BTRC | ENSG00000166167 | NCBI 8945

Details for: BTRC

Gene ID: 8945

Symbol: BTRC

Ensembl ID: ENSG00000166167

Description: beta-transducin repeat containing E3 ubiquitin protein ligase

Associated with

Activation of nf-kappab in b cells
(R-HSA-1169091)
Adaptive immune system
(R-HSA-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-HSA-983168)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Circadian clock
(R-HSA-400253)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Cytokine signaling in immune system
(R-HSA-1280215)
Deactivation of the beta-catenin transactivating complex
(R-HSA-3769402)
Dectin-1 mediated noncanonical nf-kb signaling
(R-HSA-5607761)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Degradation of gli1 by the proteasome
(R-HSA-5610780)
Degradation of gli2 by the proteasome
(R-HSA-5610783)
Disease
(R-HSA-1643685)
Downstream signaling events of b cell receptor (bcr)
(R-HSA-1168372)
Downstream tcr signaling
(R-HSA-202424)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated nf-kb activation
(R-HSA-2871837)
G2/m transition
(R-HSA-69275)
Gli3 is processed to gli3r by the proteasome
(R-HSA-5610785)
Gsk3b and btrc:cul1-mediated-degradation of nfe2l2
(R-HSA-9762114)
Hedgehog 'off' state
(R-HSA-5610787)
Hiv infection
(R-HSA-162906)
Host interactions of hiv factors
(R-HSA-162909)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Interleukin-1 signaling
(R-HSA-9020702)
Interleukin-17 signaling
(R-HSA-448424)
Keap1-nfe2l2 pathway
(R-HSA-9755511)
Map3k8 (tpl2)-dependent mapk1/3 activation
(R-HSA-5684264)
Map kinase activation
(R-HSA-450294)
Metabolism of proteins
(R-HSA-392499)
Mitotic g2-g2/m phases
(R-HSA-453274)
Myd88 cascade initiated on plasma membrane
(R-HSA-975871)
Myd88 dependent cascade initiated on endosome
(R-HSA-975155)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Neddylation
(R-HSA-8951664)
Nik-->noncanonical nf-kb signaling
(R-HSA-5676590)
Nuclear events mediated by nfe2l2
(R-HSA-9759194)
Post-translational protein modification
(R-HSA-597592)
Prolactin receptor signaling
(R-HSA-1170546)
Regulation of apc/c activators between g1/s and early anaphase
(R-HSA-176408)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of plk1 activity at g2/m transition
(R-HSA-2565942)
Scf-beta-trcp mediated degradation of emi1
(R-HSA-174113)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by interleukins
(R-HSA-449147)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by wnt
(R-HSA-195721)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Tcr signaling
(R-HSA-202403)
Tnfr2 non-canonical nf-kb pathway
(R-HSA-5668541)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-HSA-975138)
Trif(ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Viral infection pathways
(R-HSA-9824446)
Vpu mediated degradation of cd4
(R-HSA-180534)
Beta-catenin binding
(GO:0008013)
Ligase activity
(GO:0016874)
Mammary gland epithelial cell proliferation
(GO:0033598)
Non-canonical nf-kappab signal transduction
(GO:0038061)
Positive regulation of circadian rhythm
(GO:0042753)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein binding
(GO:0005515)
Protein dephosphorylation
(GO:0006470)
Protein destabilization
(GO:0031648)
Protein dimerization activity
(GO:0046983)
Protein phosphorylated amino acid binding
(GO:0045309)
Protein polyubiquitination
(GO:0000209)
Protein ubiquitination
(GO:0016567)
Regulation of canonical nf-kappab signal transduction
(GO:0043122)
Regulation of circadian rhythm
(GO:0042752)
Scf-dependent proteasomal ubiquitin-dependent protein catabolic process
(GO:0031146)
Signal transduction
(GO:0007165)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin ligase-substrate adaptor activity
(GO:1990756)
Ubiquitin ligase activator activity
(GO:1990757)
Ubiquitin protein ligase activity
(GO:0061630)
Wnt signaling pathway
(GO:0016055)

Other Information

Proteins

Genular Protein ID: 1657615637

Symbol: FBW1A_HUMAN

Name: F-box/WD repeat-containing protein 1A

UniProtKB Accession Codes:

Q9Y297 B5MD49 Q5W141 Q5W142 Q9Y213

Database IDs:

Citations:

PubMed ID: 9859996

Title: Identification of the receptor component of the IkappaBalpha-ubiquitin ligase.

PubMed ID: 9859996

DOI: 10.1038/25159

PubMed ID: 9660940

Title: A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif.

PubMed ID: 9660940

DOI: 10.1016/s1097-2765(00)80056-8

PubMed ID: 10531035

Title: Identification of a family of human F-box proteins.

PubMed ID: 10531035

DOI: 10.1016/s0960-9822(00)80020-2

PubMed ID: 20736409

Title: Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins.

PubMed ID: 20736409

DOI: 10.1074/mcp.m110.001719

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10066435

Title: IkappaBalpha ubiquitination is catalyzed by an SCF-like complex containing Skp1, cullin-1, and two F-box/WD40-repeat proteins, betaTrCP1 and betaTrCP2.

PubMed ID: 10066435

DOI: 10.1006/bbrc.1999.0289

PubMed ID: 10497169

Title: Common pathway for the ubiquitination of IkappaBalpha, IkappaBbeta, and IkappaBepsilon mediated by the F-box protein FWD1.

PubMed ID: 10497169

DOI: 10.1074/jbc.274.40.28169

PubMed ID: 9990852

Title: The SCF(beta-TRCP)-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in I-kappa-B-alpha and beta-catenin and stimulates I-kappa-B-alpha ubiquitination in vitro.

PubMed ID: 9990852

DOI: 10.1101/gad.13.3.270

PubMed ID: 10835356

Title: SCF(beta)(-TrCP) ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase.

PubMed ID: 10835356

DOI: 10.1093/emboj/19.11.2580

PubMed ID: 10644755

Title: Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination.

PubMed ID: 10644755

DOI: 10.1074/jbc.275.4.2877

PubMed ID: 10983987

Title: The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome.

PubMed ID: 10983987

DOI: 10.1016/s1097-2765(00)00040-x

PubMed ID: 11359933

Title: Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins.

PubMed ID: 11359933

DOI: 10.1091/mbc.12.5.1431

PubMed ID: 11238952

Title: ATF4 degradation relies on a phosphorylation-dependent interaction with the SCF(betaTrCP) ubiquitin ligase.

PubMed ID: 11238952

DOI: 10.1128/mcb.21.6.2192-2202.2001

PubMed ID: 11158290

Title: Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalpha.

PubMed ID: 11158290

DOI: 10.1128/mcb.21.4.1024-1035.2001

PubMed ID: 11994270

Title: Genetic evidence for the essential role of beta-transducin repeat-containing protein in the inducible processing of NF-kappa B2/p100.

PubMed ID: 11994270

DOI: 10.1074/jbc.c200151200

PubMed ID: 12077367

Title: Regulation of S33/S37 phosphorylated beta-catenin in normal and transformed cells.

PubMed ID: 12077367

DOI: 10.1242/jcs.115.13.2771

PubMed ID: 12037680

Title: CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation.

PubMed ID: 12037680

DOI: 10.1038/sj.onc.1205574

PubMed ID: 12791267

Title: Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase.

PubMed ID: 12791267

DOI: 10.1016/s1534-5807(03)00153-9

PubMed ID: 14681206

Title: SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase.

PubMed ID: 14681206

DOI: 10.1101/gad.1157503

PubMed ID: 12902344

Title: Regulation of the discs large tumor suppressor by a phosphorylation-dependent interaction with the beta-TrCP ubiquitin ligase receptor.

PubMed ID: 12902344

DOI: 10.1074/jbc.m302799200

PubMed ID: 14603323

Title: Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage.

PubMed ID: 14603323

DOI: 10.1038/nature02082

PubMed ID: 14988407

Title: Smad4 protein stability is regulated by ubiquitin ligase SCF beta-TrCP1.

PubMed ID: 14988407

DOI: 10.1074/jbc.c400005200

PubMed ID: 14673179

Title: Dual effects of IkappaB kinase beta-mediated phosphorylation on p105 fate: SCF(beta-TrCP)-dependent degradation and SCF(beta-TrCP)-independent processing.

PubMed ID: 14673179

DOI: 10.1128/mcb.24.1.475-486.2004

PubMed ID: 15448698

Title: Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition.

PubMed ID: 15448698

DOI: 10.1038/ncb1173

PubMed ID: 15647282

Title: Wnt-dependent regulation of the E-cadherin repressor snail.

PubMed ID: 15647282

DOI: 10.1074/jbc.m413878200

PubMed ID: 15917222

Title: SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein.

PubMed ID: 15917222

DOI: 10.1074/jbc.m502862200

PubMed ID: 17079684

Title: DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases.

PubMed ID: 17079684

DOI: 10.1101/gad.1483206

PubMed ID: 16705181

Title: Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP.

PubMed ID: 16705181

DOI: 10.1128/mcb.02183-05

PubMed ID: 16371461

Title: Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing.

PubMed ID: 16371461

DOI: 10.1073/pnas.0509927103

PubMed ID: 18794143

Title: HSF1 as a mitotic regulator: phosphorylation of HSF1 by Plk1 is essential for mitotic progression.

PubMed ID: 18794143

DOI: 10.1158/0008-5472.can-08-0129

PubMed ID: 18354482

Title: Control of chromosome stability by the beta-TrCP-REST-Mad2 axis.

PubMed ID: 18354482

DOI: 10.1038/nature06641

PubMed ID: 20068069

Title: Clusterin facilitates COMMD1 and I-kappaB degradation to enhance NF-kappaB activity in prostate cancer cells.

PubMed ID: 20068069

DOI: 10.1158/1541-7786.mcr-09-0277

PubMed ID: 22017875

Title: mTOR drives its own activation via SCF(betaTrCP)-dependent degradation of the mTOR inhibitor DEPTOR.

PubMed ID: 22017875

DOI: 10.1016/j.molcel.2011.08.030

PubMed ID: 22017876

Title: DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(betaTrCP) E3 ubiquitin ligase and regulates survival and autophagy.

PubMed ID: 22017876

DOI: 10.1016/j.molcel.2011.08.029

PubMed ID: 22017877

Title: mTOR generates an auto-amplification loop by triggering the betaTrCP- and CK1alpha-dependent degradation of DEPTOR.

PubMed ID: 22017877

DOI: 10.1016/j.molcel.2011.09.005

PubMed ID: 21258371

Title: Deubiquitylase HAUSP stabilizes REST and promotes maintenance of neural progenitor cells.

PubMed ID: 21258371

DOI: 10.1038/ncb2153

PubMed ID: 22087322

Title: Regulation of interleukin-10 receptor ubiquitination and stability by beta-TrCP-containing ubiquitin E3 ligase.

PubMed ID: 22087322

DOI: 10.1371/journal.pone.0027464

PubMed ID: 23468625

Title: Poxvirus targeting of E3 ligase beta-TrCP by molecular mimicry: a mechanism to inhibit NF-kappaB activation and promote immune evasion and virulence.

PubMed ID: 23468625

DOI: 10.1371/journal.ppat.1003183

PubMed ID: 25704143

Title: Cep68 can be regulated by Nek2 and SCF complex.

PubMed ID: 25704143

DOI: 10.1016/j.ejcb.2015.01.004

PubMed ID: 25503564

Title: Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing.

PubMed ID: 25503564

DOI: 10.1038/ncb3076

PubMed ID: 29420262

Title: C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions.

PubMed ID: 29420262

DOI: 10.1126/science.aan0814

PubMed ID: 33110214

Title: Deubiquitinase OTUD5 is a positive regulator of mTORC1 and mTORC2 signaling pathways.

PubMed ID: 33110214

DOI: 10.1038/s41418-020-00649-z

PubMed ID: 36608670

Title: A central role for regulated protein stability in the control of TFE3 and MITF by nutrients.

PubMed ID: 36608670

DOI: 10.1016/j.molcel.2022.12.013

PubMed ID: 12820959

Title: Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase.

PubMed ID: 12820959

DOI: 10.1016/s1097-2765(03)00234-x

PubMed ID: 17574027

Title: Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination.

PubMed ID: 17574027

DOI: 10.1016/j.cell.2007.04.042

Sequence Information:

Length: 605
Mass: 68867
Checksum: 4C67F3B7E400FD37
Sequence:

MDPAEAVLQE KALKFMCSMP RSLWLGCSSL ADSMPSLRCL YNPGTGALTA FQNSSEREDC 
NNGEPPRKII PEKNSLRQTY NSCARLCLNQ ETVCLASTAM KTENCVAKTK LANGTSSMIV 
PKQRKLSASY EKEKELCVKY FEQWSESDQV EFVEHLISQM CHYQHGHINS YLKPMLQRDF 
ITALPARGLD HIAENILSYL DAKSLCAAEL VCKEWYRVTS DGMLWKKLIE RMVRTDSLWR 
GLAERRGWGQ YLFKNKPPDG NAPPNSFYRA LYPKIIQDIE TIESNWRCGR HSLQRIHCRS 
ETSKGVYCLQ YDDQKIVSGL RDNTIKIWDK NTLECKRILT GHTGSVLCLQ YDERVIITGS 
SDSTVRVWDV NTGEMLNTLI HHCEAVLHLR FNNGMMVTCS KDRSIAVWDM ASPTDITLRR 
VLVGHRAAVN VVDFDDKYIV SASGDRTIKV WNTSTCEFVR TLNGHKRGIA CLQYRDRLVV 
SGSSDNTIRL WDIECGACLR VLEGHEELVR CIRFDNKRIV SGAYDGKIKV WDLVAALDPR 
APAGTLCLRT LVEHSGRVFR LQFDEFQIVS SSHDDTILIW DFLNDPAAQA EPPRSPSRTY 
TYISR

Genular Protein ID: 4102510037

Symbol: B7Z3H4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z3H4

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

Length: 579
Mass: 65874
Checksum: A451730CB3B4D012
Sequence:

MDPAEAVLQE KALKFMCSMP RSLWLGCSSL ADSMPSLRCL YNPGTGALTA FQTYNSCARL 
CLNQETVCLA STAMKTENCV AKTKLANGTS SMIVPKQRKL SASYEKEKEL CVKYFEQWSE 
SDQVEFVEHL ISQMCHYQHG HINSYLKPML QRDFITALPA RGLDHIAENI LSYLDAKSLC 
AAELVCKEWY RVTSDGMLWK KLIERMVRTD SLWRGLAERR GWGQYLFKNK PPDGNAPPNS 
FYRALYPKII QDIETIESNW RCGRHSLQRI HCRSETSKGV YCLQYDDQKI VSGLRDNTIK 
IWDKNTLECK RILTGHTGSV LCLQYDERVI ITGSSDSTVR VWDVNTGEML NTLIHHCEAV 
LHLRFNNGMM VTCSKDRSIA VWDMASPTDI TLRRVLVGHR AAVNVVDFDD KYIVSASGDR 
TIKVWNTSTC EFVRTLNGHK RGIACLQYRD RLVVSGSSDN TIRLWDIECG ACLRVLEGHE 
ELVRCIRFDN KRIVSGAYDG KIKVWDLVAA LDPRAPAGTL CLRTLVEHSG RVFRLQFDEF 
QIVSSSHDDT ILIWDFLNDP AAQAEPPRSP SRTYTYISR

Genular Protein ID: 1426827910

Symbol: Q68DS0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q68DS0

Database IDs:

Sequence Information:

Length: 564
Mass: 64202
Checksum: 5CCF0A7C5A59B5C1
Sequence:

MCSMPRSLWL GCSSLADSMP SLRCLYNPGT GALTAFQTYN SCARLCLNQE TVCLASTAMK 
TENCVAKTKL ANGTSSMIVP KQRKLSASYE KEKELCVKYF EQWSESDQVE FVEHLISQMC 
HYQHGHINSY LKPMLQRDFI TALPARGLDH IAENILSYLD AKSLCAAELV CKEWYRVTSD 
GMLWKKLIER MVRTDSLWRG LAERRGWGQY LFKNKPPDGN APPNSFYRAL YPKIIQDIET 
IESNWRCGRH SLQRIHCRSE TSKGVYCLQY DDQKIVSGLR DNTIKIWDKN TLECKRILTG 
HTGSVLCLQY DERVIITGSS DSTVRVWDVN TGEMLNTLIH HCEAVLHLRF NNGMMVTCSK 
DRSIAVWDMA SPTDITLRRV LVGHRAAVNV VDFDDKYIVS ASGDRTIKVW NTSTCEFVRT 
LNGHKRGIAC LQYRDRLVVS GSSDNTIRLW DIECGACLRV LEGHEELVRC IRFDNKRIVS 
GAYDGKIKVW DLVAALDPRA PAGTLCLRTL VEHSGRVFRL QFDEFQIVSS SHDDTILIWD 
FLNDPAAQAE PPRSPSRTYT YISR

Genular Protein ID: 2368157283

Symbol: B2R8L3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2R8L3

Database IDs:

Sequence Information:

Length: 569
Mass: 65035
Checksum: 8C7B3267C9B253A2
Sequence:

MDPAEAVLQE KALKFMNSSE REDCNNGEPP RKIIPEKNSL RQTYNSCARL CLNQETVCLA 
STAMKTENCV AKTKLANGTS SMIVPKQRKL SASYEKEKEL CVKYFEQWSE SDQVEFVEHL 
ISQMCHYQHG HINSYLKPML QRDFITALPA RGLDHIAENI LSYLDAKSLC AAELVCKEWY 
RVTSDGMLWK KLIERMVRTD SLWRGLAERR GWGQYLFKNK PPDGNAPPNS FYRALYPKII 
QDIETIESNW RCGRHSLQRI HCRSETSKGV YCLQYDDQKI VSGLRDNTIK IWDKNTLECK 
RILTGHTGSV LCLQYDERVI ITGSSDSTVR VWDVNTGEML NTLIHHCEAV LHLRFNNGMM 
VTCSKDRSVA VWDMASPTDI TLRRVLVGHR AAVNVVDFDD KYIVSASGDR TIKVWNTSTC 
EFVRTLNGHK RGIACLQYRD RLVVSGSSDN TIRLWDIECG ACLRVLEGHE ELVRCIRFDN 
KRIVSGAYDG KIKVWDLVAA LDPRAPAGTL CLRTLVEHSG RVFRLQFDEF QIVSSSHDDT 
ILIWDFLNDP AAQAEPPRSP SRTYTYISR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: BTRC

Associated with

Other Information

Identification of the receptor component of the IkappaBalpha-ubiquitin ligase. PubMed ID: 9859996

A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif. PubMed ID: 9660940

Identification of a family of human F-box proteins. PubMed ID: 10531035

Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins. PubMed ID: 20736409

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 10. PubMed ID: 15164054

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

IkappaBalpha ubiquitination is catalyzed by an SCF-like complex containing Skp1, cullin-1, and two F-box/WD40-repeat proteins, betaTrCP1 and betaTrCP2. PubMed ID: 10066435

Common pathway for the ubiquitination of IkappaBalpha, IkappaBbeta, and IkappaBepsilon mediated by the F-box protein FWD1. PubMed ID: 10497169

The SCF(beta-TRCP)-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in I-kappa-B-alpha and beta-catenin and stimulates I-kappa-B-alpha ubiquitination in vitro. PubMed ID: 9990852

SCF(beta)(-TrCP) ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase. PubMed ID: 10835356

Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination. PubMed ID: 10644755

The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome. PubMed ID: 10983987

Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins. PubMed ID: 11359933

ATF4 degradation relies on a phosphorylation-dependent interaction with the SCF(betaTrCP) ubiquitin ligase. PubMed ID: 11238952

Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalpha. PubMed ID: 11158290

Genetic evidence for the essential role of beta-transducin repeat-containing protein in the inducible processing of NF-kappa B2/p100. PubMed ID: 11994270

Regulation of S33/S37 phosphorylated beta-catenin in normal and transformed cells. PubMed ID: 12077367

CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation. PubMed ID: 12037680

Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase. PubMed ID: 12791267

SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase. PubMed ID: 14681206

Regulation of the discs large tumor suppressor by a phosphorylation-dependent interaction with the beta-TrCP ubiquitin ligase receptor. PubMed ID: 12902344

Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage. PubMed ID: 14603323

Smad4 protein stability is regulated by ubiquitin ligase SCF beta-TrCP1. PubMed ID: 14988407

Dual effects of IkappaB kinase beta-mediated phosphorylation on p105 fate: SCF(beta-TrCP)-dependent degradation and SCF(beta-TrCP)-independent processing. PubMed ID: 14673179

Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. PubMed ID: 15448698

Wnt-dependent regulation of the E-cadherin repressor snail. PubMed ID: 15647282

SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein. PubMed ID: 15917222

DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases. PubMed ID: 17079684

Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP. PubMed ID: 16705181

Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing. PubMed ID: 16371461

HSF1 as a mitotic regulator: phosphorylation of HSF1 by Plk1 is essential for mitotic progression. PubMed ID: 18794143

Control of chromosome stability by the beta-TrCP-REST-Mad2 axis. PubMed ID: 18354482

Clusterin facilitates COMMD1 and I-kappaB degradation to enhance NF-kappaB activity in prostate cancer cells. PubMed ID: 20068069

mTOR drives its own activation via SCF(betaTrCP)-dependent degradation of the mTOR inhibitor DEPTOR. PubMed ID: 22017875

DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(betaTrCP) E3 ubiquitin ligase and regulates survival and autophagy. PubMed ID: 22017876

mTOR generates an auto-amplification loop by triggering the betaTrCP- and CK1alpha-dependent degradation of DEPTOR. PubMed ID: 22017877

Deubiquitylase HAUSP stabilizes REST and promotes maintenance of neural progenitor cells. PubMed ID: 21258371

Regulation of interleukin-10 receptor ubiquitination and stability by beta-TrCP-containing ubiquitin E3 ligase. PubMed ID: 22087322

Poxvirus targeting of E3 ligase beta-TrCP by molecular mimicry: a mechanism to inhibit NF-kappaB activation and promote immune evasion and virulence. PubMed ID: 23468625

Cep68 can be regulated by Nek2 and SCF complex. PubMed ID: 25704143

Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing. PubMed ID: 25503564

C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions. PubMed ID: 29420262

Deubiquitinase OTUD5 is a positive regulator of mTORC1 and mTORC2 signaling pathways. PubMed ID: 33110214

A central role for regulated protein stability in the control of TFE3 and MITF by nutrients. PubMed ID: 36608670

Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase. PubMed ID: 12820959

Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination. PubMed ID: 17574027

The sequence of the human genome. PubMed ID: 11181995

The DNA sequence and comparative analysis of human chromosome 10. PubMed ID: 15164054

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. PubMed ID: 26871637

Database document:

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PubMed ID: 15917222

PubMed ID: 17079684

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PubMed ID: 18794143

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PubMed ID: 25704143

PubMed ID: 25503564

PubMed ID: 29420262

PubMed ID: 33110214

PubMed ID: 36608670

PubMed ID: 12820959

PubMed ID: 17574027

PubMed ID: 11181995

PubMed ID: 15164054

PubMed ID: 26871637