PGLYRP1 | ENSG00000008438 | NCBI 8993

Details for: PGLYRP1

Gene ID: 8993

Symbol: PGLYRP1

Ensembl ID: ENSG00000008438

Description: peptidoglycan recognition protein 1

Associated with

Antimicrobial peptides
(R-HSA-6803157)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Neutrophil degranulation
(R-HSA-6798695)
Antimicrobial humoral immune response mediated by antimicrobial peptide
(GO:0061844)
Biological process involved in interaction with host
(GO:0051701)
Defense response to gram-positive bacterium
(GO:0050830)
Detection of bacterium
(GO:0016045)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Hsp70 protein binding
(GO:0030544)
Innate immune response
(GO:0045087)
Killing of cells of another organism
(GO:0031640)
Molecular adaptor activity
(GO:0060090)
N-acetylmuramoyl-l-alanine amidase activity
(GO:0008745)
Negative regulation of inflammatory response
(GO:0050728)
Negative regulation of natural killer cell differentiation involved in immune response
(GO:0032827)
Negative regulation of type ii interferon production
(GO:0032689)
Peptidoglycan binding
(GO:0042834)
Peptidoglycan catabolic process
(GO:0009253)
Peptidoglycan immune receptor activity
(GO:0016019)
Phagocytic vesicle lumen
(GO:0097013)
Receptor ligand activity
(GO:0048018)
Signal transduction
(GO:0007165)
Specific granule lumen
(GO:0035580)
Tertiary granule lumen
(GO:1904724)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Peptidoglycan recognition protein 1

Genular Protein ID: 595209060

Symbol: PGRP1_HUMAN

Name: Peptidoglycan recognition protein 1

UniProtKB Accession Codes:

O75594 Q4VB36

Database IDs:

Citations:

PubMed ID: 9707603

Title: A peptidoglycan recognition protein in innate immunity conserved from insects to humans.

PubMed ID: 9707603

DOI: 10.1073/pnas.95.17.10078

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11461926

Title: Peptidoglycan recognition proteins: a novel family of four human innate immunity pattern recognition molecules.

PubMed ID: 11461926

DOI: 10.1074/jbc.m105566200

PubMed ID: 16354652

Title: Peptidoglycan recognition proteins are a new class of human bactericidal proteins.

PubMed ID: 16354652

DOI: 10.1074/jbc.m511631200

PubMed ID: 15769462

Title: Crystal structure of human peptidoglycan recognition protein S (PGRP-S) at 1.70 A resolution.

PubMed ID: 15769462

DOI: 10.1016/j.jmb.2005.01.070

PubMed ID: 21247889

Title: The heat shock-binding protein (HspBP1) protects cells against the cytotoxic action of the Tag7-Hsp70 complex.

PubMed ID: 21247889

DOI: 10.1074/jbc.m110.163436

PubMed ID: 26183779

Title: Tag7 (PGLYRP1) in Complex with Hsp70 Induces Alternative Cytotoxic Processes in Tumor Cells via TNFR1 Receptor.

PubMed ID: 26183779

DOI: 10.1074/jbc.m115.639732

PubMed ID: 25595774

Title: Cutting Edge: identification of neutrophil PGLYRP1 as a ligand for TREM-1.

PubMed ID: 25595774

DOI: 10.4049/jimmunol.1402303

PubMed ID: 26654597

Title: A new role for PGRP-S (Tag7) in immune defense: lymphocyte migration is induced by a chemoattractant complex of Tag7 with Mts1.

PubMed ID: 26654597

DOI: 10.1080/15384101.2015.1104440

PubMed ID: 29083508

Title: Innate immunity protein Tag7 (PGRP-S) activates lymphocytes capable of Fasl-Fas-dependent contact killing of virus-infected cells.

PubMed ID: 29083508

DOI: 10.1002/iub.1688

PubMed ID: 28977785

Title: Innate Immunity Protein Tag7 Induces 3 Distinct Populations of Cytotoxic Cells That Use Different Mechanisms to Exhibit Their Antitumor Activity on Human Leukocyte Antigen-Deficient Cancer Cells.

PubMed ID: 28977785

DOI: 10.1159/000479382

PubMed ID: 30713770

Title: Tag7-Mts1 Complex Induces Lymphocytes Migration via CCR5 and CXCR3 Receptors.

PubMed ID: 30713770

Sequence Information:

Length: 196
Mass: 21731
Checksum: D954C51440DC27DC
Sequence:

MSRRSMLLAW ALPSLLRLGA AQETEDPACC SPIVPRNEWK ALASECAQHL SLPLRYVVVS 
HTAGSSCNTP ASCQQQARNV QHYHMKTLGW CDVGYNFLIG EDGLVYEGRG WNFTGAHSGH 
LWNPMSIGIS FMGNYMDRVP TPQAIRAAQG LLACGVAQGA LRSNYVLKGH RDVQRTLSPG 
NQLYHLIQNW PHYRSP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PGLYRP1

Associated with

Other Information

A peptidoglycan recognition protein in innate immunity conserved from insects to humans. PubMed ID: 9707603

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. PubMed ID: 12975309

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Peptidoglycan recognition proteins: a novel family of four human innate immunity pattern recognition molecules. PubMed ID: 11461926

Peptidoglycan recognition proteins are a new class of human bactericidal proteins. PubMed ID: 16354652

Crystal structure of human peptidoglycan recognition protein S (PGRP-S) at 1.70 A resolution. PubMed ID: 15769462

The heat shock-binding protein (HspBP1) protects cells against the cytotoxic action of the Tag7-Hsp70 complex. PubMed ID: 21247889

Tag7 (PGLYRP1) in Complex with Hsp70 Induces Alternative Cytotoxic Processes in Tumor Cells via TNFR1 Receptor. PubMed ID: 26183779

Cutting Edge: identification of neutrophil PGLYRP1 as a ligand for TREM-1. PubMed ID: 25595774

A new role for PGRP-S (Tag7) in immune defense: lymphocyte migration is induced by a chemoattractant complex of Tag7 with Mts1. PubMed ID: 26654597

Innate immunity protein Tag7 (PGRP-S) activates lymphocytes capable of Fasl-Fas-dependent contact killing of virus-infected cells. PubMed ID: 29083508

Innate Immunity Protein Tag7 Induces 3 Distinct Populations of Cytotoxic Cells That Use Different Mechanisms to Exhibit Their Antitumor Activity on Human Leukocyte Antigen-Deficient Cancer Cells. PubMed ID: 28977785

Tag7-Mts1 Complex Induces Lymphocytes Migration via CCR5 and CXCR3 Receptors. PubMed ID: 30713770