Details for: CCNG2

Gene ID: 901

Symbol: CCNG2

Ensembl ID: ENSG00000138764

Description: cyclin G2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 233.0190
    Cell Significance Index: -36.2500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 138.2650
    Cell Significance Index: -35.0700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 88.5307
    Cell Significance Index: -36.4700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 78.8990
    Cell Significance Index: -37.2500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 71.0634
    Cell Significance Index: -28.8700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 68.4118
    Cell Significance Index: -35.1900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 55.5272
    Cell Significance Index: -37.2600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 30.5004
    Cell Significance Index: -29.1200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 29.5144
    Cell Significance Index: -36.3900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.8655
    Cell Significance Index: -34.4700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.2092
    Cell Significance Index: -36.3400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.5827
    Cell Significance Index: -23.2900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 6.7074
    Cell Significance Index: 51.7000
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 6.2721
    Cell Significance Index: 66.6400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 6.0866
    Cell Significance Index: 41.2400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.4915
    Cell Significance Index: -9.8300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 2.1351
    Cell Significance Index: 13.1400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.8545
    Cell Significance Index: 31.7800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.4812
    Cell Significance Index: 51.4700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.4221
    Cell Significance Index: 15.4600
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 1.3356
    Cell Significance Index: 11.7700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.1712
    Cell Significance Index: 61.4900
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.1163
    Cell Significance Index: 7.4100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.1048
    Cell Significance Index: 13.1700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9619
    Cell Significance Index: 104.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7746
    Cell Significance Index: 40.2400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7656
    Cell Significance Index: 418.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7163
    Cell Significance Index: 129.1300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6454
    Cell Significance Index: 38.7500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6435
    Cell Significance Index: 39.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6372
    Cell Significance Index: 29.9500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6177
    Cell Significance Index: 34.6600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5986
    Cell Significance Index: 59.2200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5665
    Cell Significance Index: 113.6300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5543
    Cell Significance Index: 65.3700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5520
    Cell Significance Index: 41.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5496
    Cell Significance Index: 75.4700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.5439
    Cell Significance Index: 13.0500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5324
    Cell Significance Index: 36.8200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5190
    Cell Significance Index: 63.8100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4824
    Cell Significance Index: 61.8400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4489
    Cell Significance Index: 12.2200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4125
    Cell Significance Index: 26.0000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3774
    Cell Significance Index: 24.3500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3559
    Cell Significance Index: 157.3500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3521
    Cell Significance Index: 4.0000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3502
    Cell Significance Index: 7.3300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.3205
    Cell Significance Index: 3.9800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2953
    Cell Significance Index: 266.6300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2936
    Cell Significance Index: 20.7700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2749
    Cell Significance Index: 3.7500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2425
    Cell Significance Index: 10.9900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2220
    Cell Significance Index: 11.5700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2063
    Cell Significance Index: 1.9000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2000
    Cell Significance Index: 5.0000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1786
    Cell Significance Index: 5.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1701
    Cell Significance Index: 61.0200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.1348
    Cell Significance Index: 1.4000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1326
    Cell Significance Index: 3.8200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1181
    Cell Significance Index: 3.3000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0924
    Cell Significance Index: 2.4300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0738
    Cell Significance Index: 14.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0726
    Cell Significance Index: 14.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0650
    Cell Significance Index: 3.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0499
    Cell Significance Index: 8.5200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0443
    Cell Significance Index: 30.6700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0297
    Cell Significance Index: 1.0500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0195
    Cell Significance Index: 2.5100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0106
    Cell Significance Index: 19.5400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0052
    Cell Significance Index: 0.1400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0003
    Cell Significance Index: -0.4500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0006
    Cell Significance Index: -0.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0006
    Cell Significance Index: -0.4300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0022
    Cell Significance Index: -4.2300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0158
    Cell Significance Index: -21.4600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0200
    Cell Significance Index: -14.8200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0303
    Cell Significance Index: -18.9400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0388
    Cell Significance Index: -24.6300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0398
    Cell Significance Index: -22.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0403
    Cell Significance Index: -30.4900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0526
    Cell Significance Index: -1.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0537
    Cell Significance Index: -5.4900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0603
    Cell Significance Index: -27.3800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0826
    Cell Significance Index: -23.7700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0859
    Cell Significance Index: -18.0900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1043
    Cell Significance Index: -12.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1163
    Cell Significance Index: -13.3200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.1400
    Cell Significance Index: -0.8700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1615
    Cell Significance Index: -3.3500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1681
    Cell Significance Index: -3.5800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1972
    Cell Significance Index: -28.6600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2999
    Cell Significance Index: -6.0200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3026
    Cell Significance Index: -23.9700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3119
    Cell Significance Index: -35.6000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3255
    Cell Significance Index: -21.8900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3370
    Cell Significance Index: -35.0900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4096
    Cell Significance Index: -25.1200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.4377
    Cell Significance Index: -3.5000
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.4582
    Cell Significance Index: -6.4400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4632
    Cell Significance Index: -35.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CCNG2 is a cyclin protein that belongs to the G2 family of cyclins, which are essential regulators of the cell cycle. It is specifically expressed in various cell types, including pulmonary interstitial fibroblasts, skeletal muscle fibroblasts, and luminal epithelial cells of the mammary gland. CCNG2 is also found to be co-expressed with other cyclins, such as cyclin E and cyclin A, suggesting a complex interaction with CDKs. **Pathways and Functions:** CCNG2 is involved in several cellular pathways, including: 1. **Cell Division**: CCNG2 regulates the transition from the mitotic to the G1 phase of the cell cycle by interacting with CDKs, such as CDK1 and CDK2. 2. **Cyclin-Dependent Protein Kinase Holoenzyme Complex**: CCNG2 forms a complex with CDKs, which is essential for the regulation of cell cycle progression. 3. **Foxo-Mediated Transcription**: CCNG2 interacts with the Forkhead box O (Foxo) transcription factor, which regulates the expression of cell cycle genes. 4. **Gene Expression (Transcription)**: CCNG2 is involved in the regulation of gene expression, particularly in the transcription of cell cycle genes. **Clinical Significance:** CCNG2 has been implicated in various diseases, including cancer, where its dysregulation can lead to uncontrolled cell proliferation. For example: 1. **Cancer**: Overexpression of CCNG2 has been observed in several types of cancer, including breast, lung, and prostate cancer, suggesting its potential role as a tumor suppressor. 2. **Neurological Disorders**: CCNG2 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where its dysregulation can lead to neuronal dysfunction. 3. **Cardiovascular Disease**: CCNG2 has been shown to play a role in the development of cardiovascular disease, where its dysregulation can lead to cardiac hypertrophy and fibrosis. In conclusion, CCNG2 is a critical regulator of the cell cycle, and its dysregulation can have significant consequences for human health. Further research is needed to fully understand the mechanisms by which CCNG2 regulates cell cycle progression and its role in various diseases.

Genular Protein ID: 2442281291

Symbol: CCNG2_HUMAN

Name: Cyclin-G2

UniProtKB Accession Codes:

Q16589 B4DF25 Q6FGA7 Q6FGC6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 14 Ensembl 4 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8806701

Title: Characterisation of human cyclin G1 and G2: DNA damage inducible genes.

PubMed ID: 8806701

PubMed ID: 8626390

Title: Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting tissue-specific and cell cycle-regulated expression.

PubMed ID: 8626390

DOI: 10.1074/jbc.271.11.6050

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 344
  • Mass: 38866
  • Checksum: D434E0CE92760301
  • Sequence:
    • MKDLGAEHLA GHEGVQLLGL LNVYLEQEER FQPREKGLSL IEATPENDNT LCPGLRNAKV 
EDLRSLANFF GSCTETFVLA VNILDRFLAL MKVKPKHLSC IGVCSFLLAA RIVEEDCNIP 
STHDVIRISQ CKCTASDIKR MEKIISEKLH YELEATTALN FLHLYHTIIL CHTSERKEIL 
SLDKLEAQLK ACNCRLIFSK AKPSVLALCL LNLEVETLKS VELLEILLLV KKHSKINDTE 
FFYWRELVSK CLAEYSSPEC CKPDLKKLVW IVSRRTAQNL HNSYYSVPEL PTIPEGGCFD 
ESESEDSCED MSCGEESLSS SPPSDQECTF FFNFKVAQTL CFPS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.