LIMD1 | ENSG00000144791 | NCBI 8994

Details for: LIMD1

Gene ID: 8994

Symbol: LIMD1

Ensembl ID: ENSG00000144791

Description: LIM domain containing 1

Associated with

Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to hypoxia
(R-HSA-1234174)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-HSA-1234176)
Adherens junction
(GO:0005912)
Cell migration
(GO:0016477)
Cytoplasm
(GO:0005737)
Cytoskeleton organization
(GO:0007010)
Cytosol
(GO:0005829)
Focal adhesion
(GO:0005925)
Metal ion binding
(GO:0046872)
Mirna-mediated gene silencing by inhibition of translation
(GO:0035278)
Mirna-mediated post-transcriptional gene silencing
(GO:0035195)
Negative regulation of canonical wnt signaling pathway
(GO:0090090)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of hippo signaling
(GO:0035331)
Negative regulation of osteoblast differentiation
(GO:0045668)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Osteoblast development
(GO:0002076)
P-body
(GO:0000932)
P-body assembly
(GO:0033962)
Phosphorylation
(GO:0016310)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Regulation of cell shape
(GO:0008360)
Regulation of dna-templated transcription
(GO:0006355)
Response to hypoxia
(GO:0001666)
Risc complex
(GO:0016442)
Transcription corepressor activity
(GO:0003714)
Transcription regulator complex
(GO:0005667)

Other Information

Proteins

LIM domain-containing protein 1

Genular Protein ID: 1007243786

Symbol: LIMD1_HUMAN

Name: LIM domain-containing protein 1

UniProtKB Accession Codes:

Q9UGP4 Q17RQ1 Q9BQQ9 Q9NQ47

Database IDs:

Citations:

PubMed ID: 10647888

Title: A novel gene containing LIM domains (LIMD1) is located within the common eliminated region 1 (C3CER1) in 3p21.3.

PubMed ID: 10647888

DOI: 10.1007/s004399900188

PubMed ID: 11352561

Title: The LZTFL1 gene is a part of a transcriptional map covering 250 kb within the common eliminated region 1 (C3CER1) in 3p21.3.

PubMed ID: 11352561

DOI: 10.1006/geno.2000.6498

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 15542589

Title: LIM domains-containing protein 1 (LIMD1), a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcription.

PubMed ID: 15542589

DOI: 10.1073/pnas.0407123101

PubMed ID: 15870274

Title: The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex.

PubMed ID: 15870274

DOI: 10.1128/mcb.25.10.4010-4022.2005

PubMed ID: 18439753

Title: Cell cycle regulated phosphorylation of LIMD1 in cell lines and expression in human breast cancers.

PubMed ID: 18439753

DOI: 10.1016/j.canlet.2008.03.015

PubMed ID: 18331720

Title: Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus.

PubMed ID: 18331720

DOI: 10.1016/j.devcel.2008.01.005

PubMed ID: 18712738

Title: Differential subcellular localisation of the tumour suppressor protein LIMD1 in breast cancer correlates with patient survival.

PubMed ID: 18712738

DOI: 10.1002/ijc.23851

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20303269

Title: Ajuba LIM proteins are negative regulators of the Hippo signaling pathway.

PubMed ID: 20303269

DOI: 10.1016/j.cub.2010.02.035

PubMed ID: 20616046

Title: LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing.

PubMed ID: 20616046

DOI: 10.1073/pnas.0914987107

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21834987

Title: Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration.

PubMed ID: 21834987

DOI: 10.1186/1741-7007-9-54

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22286099

Title: The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity.

PubMed ID: 22286099

DOI: 10.1038/ncb2424

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

Length: 676
Mass: 72190
Checksum: 085DF06F047B49E6
Sequence:

MDKYDDLGLE ASKFIEDLNM YEASKDGLFR VDKGAGNNPE FEETRRVFAT KMAKIHLQQQ 
QQQLLQEETL PRGSRGPVNG GGRLGPQARW EVVGSKLTVD GAAKPPLAAS TGAPGAVTTL 
AAGQPPYPPQ EQRSRPYLHG TRHGSQDCGS RESLATSEMS AFHQPGPCED PSCLTHGDYY 
DNLSLASPKW GDKPGVSPSI GLSVGSGWPS SPGSDPPLPK PCGDHPLNHR QLSLSSSRSS 
EGSLGGQNSG IGGRSSEKPT GLWSTASSQR VSPGLPSPNL ENGAPAVGPV QPRTPSVSAP 
LALSCPRQGG LPRSNSGLGG EVSGVMSKPN VDPQPWFQDG PKSYLSSSAP SSSPAGLDGS 
QQGAVPGLGP KPGCTDLGTG PKLSPTSLVH PVMSTLPELS CKEGPLGWSS DGSLGSVLLD 
SPSSPRVRLP CQPLVPGPEL RPSAAELKLE ALTQRLEREM DAHPKADYFG ACVKCSKGVF 
GAGQACQAMG NLYHDTCFTC AACSRKLRGK AFYFVNGKVF CEEDFLYSGF QQSADRCFLC 
GHLIMDMILQ ALGKSYHPGC FRCVICNECL DGVPFTVDSE NKIYCVRDYH KVLAPKCAAC 
GLPILPPEGS DETIRVVSMD RDYHVECYHC EDCGLELNDE DGHRCYPLED HLFCHSCHVK 
RLEKRPSSTA LHQHHF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: LIMD1

Associated with

Other Information

A novel gene containing LIM domains (LIMD1) is located within the common eliminated region 1 (C3CER1) in 3p21.3. PubMed ID: 10647888

The LZTFL1 gene is a part of a transcriptional map covering 250 kb within the common eliminated region 1 (C3CER1) in 3p21.3. PubMed ID: 11352561

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. PubMed ID: 15144186

LIM domains-containing protein 1 (LIMD1), a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcription. PubMed ID: 15542589

The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex. PubMed ID: 15870274

Cell cycle regulated phosphorylation of LIMD1 in cell lines and expression in human breast cancers. PubMed ID: 18439753

Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus. PubMed ID: 18331720

Differential subcellular localisation of the tumour suppressor protein LIMD1 in breast cancer correlates with patient survival. PubMed ID: 18712738

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Ajuba LIM proteins are negative regulators of the Hippo signaling pathway. PubMed ID: 20303269

LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing. PubMed ID: 20616046

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration. PubMed ID: 21834987

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity. PubMed ID: 22286099

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569