Details for: CCNF

Gene ID: 899

Symbol: CCNF

Ensembl ID: ENSG00000162063

Description: cyclin F

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.89
    Marker Score: 3911
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.09
    Marker Score: 2074.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71809
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48034
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.98
    Marker Score: 1996
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.98
    Marker Score: 2665
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 499
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 453
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.92
    Marker Score: 14439
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 366
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2734
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5199
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 318
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.87
    Marker Score: 274
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.79
    Marker Score: 472
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.78
    Marker Score: 455
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1252
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 389
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.75
    Marker Score: 903
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 564.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 672
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2978
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.7
    Marker Score: 6576
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.69
    Marker Score: 7095
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.66
    Marker Score: 40889
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.66
    Marker Score: 1121.5
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.64
    Marker Score: 6124
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.62
    Marker Score: 5301
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.58
    Marker Score: 728
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.58
    Marker Score: 541
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.55
    Marker Score: 375
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.55
    Marker Score: 2246
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.54
    Marker Score: 260
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.54
    Marker Score: 169
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.54
    Marker Score: 2080
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.53
    Marker Score: 342
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.53
    Marker Score: 812
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.52
    Marker Score: 1557
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.51
    Marker Score: 381
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.47
    Marker Score: 626
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.46
    Marker Score: 518
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.45
    Marker Score: 1066
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.44
    Marker Score: 6581
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.44
    Marker Score: 219
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.44
    Marker Score: 16669
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.43
    Marker Score: 140
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.42
    Marker Score: 3247
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.41
    Marker Score: 442
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.4
    Marker Score: 103
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.39
    Marker Score: 7795
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.38
    Marker Score: 214
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.38
    Marker Score: 169
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.38
    Marker Score: 381
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.37
    Marker Score: 13759
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.37
    Marker Score: 357
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.35
    Marker Score: 175
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.35
    Marker Score: 233
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.35
    Marker Score: 110
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.34
    Marker Score: 251
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.34
    Marker Score: 166
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.33
    Marker Score: 285
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.31
    Marker Score: 126
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.31
    Marker Score: 129
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.31
    Marker Score: 1269
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.31
    Marker Score: 376
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.3
    Marker Score: 87
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.3
    Marker Score: 79
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.29
    Marker Score: 305
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.29
    Marker Score: 101
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.29
    Marker Score: 807
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.28
    Marker Score: 177
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.28
    Marker Score: 176
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.28
    Marker Score: 187
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.27
    Marker Score: 1003
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.26
    Marker Score: 1085.5
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.26
    Marker Score: 106
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.25
    Marker Score: 70
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.25
    Marker Score: 147
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.25
    Marker Score: 422
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.25
    Marker Score: 312
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.25
    Marker Score: 113
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.25
    Marker Score: 73
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.24
    Marker Score: 341
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.24
    Marker Score: 289
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.24
    Marker Score: 379
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.23
    Marker Score: 1075
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.23
    Marker Score: 115
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.23
    Marker Score: 206
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.23
    Marker Score: 1379
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.23
    Marker Score: 122
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.23
    Marker Score: 472
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.23
    Marker Score: 109
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.23
    Marker Score: 874
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.22
    Marker Score: 71
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.22
    Marker Score: 877

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Other Information

## Summary CCNF is a protein that plays a crucial role in the regulation of cell cycle progression and cell division. It is a key component of the adaptive immune system and has been implicated in various cellular processes, including antigen processing, cell cycle regulation, and development. ## Key characteristics * CCNF is a protein of the CCNF family, which are characterized by the presence of a conserved cysteine-rich domain. * It is expressed in a variety of cell types, including epithelial cells, endothelial cells, neurons, and immune cells. * CCNF is a key regulator of cell cycle progression, and its expression is controlled by various signaling pathways. * It is involved in the regulation of the mitotic cell cycle, and its expression is upregulated in cells that are preparing to divide. * CCNF is also involved in the regulation of the adaptive immune system, where it helps to control the activation and differentiation of immune cells. ## Pathways and functions * CCNF is involved in the regulation of cell cycle progression through its interaction with the Cyclin-dependent protein kinase holoenzyme complex. * It also regulates the ubiquitination and proteasomal degradation of other proteins, including the tumor suppressor p53. * CCNF is involved in the processing and presentation of antigens, and it plays a role in the regulation of adaptive immune responses. * It is also involved in the development of the placenta. ## Clinical significance Mutations in the CCNF gene have been linked to various human diseases, including cancer and developmental disorders. For example, mutations in CCNF have been implicated in the development of breast cancer, lung cancer, and leukemia. CCNF is a promising target for cancer immunotherapy, as it is frequently overexpressed in cancer cells and is involved in their survival and proliferation. Several CCNF inhibitors are currently being tested in clinical trials for the treatment of cancer.

Genular Protein ID: 2569007661

Symbol: CCNF_HUMAN

Name: Cyclin-F

UniProtKB Accession Codes:

P41002 B2R8H3 Q96EG9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 19 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7813445

Title: Human cyclin F.

PubMed ID: 7813445

DOI: 10.1002/j.1460-2075.1994.tb06955.x

PubMed ID: 7896286

Title: A novel cyclin gene (CCNF) in the region of the polycystic kidney disease gene (PKD1).

PubMed ID: 7896286

DOI: 10.1006/geno.1994.1578

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8706131

Title: SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box.

PubMed ID: 8706131

DOI: 10.1016/s0092-8674(00)80098-7

PubMed ID: 10716937

Title: Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction.

PubMed ID: 10716937

DOI: 10.1093/emboj/19.6.1378

PubMed ID: 12122006

Title: Cyclin F is degraded during G2-M by mechanisms fundamentally different from other cyclins.

PubMed ID: 12122006

DOI: 10.1074/jbc.m205503200

PubMed ID: 20596027

Title: SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation.

PubMed ID: 20596027

DOI: 10.1038/nature09140

PubMed ID: 22632967

Title: Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair.

PubMed ID: 22632967

DOI: 10.1016/j.cell.2012.03.043

PubMed ID: 22441691

Title: Neurl4, a novel daughter centriole protein, prevents formation of ectopic microtubule organizing centres.

PubMed ID: 22441691

DOI: 10.1038/embor.2012.40

PubMed ID: 25557911

Title: Cyclin F suppresses B-Myb activity to promote cell cycle checkpoint control.

PubMed ID: 25557911

DOI: 10.1038/ncomms6800

PubMed ID: 27653696

Title: APC/C and SCF(cyclin F) Constitute a Reciprocal Feedback Circuit Controlling S-Phase Entry.

PubMed ID: 27653696

DOI: 10.1016/j.celrep.2016.08.058

PubMed ID: 26818844

Title: SCF(Cyclin F)-dependent degradation of CDC6 suppresses DNA re-replication.

PubMed ID: 26818844

DOI: 10.1038/ncomms10530

PubMed ID: 27080313

Title: CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia.

PubMed ID: 27080313

DOI: 10.1038/ncomms11253

PubMed ID: 28852778

Title: Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy.

PubMed ID: 28852778

DOI: 10.1007/s00018-017-2632-8

Sequence Information:

  • Length: 786
  • Mass: 87640
  • Checksum: ADB2FE41BC708898
  • Sequence:
    • MGSGGVVHCR CAKCFCYPTK RRIRRRPRNL TILSLPEDVL FHILKWLSVE DILAVRAVHS 
QLKDLVDNHA SVWACASFQE LWPSPGNLKL FERAAEKGNF EAAVKLGIAY LYNEGLSVSD 
EARAEVNGLK ASRFFSLAER LNVGAAPFIW LFIRPPWSVS GSCCKAVVHE SLRAECQLQR 
THKASILHCL GRVLSLFEDE EKQQQAHDLF EEAAHQGCLT SSYLLWESDR RTDVSDPGRC 
LHSFRKLRDY AAKGCWEAQL SLAKACANAN QLGLEVRASS EIVCQLFQAS QAVSKQQVFS 
VQKGLNDTMR YILIDWLVEV ATMKDFTSLC LHLTVECVDR YLRRRLVPRY RLQLLGIACM 
VICTRFISKE ILTIREAVWL TDNTYKYEDL VRMMGEIVSA LEGKIRVPTV VDYKEVLLTL 
VPVELRTQHL CSFLCELSLL HTSLSAYAPA RLAAAALLLA RLTHGQTQPW TTQLWDLTGF 
SYEDLIPCVL SLHKKCFHDD APKDYRQVSL TAVKQRFEDK RYGEISQEEV LSYSQLCAAL 
GVTQDSPDPP TFLSTGEIHA FLSSPSGRRT KRKRENSLQE DRGSFVTTPT AELSSQEETL 
LGSFLDWSLD CCSGYEGDQE SEGEKEGDVT APSGILDVTV VYLNPEQHCC QESSDEEACP 
EDKGPQDPQA LALDTQIPAT PGPKPLVRTS REPGKDVTTS GYSSVSTASP TSSVDGGLGA 
LPQPTSVLSL DSDSHTQPCH HQARKSCLQC RPPSPPESSV PQQQVKRINL CIHSEEEDMN 
LGLVRL

Genular Protein ID: 1278183797

Symbol: Q59HD0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59HD0

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 EMBL 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 2 RuleBase 1 SAM 1 SMART 4 SUPFAM 1

Sequence Information:

  • Length: 701
  • Mass: 77957
  • Checksum: 0E815872CB606EC5
  • Sequence:
    • RTSWPSELAA EKGNFEAAVK LGIAYLYNEG LSVSDEARAE VNGLKASRFF SLAERLNVGA 
APFIWLFIRP PWSVSGSCCK AVVHESLRAE CQLQRTHKAS ILHCLGRVLS LFEDEEKQQQ 
AHDLFEEAAH QGCLTSSYLL WESDRRTDVS DPGRCLHSFR KLRDYAAKGC WEAQLSLAKA 
CANANQLGLE VRASSEIVCQ LFQASQAVSK QQVFSVQKGL NDTMRYILID WLVEVATMKD 
FTSLCLHLTV ECVDRYLRRR LVPRYRLQLL GIACMVICTR FISKEILTIR EAVWLTDNTY 
KYEDLVRMMG EIVSALEGKI RVPTVVDYKE VLLTLVPVEL RTQHLCSFLC ELSLLHTSLS 
AYAPARLAAA ALLLARLTHG QTQPWTTQLW DLTGFSYEDL IPCVLSLHKK CFHDDAPKDY 
RQVSLTAVKQ RFEDKRYGEI SQEEVLSYSQ LCAALGVTQD SPDPPTFLST GEIHAFLSSP 
SGRRTKRKRE NSLQEDRGSF VTTPTAELSS QEETLLGSFL DWSLDCCSGY EGDQESEGEK 
EGDVTAPSGI LDVTVVYLNP EQHCCQESSD EEACPEDKGP QDPQALALDT QIPATPGPKP 
LVRTSREPGK DVTTSGYSSV STASPTSSVD GGLGALPQPT SVLSLDSDSH TQPCHHQARK 
SFLQCRPPSP PESSVPQQQV KRINLCIHSE EEDMNLGLVR L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.