Details for: CCNG1

Gene ID: 900

Symbol: CCNG1

Ensembl ID: ENSG00000113328

Description: cyclin G1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 212.9927
    Cell Significance Index: -33.1300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 105.9358
    Cell Significance Index: -43.6400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 87.1807
    Cell Significance Index: -41.1600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 86.8662
    Cell Significance Index: -35.2900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 85.7503
    Cell Significance Index: -21.7500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 80.0956
    Cell Significance Index: -41.2000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 61.2945
    Cell Significance Index: -41.1300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 37.4761
    Cell Significance Index: -35.7800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 30.5039
    Cell Significance Index: -37.6100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.5762
    Cell Significance Index: -33.6900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.0125
    Cell Significance Index: -39.5100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.4981
    Cell Significance Index: -23.0300
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.2332
    Cell Significance Index: 24.8700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.9716
    Cell Significance Index: 31.7100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.0015
    Cell Significance Index: 27.6400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.8831
    Cell Significance Index: -6.3100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.3204
    Cell Significance Index: 61.0200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.9923
    Cell Significance Index: 1798.9000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.9707
    Cell Significance Index: 41.2500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.7245
    Cell Significance Index: 46.9400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.6373
    Cell Significance Index: 17.8000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.6244
    Cell Significance Index: 97.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.5133
    Cell Significance Index: 78.6100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.5080
    Cell Significance Index: 823.5300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.4838
    Cell Significance Index: 182.4500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.3781
    Cell Significance Index: 248.4200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.3376
    Cell Significance Index: 46.4800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.3281
    Cell Significance Index: 61.9200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.2888
    Cell Significance Index: 96.0500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.1277
    Cell Significance Index: 145.7000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.0851
    Cell Significance Index: 25.0700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9049
    Cell Significance Index: 41.0200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.8322
    Cell Significance Index: 24.4400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8297
    Cell Significance Index: 11.3200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8028
    Cell Significance Index: 110.2400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7798
    Cell Significance Index: 55.1500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7579
    Cell Significance Index: 16.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7362
    Cell Significance Index: 146.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.6786
    Cell Significance Index: 115.8800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6425
    Cell Significance Index: 30.2000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6008
    Cell Significance Index: 114.3300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6006
    Cell Significance Index: 70.8300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4850
    Cell Significance Index: 12.9500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4133
    Cell Significance Index: 182.7400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3569
    Cell Significance Index: 18.5900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3530
    Cell Significance Index: 4.0100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3377
    Cell Significance Index: 43.2900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3215
    Cell Significance Index: 52.2900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.2975
    Cell Significance Index: 3.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2735
    Cell Significance Index: 8.7600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2655
    Cell Significance Index: 17.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1775
    Cell Significance Index: 35.6100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1416
    Cell Significance Index: 3.8000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0791
    Cell Significance Index: 2.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0777
    Cell Significance Index: 2.7300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0682
    Cell Significance Index: 6.7500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0625
    Cell Significance Index: 22.4000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0568
    Cell Significance Index: 1.2100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0481
    Cell Significance Index: 0.8100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0398
    Cell Significance Index: 2.0900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0259
    Cell Significance Index: 35.2200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0182
    Cell Significance Index: 12.5900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0060
    Cell Significance Index: 11.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0005
    Cell Significance Index: 0.3800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0037
    Cell Significance Index: -2.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0055
    Cell Significance Index: -4.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0078
    Cell Significance Index: -12.0800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0084
    Cell Significance Index: -6.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0097
    Cell Significance Index: -17.9100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0191
    Cell Significance Index: -1.4700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0205
    Cell Significance Index: -2.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0264
    Cell Significance Index: -16.7900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0348
    Cell Significance Index: -0.2100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0379
    Cell Significance Index: -21.4000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0541
    Cell Significance Index: -1.5500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0733
    Cell Significance Index: -33.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0753
    Cell Significance Index: -8.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0821
    Cell Significance Index: -17.2900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0968
    Cell Significance Index: -27.8400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1057
    Cell Significance Index: -2.7000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1528
    Cell Significance Index: -3.8200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1908
    Cell Significance Index: -3.2900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1978
    Cell Significance Index: -1.3400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2077
    Cell Significance Index: -23.7100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2081
    Cell Significance Index: -30.2500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2233
    Cell Significance Index: -12.5300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2274
    Cell Significance Index: -26.5000
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.2492
    Cell Significance Index: -1.5600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2503
    Cell Significance Index: -6.7000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2661
    Cell Significance Index: -16.7700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2790
    Cell Significance Index: -4.1800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3022
    Cell Significance Index: -5.3400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3194
    Cell Significance Index: -25.3000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3405
    Cell Significance Index: -20.9300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3409
    Cell Significance Index: -2.7800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3637
    Cell Significance Index: -37.8700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3941
    Cell Significance Index: -24.1600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4512
    Cell Significance Index: -13.2900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.4663
    Cell Significance Index: -2.8700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4759
    Cell Significance Index: -32.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CCNG1, also known as cyclin G1, is a protein-coding gene that belongs to the cyclin family. Its primary function is to regulate the cell cycle, particularly during the G2 phase, where DNA damage is assessed and repaired. CCNG1 interacts with TP53, a tumor suppressor protein, to modulate TP53 activity, expression, and degradation. This interaction is crucial for maintaining genomic stability and preventing cancer onset. CCNG1's expression is observed in various cell types, including epithelial cells, stem cells, and cancer cells, highlighting its potential role in immune response and disease. **Pathways and Functions:** CCNG1's regulatory functions are intricately linked to several cellular pathways: 1. **Cell Division:** CCNG1 plays a critical role in the G2 phase of the cell cycle, where DNA damage is assessed and repaired. Its interaction with TP53 ensures that cells with damaged DNA are eliminated, preventing the propagation of mutations. 2. **Cyclin-Dependent Protein Kinase (CDK) Regulation:** CCNG1 inhibits the activity of CDKs, which are essential for cell cycle progression. By regulating CDK activity, CCNG1 ensures that cells progress through the cell cycle in a controlled and accurate manner. 3. **Apoptosis Regulation:** CCNG1's interaction with TP53 is essential for regulating apoptosis, a process by which cells undergo programmed cell death in response to DNA damage or other forms of cellular stress. 4. **Transcriptional Regulation:** CCNG1 interacts with RNA polymerase II to regulate transcriptional activity, ensuring that genes involved in cell cycle progression, DNA repair, and apoptosis are expressed in a timely and regulated manner. **Clinical Significance:** The understanding of CCNG1's functions has significant implications for cancer therapy and immune modulation: 1. **Cancer Therapy:** CCNG1's role in regulating TP53 activity and expression highlights its potential as a therapeutic target in cancer treatment. Inhibiting CCNG1 or TP53 could lead to the development of novel cancer therapies. 2. **Immune Modulation:** CCNG1's expression in stem cells and cancer cells suggests its potential role in immune modulation. Understanding CCNG1's functions could lead to the development of novel immunotherapies that target CCNG1 or TP53. 3. **Genetic Diseases:** CCNG1's involvement in regulating TP53 activity and expression highlights its potential role in genetic diseases, such as Li-Fraumeni syndrome, which is characterized by TP53 mutations. In conclusion, CCNG1 is a critical cyclin G1 gene that plays a pivotal role in regulating cell cycle progression, apoptosis, and transcriptional control. Its interaction with TP53 is essential for maintaining genomic stability and preventing cancer onset. Further research on CCNG1's functions has significant implications for cancer therapy, immune modulation, and genetic disease prevention.

Genular Protein ID: 1812659882

Symbol: CCNG1_HUMAN

Name: Cyclin-G1

UniProtKB Accession Codes:

P51959 B2R7B2 B4DLW7 D3DQK7 Q15757 Q96L32

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 17 Ensembl 2 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8626390

Title: Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting tissue-specific and cell cycle-regulated expression.

PubMed ID: 8626390

DOI: 10.1074/jbc.271.11.6050

PubMed ID: 8806701

Title: Characterisation of human cyclin G1 and G2: DNA damage inducible genes.

PubMed ID: 8806701

PubMed ID: 8954786

Title: Structure and chromosomal assignment of the human cyclin G gene.

PubMed ID: 8954786

DOI: 10.1006/geno.1996.0598

PubMed ID: 10196184

Title: Altered regulation of cyclin G in human breast cancer and its specific localization at replication foci in response to DNA damage in p53+/+ cells.

PubMed ID: 10196184

DOI: 10.1074/jbc.274.16.11022

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 295
  • Mass: 34074
  • Checksum: EA0B02C83F3B6BF3
  • Sequence:
    • MIEVLTTTDS QKLLHQLNAL LEQESRCQPK VCGLRLIESA HDNGLRMTAR LRDFEVKDLL 
SLTQFFGFDT ETFSLAVNLL DRFLSKMKVQ PKHLGCVGLS CFYLAVKSIE EERNVPLATD 
LIRISQYRFT VSDLMRMEKI VLEKVCWKVK ATTAFQFLQL YYSLLQENLP LERRNSINFE 
RLEAQLKACH CRIIFSKAKP SVLALSIIAL EIQAQKCVEL TEGIECLQKH SKINGRDLTF 
WQELVSKCLT EYSSNKCSKP NVQKLKWIVS GRTARQLKHS YYRITHLPTI PEMVP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.