Details for: SLC25A14

Gene ID: 9016

Symbol: SLC25A14

Ensembl ID: ENSG00000102078

Description: solute carrier family 25 member 14

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.94
    Marker Score: 3,398
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.33
    Marker Score: 1,918
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,781
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,006
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,404
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,409
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 488
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 443
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,726
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5,088
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,268
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 311
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,248
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.76
    Marker Score: 6,534
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.75
    Marker Score: 215
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.75
    Marker Score: 1,150
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.74
    Marker Score: 6,386
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 379
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.72
    Marker Score: 551
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.71
    Marker Score: 285
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.71
    Marker Score: 6,738
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.68
    Marker Score: 42,008
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 621
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2,847
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.67
    Marker Score: 1,364
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 169
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.65
    Marker Score: 6,737
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.63
    Marker Score: 155
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.6
    Marker Score: 1,137
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.59
    Marker Score: 5,539
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.58
    Marker Score: 21,436
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.57
    Marker Score: 193
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.57
    Marker Score: 527
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.56
    Marker Score: 227
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 429
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.54
    Marker Score: 10,652
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.53
    Marker Score: 2,056
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.52
    Marker Score: 2,101
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.51
    Marker Score: 221
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.5
    Marker Score: 401
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.48
    Marker Score: 229
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.47
    Marker Score: 1,618
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.46
    Marker Score: 247
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.46
    Marker Score: 17,316
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.41
    Marker Score: 857
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.41
    Marker Score: 514
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.4
    Marker Score: 813
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.4
    Marker Score: 90
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.4
    Marker Score: 220
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4
    Marker Score: 6,188
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.39
    Marker Score: 5,803
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.38
    Marker Score: 1,045
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.38
    Marker Score: 368
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.38
    Marker Score: 141
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.38
    Marker Score: 2,889
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.37
    Marker Score: 779
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.36
    Marker Score: 238
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.36
    Marker Score: 360
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.36
    Marker Score: 124
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.35
    Marker Score: 148
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.35
    Marker Score: 148
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.35
    Marker Score: 1,463
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.35
    Marker Score: 235
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.34
    Marker Score: 11,942
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.34
    Marker Score: 229
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.34
    Marker Score: 164
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.34
    Marker Score: 154
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.33
    Marker Score: 158
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.33
    Marker Score: 348
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.33
    Marker Score: 559
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.32
    Marker Score: 300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.31
    Marker Score: 380
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.31
    Marker Score: 88
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.3
    Marker Score: 80
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.3
    Marker Score: 400
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.3
    Marker Score: 324
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.3
    Marker Score: 1,219
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.3
    Marker Score: 845
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.29
    Marker Score: 1,157
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.29
    Marker Score: 174
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.29
    Marker Score: 280
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.29
    Marker Score: 819
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.28
    Marker Score: 116
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.28
    Marker Score: 456
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.28
    Marker Score: 98
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.28
    Marker Score: 66
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.28
    Marker Score: 169
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.28
    Marker Score: 659
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.28
    Marker Score: 208
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.28
    Marker Score: 299
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.28
    Marker Score: 176
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.27
    Marker Score: 200
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.27
    Marker Score: 58
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.27
    Marker Score: 67
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.27
    Marker Score: 280
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.27
    Marker Score: 59
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.27
    Marker Score: 61
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.27
    Marker Score: 85
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.27
    Marker Score: 131
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.27
    Marker Score: 1,148

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Mitochondrial localization**: SLC25A14 is a transmembrane protein localized to the mitochondrial inner membrane, where it participates in regulating mitochondrial function and energy metabolism. 2. **Proton and anion transport**: The protein exhibits proton and inorganic anion antiporter activity, facilitating the exchange of protons and anions across the mitochondrial membrane. 3. **Uncoupling protein activity**: SLC25A14 is a member of the mitochondrial uncoupling protein family, which enables the uncoupling of ATP synthesis from oxidative phosphorylation, allowing for heat production and regulation of cellular temperature. 4. **Dimerization and homodimerization**: The protein can form homodimers, which may play a role in modulating its activity and interactions with other proteins. **Pathways and Functions:** 1. **Aerobic respiration**: SLC25A14 participates in regulating the citric acid cycle and respiratory electron transport, ensuring efficient energy production in the mitochondria. 2. **Chloride and anion transport**: The protein facilitates the exchange of chloride and inorganic anions across the mitochondrial membrane, influencing cellular homeostasis and maintaining ion balance. 3. **Proton buffering**: SLC25A14 helps regulate proton levels in the mitochondrial matrix, which is critical for maintaining mitochondrial function and preventing oxidative stress. 4. **Mitochondrial uncoupling**: The protein enables uncoupling of ATP synthesis from oxidative phosphorylation, allowing for heat production and regulation of cellular temperature. 5. **Regulation of cellular response to oxidative stress**: SLC25A14 modulates the cellular response to oxidative stress by regulating mitochondrial function and energy metabolism. **Clinical Significance:** 1. **Mitochondrial disorders**: Mutations in the SLC25A14 gene have been associated with mitochondrial disorders, such as Leigh syndrome and MERRF syndrome, highlighting the protein's critical role in mitochondrial function and energy metabolism. 2. **Neurodegenerative diseases**: Dysregulation of SLC25A14 has been implicated in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, where mitochondrial dysfunction plays a key role. 3. **Cancer**: Aberrant expression of SLC25A14 has been observed in various types of cancer, suggesting its potential as a biomarker or therapeutic target. 4. **Metabolic disorders**: The protein's role in regulating energy metabolism makes it a potential target for the treatment of metabolic disorders, such as type 2 diabetes and obesity. In conclusion, SLC25A14 is a critical regulator of mitochondrial function, energy metabolism, and cellular homeostasis. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the protein's mechanisms and potential therapeutic applications.

Genular Protein ID: 639938236

Symbol: UCP5_HUMAN

Name: Mitochondrial uncoupling protein 5

UniProtKB Accession Codes:

O95258 D3DTG2 Q0VDH7 Q9HC60 Q9HC61

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 ChEBI 36 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 5 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 3 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 2 RefSeq 4 Rhea 22 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9852133

Title: BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast.

PubMed ID: 9852133

DOI: 10.1074/jbc.273.51.34611

PubMed ID: 10928996

Title: Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation.

PubMed ID: 10928996

DOI: 10.1096/fj.14.11.1611

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20600837

Title: Mitochondrial UCP5 is neuroprotective by preserving mitochondrial membrane potential, ATP levels, and reducing oxidative stress in MPP+ and dopamine toxicity.

PubMed ID: 20600837

DOI: 10.1016/j.freeradbiomed.2010.06.017

PubMed ID: 22524567

Title: Toward understanding the mechanism of ion transport activity of neuronal uncoupling proteins UCP2, UCP4, and UCP5.

PubMed ID: 22524567

DOI: 10.1021/bi3003378

PubMed ID: 26182433

Title: A biophysical study on molecular physiology of the uncoupling proteins of the central nervous system.

PubMed ID: 26182433

DOI: 10.1042/bsr20150130

PubMed ID: 31356773

Title: The human uncoupling proteins 5 and 6 (UCP5/SLC25A14 and UCP6/SLC25A30) transport sulfur oxyanions, phosphate and dicarboxylates.

PubMed ID: 31356773

DOI: 10.1016/j.bbabio.2019.07.010

Sequence Information:

  • Length: 325
  • Mass: 36202
  • Checksum: 0447E8E3B5374982
  • Sequence:
    • MGIFPGIILI FLRVKFATAA VIVSGHQKST TVSHEMSGLN WKPFVYGGLA SIVAEFGTFP 
VDLTKTRLQV QGQSIDARFK EIKYRGMFHA LFRICKEEGV LALYSGIAPA LLRQASYGTI 
KIGIYQSLKR LFVERLEDET LLINMICGVV SGVISSTIAN PTDVLKIRMQ AQGSLFQGSM 
IGSFIDIYQQ EGTRGLWRGV VPTAQRAAIV VGVELPVYDI TKKHLILSGM MGDTILTHFV 
SSFTCGLAGA LASNPVDVVR TRMMNQRAIV GHVDLYKGTV DGILKMWKHE GFFALYKGFW 
PNWLRLGPWN IIFFITYEQL KRLQI

Genular Protein ID: 2015438471

Symbol: B4DMK1_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DMK1

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 GenomeRNAi 1 InterPro 3 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SUPFAM 1

Sequence Information:

  • Length: 240
  • Mass: 26386
  • Checksum: D3B34FD1E6933635
  • Sequence:
    • MGIFPGIILI FLRVKFATAA VIVSGHQKST TVSHEMSGLN WKPFVYGGLA SIVAEFGTFP 
VDLTKTRLQV QGQSIDARFK EIKYRGMFHA LFRICKEEGV LALYSGIAPA LLRQASYGTI 
KIGIYQSLKR LFVERLEDET LLINMICGVV SGVISSTIAN PTDVLKIRMQ AQGSLFQGSM 
IGSFIDIYQQ EGTRGLWRGV VPTAQRAAIV VGVELPVYDI TKKHLILSGM MGDTILTHFV

Genular Protein ID: 1592435734

Symbol: F6SL11_HUMAN

Name: N/A

UniProtKB Accession Codes:

F6SL11

Database IDs:

ARBA 9 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 ChiTaRS 1 DNASU 1 EMBL 2 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 3 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 Proteomes 2 RefSeq 1 RuleBase 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

Sequence Information:

  • Length: 290
  • Mass: 32450
  • Checksum: DA3A5092741F4A85
  • Sequence:
    • MSGLNWKPFV YGGLASIVAE FGTFPVDLTK TRLQVQGQSI DARFKEIKYR GMFHALFRIC 
KEEGVLALYS GIAPALLRQA SYGTIKIGIY QSLKRLFVER LEDETLLINM ICGVVSGVIS 
STIANPTDVL KIRMQAQGSL FQGSMIGSFI DIYQQEGTRG LWRGVVPTAQ RAAIVVGVEL 
PVYDITKKHL ILSGMMGDTI LTHFVSSFTC GLAGALASNP VDVVRTRMMN QRAIVGHVDL 
YKGTVDGILK MWKHEGFFAL YKGFWPNWLR LGPWNIIFFI TYEQLKRLQI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.