CCNE1 | ENSG00000105173 | NCBI 898

Details for: CCNE1

Gene ID: 898

Symbol: CCNE1

Ensembl ID: ENSG00000105173

Description: cyclin E1

Associated with

Aberrant regulation of mitotic cell cycle due to rb1 defects
(R-HSA-9687139)
Aberrant regulation of mitotic g1/s transition in cancer due to rb1 defects
(R-HSA-9659787)
Association of tric/cct with target proteins during biosynthesis
(R-HSA-390471)
Cdk-mediated phosphorylation and removal of cdc6
(R-HSA-69017)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chaperonin-mediated protein folding
(R-HSA-390466)
Cyclin a:cdk2-associated events at s phase entry
(R-HSA-69656)
Cyclin d associated events in g1
(R-HSA-69231)
Cyclin e associated events during g1/s transition
(R-HSA-69202)
Defective binding of rb1 mutants to e2f1,(e2f2, e2f3)
(R-HSA-9661069)
Disease
(R-HSA-1643685)
Diseases of mitotic cell cycle
(R-HSA-9675126)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Dna replication
(R-HSA-69306)
G0 and early g1
(R-HSA-1538133)
G1 phase
(R-HSA-69236)
G1/s-specific transcription
(R-HSA-69205)
G1/s dna damage checkpoints
(R-HSA-69615)
G1/s transition
(R-HSA-69206)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Metabolism of proteins
(R-HSA-392499)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
P53-dependent g1 dna damage response
(R-HSA-69563)
P53-dependent g1/s dna damage checkpoint
(R-HSA-69580)
Phosphorylation of proteins involved in g1/s transition by active cyclin e:cdk2 complexes
(R-HSA-69200)
Protein folding
(R-HSA-391251)
Ptk6 regulates cell cycle
(R-HSA-8849470)
Rhobtb3 atpase cycle
(R-HSA-9706019)
Rna polymerase ii transcription
(R-HSA-73857)
Scf(skp2)-mediated degradation of p27/p21
(R-HSA-187577)
Signaling by non-receptor tyrosine kinases
(R-HSA-9006927)
Signaling by ptk6
(R-HSA-8848021)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Switching of origins to a post-replicative state
(R-HSA-69052)
Synthesis of dna
(R-HSA-69239)
Tp53 regulates transcription of cell cycle genes
(R-HSA-6791312)
Tp53 regulates transcription of genes involved in g1 cell cycle arrest
(R-HSA-6804116)
Transcriptional regulation by tp53
(R-HSA-3700989)
Cell division
(GO:0051301)
Centrosome
(GO:0005813)
Cyclin-dependent protein serine/threonine kinase regulator activity
(GO:0016538)
Cyclin e1-cdk2 complex
(GO:0097134)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna replication initiation
(GO:0006270)
G1/s transition of mitotic cell cycle
(GO:0000082)
Homologous chromosome pairing at meiosis
(GO:0007129)
Kinase activity
(GO:0016301)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of g1/s transition of mitotic cell cycle
(GO:1900087)
Positive regulation of mesenchymal stem cell proliferation
(GO:1902462)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein phosphorylation
(GO:0006468)
Regulation of cell cycle
(GO:0051726)
Regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0000079)
Regulation of protein localization
(GO:0032880)
Telomere maintenance
(GO:0000723)
Wnt signaling pathway
(GO:0016055)

Other Information

Proteins

Genular Protein ID: 1423766307

Symbol: CCNE1_HUMAN

Name: G1/S-specific cyclin-E1

UniProtKB Accession Codes:

P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21

Database IDs:

Citations:

PubMed ID: 1833066

Title: Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast.

PubMed ID: 1833066

DOI: 10.1016/0092-8674(91)90042-w

PubMed ID: 1833068

Title: Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family.

PubMed ID: 1833068

DOI: 10.1016/0092-8674(91)90044-y

PubMed ID: 7739542

Title: Human cyclin E, a nuclear protein essential for the G1-to-S phase transition.

PubMed ID: 7739542

DOI: 10.1128/mcb.15.5.2612

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8649818

Title: Regulation of cyclin E transcription by E2Fs and retinoblastoma protein.

PubMed ID: 8649818

PubMed ID: 8833152

Title: Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors.

PubMed ID: 8833152

DOI: 10.1006/geno.1996.0112

PubMed ID: 8207080

Title: Alternative splicing of human cyclin E.

PubMed ID: 8207080

DOI: 10.1242/jcs.107.2.581

PubMed ID: 8861947

Title: Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E.

PubMed ID: 8861947

DOI: 10.1002/j.1460-2075.1996.tb00793.x

PubMed ID: 9840943

Title: Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins.

PubMed ID: 9840943

DOI: 10.1038/sj.onc.1202505

PubMed ID: 14536078

Title: Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation.

PubMed ID: 14536078

DOI: 10.1016/s1097-2765(03)00287-9

PubMed ID: 15178429

Title: NIRF induces G1 arrest and associates with Cdk2.

PubMed ID: 15178429

DOI: 10.1016/j.bbrc.2004.04.190

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 21952639

Title: NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor.

PubMed ID: 21952639

DOI: 10.4161/cc.10.19.17176

PubMed ID: 21540187

Title: Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling.

PubMed ID: 21540187

DOI: 10.1074/jbc.m110.203471

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 15660127

Title: The structure of cyclin E1/CDK2: implications for CDK2 activation and CDK2-independent roles.

PubMed ID: 15660127

DOI: 10.1038/sj.emboj.7600554

PubMed ID: 17434132

Title: Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases.

PubMed ID: 17434132

DOI: 10.1016/j.molcel.2007.02.022

Sequence Information:

Length: 410
Mass: 47077
Checksum: 424DF0B253B7047E
Sequence:

MPRERRERDA KERDTMKEDG GAEFSARSRK RKANVTVFLQ DPDEEMAKID RTARDQCGSQ 
PWDNNAVCAD PCSLIPTPDK EDDDRVYPNS TCKPRIIAPS RGSPLPVLSW ANREEVWKIM 
LNKEKTYLRD QHFLEQHPLL QPKMRAILLD WLMEVCEVYK LHRETFYLAQ DFFDRYMATQ 
ENVVKTLLQL IGISSLFIAA KLEEIYPPKL HQFAYVTDGA CSGDEILTME LMIMKALKWR 
LSPLTIVSWL NVYMQVAYLN DLHEVLLPQY PQQIFIQIAE LLDLCVLDVD CLEFPYGILA 
ASALYHFSSS ELMQKVSGYQ WCDIENCVKW MVPFAMVIRE TGSSKLKHFR GVADEDAHNI 
QTHRDSLDLL DKARAKKAML SEQNRASPLP SGLLTPPQSG KKQSSGPEMA

Genular Protein ID: 3296212702

Symbol: V5W5X2_HUMAN

Name: N/A

UniProtKB Accession Codes:

V5W5X2

Database IDs:

Sequence Information:

Length: 361
Mass: 41338
Checksum: 51C33D1092AEBF7C
Sequence:

MPRERRERDA KERDTMKEDG GAEFSARSRK RKANVTVFLQ DPDEEMAKID RTARDQCGSQ 
PWDNNAVCAD PCSLIPTPDK EDDDRVYPNS TCKPRIIAPS RGSPLPVLSW ANREEVWKIM 
LNKEKTYLRD QHFLEQHPLL QPKMRAILLD WLMEEIYPPK LHQFAYVTDG ACSGDEILTM 
ELMIMKALKW RLSPLTIVSW LNVYMQVAYL NDLHEVLLPQ YPQQIFIQIA ELLDLCVLDV 
DCLEFPYGIL AASALYHFSS SELMQKVSGY QWCDIENCVK WMVPFAMVIR ETGSSKLKHF 
RGVADEDAHN IQTHRDSLDL LDKARAKKAM LSEQNRASPL PSGLLTPPQS GKKQSSGPEM 
A

Genular Protein ID: 165218448

Symbol: A0A0G3DHS8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0G3DHS8

Database IDs:

Citations:

PubMed ID: 26004630

Title: Transcriptome Signature and Regulation in Human Somatic Cell Reprogramming.

PubMed ID: 26004630

DOI: 10.1016/j.stemcr.2015.04.009

Sequence Information:

Length: 365
Mass: 41739
Checksum: AFD3B387393832C3
Sequence:

MPRERRERDA KERDTMKEDG GAEFSARSRK RKANVTVFLQ DPDEEMAKID RTARDQCGSQ 
PWDNNAVCAD PCSLIPTPDK EDDDRVYPNS TCKPRIIAPS RGSPLPVLSW ANREEVWKIM 
LNKEKTYLRD QHFLEQHPLL QPKMRAILLD WLMEVCEVYK LHRETFYLAQ DFFDRYMATQ 
ENVVKTLLQL IGISSLFIAA KLEEIYPPKL HQFAYVTDGA CSGDEILTME LMIMKLLDLC 
VLDVDCLEFP YGILAASALY HFSSSELMQK VSGYQWCDIE NCVKWMVPFA MVIRETGSSK 
LKHFRGVADE DAHNIQTHRD SLDLLDKARA KKAMLSEQNR ASPLPSGLLT PPQSGKKQSS 
GPEMA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CCNE1

Associated with

Other Information

Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. PubMed ID: 1833066

Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family. PubMed ID: 1833068

Human cyclin E, a nuclear protein essential for the G1-to-S phase transition. PubMed ID: 7739542

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Regulation of cyclin E transcription by E2Fs and retinoblastoma protein. PubMed ID: 8649818

Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors. PubMed ID: 8833152

Alternative splicing of human cyclin E. PubMed ID: 8207080

Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E. PubMed ID: 8861947

Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins. PubMed ID: 9840943

Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation. PubMed ID: 14536078

NIRF induces G1 arrest and associates with Cdk2. PubMed ID: 15178429

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor. PubMed ID: 21952639

Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling. PubMed ID: 21540187

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

The structure of cyclin E1/CDK2: implications for CDK2 activation and CDK2-independent roles. PubMed ID: 15660127

Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases. PubMed ID: 17434132

Transcriptome Signature and Regulation in Human Somatic Cell Reprogramming. PubMed ID: 26004630

Database document:

PubMed ID: 1833066

PubMed ID: 1833068

PubMed ID: 7739542

PubMed ID: 14702039

PubMed ID: 15489334

PubMed ID: 8649818

PubMed ID: 8833152

PubMed ID: 8207080

PubMed ID: 8861947

PubMed ID: 9840943

PubMed ID: 14536078

PubMed ID: 15178429

PubMed ID: 18691976

PubMed ID: 18669648

PubMed ID: 19369195

PubMed ID: 21952639

PubMed ID: 21540187

PubMed ID: 23186163

PubMed ID: 15660127

PubMed ID: 17434132

PubMed ID: 26004630