -8.2700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0860
    Cell Significance Index: -1.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1085
    Cell Significance Index: -22.8500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1388
    Cell Significance Index: -39.9500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1463
    Cell Significance Index: -1.8200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1524
    Cell Significance Index: -22.1600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1733
    Cell Significance Index: -2.9200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1821
    Cell Significance Index: -4.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1822
    Cell Significance Index: -20.8800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2338
    Cell Significance Index: -3.1900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2634
    Cell Significance Index: -3.1400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2701
    Cell Significance Index: -30.8300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2766
    Cell Significance Index: -32.2300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3221
    Cell Significance Index: -33.5400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3339
    Cell Significance Index: -6.9900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3488
    Cell Significance Index: -8.3700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3568
    Cell Significance Index: -10.4800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4398
    Cell Significance Index: -34.8300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4423
    Cell Significance Index: -6.5300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4609
    Cell Significance Index: -12.1200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4658
    Cell Significance Index: -11.9000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.4915
    Cell Significance Index: -3.0300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4924
    Cell Significance Index: -2.9800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4978
    Cell Significance Index: -14.2700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5056
    Cell Significance Index: -11.6800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5260
    Cell Significance Index: -15.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5451
    Cell Significance Index: -33.4200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5517
    Cell Significance Index: -17.6700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5836
    Cell Significance Index: -12.4800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5855
    Cell Significance Index: -12.4700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.6337
    Cell Significance Index: -32.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Cell Cycle Regulation**: CCNC is a key component of the cyclin-dependent protein kinase holoenzyme complex, which regulates the G0 to G1 transition, a critical checkpoint in the cell cycle. 2. **Transcriptional Regulation**: CCNC interacts with RNA polymerase II and transcription factors, influencing the expression of genes involved in cell proliferation, differentiation, and survival. 3. **Signaling Pathways**: CCNC is involved in various signaling pathways, including Notch signaling, TGF-β signaling, and Smad-mediated transcriptional regulation. 4. **Cellular Localization**: CCNC is predominantly found in the nucleus and nucleoplasm, where it interacts with other proteins to regulate gene expression and signaling. **Pathways and Functions** 1. **Notch Signaling**: CCNC interacts with Notch1 intracellular domain, modulating its transcriptional activity and influencing the development and differentiation of various cell types. 2. **TGF-β Signaling**: CCNC regulates the activity of the TGF-β receptor complex, influencing cell growth, differentiation, and apoptosis. 3. **Smad-mediated Transcription**: CCNC interacts with Smad2/3/4 heterotrimer, regulating its transcriptional activity and influencing the expression of target genes. 4. **Cyclin-dependent Kinase Regulation**: CCNC regulates the activity of CDKs, influencing cell cycle progression and the expression of genes involved in cell proliferation and differentiation. **Clinical Significance** 1. **Cancer**: CCNC is overexpressed in various types of cancer, including prostate, breast, and lung cancer, where it may contribute to tumorigenesis and cancer progression. 2. **Neurological Disorders**: CCNC has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, where it may influence the expression of genes involved in neuronal survival and differentiation. 3. **Infectious Diseases**: CCNC has been shown to interact with viral proteins, influencing the replication and pathogenesis of viruses, such as the Respiratory Syncytial Virus (RSV). 4. **Regenerative Medicine**: CCNC may play a role in the regulation of stem cell differentiation and the development of tissues, making it a potential target for regenerative therapies. In conclusion, CCNC is a multifunctional protein that plays a critical role in various cellular processes, including cell cycle progression, transcriptional regulation, and signaling pathways. Its expression and function have significant implications for the development and progression of various diseases, including cancer, neurodegenerative disorders, and infectious diseases. Further studies are needed to fully elucidate the role of CCNC in human health and disease.

Genular Protein ID: 4197107218

Symbol: CCNC_HUMAN

Name: Cyclin-C

UniProtKB Accession Codes:

P24863 B4DPZ1 Q9H543

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CPTAC 2 CTD 1 ChEMBL 4 ChiTaRS 1 ComplexPortal 4 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 15 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 31 PDBsum 31 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 8 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1833066

Title: Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast.

PubMed ID: 1833066

DOI: 10.1016/0092-8674(91)90042-w

PubMed ID: 8833152

Title: Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors.

PubMed ID: 8833152

DOI: 10.1006/geno.1996.0112

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 8700522

Title: Cyclin C/CDK8 is a novel CTD kinase associated with RNA polymerase II.

PubMed ID: 8700522

PubMed ID: 9734358

Title: NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription.

PubMed ID: 9734358

DOI: 10.1016/s1097-2765(00)80131-8

PubMed ID: 10024883

Title: A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation.

PubMed ID: 10024883

DOI: 10.1016/s1097-2765(00)80178-1

PubMed ID: 10993082

Title: TFIIH is negatively regulated by cdk8-containing mediator complexes.

PubMed ID: 10993082

DOI: 10.1038/35024111

PubMed ID: 15175163

Title: A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.

PubMed ID: 15175163

DOI: 10.1016/j.molcel.2004.05.006

PubMed ID: 16595664

Title: Human Mediator enhances basal transcription by facilitating recruitment of transcription factor IIB during preinitiation complex assembly.

PubMed ID: 16595664

DOI: 10.1074/jbc.m601983200

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 21806996

Title: The structure of CDK8/CycC implicates specificity in the CDK/cyclin family and reveals interaction with a deep pocket binder.

PubMed ID: 21806996

DOI: 10.1016/j.jmb.2011.07.020

Sequence Information:

  • Length: 283
  • Mass: 33243
  • Checksum: CF8AC5E94E621F4C
  • Sequence:
    • MAGNFWQSSH YLQWILDKQD LLKERQKDLK FLSEEEYWKL QIFFTNVIQA LGEHLKLRQQ 
VIATATVYFK RFYARYSLKS IDPVLMAPTC VFLASKVEEF GVVSNTRLIA AATSVLKTRF 
SYAFPKEFPY RMNHILECEF YLLELMDCCL IVYHPYRPLL QYVQDMGQED MLLPLAWRIV 
NDTYRTDLCL LYPPFMIALA CLHVACVVQQ KDARQWFAEL SVDMEKILEI IRVILKLYEQ 
WKNFDERKEM ATILSKMPKP KPPPNSEGEQ GPNGSQNSSY SQS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.