WASF1 | ENSG00000112290 | NCBI 8936

Details for: WASF1

Gene ID: 8936

Symbol: WASF1

Ensembl ID: ENSG00000112290

Description: WASP family member 1

Associated with

Disease
(R-HSA-1643685)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Rac1 gtpase cycle
(R-HSA-9013149)
Rac3 gtpase cycle
(R-HSA-9013423)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Rho gtpase cycle
(R-HSA-9012999)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate wasps and waves
(R-HSA-5663213)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by vegf
(R-HSA-194138)
Signal transduction
(R-HSA-162582)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Actin binding
(GO:0003779)
Actin cytoskeleton
(GO:0015629)
Actin cytoskeleton organization
(GO:0030036)
Actin filament polymerization
(GO:0030041)
Arp2/3 complex binding
(GO:0071933)
Cellular response to brain-derived neurotrophic factor stimulus
(GO:1990416)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Dendrite extension
(GO:0097484)
Focal adhesion
(GO:0005925)
Lamellipodium
(GO:0030027)
Lamellipodium morphogenesis
(GO:0072673)
Mitochondrial outer membrane
(GO:0005741)
Mitochondrion organization
(GO:0007005)
Modification of postsynaptic actin cytoskeleton
(GO:0098885)
Positive regulation of arp2/3 complex-mediated actin nucleation
(GO:2000601)
Positive regulation of neurotrophin trk receptor signaling pathway
(GO:0051388)
Postsynapse
(GO:0098794)
Protein-containing complex
(GO:0032991)
Protein-containing complex assembly
(GO:0065003)
Protein binding
(GO:0005515)
Protein kinase a binding
(GO:0051018)
Protein kinase a regulatory subunit binding
(GO:0034237)
Rac protein signal transduction
(GO:0016601)
Receptor-mediated endocytosis
(GO:0006898)
Scar complex
(GO:0031209)
Small gtpase binding
(GO:0031267)

Other Information

Proteins

Protein WAVE-1

Genular Protein ID: 1084923808

Symbol: WASF1_HUMAN

Name: Protein WAVE-1

UniProtKB Accession Codes:

Q92558 E1P5F2 Q5SZK7

Database IDs:

Citations:

PubMed ID: 9732292

Title: SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development.

PubMed ID: 9732292

DOI: 10.1083/jcb.142.5.1325

PubMed ID: 9039502

Title: Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.

PubMed ID: 9039502

DOI: 10.1093/dnares/3.5.321

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9889097

Title: Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex.

PubMed ID: 9889097

DOI: 10.1016/s0960-9822(98)00015-3

PubMed ID: 11130076

Title: IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling.

PubMed ID: 11130076

DOI: 10.1038/35047107

PubMed ID: 18559503

Title: ArgBP2-dependent signaling regulates pancreatic cell migration, adhesion, and tumorigenicity.

PubMed ID: 18559503

DOI: 10.1158/0008-5472.can-08-0958

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 21107423

Title: Structure and control of the actin regulatory WAVE complex.

PubMed ID: 21107423

DOI: 10.1038/nature09623

PubMed ID: 29961568

Title: De Novo Truncating Mutations in WASF1 Cause Intellectual Disability with Seizures.

PubMed ID: 29961568

DOI: 10.1016/j.ajhg.2018.06.001

Sequence Information:

Length: 559
Mass: 61652
Checksum: 44B4527BDB77BC6E
Sequence:

MPLVKRNIDP RHLCHTALPR GIKNELECVT NISLANIIRQ LSSLSKYAED IFGELFNEAH 
SFSFRVNSLQ ERVDRLSVSV TQLDPKEEEL SLQDITMRKA FRSSTIQDQQ LFDRKTLPIP 
LQETYDVCEQ PPPLNILTPY RDDGKEGLKF YTNPSYFFDL WKEKMLQDTE DKRKEKRKQK 
QKNLDRPHEP EKVPRAPHDR RREWQKLAQG PELAEDDANL LHKHIEVANG PASHFETRPQ 
TYVDHMDGSY SLSALPFSQM SELLTRAEER VLVRPHEPPP PPPMHGAGDA KPIPTCISSA 
TGLIENRPQS PATGRTPVFV SPTPPPPPPP LPSALSTSSL RASMTSTPPP PVPPPPPPPA 
TALQAPAVPP PPAPLQIAPG VLHPAPPPIA PPLVQPSPPV ARAAPVCETV PVHPLPQGEV 
QGLPPPPPPP PLPPPGIRPS SPVTVTALAH PPSGLHPTPS TAPGPHVPLM PPSPPSQVIP 
ASEPKRHPST LPVISDARSV LLEAIRKGIQ LRKVEEQREQ EAKHERIEND VATILSRRIA 
VEYSDSEDDS EFDEVDWLE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: WASF1

Associated with

Other Information

SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development. PubMed ID: 9732292

Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. PubMed ID: 9039502

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex. PubMed ID: 9889097

IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling. PubMed ID: 11130076

ArgBP2-dependent signaling regulates pancreatic cell migration, adhesion, and tumorigenicity. PubMed ID: 18559503

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Structure and control of the actin regulatory WAVE complex. PubMed ID: 21107423

De Novo Truncating Mutations in WASF1 Cause Intellectual Disability with Seizures. PubMed ID: 29961568