Gene CCNG1 - ENSG00000113328 | NCBI Gene ID: 900

Details for: CCNG1

Gene ID: 900

Symbol: CCNG1

Ensembl ID: ENSG00000113328

Description: cyclin G1

Associated with

Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Regulation of tp53 activity
(R-HSA-5633007)
Regulation of tp53 degradation
(R-HSA-6804757)
Regulation of tp53 expression and degradation
(R-HSA-6806003)
Rna polymerase ii transcription
(R-HSA-73857)
Transcriptional regulation by tp53
(R-HSA-3700989)
Cell division
(GO:0051301)
Cyclin-dependent protein kinase holoenzyme complex
(GO:0000307)
Cyclin-dependent protein serine/threonine kinase regulator activity
(GO:0016538)
Cytoplasm
(GO:0005737)
Dendrite
(GO:0030425)
Mitotic cell cycle phase transition
(GO:0044772)
Mitotic g2 dna damage checkpoint signaling
(GO:0007095)
Negative regulation of apoptotic process
(GO:0043066)
Neuronal cell body
(GO:0043025)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Protein binding
(GO:0005515)
Regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0000079)
Response to gravity
(GO:0009629)
Response to organonitrogen compound
(GO:0010243)
Syncytium formation
(GO:0006949)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: mucous neck cell (CL0000651)
Fold Change: 2.02
Marker Score: 4577
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 1.97
Marker Score: 4124
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.93
Marker Score: 66804
Cell Name: kidney cell (CL1000497)
Fold Change: 1.89
Marker Score: 1264
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.83
Marker Score: 7178
Cell Name: stem cell (CL0000034)
Fold Change: 1.83
Marker Score: 4337
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.81
Marker Score: 2662
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 1.77
Marker Score: 1877
Cell Name: neural crest cell (CL0011012)
Fold Change: 1.77
Marker Score: 1890.5
Cell Name: decidual cell (CL2000002)
Fold Change: 1.75
Marker Score: 7551
Cell Name: mesodermal cell (CL0000222)
Fold Change: 1.74
Marker Score: 22889
Cell Name: theca cell (CL0000503)
Fold Change: 1.72
Marker Score: 1236
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 1.68
Marker Score: 4584
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.68
Marker Score: 6483
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 1.66
Marker Score: 2813
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1.65
Marker Score: 2925
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 1.63
Marker Score: 1534
Cell Name: enterocyte (CL0000584)
Fold Change: 1.63
Marker Score: 7812
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.61
Marker Score: 3672
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 1.6
Marker Score: 1610
Cell Name: lens fiber cell (CL0011004)
Fold Change: 1.6
Marker Score: 505
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 1.56
Marker Score: 515
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.55
Marker Score: 3282
Cell Name: pro-T cell (CL0000827)
Fold Change: 1.54
Marker Score: 6300
Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 1.52
Marker Score: 489
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 1.51
Marker Score: 1095
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 1.49
Marker Score: 3516.5
Cell Name: serous secreting cell (CL0000313)
Fold Change: 1.48
Marker Score: 589
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 1.47
Marker Score: 2416
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 1.46
Marker Score: 851
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.46
Marker Score: 3557
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 1.45
Marker Score: 547
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 1.45
Marker Score: 5147
Cell Name: peptic cell (CL0000155)
Fold Change: 1.45
Marker Score: 606
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 1.44
Marker Score: 455
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 1.42
Marker Score: 75290
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 1.42
Marker Score: 332
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.41
Marker Score: 9141
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 1.4
Marker Score: 684
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 1.38
Marker Score: 3757
Cell Name: blood cell (CL0000081)
Fold Change: 1.38
Marker Score: 16016
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 1.37
Marker Score: 479
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 1.34
Marker Score: 2066
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 1.33
Marker Score: 1389
Cell Name: neural cell (CL0002319)
Fold Change: 1.32
Marker Score: 639
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 1.32
Marker Score: 826
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.31
Marker Score: 8400
Cell Name: Unknown (CL0002371)
Fold Change: 1.31
Marker Score: 1391
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 1.3
Marker Score: 685
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 1.3
Marker Score: 2542
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.3
Marker Score: 4800
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 1.3
Marker Score: 1996
Cell Name: supporting cell (CL0000630)
Fold Change: 1.29
Marker Score: 2425
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 1.25
Marker Score: 524
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 1.25
Marker Score: 245
Cell Name: Leydig cell (CL0000178)
Fold Change: 1.23
Marker Score: 1327
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 1.22
Marker Score: 3836
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.22
Marker Score: 12271
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 1.22
Marker Score: 609
Cell Name: tracheobronchial serous cell (CL0019001)
Fold Change: 1.22
Marker Score: 445
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 1.22
Marker Score: 1468
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 1.21
Marker Score: 956
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 1.21
Marker Score: 811
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 1.21
Marker Score: 2002
Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 1.18
Marker Score: 901
Cell Name: osteoclast (CL0000092)
Fold Change: 1.18
Marker Score: 586
Cell Name: proerythroblast (CL0000547)
Fold Change: 1.18
Marker Score: 797
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 1.17
Marker Score: 3239
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 1.17
Marker Score: 7455
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.17
Marker Score: 279
Cell Name: B-1 B cell (CL0000819)
Fold Change: 1.17
Marker Score: 2032
Cell Name: precursor cell (CL0011115)
Fold Change: 1.16
Marker Score: 282
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 1.15
Marker Score: 1102
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 1.15
Marker Score: 2054
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 1.15
Marker Score: 1625
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 1.15
Marker Score: 367
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 1.13
Marker Score: 773
Cell Name: germinal center B cell (CL0000844)
Fold Change: 1.12
Marker Score: 684
Cell Name: basophil (CL0000767)
Fold Change: 1.12
Marker Score: 530
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 1.11
Marker Score: 1074
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 1.11
Marker Score: 542
Cell Name: enteric neuron (CL0007011)
Fold Change: 1.1
Marker Score: 585
Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.09
Marker Score: 1368.5
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 1.09
Marker Score: 788.5
Cell Name: epithelial cell of glomerular capsule (CL1000450)
Fold Change: 1.09
Marker Score: 278
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.09
Marker Score: 3220
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.08
Marker Score: 36743
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 1.08
Marker Score: 9284
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 1.08
Marker Score: 327
Cell Name: preosteoblast (CL0007010)
Fold Change: 1.07
Marker Score: 304
Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 1.07
Marker Score: 259
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 1.06
Marker Score: 4560
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.06
Marker Score: 679
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 1.06
Marker Score: 281
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 1.06
Marker Score: 944
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 1.06
Marker Score: 1150
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 1.05
Marker Score: 791
Cell Name: adventitial cell (CL0002503)
Fold Change: 1.05
Marker Score: 260
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 1.05
Marker Score: 2655
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 1.05
Marker Score: 579

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**Key characteristics:** * CCNG1 is a protein of the cyclin family, which are a group of proteins that regulate cell cycle progression. * It is expressed in a variety of cell types, including epithelial cells, germ cells, and cancer cells. * It is a key regulator of cell cycle entry into the G1 phase. * It is involved in the regulation of cell proliferation, differentiation, and apoptosis. **Pathways and functions:** * CCNG1 is involved in the regulation of cell cycle entry into the G1 phase. * It is a key regulator of cell cycle progression from G1 to S phase. * It is also involved in the regulation of cell cycle exit from the G1 phase. * CCNG1 is a target for a number of anti-cancer drugs. **Clinical significance:** * Mutations in CCNG1 have been linked to a number of human cancers, including breast cancer, ovarian cancer, and colon cancer. * Targeting CCNG1 has been investigated as a therapeutic strategy for cancer. * CCNG1 inhibitors are currently being tested in clinical trials for the treatment of cancer. **Additional information:** * CCNG1 is also involved in the regulation of cell cycle checkpoints, which are mechanisms that prevent cells from dividing in the presence of DNA damage. * It is a key regulator of the p53 tumor suppressor protein. * CCNG1 is a highly conserved protein, with a similar protein found in all eukaryotes.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Cyclin-G1

Genular Protein ID: 1812659882

Symbol: CCNG1_HUMAN

Name: Cyclin-G1

UniProtKB Accession Codes:

P51959 B2R7B2 B4DLW7 D3DQK7 Q15757 Q96L32

Database IDs:

Citations:

PubMed ID: 8626390

Title: Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting tissue-specific and cell cycle-regulated expression.

PubMed ID: 8626390

DOI: 10.1074/jbc.271.11.6050

PubMed ID: 8806701

Title: Characterisation of human cyclin G1 and G2: DNA damage inducible genes.

PubMed ID: 8806701

PubMed ID: 8954786

Title: Structure and chromosomal assignment of the human cyclin G gene.

PubMed ID: 8954786

DOI: 10.1006/geno.1996.0598

PubMed ID: 10196184

Title: Altered regulation of cyclin G in human breast cancer and its specific localization at replication foci in response to DNA damage in p53+/+ cells.

PubMed ID: 10196184

DOI: 10.1074/jbc.274.16.11022

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 295
Mass: 34074
Checksum: EA0B02C83F3B6BF3
Sequence:

MIEVLTTTDS QKLLHQLNAL LEQESRCQPK VCGLRLIESA HDNGLRMTAR LRDFEVKDLL 
SLTQFFGFDT ETFSLAVNLL DRFLSKMKVQ PKHLGCVGLS CFYLAVKSIE EERNVPLATD 
LIRISQYRFT VSDLMRMEKI VLEKVCWKVK ATTAFQFLQL YYSLLQENLP LERRNSINFE 
RLEAQLKACH CRIIFSKAKP SVLALSIIAL EIQAQKCVEL TEGIECLQKH SKINGRDLTF 
WQELVSKCLT EYSSNKCSKP NVQKLKWIVS GRTARQLKHS YYRITHLPTI PEMVP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: CCNG1

Associated with

Cells (max top 100)

Other Information

Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting tissue-specific and cell cycle-regulated expression. PubMed ID: 8626390

Characterisation of human cyclin G1 and G2: DNA damage inducible genes. PubMed ID: 8806701

Structure and chromosomal assignment of the human cyclin G gene. PubMed ID: 8954786

Altered regulation of cyclin G in human breast cancer and its specific localization at replication foci in response to DNA damage in p53+/+ cells. PubMed ID: 10196184

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 5. PubMed ID: 15372022

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334