Details for: CDKL2

Gene ID: 8999

Symbol: CDKL2

Ensembl ID: ENSG00000138769

Description: cyclin dependent kinase like 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.65
    Marker Score: 6,386
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.57
    Marker Score: 23,505
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.53
    Marker Score: 6,220
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.51
    Marker Score: 11,542
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.48
    Marker Score: 14,099
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.41
    Marker Score: 12,126
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.39
    Marker Score: 13,120
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.39
    Marker Score: 85,621
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.39
    Marker Score: 51,358
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.39
    Marker Score: 1,470
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.38
    Marker Score: 52,593
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 867
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.34
    Marker Score: 2,064
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.32
    Marker Score: 26,306
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.32
    Marker Score: 5,457
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.29
    Marker Score: 539
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.19
    Marker Score: 12,315
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.06
    Marker Score: 291
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.04
    Marker Score: 6,776
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.03
    Marker Score: 1,655
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,815
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,039
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1
    Marker Score: 1,740
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.96
    Marker Score: 651
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,314
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.93
    Marker Score: 385
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 371
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,738
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.89
    Marker Score: 1,810
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,285
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.87
    Marker Score: 13,972
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.84
    Marker Score: 3,511
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.83
    Marker Score: 1,198
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.78
    Marker Score: 1,845
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 598
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.78
    Marker Score: 844
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,258
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.77
    Marker Score: 780
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 698
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.76
    Marker Score: 589
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.72
    Marker Score: 3,011
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.72
    Marker Score: 1,574
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.71
    Marker Score: 3,754
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.66
    Marker Score: 10,278
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.62
    Marker Score: 1,175
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.61
    Marker Score: 20,443
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.59
    Marker Score: 1,198
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 234
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.55
    Marker Score: 355
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.55
    Marker Score: 164
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.55
    Marker Score: 199
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.54
    Marker Score: 506
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.53
    Marker Score: 320
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.53
    Marker Score: 642
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.53
    Marker Score: 4,593
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.52
    Marker Score: 123
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.52
    Marker Score: 345
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.52
    Marker Score: 271
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.51
    Marker Score: 1,220
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.48
    Marker Score: 1,220
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.47
    Marker Score: 138
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.45
    Marker Score: 88
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.44
    Marker Score: 1,824
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.44
    Marker Score: 255
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.42
    Marker Score: 1,481
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.42
    Marker Score: 187
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.42
    Marker Score: 504
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.41
    Marker Score: 159
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.4
    Marker Score: 1,382
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.4
    Marker Score: 188
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.4
    Marker Score: 342
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.39
    Marker Score: 551
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.39
    Marker Score: 157
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.38
    Marker Score: 202
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.38
    Marker Score: 119
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.37
    Marker Score: 7,956
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.37
    Marker Score: 98
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.36
    Marker Score: 688
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.35
    Marker Score: 471
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.35
    Marker Score: 349
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.35
    Marker Score: 233
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.34
    Marker Score: 1,306
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.33
    Marker Score: 105
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.33
    Marker Score: 294
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.33
    Marker Score: 110
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.32
    Marker Score: 233
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.32
    Marker Score: 79
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.32
    Marker Score: 144
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.31
    Marker Score: 172
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.3
    Marker Score: 98

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** CDKL2 is predominantly expressed in the developing brain, with high levels detected in caudal ganglionic eminence-derived GABAergic cortical interneurons, corticothalamic-projecting glutamatergic cortical neurons, and other neuronal populations. 2. **Kinase Activity:** CDKL2 possesses a unique kinase domain, which enables it to phosphorylate and regulate various substrates involved in cellular signaling pathways. 3. **Cellular Localization:** The gene is primarily localized to the nucleus, where it is thought to regulate transcriptional and post-transcriptional processes. **Pathways and Functions:** 1. **Regulation of the Cell Cycle:** CDKL2 is involved in the regulation of the cell cycle, particularly in the G1 phase, where it phosphorylates and activates key cyclin-dependent kinases. 2. **Signaling Transduction:** The kinase activity of CDKL2 is also implicated in signal transduction pathways, including those involved in neuronal migration, differentiation, and synaptic plasticity. 3. **Protein Phosphorylation:** CDKL2 phosphorylates and regulates various proteins, including transcription factors, receptors, and adhesion molecules, which are essential for neuronal development and function. 4. **Epigenetic Regulation:** The gene is also thought to play a role in epigenetic regulation, influencing chromatin structure and gene expression. **Clinical Significance:** 1. **Neurodevelopmental Disorders:** Mutations in the CDKL2 gene have been associated with severe neurological disorders, including epilepsy, seizures, and intellectual disability. 2. **Epilepsy:** CDKL2 mutations have been identified in patients with epilepsy, particularly those with infantile spasms and early-onset epilepsy. 3. **Neurodegenerative Diseases:** Research suggests that CDKL2 may also play a role in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 4. **Therapeutic Potential:** The understanding of CDKL2's role in neuronal development and function has implications for the development of novel therapeutic strategies for neurodevelopmental disorders and neurodegenerative diseases. In conclusion, CDKL2 is a critical gene that plays a pivotal role in the regulation of neuronal development and function. Further research is necessary to fully elucidate the mechanisms underlying CDKL2's functions and to explore its therapeutic potential in the treatment of neurological disorders.

Genular Protein ID: 3880967034

Symbol: CDKL2_HUMAN

Name: Serine/threonine-protein kinase KKIAMRE

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9000130

Title: Molecular cloning of the epidermal growth factor-stimulated protein kinase p56 KKIAMRE.

PubMed ID: 9000130

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 29420175

Title: CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function.

PubMed ID: 29420175

DOI: 10.1016/j.celrep.2017.12.083

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 493
  • Mass: 56019
  • Checksum: 5CC20A91CBF89EFE
  • Sequence:
  • MEKYENLGLV GEGSYGMVMK CRNKDTGRIV AIKKFLESDD DKMVKKIAMR EIKLLKQLRH 
    ENLVNLLEVC KKKKRWYLVF EFVDHTILDD LELFPNGLDY QVVQKYLFQI INGIGFCHSH 
    NIIHRDIKPE NILVSQSGVV KLCDFGFART LAAPGEVYTD YVATRWYRAP ELLVGDVKYG 
    KAVDVWAIGC LVTEMFMGEP LFPGDSDIDQ LYHIMMCLGN LIPRHQELFN KNPVFAGVRL 
    PEIKEREPLE RRYPKLSEVV IDLAKKCLHI DPDKRPFCAE LLHHDFFQMD GFAERFSQEL 
    QLKVQKDARN VSLSKKSQNR KKEKEKDDSL VEERKTLVVQ DTNADPKIKD YKLFKIKGSK 
    IDGEKAEKGN RASNASCLHD SRTSHNKIVP STSLKDCSNV SVDHTRNPSV AIPPLTHNLS 
    AVAPSINSGM GTETIPIQGY RVDEKTKKCS IPFVKPNRHS PSGIYNINVT TLVSGPPLSD 
    DSGADLPQME HQH

Genular Protein ID: 1240773223

Symbol: J3KNE8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 570
  • Mass: 64840
  • Checksum: 8BC3ED5C80F7DB77
  • Sequence:
  • MEKYENLGLV GEGSYGMVMK CRNKDTGRIV AIKKFLESDD DKMVKKIAMR EIKLLKQLRH 
    ENLVNLLEVC KKKKRWYLVF EFVDHTILDD LELFPNGLDY QVVQKYLFQI INGIGFCHSH 
    NIIHRDIKPE NILVSQSGVV KLCDFGFART LAAPGEVYTD YVATRWYRAP ELLVGDVKYG 
    KAVDVWAIGC LVTEMFMGEP LFPGDSDIDQ LYHIMMCLGN LIPRHQELFN KNPVFAGVRL 
    PEIKEREPLE RRYPKLSEVV IDLAKKCLHI DPDKRPFCAE LLHHDFFQMD GFAERFSQEL 
    QLKVQKDARN VSLSKKSQNR KKEKEKDDSL VEERKTLVVQ DTNADPKIKD YKLFKIKGSK 
    IDGEKAEKGN RASNASCLHD SRTSHNKIVP STSLKDCSNV SVDHTRNPSV AIPPLTHNLS 
    AVAPSINSGM GTETIPIQGY RVDEKTKKCS IPFVKPNRHS PSGIYNINVT TLVSSEKNLF 
    WASKKRREYS RTDVRLPELN YNHLPELRAL GGIARNSRLT KKESKILSES RIPSLAAIDL 
    HTPSITLHQV SGPPLSDDSG ADLPQMEHQH

Genular Protein ID: 4002699490

Symbol: B4DH08_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 570
  • Mass: 64868
  • Checksum: 9CF3E36C99F7DB77
  • Sequence:
  • MEKYENLGLV GEGSYGMVMK CRNKDTGRIV AIKKFLESDD DKMVKKIAMR EIKLLKQLRH 
    ENLVNLLEVC KKKKRWYLVF EFVDHTILDD LELFPNGLDY QVVQKYLFQI INGIGFCHSH 
    NIIHRDIKPE NILVSQSGVV KLCDFGFART LAAPGEVYTD YVATRWYRAP ELLVGDVKYG 
    KAVDVWAIGC LVTEMFMGEP LFPGDSDIDQ LYHIMMCLGN LIPRHQELFN KNPVFAGVRL 
    PEIKEREPLE RRYPKLSEVV IDLAKKCLHI DPDKRPFCAE LLHHDFFQMD GFAERFSQEL 
    QLKVQKDARN VSLSKKSQNR KKEKEKDDSL VEERKTLVVQ DTNADPKIKD YKLFKIKGSK 
    IDGEKAEKGN RASNASCLHD SRTSHNKIVP STSLKDCSNV SVDHTRNPSV AIPPLTHNLS 
    AVAPSINSGM GTETIPIQGY RVDEKTKRCS IPFVKPNRHS PSGIYNINVT TLVSSEKNLF 
    WASKKRREYS RTDVRLPELN YNHLPELRAL GGIARNSRLT KKESKILSES RIPSLAAIDL 
    HTPSITLHQV SGPPLSDDSG ADLPQMEHQH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.