USP13 | ENSG00000058056 | NCBI 8975

Details for: USP13

Gene ID: 8975

Symbol: USP13

Ensembl ID: ENSG00000058056

Description: ubiquitin specific peptidase 13

Associated with

Deubiquitination
(R-HSA-5688426)
Intracellular signaling by second messengers
(R-HSA-9006925)
Metabolism of proteins
(R-HSA-392499)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-translational protein modification
(R-HSA-597592)
Pten regulation
(R-HSA-6807070)
Regulation of pten stability and activity
(R-HSA-8948751)
Signal transduction
(R-HSA-162582)
Ub-specific processing proteases
(R-HSA-5689880)
Autophagy
(GO:0006914)
Bat3 complex binding
(GO:1904288)
Cell population proliferation
(GO:0008283)
Cysteine-type deubiquitinase activity
(GO:0004843)
Cysteine-type endopeptidase activity
(GO:0004197)
Cytosol
(GO:0005829)
K48-linked deubiquitinase activity
(GO:1990380)
Maintenance of unfolded protein
(GO:0036506)
Melanocyte differentiation
(GO:0030318)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of erad pathway
(GO:1904294)
Proteasome binding
(GO:0070628)
Protein-folding chaperone binding
(GO:0051087)
Protein binding
(GO:0005515)
Protein deubiquitination
(GO:0016579)
Protein k6-linked deubiquitination
(GO:0044313)
Protein k29-linked deubiquitination
(GO:0035523)
Protein k63-linked deubiquitination
(GO:0070536)
Protein stabilization
(GO:0050821)
Proteolysis
(GO:0006508)
Regulation of autophagy
(GO:0010506)
Regulation of dna-templated transcription
(GO:0006355)
Ubiquitin-like protein ligase binding
(GO:0044389)
Ubiquitin binding
(GO:0043130)
Ubiquitin protein ligase binding
(GO:0031625)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Ubiquitin carboxyl-terminal hydrolase 13

Genular Protein ID: 698884111

Symbol: UBP13_HUMAN

Name: Ubiquitin carboxyl-terminal hydrolase 13

UniProtKB Accession Codes:

Q92995 A8K2S3 B4DYF3 D3DNS2 Q96B25

Database IDs:

Citations:

PubMed ID: 9841226

Title: The genomic organization of Isopeptidase T-3 (ISOT-3), a new member of the ubiquitin specific protease family (UBP).

PubMed ID: 9841226

DOI: 10.1016/s0378-1119(98)00341-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17653289

Title: Screen for ISG15-crossreactive deubiquitinases.

PubMed ID: 17653289

DOI: 10.1371/journal.pone.0000679

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21962518

Title: Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13.

PubMed ID: 21962518

DOI: 10.1016/j.cell.2011.08.037

PubMed ID: 21659512

Title: USP13 enzyme regulates Siah2 ligase stability and activity via noncatalytic ubiquitin-binding domains.

PubMed ID: 21659512

DOI: 10.1074/jbc.m111.218214

PubMed ID: 21811243

Title: Regulation of MITF stability by the USP13 deubiquitinase.

PubMed ID: 21811243

DOI: 10.1038/ncomms1421

PubMed ID: 21571647

Title: Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control.

PubMed ID: 21571647

DOI: 10.1073/pnas.1100028108

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23940278

Title: Ubiquitin-specific protease 13 regulates IFN signaling by stabilizing STAT1.

PubMed ID: 23940278

DOI: 10.4049/jimmunol.1300225

PubMed ID: 24424410

Title: USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation.

PubMed ID: 24424410

DOI: 10.7554/elife.01369

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 28534493

Title: USP13 negatively regulates antiviral responses by deubiquitinating STING.

PubMed ID: 28534493

DOI: 10.1038/ncomms15534

PubMed ID: 32101753

Title: Auto-ubiquitination of NEDD4-1 Recruits USP13 to Facilitate Autophagy through Deubiquitinating VPS34.

PubMed ID: 32101753

DOI: 10.1016/j.celrep.2020.01.088

PubMed ID: 32772043

Title: USP13 controls the stability of Aurora B impacting progression through the cell cycle.

PubMed ID: 32772043

DOI: 10.1038/s41388-020-01396-8

PubMed ID: 33592542

Title: USP13 regulates the replication stress response by deubiquitinating TopBP1.

PubMed ID: 33592542

DOI: 10.1016/j.dnarep.2021.103063

PubMed ID: 36585612

Title: USP13 regulates HMGB1 stability and secretion through its deubiquitinase activity.

PubMed ID: 36585612

DOI: 10.1186/s10020-022-00596-0

PubMed ID: 22216260

Title: Domain analysis reveals that a deubiquitinating enzyme USP13 performs non-activating catalysis for Lys63-linked polyubiquitin.

PubMed ID: 22216260

DOI: 10.1371/journal.pone.0029362

Sequence Information:

Length: 863
Mass: 97327
Checksum: 988713ADF8C0B938
Sequence:

MQRRGALFGM PGGSGGRKMA AGDIGELLVP HMPTIRVPRS GDRVYKNECA FSYDSPNSEG 
GLYVCMNTFL AFGREHVERH FRKTGQSVYM HLKRHVREKV RGASGGALPK RRNSKIFLDL 
DTDDDLNSDD YEYEDEAKLV IFPDHYEIAL PNIEELPALV TIACDAVLSS KSPYRKQDPD 
TWENELPVSK YANNLTQLDN GVRIPPSGWK CARCDLRENL WLNLTDGSVL CGKWFFDSSG 
GNGHALEHYR DMGYPLAVKL GTITPDGADV YSFQEEEPVL DPHLAKHLAH FGIDMLHMHG 
TENGLQDNDI KLRVSEWEVI QESGTKLKPM YGPGYTGLKN LGNSCYLSSV MQAIFSIPEF 
QRAYVGNLPR IFDYSPLDPT QDFNTQMTKL GHGLLSGQYS KPPVKSELIE QVMKEEHKPQ 
QNGISPRMFK AFVSKSHPEF SSNRQQDAQE FFLHLVNLVE RNRIGSENPS DVFRFLVEER 
IQCCQTRKVR YTERVDYLMQ LPVAMEAATN KDELIAYELT RREAEANRRP LPELVRAKIP 
FSACLQAFSE PENVDDFWSS ALQAKSAGVK TSRFASFPEY LVVQIKKFTF GLDWVPKKFD 
VSIDMPDLLD INHLRARGLQ PGEEELPDIS PPIVIPDDSK DRLMNQLIDP SDIDESSVMQ 
LAEMGFPLEA CRKAVYFTGN MGAEVAFNWI IVHMEEPDFA EPLTMPGYGG AASAGASVFG 
ASGLDNQPPE EIVAIITSMG FQRNQAIQAL RATNNNLERA LDWIFSHPEF EEDSDFVIEM 
ENNANANIIS EAKPEGPRVK DGSGTYELFA FISHMGTSTM SGHYICHIKK EGRWVIYNDH 
KVCASERPPK DLGYMYFYRR IPS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: USP13

Associated with

Other Information

The genomic organization of Isopeptidase T-3 (ISOT-3), a new member of the ubiquitin specific protease family (UBP). PubMed ID: 9841226

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Screen for ISG15-crossreactive deubiquitinases. PubMed ID: 17653289

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Initial characterization of the human central proteome. PubMed ID: 21269460

Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. PubMed ID: 21962518

USP13 enzyme regulates Siah2 ligase stability and activity via noncatalytic ubiquitin-binding domains. PubMed ID: 21659512

Regulation of MITF stability by the USP13 deubiquitinase. PubMed ID: 21811243

Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control. PubMed ID: 21571647

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Ubiquitin-specific protease 13 regulates IFN signaling by stabilizing STAT1. PubMed ID: 23940278

USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation. PubMed ID: 24424410

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

USP13 negatively regulates antiviral responses by deubiquitinating STING. PubMed ID: 28534493

Auto-ubiquitination of NEDD4-1 Recruits USP13 to Facilitate Autophagy through Deubiquitinating VPS34. PubMed ID: 32101753

USP13 controls the stability of Aurora B impacting progression through the cell cycle. PubMed ID: 32772043

USP13 regulates the replication stress response by deubiquitinating TopBP1. PubMed ID: 33592542

USP13 regulates HMGB1 stability and secretion through its deubiquitinase activity. PubMed ID: 36585612

Domain analysis reveals that a deubiquitinating enzyme USP13 performs non-activating catalysis for Lys63-linked polyubiquitin. PubMed ID: 22216260