Details for: PGLYRP1

Gene ID: 8993

Symbol: PGLYRP1

Ensembl ID: ENSG00000008438

Description: peptidoglycan recognition protein 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glial cell (CL0000125)
    Fold Change: 9.73
    Marker Score: 10,701
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 9.48
    Marker Score: 30,373
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 7.56
    Marker Score: 10,482
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 5.76
    Marker Score: 16,793
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 5.68
    Marker Score: 7,078
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 4.96
    Marker Score: 14,707
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 4.58
    Marker Score: 4,394
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 3.78
    Marker Score: 10,853
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.5
    Marker Score: 29,579
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.32
    Marker Score: 9,468
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.21
    Marker Score: 2,225
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.2
    Marker Score: 1,515
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.36
    Marker Score: 588
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,693
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 799
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,826
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,050
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,350
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,287
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.74
    Marker Score: 371
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.65
    Marker Score: 432
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.63
    Marker Score: 367
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.61
    Marker Score: 488
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.48
    Marker Score: 247
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.37
    Marker Score: 99
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.36
    Marker Score: 202
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.34
    Marker Score: 144
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.34
    Marker Score: 646
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.33
    Marker Score: 509
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.31
    Marker Score: 106
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.31
    Marker Score: 2,621
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.3
    Marker Score: 185
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.28
    Marker Score: 139
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.28
    Marker Score: 130
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.28
    Marker Score: 163
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.28
    Marker Score: 175
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.27
    Marker Score: 123
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.26
    Marker Score: 158
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.26
    Marker Score: 110
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.25
    Marker Score: 163
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.24
    Marker Score: 491
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.23
    Marker Score: 143
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.23
    Marker Score: 68
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.21
    Marker Score: 3,362
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.21
    Marker Score: 424
  • Cell Name: immature neutrophil (CL0000776)
    Fold Change: 0.2
    Marker Score: 69
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.2
    Marker Score: 91
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.2
    Marker Score: 81
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.19
    Marker Score: 81
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.19
    Marker Score: 180
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.18
    Marker Score: 49
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.18
    Marker Score: 167
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.17
    Marker Score: 54
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.17
    Marker Score: 53
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.16
    Marker Score: 1,542
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.16
    Marker Score: 167
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.16
    Marker Score: 82
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.15
    Marker Score: 87
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.15
    Marker Score: 9,182
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.15
    Marker Score: 79
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.14
    Marker Score: 832
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.14
    Marker Score: 154
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.14
    Marker Score: 137
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.13
    Marker Score: 1,745
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.13
    Marker Score: 160
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.13
    Marker Score: 204
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.13
    Marker Score: 97
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.12
    Marker Score: 25
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.12
    Marker Score: 74
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.12
    Marker Score: 1,102
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.11
    Marker Score: 25
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.11
    Marker Score: 98
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.11
    Marker Score: 455
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.11
    Marker Score: 83
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.11
    Marker Score: 51
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.1
    Marker Score: 190
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.1
    Marker Score: 32
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.1
    Marker Score: 24
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.09
    Marker Score: 3,504
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.09
    Marker Score: 85
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.09
    Marker Score: 25
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.09
    Marker Score: 88
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.09
    Marker Score: 347
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.09
    Marker Score: 35
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.09
    Marker Score: 51
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.08
    Marker Score: 1,670
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.08
    Marker Score: 41
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.08
    Marker Score: 40
  • Cell Name: S cone cell (CL0003050)
    Fold Change: 0.08
    Marker Score: 24

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** PGLYRP1 is a small, secreted protein that belongs to the peptidoglycan recognition protein family. It is characterized by its ability to recognize and bind to PGN structures, which are common components of bacterial cell walls. This recognition is mediated by the protein's N-terminal domain, which contains a peptidoglycan-binding site. PGLYRP1 has been shown to interact with various immune cells, including neutrophils and macrophages, and to regulate their functions, including phagocytosis, degranulation, and cytokine production. **Pathways and Functions** PGLYRP1 is involved in several key immune-related pathways, including: 1. **Antimicrobial Humoral Immune Response**: PGLYRP1 recognizes and binds to PGN structures, which triggers an immune response against bacterial infections. 2. **Antimicrobial Peptide Production**: PGLYRP1 interacts with neutrophils and macrophages to stimulate the production of antimicrobial peptides, which are essential for killing bacteria. 3. **Negative Regulation of Inflammatory Response**: PGLYRP1 has been shown to negatively regulate the production of pro-inflammatory cytokines, which helps to prevent excessive inflammation and tissue damage. 4. **Immune Cell Regulation**: PGLYRP1 interacts with immune cells, including neutrophils and macrophages, to regulate their functions and modulate the immune response. **Clinical Significance** PGLYRP1 has been implicated in several diseases, including: 1. **Autoimmune Disorders**: PGLYRP1 has been shown to contribute to the pathogenesis of autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis, by regulating immune cell function and cytokine production. 2. **Infectious Diseases**: PGLYRP1 has been implicated in the regulation of the immune response to bacterial infections, such as tuberculosis and sepsis. 3. **Eye Diseases**: PGLYRP1 has been shown to play a role in the regulation of immune responses in the eye, which may contribute to the pathogenesis of eye diseases, such as uveitis and age-related macular degeneration. In conclusion, PGLYRP1 is a multifunctional protein that plays a crucial role in the innate immune response, particularly in the recognition and binding of peptidoglycan structures. Its dysregulation has been implicated in various diseases, highlighting the importance of this protein in maintaining immune homeostasis and preventing disease.

Genular Protein ID: 595209060

Symbol: PGRP1_HUMAN

Name: Peptidoglycan recognition protein 1

UniProtKB Accession Codes:

O75594 Q4VB36

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 1 EvolutionaryTrace 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9707603

Title: A peptidoglycan recognition protein in innate immunity conserved from insects to humans.

PubMed ID: 9707603

DOI: 10.1073/pnas.95.17.10078

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11461926

Title: Peptidoglycan recognition proteins: a novel family of four human innate immunity pattern recognition molecules.

PubMed ID: 11461926

DOI: 10.1074/jbc.m105566200

PubMed ID: 16354652

Title: Peptidoglycan recognition proteins are a new class of human bactericidal proteins.

PubMed ID: 16354652

DOI: 10.1074/jbc.m511631200

PubMed ID: 15769462

Title: Crystal structure of human peptidoglycan recognition protein S (PGRP-S) at 1.70 A resolution.

PubMed ID: 15769462

DOI: 10.1016/j.jmb.2005.01.070

PubMed ID: 21247889

Title: The heat shock-binding protein (HspBP1) protects cells against the cytotoxic action of the Tag7-Hsp70 complex.

PubMed ID: 21247889

DOI: 10.1074/jbc.m110.163436

PubMed ID: 26183779

Title: Tag7 (PGLYRP1) in Complex with Hsp70 Induces Alternative Cytotoxic Processes in Tumor Cells via TNFR1 Receptor.

PubMed ID: 26183779

DOI: 10.1074/jbc.m115.639732

PubMed ID: 25595774

Title: Cutting Edge: identification of neutrophil PGLYRP1 as a ligand for TREM-1.

PubMed ID: 25595774

DOI: 10.4049/jimmunol.1402303

PubMed ID: 26654597

Title: A new role for PGRP-S (Tag7) in immune defense: lymphocyte migration is induced by a chemoattractant complex of Tag7 with Mts1.

PubMed ID: 26654597

DOI: 10.1080/15384101.2015.1104440

PubMed ID: 29083508

Title: Innate immunity protein Tag7 (PGRP-S) activates lymphocytes capable of Fasl-Fas-dependent contact killing of virus-infected cells.

PubMed ID: 29083508

DOI: 10.1002/iub.1688

PubMed ID: 28977785

Title: Innate Immunity Protein Tag7 Induces 3 Distinct Populations of Cytotoxic Cells That Use Different Mechanisms to Exhibit Their Antitumor Activity on Human Leukocyte Antigen-Deficient Cancer Cells.

PubMed ID: 28977785

DOI: 10.1159/000479382

PubMed ID: 30713770

Title: Tag7-Mts1 Complex Induces Lymphocytes Migration via CCR5 and CXCR3 Receptors.

PubMed ID: 30713770

Sequence Information:

  • Length: 196
  • Mass: 21731
  • Checksum: D954C51440DC27DC
  • Sequence:
    • MSRRSMLLAW ALPSLLRLGA AQETEDPACC SPIVPRNEWK ALASECAQHL SLPLRYVVVS 
HTAGSSCNTP ASCQQQARNV QHYHMKTLGW CDVGYNFLIG EDGLVYEGRG WNFTGAHSGH 
LWNPMSIGIS FMGNYMDRVP TPQAIRAAQG LLACGVAQGA LRSNYVLKGH RDVQRTLSPG 
NQLYHLIQNW PHYRSP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.