Details for: TRPA1

Gene ID: 8989

Symbol: TRPA1

Ensembl ID: ENSG00000104321

Description: transient receptor potential cation channel subfamily A member 1

Associated with

Other Information

Genular Protein ID: 4213393821

Symbol: TRPA1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10066796

Title: An ankyrin-like protein with transmembrane domains is specifically lost after oncogenic transformation of human fibroblasts.

PubMed ID: 10066796

DOI: 10.1074/jbc.274.11.7325

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 17164327

Title: TRP channel activation by reversible covalent modification.

PubMed ID: 17164327

DOI: 10.1073/pnas.0609598103

PubMed ID: 17567811

Title: Requirement of a soluble intracellular factor for activation of transient receptor potential A1 by pungent chemicals: role of inorganic polyphosphates.

PubMed ID: 17567811

DOI: 10.1523/jneurosci.0623-07.2007

PubMed ID: 21873995

Title: TRPA1 underlies a sensing mechanism for O2.

PubMed ID: 21873995

DOI: 10.1038/nchembio.640

PubMed ID: 21402443

Title: Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation.

PubMed ID: 21402443

DOI: 10.1016/j.pain.2011.01.049

PubMed ID: 23199233

Title: Modulation of cough response by sensory inputs from the nose - role of trigeminal TRPA1 versus TRPM8 channels.

PubMed ID: 23199233

DOI: 10.1186/1745-9974-8-11

PubMed ID: 25389312

Title: Human TRPA1 is intrinsically cold- and chemosensitive with and without its N-terminal ankyrin repeat domain.

PubMed ID: 25389312

DOI: 10.1073/pnas.1412689111

PubMed ID: 27241698

Title: The exceptionally high reactivity of Cys 621 is critical for electrophilic activation of the sensory nerve ion channel TRPA1.

PubMed ID: 27241698

DOI: 10.1085/jgp.201611581

PubMed ID: 31447178

Title: A cell-penetrating scorpion toxin enables mode-specific modulation of TRPA1 and pain.

PubMed ID: 31447178

DOI: 10.1016/j.cell.2019.07.014

PubMed ID: 30878828

Title: N-Cinnamoylanthranilates as human TRPA1 modulators: structure-activity relationships and channel binding sites.

PubMed ID: 30878828

DOI: 10.1016/j.ejmech.2019.02.074

PubMed ID: 25855297

Title: Structure of the TRPA1 ion channel suggests regulatory mechanisms.

PubMed ID: 25855297

DOI: 10.1038/nature14367

PubMed ID: 26200340

Title:

PubMed ID: 26200340

DOI: 10.1038/nature14871

PubMed ID: 20547126

Title: A gain-of-function mutation in TRPA1 causes familial episodic pain syndrome.

PubMed ID: 20547126

DOI: 10.1016/j.neuron.2010.04.030

Sequence Information:

  • Length: 1119
  • Mass: 127501
  • Checksum: 283BF31BC77CF71B
  • Sequence:
  • MKRSLRKMWR PGEKKEPQGV VYEDVPDDTE DFKESLKVVF EGSAYGLQNF NKQKKLKRCD 
    DMDTFFLHYA AAEGQIELME KITRDSSLEV LHEMDDYGNT PLHCAVEKNQ IESVKFLLSR 
    GANPNLRNFN MMAPLHIAVQ GMNNEVMKVL LEHRTIDVNL EGENGNTAVI IACTTNNSEA 
    LQILLKKGAK PCKSNKWGCF PIHQAAFSGS KECMEIILRF GEEHGYSRQL HINFMNNGKA 
    TPLHLAVQNG DLEMIKMCLD NGAQIDPVEK GRCTAIHFAA TQGATEIVKL MISSYSGSVD 
    IVNTTDGCHE TMLHRASLFD HHELADYLIS VGADINKIDS EGRSPLILAT ASASWNIVNL 
    LLSKGAQVDI KDNFGRNFLH LTVQQPYGLK NLRPEFMQMQ QIKELVMDED NDGCTPLHYA 
    CRQGGPGSVN NLLGFNVSIH SKSKDKKSPL HFAASYGRIN TCQRLLQDIS DTRLLNEGDL 
    HGMTPLHLAA KNGHDKVVQL LLKKGALFLS DHNGWTALHH ASMGGYTQTM KVILDTNLKC 
    TDRLDEDGNT ALHFAAREGH AKAVALLLSH NADIVLNKQQ ASFLHLALHN KRKEVVLTII 
    RSKRWDECLK IFSHNSPGNK CPITEMIEYL PECMKVLLDF CMLHSTEDKS CRDYYIEYNF 
    KYLQCPLEFT KKTPTQDVIY EPLTALNAMV QNNRIELLNH PVCKEYLLMK WLAYGFRAHM 
    MNLGSYCLGL IPMTILVVNI KPGMAFNSTG IINETSDHSE ILDTTNSYLI KTCMILVFLS 
    SIFGYCKEAG QIFQQKRNYF MDISNVLEWI IYTTGIIFVL PLFVEIPAHL QWQCGAIAVY 
    FYWMNFLLYL QRFENCGIFI VMLEVILKTL LRSTVVFIFL LLAFGLSFYI LLNLQDPFSS 
    PLLSIIQTFS MMLGDINYRE SFLEPYLRNE LAHPVLSFAQ LVSFTIFVPI VLMNLLIGLA 
    VGDIAEVQKH ASLKRIAMQV ELHTSLEKKL PLWFLRKVDQ KSTIVYPNKP RSGGMLFHIF 
    CFLFCTGEIR QEIPNADKSL EMEILKQKYR LKDLTFLLEK QHELIKLIIQ KMEIISETED 
    DDSHCSFQDR FKKEQMEQRN SRWNTVLRAV KAKTHHLEP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.