CCNC | ENSG00000112237 | NCBI 892

Details for: CCNC

Gene ID: 892

Symbol: CCNC

Ensembl ID: ENSG00000112237

Description: cyclin C

Associated with

Constitutive signaling by notch1 hd+pest domain mutants
(R-HSA-2894862)
Constitutive signaling by notch1 pest domain mutants
(R-HSA-2644606)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Infectious disease
(R-HSA-5663205)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Notch1 intracellular domain regulates transcription
(R-HSA-2122947)
Ppara activates gene expression
(R-HSA-1989781)
Regulation of lipid metabolism by pparalpha
(R-HSA-400206)
Respiratory syncytial virus infection pathway
(R-HSA-9820952)
Rna polymerase ii transcription
(R-HSA-73857)
Rsv-host interactions
(R-HSA-9833110)
Signaling by notch
(R-HSA-157118)
Signaling by notch1
(R-HSA-1980143)
Signaling by notch1 hd+pest domain mutants in cancer
(R-HSA-2894858)
Signaling by notch1 in cancer
(R-HSA-2644603)
Signaling by notch1 pest domain mutants in cancer
(R-HSA-2644602)
Signaling by tgf-beta receptor complex
(R-HSA-170834)
Signaling by tgfb family members
(R-HSA-9006936)
Signal transduction
(R-HSA-162582)
Smad2/smad3:smad4 heterotrimer regulates transcription
(R-HSA-2173796)
Transcriptional activity of smad2/smad3:smad4 heterotrimer
(R-HSA-2173793)
Transcriptional regulation of white adipocyte differentiation
(R-HSA-381340)
Viral infection pathways
(R-HSA-9824446)
Ckm complex
(GO:1990508)
Cyclin-dependent protein kinase holoenzyme complex
(GO:0000307)
Cyclin-dependent protein serine/threonine kinase regulator activity
(GO:0016538)
G0 to g1 transition
(GO:0045023)
Identical protein binding
(GO:0042802)
Mediator complex
(GO:0016592)
Negative regulation of notch signaling pathway
(GO:0045746)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)

Other Information

Proteins

Cyclin-C

Genular Protein ID: 4197107218

Symbol: CCNC_HUMAN

Name: Cyclin-C

UniProtKB Accession Codes:

P24863 B4DPZ1 Q9H543

Database IDs:

Citations:

PubMed ID: 1833066

Title: Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast.

PubMed ID: 1833066

DOI: 10.1016/0092-8674(91)90042-w

PubMed ID: 8833152

Title: Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors.

PubMed ID: 8833152

DOI: 10.1006/geno.1996.0112

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 8700522

Title: Cyclin C/CDK8 is a novel CTD kinase associated with RNA polymerase II.

PubMed ID: 8700522

PubMed ID: 9734358

Title: NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription.

PubMed ID: 9734358

DOI: 10.1016/s1097-2765(00)80131-8

PubMed ID: 10024883

Title: A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation.

PubMed ID: 10024883

DOI: 10.1016/s1097-2765(00)80178-1

PubMed ID: 10993082

Title: TFIIH is negatively regulated by cdk8-containing mediator complexes.

PubMed ID: 10993082

DOI: 10.1038/35024111

PubMed ID: 15175163

Title: A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.

PubMed ID: 15175163

DOI: 10.1016/j.molcel.2004.05.006

PubMed ID: 16595664

Title: Human Mediator enhances basal transcription by facilitating recruitment of transcription factor IIB during preinitiation complex assembly.

PubMed ID: 16595664

DOI: 10.1074/jbc.m601983200

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 21806996

Title: The structure of CDK8/CycC implicates specificity in the CDK/cyclin family and reveals interaction with a deep pocket binder.

PubMed ID: 21806996

DOI: 10.1016/j.jmb.2011.07.020

Sequence Information:

Length: 283
Mass: 33243
Checksum: CF8AC5E94E621F4C
Sequence:

MAGNFWQSSH YLQWILDKQD LLKERQKDLK FLSEEEYWKL QIFFTNVIQA LGEHLKLRQQ 
VIATATVYFK RFYARYSLKS IDPVLMAPTC VFLASKVEEF GVVSNTRLIA AATSVLKTRF 
SYAFPKEFPY RMNHILECEF YLLELMDCCL IVYHPYRPLL QYVQDMGQED MLLPLAWRIV 
NDTYRTDLCL LYPPFMIALA CLHVACVVQQ KDARQWFAEL SVDMEKILEI IRVILKLYEQ 
WKNFDERKEM ATILSKMPKP KPPPNSEGEQ GPNGSQNSSY SQS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CCNC

Associated with

Other Information

Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. PubMed ID: 1833066

Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors. PubMed ID: 8833152

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

Cyclin C/CDK8 is a novel CTD kinase associated with RNA polymerase II. PubMed ID: 8700522

NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription. PubMed ID: 9734358

A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. PubMed ID: 10024883

TFIIH is negatively regulated by cdk8-containing mediator complexes. PubMed ID: 10993082

A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. PubMed ID: 15175163

Human Mediator enhances basal transcription by facilitating recruitment of transcription factor IIB during preinitiation complex assembly. PubMed ID: 16595664

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. PubMed ID: 17525332

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

The structure of CDK8/CycC implicates specificity in the CDK/cyclin family and reveals interaction with a deep pocket binder. PubMed ID: 21806996