AP3D1 | ENSG00000065000 | NCBI 8943

Details for: AP3D1

Gene ID: 8943

Symbol: AP3D1

Ensembl ID: ENSG00000065000

Description: adaptor related protein complex 3 subunit delta 1

Associated with

Anterograde axonal transport
(GO:0008089)
Anterograde synaptic vesicle transport
(GO:0048490)
Antigen processing and presentation, exogenous lipid antigen via mhc class ib
(GO:0048007)
Ap-3 adaptor complex
(GO:0030123)
Axon cytoplasm
(GO:1904115)
Clathrin-coated vesicle cargo loading, ap-3-mediated
(GO:0035654)
Early endosome
(GO:0005769)
Endosome membrane
(GO:0010008)
Endosome to melanosome transport
(GO:0035646)
Glutamatergic synapse
(GO:0098978)
Golgi apparatus
(GO:0005794)
Golgi membrane
(GO:0000139)
Golgi to vacuole transport
(GO:0006896)
Intracellular protein transport
(GO:0006886)
Intracellular transport
(GO:0046907)
Lysosomal membrane
(GO:0005765)
Melanosome assembly
(GO:1903232)
Melanosome organization
(GO:0032438)
Membrane
(GO:0016020)
Neurotransmitter receptor transport, postsynaptic endosome to lysosome
(GO:0098943)
Platelet dense granule organization
(GO:0060155)
Positive regulation of nk t cell differentiation
(GO:0051138)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Postsynapse
(GO:0098794)
Presynaptic endosome
(GO:0098830)
Protein binding
(GO:0005515)
Protein localization to membrane
(GO:0072657)
Protein targeting to vacuole
(GO:0006623)
Synaptic vesicle budding from endosome
(GO:0016182)
Synaptic vesicle coating
(GO:0016183)
Synaptic vesicle membrane organization
(GO:0048499)
Synaptic vesicle recycling
(GO:0036465)
Terminal bouton
(GO:0043195)
Vesicle-mediated transport
(GO:0016192)
Zinc ion import into lysosome
(GO:0140916)

Other Information

Proteins

AP-3 complex subunit delta-1

Genular Protein ID: 618800671

Symbol: AP3D1_HUMAN

Name: AP-3 complex subunit delta-1

UniProtKB Accession Codes:

O14617 O00202 O75262 Q59HF5 Q96G11 Q9H3C6

Database IDs:

Citations:

PubMed ID: 9303295

Title: Altered expression of a novel adaptin leads to defective pigment granule biogenesis in the Drosophila eye color mutant garnet.

PubMed ID: 9303295

DOI: 10.1093/emboj/16.15.4508

PubMed ID: 9151686

Title: Characterization of the adaptor-related protein complex, AP-3.

PubMed ID: 9151686

DOI: 10.1083/jcb.137.4.835

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15598649

Title: AP-1 and AP-3 facilitate lysosomal targeting of Batten disease protein CLN3 via its dileucine motif.

PubMed ID: 15598649

DOI: 10.1074/jbc.m411862200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25808614

Title: TNFalpha post-translationally targets ZnT2 to accumulate zinc in lysosomes.

PubMed ID: 25808614

DOI: 10.1002/jcp.24992

PubMed ID: 26744459

Title: Mutations in AP3D1 associated with immunodeficiency and seizures define a new type of Hermansky-Pudlak syndrome.

PubMed ID: 26744459

DOI: 10.1182/blood-2015-09-671636

Sequence Information:

Length: 1153
Mass: 130158
Checksum: 1B491DD64EAD5096
Sequence:

MALKMVKGSI DRMFDKNLQD LVRGIRNHKE DEAKYISQCI DEIKQELKQD NIAVKANAVC 
KLTYLQMLGY DISWAAFNII EVMSASKFTF KRIGYLAASQ SFHEGTDVIM LTTNQIRKDL 
SSPSQYDTGV ALTGLSCFVT PDLARDLAND IMTLMSHTKP YIRKKAVLIM YKVFLKYPES 
LRPAFPRLKE KLEDPDPGVQ SAAVNVICEL ARRNPKNYLS LAPLFFKLMT SSTNNWVLIK 
IIKLFGALTP LEPRLGKKLI EPLTNLIHST SAMSLLYECV NTVIAVLISL SSGMPNHSAS 
IQLCVQKLRI LIEDSDQNLK YLGLLAMSKI LKTHPKSVQS HKDLILQCLD DKDESIRLRA 
LDLLYGMVSK KNLMEIVKKL MTHVDKAEGT TYRDELLTKI IDICSQSNYQ YITNFEWYIS 
ILVELTRLEG TRHGHLIAAQ MLDVAIRVKA IRKFAVSQMS ALLDSAHLLA SSTQRNGICE 
VLYAAAWICG EFSEHLQEPH HTLEAMLRPR VTTLPGHIQA VYVQNVVKLY ASILQQKEQA 
GEAEGAQAVT QLMVDRLPQF VQSADLEVQE RASCILQLVK HIQKLQAKDV PVAEEVSALF 
AGELNPVAPK AQKKVPVPEG LDLDAWINEP LSDSESEDER PRAVFHEEEQ RRPKHRPSEA 
DEEELARRRE ARKQEQANNP FYIKSSPSPQ KRYQDTPGVE HIPVVQIDLS VPLKVPGLPM 
SDQYVKLEEE RRHRQKLEKD KRRKKRKEKE KKGKRRHSSL PTESDEDIAP AQQVDIVTEE 
MPENALPSDE DDKDPNDPYR ALDIDLDKPL ADSEKLPIQK HRNTETSKSP EKDVPMVEKK 
SKKPKKKEKK HKEKERDKEK KKEKEKKKSP KPKKKKHRKE KEERTKGKKK SKKQPPGSEE 
AAGEPVQNGA PEEEQLPPES SYSLLAENSY VKMTCDIRGS LQEDSQVTVA IVLENRSSSI 
LKGMELSVLD SLNARMARPQ GSSVHDGVPV PFQLPPGVSN EAQYVFTIQS IVMAQKLKGT 
LSFIAKNDEG ATHEKLDFRL HFSCSSYLIT TPCYSDAFAK LLESGDLSMS SIKVDGIRMS 
FQNLLAKICF HHHFSVVERV DSCASMYSRS IQGHHVCLLV KKGENSVSVD GKCSDSTLLS 
NLLEEMKATL AKC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: AP3D1

Associated with

Other Information

Altered expression of a novel adaptin leads to defective pigment granule biogenesis in the Drosophila eye color mutant garnet. PubMed ID: 9303295

Characterization of the adaptor-related protein complex, AP-3. PubMed ID: 9151686

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

AP-1 and AP-3 facilitate lysosomal targeting of Batten disease protein CLN3 via its dileucine motif. PubMed ID: 15598649

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Phosphoproteome of resting human platelets. PubMed ID: 18088087

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

TNFalpha post-translationally targets ZnT2 to accumulate zinc in lysosomes. PubMed ID: 25808614

Mutations in AP3D1 associated with immunodeficiency and seizures define a new type of Hermansky-Pudlak syndrome. PubMed ID: 26744459