Details for: ATP6V0E1

Gene ID: 8992

Symbol: ATP6V0E1

Ensembl ID: ENSG00000113732

Description: ATPase H+ transporting V0 subunit e1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 4.33
    Marker Score: 2,308
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.73
    Marker Score: 9,401
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.72
    Marker Score: 2,912
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.64
    Marker Score: 36,018
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.52
    Marker Score: 196,789
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.49
    Marker Score: 118,818
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.45
    Marker Score: 9,255
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.43
    Marker Score: 39,927
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 3.3
    Marker Score: 5,478
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.25
    Marker Score: 21,178
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 3.18
    Marker Score: 42,681
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.1
    Marker Score: 3,551
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 3.06
    Marker Score: 5,584
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 3.02
    Marker Score: 8,808
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 3.01
    Marker Score: 3,049
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.96
    Marker Score: 2,962
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.94
    Marker Score: 8,130
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.93
    Marker Score: 699
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.89
    Marker Score: 5,629
  • Cell Name: basophil (CL0000767)
    Fold Change: 2.88
    Marker Score: 1,370
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.88
    Marker Score: 3,057
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.88
    Marker Score: 10,217
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.87
    Marker Score: 99,458
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.86
    Marker Score: 6,996
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.86
    Marker Score: 4,602
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.85
    Marker Score: 14,990
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.85
    Marker Score: 4,032
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.84
    Marker Score: 1,668
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 2.83
    Marker Score: 3,140
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.81
    Marker Score: 8,873
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.81
    Marker Score: 4,068
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.78
    Marker Score: 71,298
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.75
    Marker Score: 7,210
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.74
    Marker Score: 4,353
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.73
    Marker Score: 10,536
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 2.71
    Marker Score: 2,424
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.7
    Marker Score: 6,529
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.7
    Marker Score: 6,870
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.7
    Marker Score: 20,092
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.7
    Marker Score: 2,041
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 2.69
    Marker Score: 1,641
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.69
    Marker Score: 3,140
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.68
    Marker Score: 3,689
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.68
    Marker Score: 11,571
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.68
    Marker Score: 20,945
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.67
    Marker Score: 23,028
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.66
    Marker Score: 2,095
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.66
    Marker Score: 2,568
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.65
    Marker Score: 2,363
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.63
    Marker Score: 4,315
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.63
    Marker Score: 1,094
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.62
    Marker Score: 1,493
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.62
    Marker Score: 1,524
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.62
    Marker Score: 5,959
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 2.61
    Marker Score: 1,683
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.61
    Marker Score: 5,217
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 2.6
    Marker Score: 949
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.59
    Marker Score: 6,440
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.57
    Marker Score: 12,621
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 2.57
    Marker Score: 1,167
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.56
    Marker Score: 7,195
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 2.56
    Marker Score: 834
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.56
    Marker Score: 4,815
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.54
    Marker Score: 2,766
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 2.54
    Marker Score: 1,593
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.53
    Marker Score: 1,722
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.53
    Marker Score: 2,220
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.52
    Marker Score: 6,534
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.52
    Marker Score: 2,256
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.52
    Marker Score: 2,949
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.52
    Marker Score: 1,194
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.5
    Marker Score: 16,014
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 2.5
    Marker Score: 617
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.49
    Marker Score: 1,017
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 2.49
    Marker Score: 1,805
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.49
    Marker Score: 28,014
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 2.47
    Marker Score: 1,697
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.47
    Marker Score: 853
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.47
    Marker Score: 3,212
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.47
    Marker Score: 876
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.46
    Marker Score: 129,886
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.46
    Marker Score: 4,352
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.46
    Marker Score: 1,927
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.45
    Marker Score: 2,635
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.45
    Marker Score: 2,107
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 2.45
    Marker Score: 1,057
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 2.44
    Marker Score: 694
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.44
    Marker Score: 1,254
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 2.43
    Marker Score: 557
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.43
    Marker Score: 2,926
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.42
    Marker Score: 3,562
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 2.41
    Marker Score: 636
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 2.41
    Marker Score: 1,250
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 2.41
    Marker Score: 599
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 2.41
    Marker Score: 2,325
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.4
    Marker Score: 5,453
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.4
    Marker Score: 1,198
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.39
    Marker Score: 596
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 2.39
    Marker Score: 634
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 2.39
    Marker Score: 1,070

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Proton-Transporting Activity:** ATP6V0E1 is a subunit of the V-type proton-transporting ATPase, which is responsible for the transport of protons across cellular membranes. 2. **Multi-Subunit Enzyme:** The V-ATPase is a multi-subunit enzyme, consisting of several subunits, including the ATP6V0E1 subunit. 3. **Significant Expression:** ATP6V0E1 is significantly expressed in various cell types, including renal intercalated cells, kidney collecting duct principal cells, thyroid follicular cells, mature T cells, and fibroblasts of the mammary gland. 4. **Ion Transport:** The V-ATPase plays a crucial role in ion transport, including the transport of protons, sodium, and potassium ions across cellular membranes. **Pathways and Functions:** 1. **Cellular Acidification:** The V-ATPase, in which ATP6V0E1 plays a vital role, is responsible for the acidification of cellular compartments, such as the lysosome and the endosome. 2. **Ion Transport:** The V-ATPase is involved in the transport of ions across cellular membranes, including the transport of protons, sodium, and potassium ions. 3. **Regulation of Immune Response:** The V-ATPase plays a crucial role in the regulation of the immune response, including the transport of ions and the regulation of the activity of immune cells, such as macrophages and T cells. 4. **Regulation of Autophagy:** The V-ATPase, in which ATP6V0E1 is a critical component, is involved in the regulation of autophagy, a cellular process that involves the degradation and recycling of cellular components. **Clinical Significance:** 1. **Renal Disease:** Mutations in the ATP6V0A1 gene, which encodes the alpha subunit of the V-ATPase, have been associated with renal disease, including nephrolithiasis and nephrotic syndrome. 2. **Thyroid Disease:** Mutations in the ATP6I gene, which encodes the beta subunit of the V-ATPase, have been associated with thyroid disease, including hypothyroidism and hyperthyroidism. 3. **Immune System Disorders:** The V-ATPase, in which ATP6V0E1 plays a vital role, is involved in the regulation of the immune response, and mutations in the ATP6V0E1 gene may be associated with immune system disorders, including autoimmune diseases and immunodeficiency disorders. 4. **Cancer:** The V-ATPase, in which ATP6V0E1 is a critical component, is involved in the regulation of cellular processes, including cell growth and survival, and may be associated with cancer. In conclusion, the ATP6V0E1 gene plays a critical role in the regulation of various cellular processes, including cellular acidification, ion transport, and regulation of the immune response. Mutations in the ATP6V0E1 gene may be associated with various diseases, including renal disease, thyroid disease, immune system disorders, and cancer. Further research is needed to fully understand the role of the ATP6V0E1 gene in human health and disease.

Genular Protein ID: 2317602172

Symbol: VA0E1_HUMAN

Name: V-type proton ATPase subunit e 1

UniProtKB Accession Codes:

O15342 B2R557 D3DQM1 Q6IBE8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 8 EMDB 6 Ensembl 2 ExpressionAtlas 1 GO 10 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 6 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 5 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9556572

Title: Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules.

PubMed ID: 9556572

DOI: 10.1074/jbc.273.18.10939

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17350184

Title: Molecular cloning and characterization of a novel form of the human vacuolar H+-ATPase e-subunit: an essential proton pump component.

PubMed ID: 17350184

DOI: 10.1016/j.gene.2007.01.020

PubMed ID: 33065002

Title: Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly.

PubMed ID: 33065002

DOI: 10.1016/j.molcel.2020.09.029

Sequence Information:

  • Length: 81
  • Mass: 9374
  • Checksum: 9A47F16FDD2B2027
  • Sequence:
    • MAYHGLTVPL IVMSVFWGFV GFLVPWFIPK GPNRGVIITM LVTCSVCCYL FWLIAILAQL 
NPLFGPQLKN ETIWYLKYHW P

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.