Details for: CCND2

Gene ID: 894

Symbol: CCND2

Ensembl ID: ENSG00000118971

Description: cyclin D2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 342.6656
    Cell Significance Index: -53.3000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 179.4251
    Cell Significance Index: -45.5100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 129.2640
    Cell Significance Index: -53.2500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 116.7281
    Cell Significance Index: -55.1100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 107.2154
    Cell Significance Index: -55.1500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 82.2030
    Cell Significance Index: -55.1600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 43.9107
    Cell Significance Index: -54.1400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.0553
    Cell Significance Index: -43.0100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.8848
    Cell Significance Index: -54.7900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.3306
    Cell Significance Index: -31.7300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.0502
    Cell Significance Index: -15.4300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 3.5300
    Cell Significance Index: 92.8200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.1211
    Cell Significance Index: 33.9300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.6593
    Cell Significance Index: 78.1000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.3659
    Cell Significance Index: 384.8000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.3171
    Cell Significance Index: 48.5000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.1093
    Cell Significance Index: 56.5200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.0210
    Cell Significance Index: 58.2300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.6902
    Cell Significance Index: 42.2500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6364
    Cell Significance Index: 328.2700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.5676
    Cell Significance Index: 1415.4700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.4614
    Cell Significance Index: 524.1800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3289
    Cell Significance Index: 79.7800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.2982
    Cell Significance Index: 89.7800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2578
    Cell Significance Index: 57.0100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.1466
    Cell Significance Index: 17.7400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.0617
    Cell Significance Index: 65.2600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.0572
    Cell Significance Index: 28.2800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.0353
    Cell Significance Index: 23.9200
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.9496
    Cell Significance Index: 13.3200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.8988
    Cell Significance Index: 21.5600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8939
    Cell Significance Index: 24.3300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.8571
    Cell Significance Index: 24.5700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8519
    Cell Significance Index: 169.0600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.8383
    Cell Significance Index: 29.1300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8342
    Cell Significance Index: 64.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8183
    Cell Significance Index: 361.8100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6155
    Cell Significance Index: 43.5300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.6144
    Cell Significance Index: 104.9100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5649
    Cell Significance Index: 55.8800
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.4475
    Cell Significance Index: 2.3600
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.3939
    Cell Significance Index: 4.1900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3254
    Cell Significance Index: 9.1000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2381
    Cell Significance Index: 5.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1830
    Cell Significance Index: 34.8300
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.1764
    Cell Significance Index: 1.7800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.1690
    Cell Significance Index: 2.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1417
    Cell Significance Index: 25.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0964
    Cell Significance Index: 4.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0652
    Cell Significance Index: 8.9500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0642
    Cell Significance Index: 3.3700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0515
    Cell Significance Index: 6.6000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0438
    Cell Significance Index: 12.6200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0269
    Cell Significance Index: 0.3400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0167
    Cell Significance Index: 0.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0057
    Cell Significance Index: 3.1300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0154
    Cell Significance Index: -10.6400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0195
    Cell Significance Index: -36.6300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0264
    Cell Significance Index: -3.2400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0275
    Cell Significance Index: -20.3700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0309
    Cell Significance Index: -23.4200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0329
    Cell Significance Index: -60.6600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0384
    Cell Significance Index: -23.9900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0394
    Cell Significance Index: -60.5800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0415
    Cell Significance Index: -0.4300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0684
    Cell Significance Index: -38.5600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0709
    Cell Significance Index: -51.9900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0811
    Cell Significance Index: -51.5300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1037
    Cell Significance Index: -47.0800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1450
    Cell Significance Index: -30.5400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1937
    Cell Significance Index: -10.0600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2041
    Cell Significance Index: -23.7800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2207
    Cell Significance Index: -7.0700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3024
    Cell Significance Index: -14.1000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3032
    Cell Significance Index: -11.4800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3058
    Cell Significance Index: -34.9100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3421
    Cell Significance Index: -49.7300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3708
    Cell Significance Index: -42.4800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3997
    Cell Significance Index: -47.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.4175
    Cell Significance Index: -42.6500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.4178
    Cell Significance Index: -53.9800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4550
    Cell Significance Index: -25.5300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4999
    Cell Significance Index: -12.7700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5239
    Cell Significance Index: -54.5600
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.5456
    Cell Significance Index: -2.6100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.5730
    Cell Significance Index: -6.5100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5809
    Cell Significance Index: -37.4800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.6294
    Cell Significance Index: -29.5800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6650
    Cell Significance Index: -52.6700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.6902
    Cell Significance Index: -7.5200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.7302
    Cell Significance Index: -54.4200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7555
    Cell Significance Index: -46.3200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8107
    Cell Significance Index: -25.8200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.8345
    Cell Significance Index: -56.1100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.8641
    Cell Significance Index: -54.4600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.9028
    Cell Significance Index: -17.6200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9277
    Cell Significance Index: -30.3700
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -1.0238
    Cell Significance Index: -10.1300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.0622
    Cell Significance Index: -21.3300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -1.0842
    Cell Significance Index: -22.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CCND2 exhibits the following key characteristics: 1. **Cell cycle regulation**: CCND2 binds to and activates CDK4/6, leading to the phosphorylation and activation of downstream targets, including E2F transcription factors, which drive the cell cycle forward. 2. **Rb-dependent regulation**: CCND2 is regulated by the Rb protein, which binds to CCND2 and inhibits its activity. Mutations in Rb that lead to its loss of function result in the overexpression of CCND2 and subsequent cell cycle dysregulation. 3. **Cancer association**: CCND2 overexpression has been implicated in various types of cancer, including breast, lung, and colon cancer, where it contributes to tumorigenesis and poor prognosis. 4. **Neurological function**: CCND2 has been shown to play a role in adult locomotory behavior and long-term memory, highlighting its importance in neural function and development. 5. **Transcriptional regulation**: CCND2 regulates the expression of other genes, including Runx1, through transcriptional control, further emphasizing its role in cellular processes beyond cell cycle regulation. **Pathways and Functions** CCND2 is involved in the following pathways and functions: 1. **Aberrant regulation of mitotic cell cycle**: CCND2 overexpression leads to the dysregulation of the mitotic cell cycle, resulting in uncontrolled cell proliferation and tumorigenesis. 2. **Regulation of G1/S transition**: CCND2 plays a critical role in regulating the transition from the G1 phase to the S phase of the cell cycle, ensuring proper DNA replication and cell division. 3. **Regulation of protein phosphorylation**: CCND2 regulates the activity of CDK4/6, which phosphorylates and activates downstream targets, including E2F transcription factors. 4. **Regulation of apoptosis**: CCND2 inhibits the apoptotic process, allowing cells to survive and proliferate. 5. **Regulation of gene expression**: CCND2 regulates the expression of other genes, including Runx1, through transcriptional control. **Clinical Significance** CCND2 has significant clinical implications, including: 1. **Cancer diagnosis and prognosis**: CCND2 overexpression is a diagnostic marker for various types of cancer, including breast, lung, and colon cancer. 2. **Therapeutic targeting**: CCND2 is a potential therapeutic target for cancer treatment, as its inhibition can lead to the suppression of tumorigenesis. 3. **Neurological disorders**: CCND2 dysregulation has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease, highlighting the importance of CCND2 in maintaining neural function and development. 4. **Immunological disorders**: CCND2 has been shown to regulate the activity of immune cells, including natural killer cells and T cells, further emphasizing its importance in immunological function. In conclusion, CCND2 is a critical regulator of the cell cycle, with implications for cancer diagnosis, prognosis, and treatment. Its dysregulation has also been implicated in neurological and immunological disorders, highlighting the importance of CCND2 in maintaining cellular homeostasis and overall health.

Genular Protein ID: 3484708618

Symbol: CCND2_HUMAN

Name: N/A

UniProtKB Accession Codes:

P30279 A8K531 Q13955 Q5U035

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 3 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 15 Ensembl 3 ExpressionAtlas 1 GO 23 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1386336

Title: Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins.

PubMed ID: 1386336

DOI: 10.1016/0888-7543(92)90127-e

PubMed ID: 8455931

Title: Cyclins D1 and D2 are differentially expressed in human B-lymphoid cell lines.

PubMed ID: 8455931

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1386335

Title: Genomic organization, chromosomal localization, and independent expression of human cyclin D genes.

PubMed ID: 1386335

DOI: 10.1016/0888-7543(92)90126-d

PubMed ID: 8114739

Title: Identification of G1 kinase activity for cdk6, a novel cyclin D partner.

PubMed ID: 8114739

DOI: 10.1128/mcb.14.3.2077-2086.1994

PubMed ID: 18827403

Title: Migratory localization of cyclin D2-Cdk4 complex suggests a spatial regulation of the G1-S transition.

PubMed ID: 18827403

DOI: 10.1247/csf.08019

PubMed ID: 17873913

Title: Human and mouse cyclin D2 splice variants: transforming activity and subcellular localization.

PubMed ID: 17873913

DOI: 10.1038/sj.onc.1210750

PubMed ID: 22323446

Title: F-box protein FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation.

PubMed ID: 22323446

DOI: 10.1182/blood-2011-06-358911

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24705253

Title: De novo CCND2 mutations leading to stabilization of cyclin D2 cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome.

PubMed ID: 24705253

DOI: 10.1038/ng.2948

PubMed ID: 33854235

Title: CRL4AMBRA1 is a master regulator of D-type cyclins.

PubMed ID: 33854235

DOI: 10.1038/s41586-021-03445-y

PubMed ID: 33854239

Title: The AMBRA1 E3 ligase adaptor regulates the stability of cyclin D.

PubMed ID: 33854239

DOI: 10.1038/s41586-021-03474-7

Sequence Information:

  • Length: 289
  • Mass: 33067
  • Checksum: E4E5FEF476D76D90
  • Sequence:
    • MELLCHEVDP VRRAVRDRNL LRDDRVLQNL LTIEERYLPQ CSYFKCVQKD IQPYMRRMVA 
TWMLEVCEEQ KCEEEVFPLA MNYLDRFLAG VPTPKSHLQL LGAVCMFLAS KLKETSPLTA 
EKLCIYTDNS IKPQELLEWE LVVLGKLKWN LAAVTPHDFI EHILRKLPQQ REKLSLIRKH 
AQTFIALCAT DFKFAMYPPS MIATGSVGAA ICGLQQDEEV SSLTCDALTE LLAKITNTDV 
DCLKACQEQI EAVLLNSLQQ YRQDQRDGSK SEDELDQAST PTDVRDIDL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.