Details for: F2RL3

Gene ID: 9002

Symbol: F2RL3

Ensembl ID: ENSG00000127533

Description: F2R like thrombin or trypsin receptor 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.32
    Marker Score: 3365
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.2
    Marker Score: 5598
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 874
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.24
    Marker Score: 2351.5
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251818
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1
    Marker Score: 2550
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71835
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48060
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.94
    Marker Score: 238
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5339
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.9
    Marker Score: 282
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 634
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.81
    Marker Score: 188
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.7
    Marker Score: 1186
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.7
    Marker Score: 655
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6
    Marker Score: 9443
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 472
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.58
    Marker Score: 844
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.55
    Marker Score: 497
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.53
    Marker Score: 139
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.48
    Marker Score: 363.5
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.48
    Marker Score: 237
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.47
    Marker Score: 197
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.44
    Marker Score: 170
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.43
    Marker Score: 458
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.41
    Marker Score: 2731
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.35
    Marker Score: 705
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.33
    Marker Score: 459
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.33
    Marker Score: 203
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.3
    Marker Score: 1753
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.29
    Marker Score: 290
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.28
    Marker Score: 116
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.28
    Marker Score: 250
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.27
    Marker Score: 1146
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.27
    Marker Score: 95
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.26
    Marker Score: 228
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.26
    Marker Score: 175
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.26
    Marker Score: 61
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 89
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.2
    Marker Score: 243
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.18
    Marker Score: 49
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.17
    Marker Score: 117
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.16
    Marker Score: 97
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.16
    Marker Score: 70
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.16
    Marker Score: 84
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.15
    Marker Score: 2451
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.14
    Marker Score: 37
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.14
    Marker Score: 79
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.14
    Marker Score: 82
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.13
    Marker Score: 60
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.12
    Marker Score: 30
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.12
    Marker Score: 249
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.12
    Marker Score: 69
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.12
    Marker Score: 29
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.11
    Marker Score: 50
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.11
    Marker Score: 38
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.11
    Marker Score: 29
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.1
    Marker Score: 119
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1
    Marker Score: 1027
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.1
    Marker Score: 62
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.1
    Marker Score: 5171
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.09
    Marker Score: 879
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.09
    Marker Score: 84
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.09
    Marker Score: 31
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.09
    Marker Score: 4764
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.08
    Marker Score: 48
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.08
    Marker Score: 83
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.08
    Marker Score: 88
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.08
    Marker Score: 25
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.08
    Marker Score: 39
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.08
    Marker Score: 108
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.07
    Marker Score: 82
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.07
    Marker Score: 2483
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.07
    Marker Score: 142
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.07
    Marker Score: 23
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.07
    Marker Score: 71
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.07
    Marker Score: 79
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.07
    Marker Score: 113
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.07
    Marker Score: 143
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.07
    Marker Score: 16
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.07
    Marker Score: 30
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.07
    Marker Score: 31
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.07
    Marker Score: 67
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.07
    Marker Score: 67.5
  • Cell Name: surface ectodermal cell (CL0000114)
    Fold Change: 0.07
    Marker Score: 24
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.07
    Marker Score: 211
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.07
    Marker Score: 39
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.06
    Marker Score: 317
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.06
    Marker Score: 44
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.06
    Marker Score: 31
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.06
    Marker Score: 30

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Other Information

**Key characteristics:** * F2RL3 is a transmembrane protein with a single extracellular domain and a cytoplasmic domain. * It is a member of the blood coagulation cascade, which is a complex network of proteins that is involved in the blood clotting process. * It is expressed in various cell types, including endothelial cells, immune cells, and cancer cells. * It is a receptor for thrombin, a protease that is involved in blood coagulation. **Pathways and functions:** * F2RL3 is a receptor for thrombin, a protease that is involved in blood coagulation. * Thrombin activates F2RL3, which triggers a cascade of events that leads to the formation of thrombin-activated platelets. * Thrombin-activated platelets can aggregate together to form a blood clot. **Clinical significance:** * Mutations in F2RL3 have been linked to a number of human diseases, including hemophilia A and von Willebrand disease. * F2RL3 is a potential target for therapy in these diseases. **Additional information:** * F2RL3 is a relatively new protein, with the gene encoding it first identified in 2000. * It is a highly conserved protein, with a similar sequence found in organisms from humans to flies. * F2RL3 is a promising target for therapy because it is expressed in a variety of cell types and is involved in a critical pathway in blood coagulation.

Genular Protein ID: 1431212258

Symbol: PAR4_HUMAN

Name: Proteinase-activated receptor 4

UniProtKB Accession Codes:

Q96RI0 O76067 Q6DK42

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 ELM 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9722561

Title: Gene and locus structure and chromosomal localization of the protease-activated receptor gene family.

PubMed ID: 9722561

DOI: 10.1074/jbc.273.36.23290

PubMed ID: 9716134

Title: A dual thrombin receptor system for platelet activation.

PubMed ID: 9716134

DOI: 10.1038/29325

PubMed ID: 9618465

Title: Cloning and characterization of human protease-activated receptor 4.

PubMed ID: 9618465

DOI: 10.1073/pnas.95.12.6642

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10079109

Title: Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin.

PubMed ID: 10079109

DOI: 10.1172/jci6042

PubMed ID: 18434511

Title: Cowhage-evoked itch is mediated by a novel cysteine protease: a ligand of protease-activated receptors.

PubMed ID: 18434511

DOI: 10.1523/jneurosci.0716-08.2008

Sequence Information:

  • Length: 385
  • Mass: 41133
  • Checksum: FACE32F10D5C561E
  • Sequence:
    • MWGRLLLWPL VLGFSLSGGT QTPSVYDESG STGGGDDSTP SILPAPRGYP GQVCANDSDT 
LELPDSSRAL LLGWVPTRLV PALYGLVLVV GLPANGLALW VLATQAPRLP STMLLMNLAA 
ADLLLALALP PRIAYHLRGQ RWPFGEAACR LATAALYGHM YGSVLLLAAV SLDRYLALVH 
PLRARALRGR RLALGLCMAA WLMAAALALP LTLQRQTFRL ARSDRVLCHD ALPLDAQASH 
WQPAFTCLAL LGCFLPLLAM LLCYGATLHT LAASGRRYGH ALRLTAVVLA SAVAFFVPSN 
LLLLLHYSDP SPSAWGNLYG AYVPSLALST LNSCVDPFIY YYVSAEFRDK VRAGLFQRSP 
GDTVASKASA EGGSRGMGTH SSLLQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.