CCND2 | ENSG00000118971 | NCBI 894

Details for: CCND2

Gene ID: 894

Symbol: CCND2

Ensembl ID: ENSG00000118971

Description: cyclin D2

Associated with

Aberrant regulation of mitotic cell cycle due to rb1 defects
(R-HSA-9687139)
Aberrant regulation of mitotic g1/s transition in cancer due to rb1 defects
(R-HSA-9659787)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cyclin d associated events in g1
(R-HSA-69231)
Defective binding of rb1 mutants to e2f1,(e2f2, e2f3)
(R-HSA-9661069)
Disease
(R-HSA-1643685)
Diseases of mitotic cell cycle
(R-HSA-9675126)
Drug-mediated inhibition of cdk4/cdk6 activity
(R-HSA-9754119)
G1 phase
(R-HSA-69236)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Regulation of runx1 expression and activity
(R-HSA-8934593)
Rna polymerase ii transcription
(R-HSA-73857)
Transcriptional regulation by runx1
(R-HSA-8878171)
Adult locomotory behavior
(GO:0008344)
Cell division
(GO:0051301)
Cellular response to x-ray
(GO:0071481)
Centrosome
(GO:0005813)
Chromatin
(GO:0000785)
Cyclin-dependent protein kinase holoenzyme complex
(GO:0000307)
Cyclin-dependent protein serine/threonine kinase activator activity
(GO:0061575)
Cyclin-dependent protein serine/threonine kinase regulator activity
(GO:0016538)
Cyclin d2-cdk4 complex
(GO:0097129)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
G1/s transition of mitotic cell cycle
(GO:0000082)
Long-term memory
(GO:0007616)
Negative regulation of apoptotic process
(GO:0043066)
Nuclear membrane
(GO:0031965)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0045737)
Positive regulation of g1/s transition of mitotic cell cycle
(GO:1900087)
Positive regulation of protein phosphorylation
(GO:0001934)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0000079)

Other Information

Proteins

CCND2_HUMAN

Genular Protein ID: 3484708618

Symbol: CCND2_HUMAN

Name: N/A

UniProtKB Accession Codes:

P30279 A8K531 Q13955 Q5U035

Database IDs:

Citations:

PubMed ID: 1386336

Title: Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins.

PubMed ID: 1386336

DOI: 10.1016/0888-7543(92)90127-e

PubMed ID: 8455931

Title: Cyclins D1 and D2 are differentially expressed in human B-lymphoid cell lines.

PubMed ID: 8455931

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1386335

Title: Genomic organization, chromosomal localization, and independent expression of human cyclin D genes.

PubMed ID: 1386335

DOI: 10.1016/0888-7543(92)90126-d

PubMed ID: 8114739

Title: Identification of G1 kinase activity for cdk6, a novel cyclin D partner.

PubMed ID: 8114739

DOI: 10.1128/mcb.14.3.2077-2086.1994

PubMed ID: 18827403

Title: Migratory localization of cyclin D2-Cdk4 complex suggests a spatial regulation of the G1-S transition.

PubMed ID: 18827403

DOI: 10.1247/csf.08019

PubMed ID: 17873913

Title: Human and mouse cyclin D2 splice variants: transforming activity and subcellular localization.

PubMed ID: 17873913

DOI: 10.1038/sj.onc.1210750

PubMed ID: 22323446

Title: F-box protein FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation.

PubMed ID: 22323446

DOI: 10.1182/blood-2011-06-358911

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24705253

Title: De novo CCND2 mutations leading to stabilization of cyclin D2 cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome.

PubMed ID: 24705253

DOI: 10.1038/ng.2948

PubMed ID: 33854235

Title: CRL4AMBRA1 is a master regulator of D-type cyclins.

PubMed ID: 33854235

DOI: 10.1038/s41586-021-03445-y

PubMed ID: 33854239

Title: The AMBRA1 E3 ligase adaptor regulates the stability of cyclin D.

PubMed ID: 33854239

DOI: 10.1038/s41586-021-03474-7

Sequence Information:

Length: 289
Mass: 33067
Checksum: E4E5FEF476D76D90
Sequence:

MELLCHEVDP VRRAVRDRNL LRDDRVLQNL LTIEERYLPQ CSYFKCVQKD IQPYMRRMVA 
TWMLEVCEEQ KCEEEVFPLA MNYLDRFLAG VPTPKSHLQL LGAVCMFLAS KLKETSPLTA 
EKLCIYTDNS IKPQELLEWE LVVLGKLKWN LAAVTPHDFI EHILRKLPQQ REKLSLIRKH 
AQTFIALCAT DFKFAMYPPS MIATGSVGAA ICGLQQDEEV SSLTCDALTE LLAKITNTDV 
DCLKACQEQI EAVLLNSLQQ YRQDQRDGSK SEDELDQAST PTDVRDIDL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CCND2

Associated with

Other Information

Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins. PubMed ID: 1386336

Cyclins D1 and D2 are differentially expressed in human B-lymphoid cell lines. PubMed ID: 8455931

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The finished DNA sequence of human chromosome 12. PubMed ID: 16541075

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Genomic organization, chromosomal localization, and independent expression of human cyclin D genes. PubMed ID: 1386335

Identification of G1 kinase activity for cdk6, a novel cyclin D partner. PubMed ID: 8114739

Migratory localization of cyclin D2-Cdk4 complex suggests a spatial regulation of the G1-S transition. PubMed ID: 18827403

Human and mouse cyclin D2 splice variants: transforming activity and subcellular localization. PubMed ID: 17873913

F-box protein FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation. PubMed ID: 22323446

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

De novo CCND2 mutations leading to stabilization of cyclin D2 cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome. PubMed ID: 24705253

CRL4AMBRA1 is a master regulator of D-type cyclins. PubMed ID: 33854235

The AMBRA1 E3 ligase adaptor regulates the stability of cyclin D. PubMed ID: 33854239