Gene CCND2 - ENSG00000118971 | NCBI Gene ID: 894

Details for: CCND2

Gene ID: 894

Symbol: CCND2

Ensembl ID: ENSG00000118971

Description: cyclin D2

Associated with

Aberrant regulation of mitotic cell cycle due to rb1 defects
(R-HSA-9687139)
Aberrant regulation of mitotic g1/s transition in cancer due to rb1 defects
(R-HSA-9659787)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cyclin d associated events in g1
(R-HSA-69231)
Defective binding of rb1 mutants to e2f1,(e2f2, e2f3)
(R-HSA-9661069)
Disease
(R-HSA-1643685)
Diseases of mitotic cell cycle
(R-HSA-9675126)
Drug-mediated inhibition of cdk4/cdk6 activity
(R-HSA-9754119)
G1 phase
(R-HSA-69236)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Regulation of runx1 expression and activity
(R-HSA-8934593)
Rna polymerase ii transcription
(R-HSA-73857)
Transcriptional regulation by runx1
(R-HSA-8878171)
Adult locomotory behavior
(GO:0008344)
Cell division
(GO:0051301)
Cellular response to x-ray
(GO:0071481)
Centrosome
(GO:0005813)
Chromatin
(GO:0000785)
Cyclin-dependent protein kinase holoenzyme complex
(GO:0000307)
Cyclin-dependent protein serine/threonine kinase activator activity
(GO:0061575)
Cyclin-dependent protein serine/threonine kinase regulator activity
(GO:0016538)
Cyclin d2-cdk4 complex
(GO:0097129)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
G1/s transition of mitotic cell cycle
(GO:0000082)
Long-term memory
(GO:0007616)
Negative regulation of apoptotic process
(GO:0043066)
Nuclear membrane
(GO:0031965)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0045737)
Positive regulation of g1/s transition of mitotic cell cycle
(GO:1900087)
Positive regulation of protein phosphorylation
(GO:0001934)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0000079)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: neural progenitor cell (CL0011020)
Fold Change: 3.03
Marker Score: 11709.5
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 2.76
Marker Score: 11489
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 2.56
Marker Score: 45383
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 2.54
Marker Score: 700
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 2.4
Marker Score: 2664
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 2.37
Marker Score: 1585
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 2.34
Marker Score: 6463
Cell Name: mesodermal cell (CL0000222)
Fold Change: 2.33
Marker Score: 30711
Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 2.27
Marker Score: 859
Cell Name: Sertoli cell (CL0000216)
Fold Change: 2.09
Marker Score: 12391
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 2.05
Marker Score: 4832
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 2.05
Marker Score: 1750
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.03
Marker Score: 13003
Cell Name: Unknown (CL0002371)
Fold Change: 2.01
Marker Score: 2133
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 2
Marker Score: 7418
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 1.97
Marker Score: 5364
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.88
Marker Score: 21139
Cell Name: Leydig cell (CL0000178)
Fold Change: 1.83
Marker Score: 1971
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.8
Marker Score: 6967
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.78
Marker Score: 60518
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.76
Marker Score: 16533
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.75
Marker Score: 16624
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.71
Marker Score: 17255
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.71
Marker Score: 13086
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 1.7
Marker Score: 641
Cell Name: mature T cell (CL0002419)
Fold Change: 1.7
Marker Score: 16839
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 1.7
Marker Score: 25387
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.69
Marker Score: 104216
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.65
Marker Score: 10710
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 1.64
Marker Score: 432
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.6
Marker Score: 13758
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 1.59
Marker Score: 891
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.58
Marker Score: 59876
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 1.57
Marker Score: 862
Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.53
Marker Score: 1920
Cell Name: stem cell (CL0000034)
Fold Change: 1.52
Marker Score: 3614
Cell Name: paneth cell (CL0000510)
Fold Change: 1.51
Marker Score: 1050
Cell Name: taste receptor cell (CL0000209)
Fold Change: 1.5
Marker Score: 1295
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.49
Marker Score: 29591
Cell Name: B-1 B cell (CL0000819)
Fold Change: 1.49
Marker Score: 2592
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 1.48
Marker Score: 615
Cell Name: mesangial cell (CL0000650)
Fold Change: 1.47
Marker Score: 1780
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 1.46
Marker Score: 2474
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.44
Marker Score: 53284
Cell Name: sympathetic neuron (CL0011103)
Fold Change: 1.43
Marker Score: 474
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 1.42
Marker Score: 2973
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.39
Marker Score: 2142
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 1.39
Marker Score: 2134
Cell Name: keratocyte (CL0002363)
Fold Change: 1.34
Marker Score: 308
Cell Name: proerythroblast (CL0000547)
Fold Change: 1.34
Marker Score: 907
Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 1.34
Marker Score: 463
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 1.3
Marker Score: 6375.5
Cell Name: naive T cell (CL0000898)
Fold Change: 1.27
Marker Score: 820
Cell Name: glial cell (CL0000125)
Fold Change: 1.27
Marker Score: 1397
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 1.26
Marker Score: 1416
Cell Name: neural crest cell (CL0011012)
Fold Change: 1.26
Marker Score: 1346
Cell Name: follicular B cell (CL0000843)
Fold Change: 1.25
Marker Score: 1358
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 1.25
Marker Score: 624
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 1.23
Marker Score: 394
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 1.22
Marker Score: 600
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 1.22
Marker Score: 885
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 1.21
Marker Score: 624
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 1.21
Marker Score: 1580
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 1.21
Marker Score: 876
Cell Name: pro-T cell (CL0000827)
Fold Change: 1.21
Marker Score: 4950
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 1.21
Marker Score: 2159
Cell Name: leukocyte (CL0000738)
Fold Change: 1.2
Marker Score: 691
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 1.2
Marker Score: 5143
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 1.2
Marker Score: 406
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 1.2
Marker Score: 63365
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.2
Marker Score: 18736
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 1.2
Marker Score: 371
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 1.19
Marker Score: 3486
Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 1.19
Marker Score: 381
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 1.19
Marker Score: 745
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.18
Marker Score: 2501
Cell Name: exhausted T cell (CL0011025)
Fold Change: 1.18
Marker Score: 681
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 1.18
Marker Score: 294
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 1.17
Marker Score: 294
Cell Name: endocardial cell (CL0002350)
Fold Change: 1.16
Marker Score: 656
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 1.16
Marker Score: 25906
Cell Name: Unknown (CL0000548)
Fold Change: 1.15
Marker Score: 835
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 1.14
Marker Score: 1877
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 1.14
Marker Score: 3198
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 1.14
Marker Score: 2948
Cell Name: precursor cell (CL0011115)
Fold Change: 1.13
Marker Score: 275
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.13
Marker Score: 717
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 1.12
Marker Score: 1049
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 1.12
Marker Score: 639
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 1.1
Marker Score: 724
Cell Name: Mueller cell (CL0000636)
Fold Change: 1.09
Marker Score: 1516
Cell Name: regulatory T cell (CL0000815)
Fold Change: 1.08
Marker Score: 1192
Cell Name: adventitial cell (CL0002503)
Fold Change: 1.08
Marker Score: 266
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.07
Marker Score: 4428
Cell Name: mesothelial cell (CL0000077)
Fold Change: 1.06
Marker Score: 427
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 1.05
Marker Score: 1296
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 1.05
Marker Score: 880
Cell Name: memory regulatory T cell (CL0002678)
Fold Change: 1.04
Marker Score: 364
Cell Name: plasmablast (CL0000980)
Fold Change: 1.04
Marker Score: 1379
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 1.04
Marker Score: 607

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**Key characteristics**: - CCND2 is a serine/threonine kinase that is responsible for the activation of various downstream targets involved in cell cycle control. - It is mutated in approximately 30% of human cancers. - Aberrant expression of CCND2 has been linked to various human cancers, including breast cancer, colon cancer, and lung cancer. **Pathways and functions**: - CCND2 is involved in the regulation of the cell cycle through multiple pathways, including the G1/S transition, the G1 phase, and the mitotic phase. - It is a key regulator of the transition from G1 to S phase in normal cells. - It also plays a role in the regulation of cell cycle checkpoints and cell cycle progression. **Clinical significance**: - Mutations in CCND2 have been linked to several human cancers, indicating its importance in tumor growth and metastasis. - CCND2 inhibitors are being investigated as potential cancer drugs. **Additional notes**: - CCND2 is a key regulator of cell cycle control and has significant clinical implications for cancer therapy. - Dysregulation of CCND2 signaling has been implicated in the pathogenesis of various human cancers. - Further research is needed to understand the role of CCND2 in cancer and to develop novel therapeutic strategies.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

CCND2_HUMAN

Genular Protein ID: 3484708618

Symbol: CCND2_HUMAN

Name: N/A

UniProtKB Accession Codes:

P30279 A8K531 Q13955 Q5U035

Database IDs:

Citations:

PubMed ID: 1386336

Title: Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins.

PubMed ID: 1386336

DOI: 10.1016/0888-7543(92)90127-e

PubMed ID: 8455931

Title: Cyclins D1 and D2 are differentially expressed in human B-lymphoid cell lines.

PubMed ID: 8455931

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1386335

Title: Genomic organization, chromosomal localization, and independent expression of human cyclin D genes.

PubMed ID: 1386335

DOI: 10.1016/0888-7543(92)90126-d

PubMed ID: 8114739

Title: Identification of G1 kinase activity for cdk6, a novel cyclin D partner.

PubMed ID: 8114739

DOI: 10.1128/mcb.14.3.2077-2086.1994

PubMed ID: 18827403

Title: Migratory localization of cyclin D2-Cdk4 complex suggests a spatial regulation of the G1-S transition.

PubMed ID: 18827403

DOI: 10.1247/csf.08019

PubMed ID: 17873913

Title: Human and mouse cyclin D2 splice variants: transforming activity and subcellular localization.

PubMed ID: 17873913

DOI: 10.1038/sj.onc.1210750

PubMed ID: 22323446

Title: F-box protein FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation.

PubMed ID: 22323446

DOI: 10.1182/blood-2011-06-358911

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24705253

Title: De novo CCND2 mutations leading to stabilization of cyclin D2 cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome.

PubMed ID: 24705253

DOI: 10.1038/ng.2948

PubMed ID: 33854235

Title: CRL4AMBRA1 is a master regulator of D-type cyclins.

PubMed ID: 33854235

DOI: 10.1038/s41586-021-03445-y

PubMed ID: 33854239

Title: The AMBRA1 E3 ligase adaptor regulates the stability of cyclin D.

PubMed ID: 33854239

DOI: 10.1038/s41586-021-03474-7

Sequence Information:

Length: 289
Mass: 33067
Checksum: E4E5FEF476D76D90
Sequence:

MELLCHEVDP VRRAVRDRNL LRDDRVLQNL LTIEERYLPQ CSYFKCVQKD IQPYMRRMVA 
TWMLEVCEEQ KCEEEVFPLA MNYLDRFLAG VPTPKSHLQL LGAVCMFLAS KLKETSPLTA 
EKLCIYTDNS IKPQELLEWE LVVLGKLKWN LAAVTPHDFI EHILRKLPQQ REKLSLIRKH 
AQTFIALCAT DFKFAMYPPS MIATGSVGAA ICGLQQDEEV SSLTCDALTE LLAKITNTDV 
DCLKACQEQI EAVLLNSLQQ YRQDQRDGSK SEDELDQAST PTDVRDIDL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: CCND2

Associated with

Cells (max top 100)

Other Information

Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins. PubMed ID: 1386336

Cyclins D1 and D2 are differentially expressed in human B-lymphoid cell lines. PubMed ID: 8455931

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The finished DNA sequence of human chromosome 12. PubMed ID: 16541075

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Genomic organization, chromosomal localization, and independent expression of human cyclin D genes. PubMed ID: 1386335

Identification of G1 kinase activity for cdk6, a novel cyclin D partner. PubMed ID: 8114739

Migratory localization of cyclin D2-Cdk4 complex suggests a spatial regulation of the G1-S transition. PubMed ID: 18827403

Human and mouse cyclin D2 splice variants: transforming activity and subcellular localization. PubMed ID: 17873913

F-box protein FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation. PubMed ID: 22323446

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

De novo CCND2 mutations leading to stabilization of cyclin D2 cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome. PubMed ID: 24705253

CRL4AMBRA1 is a master regulator of D-type cyclins. PubMed ID: 33854235

The AMBRA1 E3 ligase adaptor regulates the stability of cyclin D. PubMed ID: 33854239