Details for: LIMD1

Gene ID: 8994

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: LIMD1

Ensembl ID: ENSG00000144791

Description: LIM domain containing 1

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • mature B cell CL0000785
    CSI 11
    rCSI 9.56%
    PRS 79.78
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 7.52
    rCSI 9.09%
    PRS 78.12
  • alveolar macrophage CL0000583
    CSI 6.08
    rCSI 10.01%
    PRS 74.44
  • intestinal tuft cell CL0019032
    CSI 5.27
    rCSI 8.05%
    PRS 73.61
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 4.99
    rCSI 3.84%
    PRS 70.79
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 4.67
    rCSI 5.39%
    PRS 61.78
  • renal beta-intercalated cell CL0002201
    CSI 4.6
    rCSI 10.96%
    PRS 69.45
  • glioblast CL0000030
    CSI 4.27
    rCSI 6.8%
    PRS 61
  • naive B cell CL0000788
    CSI 4.09
    rCSI 3.51%
    PRS 76.94
  • tuft cell of colon CL0009041
    CSI 3.9
    rCSI 9.08%
    PRS 78.59
  • stromal cell CL0000499
    CSI 3.62
    rCSI 10.18%
    PRS 65.33
  • mesothelial cell CL0000077
    CSI 3.46
    rCSI 13.55%
    PRS 46.2
  • pancreatic ductal cell CL0002079
    CSI 3.42
    rCSI 6.65%
    PRS 72.42
  • chondrocyte CL0000138
    CSI 3.34
    rCSI 5.32%
    PRS 61.8
  • astrocyte of the cerebral cortex CL0002605
    CSI 3.34
    rCSI 7.49%
    PRS 51.06
  • retinal pigment epithelial cell CL0002586
    CSI 3.32
    rCSI 6.59%
    PRS 65.74
  • luminal epithelial cell of mammary gland CL0002326
    CSI 2.96
    rCSI 5.37%
    PRS 82.8
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 2.95
    rCSI 5.35%
    PRS 60.37
  • lymphoid lineage restricted progenitor cell CL0000838
    CSI 2.8
    rCSI 10.9%
    PRS 87.35
  • midzonal region hepatocyte CL0019028
    CSI 2.79
    rCSI 6.56%
    PRS 71.86
  • cardiac endothelial cell CL0010008
    CSI 2.75
    rCSI 11.09%
    PRS 68.36
  • hepatocyte CL0000182
    CSI 2.74
    rCSI 4.9%
    PRS 68.48
  • choroid plexus epithelial cell CL0000706
    CSI 2.71
    rCSI 4.44%
    PRS 58.22
  • melanocyte CL0000148
    CSI 2.67
    rCSI 1.98%
    PRS 62.01
  • neural crest cell CL0011012
    CSI 2.66
    rCSI 2.11%
    PRS 56.38
  • precursor B cell CL0000817
    CSI 2.63
    rCSI 2.3%
    PRS 78.03
  • goblet cell CL0000160
    CSI 2.61
    rCSI 2.47%
    PRS 68.45
  • Mueller cell CL0000636
    CSI 2.58
    rCSI 5.9%
    PRS 60.61
  • secretory cell CL0000151
    CSI 2.57
    rCSI 2.68%
    PRS 69.25
  • respiratory suprabasal cell CL4033048
    CSI 2.5
    rCSI 3.21%
    PRS 73.56
  • epithelial cell of lung CL0000082
    CSI 2.46
    rCSI 2.04%
    PRS 69.09
  • mononuclear phagocyte CL0000113
    CSI 2.41
    rCSI 5.31%
    PRS 73.24
  • epithelial cell of lower respiratory tract CL0002632
    CSI 2.39
    rCSI 1.85%
    PRS 72.21
  • plasmacytoid dendritic cell, human CL0001058
    CSI 2.35
    rCSI 1.64%
    PRS 72.16
  • Kupffer cell CL0000091
    CSI 2.32
    rCSI 5.31%
    PRS 69.69
  • lung ciliated cell CL1000271
    CSI 2.29
    rCSI 2.64%
    PRS 60.05
  • pro-B cell CL0000826
    CSI 2.27
    rCSI 1.88%
    PRS 71.63
  • CD14-positive monocyte CL0001054
    CSI 2.23
    rCSI 2.78%
    PRS 79.64
  • stem cell CL0000034
    CSI 2.21
    rCSI 2.13%
    PRS 60.81
  • plasmablast CL0000980
    CSI 2.2
    rCSI 1.73%
    PRS 75.74
  • alveolar type 1 fibroblast cell CL4028004
    CSI 2.19
    rCSI 2.4%
    PRS 72.53
  • fibroblast of lung CL0002553
    CSI 2.15
    rCSI 2%
    PRS 69.94
  • pancreatic A cell CL0000171
    CSI 2.14
    rCSI 2.24%
    PRS 72.74
  • hepatic stellate cell CL0000632
    CSI 2.12
    rCSI 7.92%
    PRS 61.16
  • multi-ciliated epithelial cell CL0005012
    CSI 2.1
    rCSI 2.1%
    PRS 62.65
  • brush cell of tracheobronchial tree CL0002075
    CSI 2.06
    rCSI 6.1%
    PRS 78.87
  • conjunctival epithelial cell CL1000432
    CSI 2.02
    rCSI 3.09%
    PRS 69.8
  • innate lymphoid cell CL0001065
    CSI 1.98
    rCSI 4.09%
    PRS 68.8
  • lung secretory cell CL1000272
    CSI 1.93
    rCSI 4.78%
    PRS 67.92
  • blood vessel endothelial cell CL0000071
    CSI 1.89
    rCSI 3.93%
    PRS 66.14
  • IgG plasma cell CL0000985
    CSI 1.86
    rCSI 2.22%
    PRS 83.74
  • CD14-positive, CD16-positive monocyte CL0002397
    CSI 1.84
    rCSI 2.42%
    PRS 81.92
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 1.84
    rCSI 2.28%
    PRS 48.4
  • vascular leptomeningeal cell CL4023051
    CSI 1.82
    rCSI 3.18%
    PRS 61.55
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 1.81
    rCSI 4.72%
    PRS 69.41
  • cerebral cortex endothelial cell CL1001602
    CSI 1.81
    rCSI 3.12%
    PRS 59.55
  • pulmonary alveolar type 2 cell CL0002063
    CSI 1.78
    rCSI 2.76%
    PRS 75.53
  • periportal region hepatocyte CL0019026
    CSI 1.76
    rCSI 6.83%
    PRS 71.63
  • contractile cell CL0000183
    CSI 1.74
    rCSI 5.14%
    PRS 67.98
  • lung pericyte CL0009089
    CSI 1.73
    rCSI 4.56%
    PRS 77.6
  • cardiac muscle cell CL0000746
    CSI 1.69
    rCSI 2.42%
    PRS 58.62
  • extravillous trophoblast CL0008036
    CSI 1.63
    rCSI 2.02%
    PRS 66.09
  • VIP GABAergic cortical interneuron CL4023016
    CSI 1.63
    rCSI 1.95%
    PRS 50.12
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 1.59
    rCSI 2.26%
    PRS 65.31
  • myeloid dendritic cell CL0000782
    CSI 1.56
    rCSI 2.26%
    PRS 84.17
  • common dendritic progenitor CL0001029
    CSI 1.55
    rCSI 1.94%
    PRS 79.37
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 1.46
    rCSI 2.45%
    PRS 50.33
  • brush cell CL0002204
    CSI 1.42
    rCSI 2.81%
    PRS 82.56
  • epithelial cell of proximal tubule CL0002306
    CSI 1.41
    rCSI 3.44%
    PRS 62.16
  • centrilobular region hepatocyte CL0019029
    CSI 1.38
    rCSI 3.6%
    PRS 70.62
  • renal interstitial pericyte CL1001318
    CSI 1.37
    rCSI 3.79%
    PRS 64.11
  • regular atrial cardiac myocyte CL0002129
    CSI 1.33
    rCSI 4.27%
    PRS 66.66
  • intermediate monocyte CL0002393
    CSI 1.29
    rCSI 1.95%
    PRS 74.18
  • cholangiocyte CL1000488
    CSI 1.25
    rCSI 7.48%
    PRS 74.22
  • fibroblast of cardiac tissue CL0002548
    CSI 1.23
    rCSI 5.9%
    PRS 69.04
  • pulmonary alveolar type 1 cell CL0002062
    CSI 1.21
    rCSI 6.99%
    PRS 66.93
  • dendritic cell, human CL0001056
    CSI 1.18
    rCSI 1.81%
    PRS 78.44
  • Hofbauer cell CL3000001
    CSI 1.14
    rCSI 2.15%
    PRS 79.07
  • parietal epithelial cell CL1000452
    CSI 1.03
    rCSI 2.76%
    PRS 60.08
  • intestinal crypt stem cell of small intestine CL0009017
    CSI 1.02
    rCSI 2.74%
    PRS 75.41
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 0.99
    rCSI 1.75%
    PRS 49.46
  • kidney connecting tubule epithelial cell CL1000768
    CSI 0.86
    rCSI 2.19%
    PRS 58.75
  • placental villous trophoblast CL2000060
    CSI 0.85
    rCSI 1.32%
    PRS 67.88
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 0.78
    rCSI 1.91%
    PRS 48.74
  • glial cell CL0000125
    CSI 0.68
    rCSI 2.59%
    PRS 59.56
  • H2 horizontal cell CL0004218
    CSI 0.64
    rCSI 3.2%
    PRS 65.33
  • regular ventricular cardiac myocyte CL0002131
    CSI 0.64
    rCSI 3.98%
    PRS 60.64
  • blood vessel smooth muscle cell CL0019018
    CSI 0.56
    rCSI 4.58%
    PRS 62.65

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [LIMD1](/details-gene/8994) (LIM domain containing 1) is a protein-coding gene located on chromosome 3p21.31, a region frequently deleted in various human cancers, suggesting its role as a tumor suppressor ([Link](https://doi.org/10.1007/s004399900188)). The protein product functions as a molecular scaffold, participating in a diverse range of cellular processes. It acts as a transcriptional corepressor in the nucleus, notably by binding to the retinoblastoma protein (pRB) to repress E2F-driven transcription ([Link](https://doi.org/10.1073/pnas.0407123101)). In the cytoplasm, it is a crucial component of the RNA-induced silencing complex (RISC), where it is required for microRNA-mediated gene silencing ([Link](https://doi.org/10.1073/pnas.0914987107)). **Overall**, [LIMD1](/details-gene/8994) shows significant expression in various immune cell populations, particularly in [mature B cells](/details-cell/CL0000785) and myeloid dendritic cells, indicating a key regulatory function in both innate and adaptive immunity. ## Cellular Roles and Expression Landscape The expression profile of [LIMD1](/details-gene/8994) highlights its prominent role within the hematopoietic system. **Overall**, it exhibits its most significant expression in several key immune cell types, including [mature B cells](/details-cell/CL0000785) (CSI: 11.00), [CD1c-positive myeloid dendritic cells](/details-cell/CL0002399) (CSI: 7.52), [alveolar macrophages](/details-cell/CL0000583) (CSI: 6.08), and [CD14-low, CD16-positive monocytes](/details-cell/CL0002396) (CSI: 4.99). This pattern suggests that [LIMD1](/details-gene/8994) is a fundamental regulator of immune cell function, potentially influencing antigen presentation, cell signaling, and post-transcriptional gene regulation. Beyond the immune compartment, [LIMD1](/details-gene/8994) is also significantly expressed in several specialized cell types, including [intestinal tuft cells](/details-cell/CL0019032) (CSI: 5.27), [mesothelial cells](/details-cell/CL0000077) (CSI: 3.46), and [chondrocytes](/details-cell/CL0000138) (CSI: 3.34). Its presence in these diverse cell types is consistent with its reported functions in cytoskeleton organization and cell migration. The relatively lower significance in many other major cell lineages suggests a specialized rather than a ubiquitous housekeeping role. ## Pathways and Molecular Function [LIMD1](/details-gene/8994) is a multifunctional protein that localizes to various subcellular compartments to execute distinct roles. Functionally, it is involved in [protein binding](/details-ontology/GO:0005515) and acts as a [transcription corepressor](/details-ontology/GO:0003714), localizing to the [nucleus](/details-ontology/GO:0005634) and participating in [transcription regulator complexes](/details-ontology/GO:0005667). This is consistent with its known interaction with pRB to negatively regulate transcription ([Link](https://doi.org/10.1073/pnas.0407123101)). In the [cytoplasm](/details-ontology/GO:0005737), [LIMD1](/details-gene/8994) is a key player in post-transcriptional gene silencing. It is a component of the [RISC complex](/details-ontology/GO:0016442) and is involved in [miRNA-mediated gene silencing](/details-ontology/GO:0035195) and [p-body assembly](/details-ontology/GO:0033962), processes critical for controlling mRNA translation and stability ([Link](https://doi.org/10.1073/pnas.0914987107)). Furthermore, [LIMD1](/details-gene/8994) contributes to the regulation of cell structure and motility through its involvement in [cytoskeleton organization](/details-ontology/GO:0007010) and [cell migration](/details-ontology/GO:0016477). Its localization to [adherens junctions](/details-ontology/GO:0005912) and [focal adhesions](/details-ontology/GO:0005925) underscores its role as a scaffold protein that integrates signaling pathways with the cellular architecture. Its participation in pathways like [negative regulation of Hippo signaling](/details-ontology/GO:0035331) ([Link](https://doi.org/10.1016/j.cub.2010.02.035)) and the [cellular response to hypoxia](/details-ontology/R-HSA-1234174) further extends its function to stress response and tissue homeostasis. ## Research Directions The diverse functions of [LIMD1](/details-gene/8994) and its specific expression patterns present several avenues for future research, particularly concerning its role in immunology and oncology. **Proposed Hypotheses:** 1. Given its high significance in [mature B cells](/details-cell/CL0000785) and its integral role in the RISC complex, [LIMD1](/details-gene/8994) may function as a master regulator of B cell terminal differentiation by controlling the expression of key transcription factors, such as BLIMP-1 and PAX5, through miRNA-mediated silencing. 2. Based on its expression in [alveolar macrophages](/details-cell/CL0000583) and its involvement in [cytoskeleton organization](/details-ontology/GO:0007010), [LIMD1](/details-gene/8994) could be essential for macrophage phagocytic activity and migration within the lung interstitium, potentially by mediating the link between cell surface receptors and the actin cytoskeleton at phagocytic cups. **Experimental Approach:** To test the first hypothesis regarding its role in B cells, a B-cell-specific conditional knockout of [LIMD1](/details-gene/8994) could be generated in mice (e.g., using a CD19-Cre driver). Following immunization, the ability of these mice to form germinal centers and produce high-affinity, class-switched antibodies could be evaluated using flow cytometry and ELISA. To identify its molecular targets, co-immunoprecipitation of [LIMD1](/details-gene/8994) from activated primary B cells followed by mass spectrometry would identify protein interactors, while RNA-immunoprecipitation followed by sequencing (RIP-seq) would reveal the specific mRNAs and miRNAs it binds, providing direct evidence of its regulatory targets during B cell differentiation. **Therapeutic Potential:** As [LIMD1](/details-gene/8994) is established as a tumor suppressor frequently lost in cancers, therapeutic strategies should focus on the **restoration or activation** of its function rather than inhibition. Its role as a transcriptional corepressor and a component of the miRNA machinery suggests that its loss dysregulates multiple oncogenic pathways simultaneously. Therefore, reactivating [LIMD1](/details-gene/8994) could have potent anti-tumor effects. Given the challenge of directly activating a scaffold protein, an alternative approach could be to develop small molecules that inhibit downstream effectors that become overactive in the absence of [LIMD1](/details-gene/8994). Gene therapy approaches to reintroduce [LIMD1](/details-gene/8994) expression in tumor cells could also be explored, although targeted delivery would be critical to avoid unforeseen effects in healthy tissues, particularly in the immune system where it is highly expressed.

Genular Protein ID: 1007243786

Symbol: LIMD1_HUMAN

Name: LIM domain-containing protein 1

UniProtKB Accession Codes:

Q9UGP4 Q17RQ1 Q9BQQ9 Q9NQ47

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 26 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10647888

Title: A novel gene containing LIM domains (LIMD1) is located within the common eliminated region 1 (C3CER1) in 3p21.3.

PubMed ID: 10647888

DOI: 10.1007/s004399900188

PubMed ID: 11352561

Title: The LZTFL1 gene is a part of a transcriptional map covering 250 kb within the common eliminated region 1 (C3CER1) in 3p21.3.

PubMed ID: 11352561

DOI: 10.1006/geno.2000.6498

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 15542589

Title: LIM domains-containing protein 1 (LIMD1), a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcription.

PubMed ID: 15542589

DOI: 10.1073/pnas.0407123101

PubMed ID: 15870274

Title: The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex.

PubMed ID: 15870274

DOI: 10.1128/mcb.25.10.4010-4022.2005

PubMed ID: 18439753

Title: Cell cycle regulated phosphorylation of LIMD1 in cell lines and expression in human breast cancers.

PubMed ID: 18439753

DOI: 10.1016/j.canlet.2008.03.015

PubMed ID: 18331720

Title: Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus.

PubMed ID: 18331720

DOI: 10.1016/j.devcel.2008.01.005

PubMed ID: 18712738

Title: Differential subcellular localisation of the tumour suppressor protein LIMD1 in breast cancer correlates with patient survival.

PubMed ID: 18712738

DOI: 10.1002/ijc.23851

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20303269

Title: Ajuba LIM proteins are negative regulators of the Hippo signaling pathway.

PubMed ID: 20303269

DOI: 10.1016/j.cub.2010.02.035

PubMed ID: 20616046

Title: LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing.

PubMed ID: 20616046

DOI: 10.1073/pnas.0914987107

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21834987

Title: Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration.

PubMed ID: 21834987

DOI: 10.1186/1741-7007-9-54

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22286099

Title: The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity.

PubMed ID: 22286099

DOI: 10.1038/ncb2424

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 676
  • Mass: 72190
  • Checksum: 085DF06F047B49E6
  • Sequence:
    • MDKYDDLGLE ASKFIEDLNM YEASKDGLFR VDKGAGNNPE FEETRRVFAT KMAKIHLQQQ 
QQQLLQEETL PRGSRGPVNG GGRLGPQARW EVVGSKLTVD GAAKPPLAAS TGAPGAVTTL 
AAGQPPYPPQ EQRSRPYLHG TRHGSQDCGS RESLATSEMS AFHQPGPCED PSCLTHGDYY 
DNLSLASPKW GDKPGVSPSI GLSVGSGWPS SPGSDPPLPK PCGDHPLNHR QLSLSSSRSS 
EGSLGGQNSG IGGRSSEKPT GLWSTASSQR VSPGLPSPNL ENGAPAVGPV QPRTPSVSAP 
LALSCPRQGG LPRSNSGLGG EVSGVMSKPN VDPQPWFQDG PKSYLSSSAP SSSPAGLDGS 
QQGAVPGLGP KPGCTDLGTG PKLSPTSLVH PVMSTLPELS CKEGPLGWSS DGSLGSVLLD 
SPSSPRVRLP CQPLVPGPEL RPSAAELKLE ALTQRLEREM DAHPKADYFG ACVKCSKGVF 
GAGQACQAMG NLYHDTCFTC AACSRKLRGK AFYFVNGKVF CEEDFLYSGF QQSADRCFLC 
GHLIMDMILQ ALGKSYHPGC FRCVICNECL DGVPFTVDSE NKIYCVRDYH KVLAPKCAAC 
GLPILPPEGS DETIRVVSMD RDYHVECYHC EDCGLELNDE DGHRCYPLED HLFCHSCHVK 
RLEKRPSSTA LHQHHF