Details for: NAT1

Gene ID: 9

Symbol: NAT1

Ensembl ID: ENSG00000171428

Description: N-acetyltransferase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.09
    Marker Score: 9428
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.01
    Marker Score: 1912
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71808
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48033
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.98
    Marker Score: 3354
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.97
    Marker Score: 15183
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 494
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.95
    Marker Score: 6128
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 449
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5295
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2732
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 315
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5277
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.84
    Marker Score: 3611
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.81
    Marker Score: 549
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.75
    Marker Score: 4031.5
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 385
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 665
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.72
    Marker Score: 547
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.69
    Marker Score: 277
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2859
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.66
    Marker Score: 1342
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.65
    Marker Score: 393
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.65
    Marker Score: 2079
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.64
    Marker Score: 1509
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.63
    Marker Score: 301
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.63
    Marker Score: 1196
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.61
    Marker Score: 544
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.6
    Marker Score: 2895
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.57
    Marker Score: 701
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 437
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.49
    Marker Score: 313
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.47
    Marker Score: 152
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.44
    Marker Score: 548
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.41
    Marker Score: 270
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.41
    Marker Score: 1337
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.39
    Marker Score: 1217
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.38
    Marker Score: 119
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.38
    Marker Score: 142.5
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.37
    Marker Score: 367
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.37
    Marker Score: 249
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.37
    Marker Score: 174.5
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.36
    Marker Score: 164
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.33
    Marker Score: 351
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3
    Marker Score: 75
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3
    Marker Score: 300
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.3
    Marker Score: 299
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.3
    Marker Score: 475
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.3
    Marker Score: 202
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.29
    Marker Score: 1877
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.29
    Marker Score: 128
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.28
    Marker Score: 138
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.27
    Marker Score: 649
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.27
    Marker Score: 494
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.27
    Marker Score: 260
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.27
    Marker Score: 116
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.26
    Marker Score: 74
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.25
    Marker Score: 146
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.24
    Marker Score: 231
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.24
    Marker Score: 160.5
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.24
    Marker Score: 110
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.23
    Marker Score: 489.5
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.23
    Marker Score: 152
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.22
    Marker Score: 84
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.22
    Marker Score: 1322
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 62
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.22
    Marker Score: 1863
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.22
    Marker Score: 56
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.22
    Marker Score: 57
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.21
    Marker Score: 52
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.21
    Marker Score: 546
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.21
    Marker Score: 822
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.21
    Marker Score: 377.5
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.21
    Marker Score: 242
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.21
    Marker Score: 86
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2
    Marker Score: 84
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.2
    Marker Score: 156
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.2
    Marker Score: 218
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.2
    Marker Score: 179
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.2
    Marker Score: 117.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.19
    Marker Score: 689
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.19
    Marker Score: 75
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.19
    Marker Score: 61
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.19
    Marker Score: 4917
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.19
    Marker Score: 42
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.19
    Marker Score: 324
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.18
    Marker Score: 41.5
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.18
    Marker Score: 106
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.18
    Marker Score: 191
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.18
    Marker Score: 47
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.18
    Marker Score: 61
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.18
    Marker Score: 40.5
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.17
    Marker Score: 65
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.17
    Marker Score: 34.5
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.17
    Marker Score: 49
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.17
    Marker Score: 162

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Other Information

**Key characteristics:** - It is a protein of the cytochrome P450 family. - It is responsible for the acetylation of various substrates, including proteins, lipids, and carbohydrates. - It is involved in a variety of cellular processes, including cell cycle regulation, inflammation, and metabolism. **Pathways and functions:** - Nat1 is involved in the acetylation of proteins involved in cell cycle regulation, such as p53 and p21 proteins. - It is also involved in the acetylation of inflammatory mediators, such as IL-1 beta and TNF-alpha. - It is involved in the metabolism of drugs, such as paracetamol. - It is involved in the detoxification of xenobiotics. **Clinical significance:** - Mutations in the NAT1 gene have been linked to a number of human diseases, including liver cancer, heart disease, and inflammation. - Overexpression of NAT1 has been linked to the development of liver cancer. - Inhibition of NAT1 has been shown to reduce cancer cell growth.

Genular Protein ID: 4088468756

Symbol: ARY1_HUMAN

Name: Arylamine N-acetyltransferase 1

UniProtKB Accession Codes:

P18440 A8K4E7 O15159 O15300 Q546N1 Q96TE9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 2 EMBL 100 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 9 Rhea 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2340091

Title: Human arylamine N-acetyltransferase genes: isolation, chromosomal localization, and functional expression.

PubMed ID: 2340091

DOI: 10.1089/dna.1990.9.193

PubMed ID: 1968463

Title: Cloning and expression of cDNAs for polymorphic and monomorphic arylamine N-acetyltransferases from human liver.

PubMed ID: 1968463

DOI: 10.1016/s0021-9258(19)39609-7

PubMed ID: 8442668

Title: Structural heterogeneity of Caucasian N-acetyltransferase at the NAT1 gene locus.

PubMed ID: 8442668

DOI: 10.1006/abbi.1993.1116

PubMed ID: 9168895

Title: Identification of a novel allele at the human NAT1 acetyltransferase locus.

PubMed ID: 9168895

DOI: 10.1006/bbrc.1997.6501

PubMed ID: 9511183

Title: Functional polymorphism of the human arylamine N-acetyltransferase type 1 gene caused by C190T and G560A mutations.

PubMed ID: 9511183

DOI: 10.1097/00008571-199802000-00009

PubMed ID: 10862520

Title: Molecular analysis of the N-acetyltransferase 1 gene (NAT1*) using polymerase chain reaction-restriction fragment-single strand conformation polymorphism assay.

PubMed ID: 10862520

DOI: 10.1097/00008571-200006000-00003

PubMed ID: 16416399

Title: Deciphering the ancient and complex evolutionary history of human arylamine N-acetyltransferase genes.

PubMed ID: 16416399

DOI: 10.1086/500614

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1676262

Title: Structure and restriction fragment length polymorphism of genes for human liver arylamine N-acetyltransferases.

PubMed ID: 1676262

DOI: 10.1016/0006-291x(91)90676-x

PubMed ID: 9173883

Title: Study of the role of the highly conserved residues Arg9 and Arg64 in the catalytic function of human N-acetyltransferases NAT1 and NAT2 by site-directed mutagenesis.

PubMed ID: 9173883

DOI: 10.1042/bj3230207

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 17656365

Title: Structural basis of substrate-binding specificity of human arylamine N-acetyltransferases.

PubMed ID: 17656365

DOI: 10.1074/jbc.m704138200

PubMed ID: 7585580

Title: Polymorphism in the N-acetyltransferase 1 (NAT1) polyadenylation signal: association of NAT1*10 allele with higher N-acetylation activity in bladder and colon tissue.

PubMed ID: 7585580

PubMed ID: 9511182

Title: Identification and characterization of variant alleles of human acetyltransferase NAT1 with defective function using p-aminosalicylate as an in-vivo and in-vitro probe.

PubMed ID: 9511182

DOI: 10.1097/00008571-199802000-00008

PubMed ID: 9682272

Title: Variants of N-acetyltransferase NAT1 and a case-control study of colorectal adenomas.

PubMed ID: 9682272

DOI: 10.1097/00008571-199806000-00009

Sequence Information:

  • Length: 290
  • Mass: 33899
  • Checksum: C015F7F3D4830107
  • Sequence:
    • MDIEAYLERI GYKKSRNKLD LETLTDILQH QIRAVPFENL NIHCGDAMDL GLEAIFDQVV 
RRNRGGWCLQ VNHLLYWALT TIGFETTMLG GYVYSTPAKK YSTGMIHLLL QVTIDGRNYI 
VDAGFGRSYQ MWQPLELISG KDQPQVPCVF RLTEENGFWY LDQIRREQYI PNEEFLHSDL 
LEDSKYRKIY SFTLKPRTIE DFESMNTYLQ TSPSSVFTSK SFCSLQTPDG VHCLVGFTLT 
HRRFNYKDNT DLIEFKTLSE EEIEKVLKNI FNISLQRKLV PKHGDRFFTI

Genular Protein ID: 1510724687

Symbol: F5H5R8_HUMAN

Name: N/A

UniProtKB Accession Codes:

F5H5R8

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 EPD 2 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 InterPro 2 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 1 PhylomeDB 1 Proteomes 2 ProteomicsDB 1 RefSeq 6 RuleBase 1 SMR 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 352
  • Mass: 40846
  • Checksum: 341005CE6234D94F
  • Sequence:
    • MLLLLLHKEA ALEPQGPAVG YNSLPVSDDH HVSGIQARKK QQSVFWIKTE DQPTFNLLRK 
GIMDIEAYLE RIGYKKSRNK LDLETLTDIL QHQIRAVPFE NLNIHCGDAM DLGLEAIFDQ 
VVRRNRGGWC LQVNHLLYWA LTTIGFETTM LGGYVYSTPA KKYSTGMIHL LLQVTIDGRN 
YIVDAGFGRS YQMWQPLELI SGKDQPQVPC VFRLTEENGF WYLDQIRREQ YIPNEEFLHS 
DLLEDSKYRK IYSFTLKPRT IEDFESMNTY LQTSPSSVFT SKSFCSLQTP DGVHCLVGFT 
LTHRRFNYKD NTDLIEFKTL SEEEIEKVLK NIFNISLQRK LVPKHGDRFF TI

Genular Protein ID: 219526902

Symbol: Q400J6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q400J6

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 9 GO 1 Gene3D 1 GenomeRNAi 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 5 RuleBase 1 SUPFAM 1

Sequence Information:

  • Length: 92
  • Mass: 10628
  • Checksum: EE6E18B558D2559C
  • Sequence:
    • MDIEAYLERI GYKKSRNKLD LETLTDILQH QIRAVPFENL NIHCGDAMDL GLEAIFDQVV 
RRNRGGWCLQ VNHLLYWALT TIGFETTMLG GY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.