Details for: CCND3

Gene ID: 896

Symbol: CCND3

Ensembl ID: ENSG00000112576

Description: cyclin D3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 3.79
    Marker Score: 3364.5
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 3.65
    Marker Score: 10643
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 3.37
    Marker Score: 10632
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.01
    Marker Score: 12890.5
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.95
    Marker Score: 8158
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.93
    Marker Score: 2832.5
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 2.93
    Marker Score: 7137
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.91
    Marker Score: 28807
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.91
    Marker Score: 153624.5
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.83
    Marker Score: 32921
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.81
    Marker Score: 4136
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.8
    Marker Score: 4058
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.79
    Marker Score: 1392
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.74
    Marker Score: 2407
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.73
    Marker Score: 1178
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.72
    Marker Score: 7639
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.68
    Marker Score: 2102
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 2.55
    Marker Score: 1064
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.51
    Marker Score: 25390
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.45
    Marker Score: 4797
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.43
    Marker Score: 1688
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.43
    Marker Score: 4336
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.41
    Marker Score: 15436.5
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 2.41
    Marker Score: 2143
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.4
    Marker Score: 745
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.37
    Marker Score: 2682
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.35
    Marker Score: 3241.5
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.33
    Marker Score: 9695
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 2.32
    Marker Score: 3978
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 2.29
    Marker Score: 6228
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.28
    Marker Score: 1920
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 2.27
    Marker Score: 1856
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.26
    Marker Score: 36363
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.26
    Marker Score: 1317
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 2.23
    Marker Score: 1631
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.18
    Marker Score: 2041
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 2.14
    Marker Score: 771
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 2.14
    Marker Score: 1181
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.13
    Marker Score: 1552
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 2.12
    Marker Score: 537
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 2.09
    Marker Score: 2187
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 2.06
    Marker Score: 626
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 2.05
    Marker Score: 1480
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 2.05
    Marker Score: 1259
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 2.03
    Marker Score: 2399
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.03
    Marker Score: 43288
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.03
    Marker Score: 5150
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 2.02
    Marker Score: 665
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.01
    Marker Score: 1523
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.01
    Marker Score: 5956
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.98
    Marker Score: 2283
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.98
    Marker Score: 1159
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 1.98
    Marker Score: 1742
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.95
    Marker Score: 109113
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.94
    Marker Score: 1977
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.93
    Marker Score: 697
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.91
    Marker Score: 2312
  • Cell Name: platelet (CL0000233)
    Fold Change: 1.89
    Marker Score: 856
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.86
    Marker Score: 2632.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.85
    Marker Score: 1105
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.83
    Marker Score: 3528
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.83
    Marker Score: 4424
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.82
    Marker Score: 2651
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.82
    Marker Score: 1512
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.82
    Marker Score: 1625
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.81
    Marker Score: 1748
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.81
    Marker Score: 354.5
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.81
    Marker Score: 781
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.79
    Marker Score: 1206
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.77
    Marker Score: 1907
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.76
    Marker Score: 3423
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.76
    Marker Score: 1330
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.75
    Marker Score: 1901
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.74
    Marker Score: 1148
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.74
    Marker Score: 1718
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.74
    Marker Score: 944
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.74
    Marker Score: 4330
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.73
    Marker Score: 702
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.73
    Marker Score: 106277
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.72
    Marker Score: 1247.5
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.71
    Marker Score: 842
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.7
    Marker Score: 6686.5
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.7
    Marker Score: 993.5
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.68
    Marker Score: 1853
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.66
    Marker Score: 827
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.65
    Marker Score: 571
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.64
    Marker Score: 1763
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.63
    Marker Score: 1646
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 1.63
    Marker Score: 3671
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 1.63
    Marker Score: 529
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.62
    Marker Score: 661
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.62
    Marker Score: 352
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.61
    Marker Score: 603
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.61
    Marker Score: 384
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.61
    Marker Score: 368
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 1.6
    Marker Score: 372
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 1.6
    Marker Score: 2070
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.59
    Marker Score: 566
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.59
    Marker Score: 10367
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 1.59
    Marker Score: 666

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Other Information

**Key characteristics** * CCND3 is a member of the cyclin D family of cyclins. * It is involved in the regulation of the G1/S transition in mammalian cells. * It is frequently mutated in human cancer, where it is often found to be hyperactive. **Pathways and functions** * CCND3 is a key regulator of the cell cycle, and its expression is regulated by various factors, including the tumor suppressor protein RB1. * In normal cells, CCND3 is expressed in cells in the G1 phase of the cell cycle. * In cancer cells, CCND3 is often overexpressed and this leads to the uncontrolled proliferation of cancer cells. * CCND3 is also involved in the regulation of apoptosis, and its overexpression has been linked to the development of cancer. **Clinical significance** * Mutations in the CCND3 gene have been linked to a number of human cancers, including breast cancer, lung cancer, and colorectal cancer. * Targeting CCND3 has been explored as a therapeutic strategy for cancer, but it has not been successful to date. * Further research is needed to understand the role of CCND3 in cancer development and to develop effective therapies. **Additional information** * CCND3 is a highly conserved gene, and its expression is similar in cells from different species. * CCND3 is a target for several drugs, including the chemotherapy drugs cyclin D inhibitors. * CCND3 is a key target for the development of new cancer therapies.

Genular Protein ID: 318463773

Symbol: CCND3_HUMAN

Name: N/A

UniProtKB Accession Codes:

P30281 B2RD63 B3KQ22 E9PAS4 E9PB36 Q5T8J0 Q6FG62 Q96F49

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 2 CORUM 1 CPTAC 2 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 16 EPD 1 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 6 RefSeq 6 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1386336

Title: Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins.

PubMed ID: 1386336

DOI: 10.1016/0888-7543(92)90127-e

PubMed ID: 1383201

Title: Cloning and characterization of human cyclin D3, a cDNA closely related in sequence to the PRAD1/cyclin D1 proto-oncogene.

PubMed ID: 1383201

DOI: 10.1016/s0021-9258(19)88717-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1386335

Title: Genomic organization, chromosomal localization, and independent expression of human cyclin D genes.

PubMed ID: 1386335

DOI: 10.1016/0888-7543(92)90126-d

PubMed ID: 8114739

Title: Identification of G1 kinase activity for cdk6, a novel cyclin D partner.

PubMed ID: 8114739

DOI: 10.1128/mcb.14.3.2077-2086.1994

PubMed ID: 9106657

Title: New functional activities for the p21 family of CDK inhibitors.

PubMed ID: 9106657

DOI: 10.1101/gad.11.7.847

PubMed ID: 15358120

Title: Cyclin D3 interacts with human activating transcription factor 5 and potentiates its transcription activity.

PubMed ID: 15358120

DOI: 10.1016/j.bbrc.2004.07.053

PubMed ID: 15327989

Title: Identification of the p28 subunit of eukaryotic initiation factor 3(eIF3k) as a new interaction partner of cyclin D3.

PubMed ID: 15327989

DOI: 10.1016/j.febslet.2004.07.071

PubMed ID: 16782892

Title: Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK 'inhibitors'.

PubMed ID: 16782892

DOI: 10.1128/mcb.02006-05

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 22020328

Title: F-box protein FBXL2 exerts human lung tumor suppressor-like activity by ubiquitin-mediated degradation of cyclin D3 resulting in cell cycle arrest.

PubMed ID: 22020328

DOI: 10.1038/onc.2011.432

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 33854235

Title: CRL4AMBRA1 is a master regulator of D-type cyclins.

PubMed ID: 33854235

DOI: 10.1038/s41586-021-03445-y

PubMed ID: 33854239

Title: The AMBRA1 E3 ligase adaptor regulates the stability of cyclin D.

PubMed ID: 33854239

DOI: 10.1038/s41586-021-03474-7

PubMed ID: 19237555

Title: The structure of CDK4/cyclin D3 has implications for models of CDK activation.

PubMed ID: 19237555

DOI: 10.1073/pnas.0809674106

Sequence Information:

  • Length: 292
  • Mass: 32520
  • Checksum: 16E7B1604FEB0029
  • Sequence:
    • MELLCCEGTR HAPRAGPDPR LLGDQRVLQS LLRLEERYVP RASYFQCVQR EIKPHMRKML 
AYWMLEVCEE QRCEEEVFPL AMNYLDRYLS CVPTRKAQLQ LLGAVCMLLA SKLRETTPLT 
IEKLCIYTDH AVSPRQLRDW EVLVLGKLKW DLAAVIAHDF LAFILHRLSL PRDRQALVKK 
HAQTFLALCA TDYTFAMYPP SMIATGSIGA AVQGLGACSM SGDELTELLA GITGTEVDCL 
RACQEQIEAA LRESLREASQ TSSSPAPKAP RGSSSQGPSQ TSTPTDVTAI HL

Genular Protein ID: 3649261100

Symbol: Q5T8J1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5T8J1

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 EPD 1 Ensembl 2 ExpressionAtlas 1 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 5 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 4 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 242
  • Mass: 26233
  • Checksum: 0CBD534DB16B5730
  • Sequence:
    • MKSAGGSGRS LLPSPRVCEE QRCEEEVFPL AMNYLDRYLS CVPTRKAQLQ LLGAVCMLLA 
SKLRETTPLT IEKLCIYTDH AVSPRQLRDW EVLVLGKLKW DLAAVIAHDF LAFILHRLSL 
PRDRQALVKK HAQTFLALCA TDYTFAMYPP SMIATGSIGA AVQGLGACSM SGDELTELLA 
GITGTEVDCL RACQEQIEAA LRESLREASQ TSSSPAPKAP RGSSSQGPSQ TSTPTDVTAI 
HL

Genular Protein ID: 282581155

Symbol: B3KP19_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KP19

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 Gene3D 1 GenomeRNAi 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 RefSeq 1 RuleBase 1 SAM 1 SMART 4 SMR 1 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 242
  • Mass: 26245
  • Checksum: 125ABA333F65A920
  • Sequence:
    • MKSAGGSGRS LLPSPRVCEE QRCEEEVFPL AMNYLDRYLS CVPTRKAQLQ LLGAVCMLLA 
SKLRETTPLT IEKLCIYTDH AVSPRQLRDW EVLVLGKLKW DLAAVIAHDF LAFILHRLSL 
PRDRQALVKK HAQTFLALCA TDYTFVMYPP SMIATGSIGA AVQGLGACSM SGDELTELLA 
GITGTEVDCL RACQEQIEAA LRESLREAAQ TSSSPAPKAP RGSSSQGPSQ TSTPTDVTAI 
HL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.