Details for: HSPB3

Gene ID: 8988

Symbol: HSPB3

Ensembl ID: ENSG00000169271

Description: heat shock protein family B (small) member 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 3.51
    Marker Score: 13,574
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 2.92
    Marker Score: 1,619
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.86
    Marker Score: 64,016
  • Cell Name: T cell (CL0000084)
    Fold Change: 2.23
    Marker Score: 3,851
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.19
    Marker Score: 1,513
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 2.08
    Marker Score: 683
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.02
    Marker Score: 7,182
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1,172
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,478
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 872
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.29
    Marker Score: 1,782
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.27
    Marker Score: 1,415
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 857
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,683
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,811
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.14
    Marker Score: 17,781
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.04
    Marker Score: 430
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,821
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,043
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 511
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 464
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.97
    Marker Score: 512
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 376
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,350
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.88
    Marker Score: 672
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,295
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.84
    Marker Score: 426
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.78
    Marker Score: 4,667
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.77
    Marker Score: 319
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.75
    Marker Score: 1,205
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.73
    Marker Score: 1,392
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.65
    Marker Score: 1,325
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.64
    Marker Score: 409
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.64
    Marker Score: 388
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.64
    Marker Score: 420
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 482
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.59
    Marker Score: 564
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.59
    Marker Score: 450
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.58
    Marker Score: 241
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.51
    Marker Score: 293
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 477
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.44
    Marker Score: 186
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.42
    Marker Score: 1,134
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.41
    Marker Score: 188
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.4
    Marker Score: 129
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.39
    Marker Score: 486
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.39
    Marker Score: 5,135
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.37
    Marker Score: 113
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.37
    Marker Score: 181
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.37
    Marker Score: 464
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 374
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.36
    Marker Score: 326
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.34
    Marker Score: 164
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.34
    Marker Score: 206
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.31
    Marker Score: 683
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.29
    Marker Score: 106
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.28
    Marker Score: 91
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.28
    Marker Score: 168
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.27
    Marker Score: 89
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.25
    Marker Score: 241
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.24
    Marker Score: 2,419
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.24
    Marker Score: 992
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.23
    Marker Score: 8,325
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.22
    Marker Score: 236
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.2
    Marker Score: 58
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.2
    Marker Score: 642
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2
    Marker Score: 200
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.19
    Marker Score: 900
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.19
    Marker Score: 104
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.19
    Marker Score: 108
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.18
    Marker Score: 101
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.18
    Marker Score: 87
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.18
    Marker Score: 118
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.18
    Marker Score: 160
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.17
    Marker Score: 10,555
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.17
    Marker Score: 187
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.17
    Marker Score: 75
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.17
    Marker Score: 160
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.16
    Marker Score: 71
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.15
    Marker Score: 54
  • Cell Name: fibrocyte (CL0000135)
    Fold Change: 0.15
    Marker Score: 45
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.15
    Marker Score: 37
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.14
    Marker Score: 186
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.14
    Marker Score: 41
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.14
    Marker Score: 34
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.13
    Marker Score: 34
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.12
    Marker Score: 50

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular localization:** HSPB3 is predominantly found in the cytoplasm, with a smaller fraction localized in the nucleus. 2. **Expression pattern:** HSPB3 is highly expressed in various cell types, including neural progenitor cells, erythrocytes, cardiac myocytes, T cells, dendritic cells, and colon goblet cells. 3. **Protein structure:** HSPB3 is a small, acidic protein with a molecular weight of approximately 17 kDa, consisting of a single polypeptide chain. 4. **Chaperone function:** HSPB3 acts as a molecular chaperone, helping to fold and unfold proteins, and preventing protein aggregation and misfolding. **Pathways and Functions:** 1. **Protein folding and degradation:** HSPB3 plays a crucial role in protein folding and degradation, ensuring that proteins are properly folded and degraded, thereby maintaining protein homeostasis. 2. **Cellular stress response:** HSPB3 is activated in response to various cellular stresses, including heat shock, oxidative stress, and unfolded protein response (UPR). 3. **Immune response:** HSPB3 is involved in the regulation of immune responses, particularly in the context of antigen presentation and T cell activation. 4. **Cell survival and apoptosis:** HSPB3 helps to regulate cell survival and apoptosis by preventing protein misfolding and aggregation, which can lead to cell death. **Clinical Significance:** 1. **Neurodegenerative diseases:** HSPB3 has been implicated in various neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS), where its dysregulation can contribute to protein aggregation and neuronal damage. 2. **Cardiac disease:** HSPB3 has been shown to play a critical role in maintaining cardiac function and preventing cardiac dysfunction in various cardiac diseases, including heart failure and arrhythmias. 3. **Cancer:** HSPB3 has been implicated in cancer progression and metastasis, where its dysregulation can contribute to protein misfolding and aggregation, leading to tumor growth and spread. 4. **Immunological disorders:** HSPB3 has been shown to play a role in regulating immune responses, particularly in the context of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. In conclusion, HSPB3 is a multifaceted protein that plays a critical role in maintaining protein homeostasis, responding to cellular stresses, and regulating immune responses. Its dysregulation has been implicated in various diseases, including neurodegenerative, cardiac, and immunological disorders. Further studies are needed to fully elucidate the functions of HSPB3 and its potential as a therapeutic target for disease prevention and treatment.

Genular Protein ID: 3148052739

Symbol: HSPB3_HUMAN

Name: Heat shock protein beta-3

UniProtKB Accession Codes:

Q12988

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9858786

Title: HspB3, the most deviating of the six known human small heat shock proteins.

PubMed ID: 9858786

DOI: 10.1016/s0167-4838(98)00215-5

PubMed ID: 8972725

Title: Isolation and characterization of a human heart cDNA encoding a new member of the small heat shock protein family -- HSPL27.

PubMed ID: 8972725

DOI: 10.1016/s0167-4889(96)00121-8

PubMed ID: 19464326

Title: HSPB7 is a SC35 speckle resident small heat shock protein.

PubMed ID: 19464326

DOI: 10.1016/j.bbamcr.2009.05.005

PubMed ID: 20142617

Title: Mutant small heat shock protein B3 causes motor neuropathy: utility of a candidate gene approach.

PubMed ID: 20142617

DOI: 10.1212/wnl.0b013e3181cef84a

Sequence Information:

  • Length: 150
  • Mass: 16966
  • Checksum: CE5A4DF34CD38715
  • Sequence:
    • MAKIILRHLI EIPVRYQEEF EARGLEDCRL DHALYALPGP TIVDLRKTRA AQSPPVDSAA 
ETPPREGKSH FQILLDVVQF LPEDIIIQTF EGWLLIKAQH GTRMDEHGFI SRSFTRQYKL 
PDGVEIKDLS AVLCHDGILV VEVKDPVGTK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.