Details for: CCNG2

Gene ID: 901

Symbol: CCNG2

Ensembl ID: ENSG00000138764

Description: cyclin G2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.67
    Marker Score: 2134
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.28
    Marker Score: 1500
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.84
    Marker Score: 3261.5
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.77
    Marker Score: 1203
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.76
    Marker Score: 3586
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.63
    Marker Score: 61948
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.6
    Marker Score: 1256
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.56
    Marker Score: 1880
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.54
    Marker Score: 5720
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.44
    Marker Score: 836
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.41
    Marker Score: 1328
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.38
    Marker Score: 5764.5
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.32
    Marker Score: 2763
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.31
    Marker Score: 2013
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.3
    Marker Score: 3062
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.3
    Marker Score: 976
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.3
    Marker Score: 483
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.29
    Marker Score: 1900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.28
    Marker Score: 1350
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.25
    Marker Score: 3141
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.24
    Marker Score: 42795
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.2
    Marker Score: 2089
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.19
    Marker Score: 18544
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.18
    Marker Score: 380
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.16
    Marker Score: 1306
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.16
    Marker Score: 3109
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.16
    Marker Score: 1965.5
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.14
    Marker Score: 268
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.14
    Marker Score: 684
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.14
    Marker Score: 4404
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.11
    Marker Score: 647
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.08
    Marker Score: 723
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.03
    Marker Score: 238
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.02
    Marker Score: 960
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.02
    Marker Score: 199
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.02
    Marker Score: 1085
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1
    Marker Score: 36893
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71676
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47901
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.99
    Marker Score: 281.5
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.99
    Marker Score: 546
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.98
    Marker Score: 33478
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30386
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.98
    Marker Score: 4051
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.97
    Marker Score: 1616
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.96
    Marker Score: 3720
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.95
    Marker Score: 1009
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.95
    Marker Score: 5710
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.95
    Marker Score: 8174
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2387
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.94
    Marker Score: 2779
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.94
    Marker Score: 279
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.93
    Marker Score: 500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 475
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.92
    Marker Score: 233
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 431
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2686
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.89
    Marker Score: 907
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.89
    Marker Score: 3834
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.88
    Marker Score: 277
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.87
    Marker Score: 490.5
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.87
    Marker Score: 1227
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.86
    Marker Score: 744
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5217
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.86
    Marker Score: 370
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 304
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.84
    Marker Score: 1371
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.84
    Marker Score: 984
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.84
    Marker Score: 527
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.84
    Marker Score: 207
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.83
    Marker Score: 394
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.82
    Marker Score: 993.5
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.82
    Marker Score: 4694
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.82
    Marker Score: 989
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.82
    Marker Score: 467
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.81
    Marker Score: 2216
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.81
    Marker Score: 164
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.81
    Marker Score: 3738
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.8
    Marker Score: 859
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.8
    Marker Score: 2851
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.8
    Marker Score: 716
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.79
    Marker Score: 6812
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 316
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.78
    Marker Score: 177
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.78
    Marker Score: 543
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.78
    Marker Score: 166
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.78
    Marker Score: 3826
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.78
    Marker Score: 5054
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.78
    Marker Score: 1934
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 593
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.77
    Marker Score: 747.5
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.77
    Marker Score: 471
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.77
    Marker Score: 8696.5
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.77
    Marker Score: 425
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.77
    Marker Score: 654
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.77
    Marker Score: 827
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.76
    Marker Score: 406
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.76
    Marker Score: 1249
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.76
    Marker Score: 2071.5
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.75
    Marker Score: 497

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Other Information

**Key characteristics:** - CCNG2 is a protein with a molecular weight of approximately 130 kDa. - It is a member of the cyclin family of proteins. - CCNG2 is highly expressed in various cell types, including pulmonary interstitial fibroblast, skeletal muscle fibroblast, luminal epithelial cell of mammary gland, squamous epithelial cell, GABAergic amacrine cell, vip GABAergic cortical interneuron, thyroid follicular cell, glycinergic neuron, cortical thymic epithelial cell, and luminal cell of prostate epithelium. **Pathways and functions:** - CCNG2 is involved in cell cycle progression and cell cycle phase transition. - It is a key regulator of the G1/S transition, where cells decide whether to divide or remain quiescent. - CCNG2 is also involved in the regulation of cell cycle progression from G1 to S phase. - It is a key regulator of the G2/M transition, where cells prepare for DNA replication. - CCNG2 is involved in the regulation of cell growth and differentiation. **Clinical significance:** - Mutations in the CCNG2 gene have been linked to various human cancers, including lung cancer, breast cancer, and colorectal cancer. - CCNG2 inhibitors are being investigated as potential cancer therapies.

Genular Protein ID: 2442281291

Symbol: CCNG2_HUMAN

Name: Cyclin-G2

UniProtKB Accession Codes:

Q16589 B4DF25 Q6FGA7 Q6FGC6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 14 Ensembl 4 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 3 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8806701

Title: Characterisation of human cyclin G1 and G2: DNA damage inducible genes.

PubMed ID: 8806701

PubMed ID: 8626390

Title: Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting tissue-specific and cell cycle-regulated expression.

PubMed ID: 8626390

DOI: 10.1074/jbc.271.11.6050

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 344
  • Mass: 38866
  • Checksum: D434E0CE92760301
  • Sequence:
    • MKDLGAEHLA GHEGVQLLGL LNVYLEQEER FQPREKGLSL IEATPENDNT LCPGLRNAKV 
EDLRSLANFF GSCTETFVLA VNILDRFLAL MKVKPKHLSC IGVCSFLLAA RIVEEDCNIP 
STHDVIRISQ CKCTASDIKR MEKIISEKLH YELEATTALN FLHLYHTIIL CHTSERKEIL 
SLDKLEAQLK ACNCRLIFSK AKPSVLALCL LNLEVETLKS VELLEILLLV KKHSKINDTE 
FFYWRELVSK CLAEYSSPEC CKPDLKKLVW IVSRRTAQNL HNSYYSVPEL PTIPEGGCFD 
ESESEDSCED MSCGEESLSS SPPSDQECTF FFNFKVAQTL CFPS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.