CCNH | ENSG00000134480 | NCBI 902

Details for: CCNH

Gene ID: 902

Symbol: CCNH

Ensembl ID: ENSG00000134480

Description: cyclin H

Associated with

Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cyclin a/b1/b2 associated events during g2/m transition
(R-HSA-69273)
Cyclin a:cdk2-associated events at s phase entry
(R-HSA-69656)
Cyclin d associated events in g1
(R-HSA-69231)
Cyclin e associated events during g1/s transition
(R-HSA-69202)
Disease
(R-HSA-1643685)
Dna repair
(R-HSA-73894)
Dual incision in tc-ner
(R-HSA-6782135)
Epigenetic regulation of gene expression
(R-HSA-212165)
Formation of hiv-1 elongation complex containing hiv-1 tat
(R-HSA-167200)
Formation of hiv elongation complex in the absence of hiv tat
(R-HSA-167152)
Formation of incision complex in gg-ner
(R-HSA-5696395)
Formation of rna pol ii elongation complex
(R-HSA-112382)
Formation of tc-ner pre-incision complex
(R-HSA-6781823)
Formation of the early elongation complex
(R-HSA-113418)
Formation of the hiv-1 early elongation complex
(R-HSA-167158)
G1 phase
(R-HSA-69236)
G1/s transition
(R-HSA-69206)
G2/m transition
(R-HSA-69275)
Gap-filling dna repair synthesis and ligation in tc-ner
(R-HSA-6782210)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Global genome nucleotide excision repair (gg-ner)
(R-HSA-5696399)
Hiv infection
(R-HSA-162906)
Hiv life cycle
(R-HSA-162587)
Hiv transcription elongation
(R-HSA-167169)
Hiv transcription initiation
(R-HSA-167161)
Infectious disease
(R-HSA-5663205)
Late phase of hiv life cycle
(R-HSA-162599)
Metabolism of rna
(R-HSA-8953854)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mrna capping
(R-HSA-72086)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleotide excision repair
(R-HSA-5696398)
Rna pol ii ctd phosphorylation and interaction with ce
(R-HSA-77075)
Rna pol ii ctd phosphorylation and interaction with ce during hiv infection
(R-HSA-167160)
Rna polymerase ii hiv promoter escape
(R-HSA-167162)
Rna polymerase ii pre-transcription events
(R-HSA-674695)
Rna polymerase ii promoter escape
(R-HSA-73776)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase ii transcription elongation
(R-HSA-75955)
Rna polymerase ii transcription initiation
(R-HSA-75953)
Rna polymerase ii transcription initiation and promoter clearance
(R-HSA-76042)
Rna polymerase ii transcription pre-initiation and promoter opening
(R-HSA-73779)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i transcription
(R-HSA-73864)
Rna polymerase i transcription initiation
(R-HSA-73762)
Rna polymerase i transcription termination
(R-HSA-73863)
Runx1 regulates transcription of genes involved in differentiation of hscs
(R-HSA-8939236)
S phase
(R-HSA-69242)
Tat-mediated elongation of the hiv-1 transcript
(R-HSA-167246)
Tp53 regulates transcription of dna repair genes
(R-HSA-6796648)
Transcription-coupled nucleotide excision repair (tc-ner)
(R-HSA-6781827)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by tp53
(R-HSA-3700989)
Transcription of the hiv genome
(R-HSA-167172)
Viral infection pathways
(R-HSA-9824446)
Cak-ercc2 complex
(GO:0070516)
Cyclin-dependent protein kinase holoenzyme complex
(GO:0000307)
Cyclin-dependent protein serine/threonine kinase regulator activity
(GO:0016538)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Protein stabilization
(GO:0050821)
Regulation of g1/s transition of mitotic cell cycle
(GO:2000045)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii general transcription initiation factor activity
(GO:0016251)
Transcription factor tfiih core complex
(GO:0000439)
Transcription factor tfiih holo complex
(GO:0005675)
Transcription factor tfiik complex
(GO:0070985)
Transcription initiation at rna polymerase ii promoter
(GO:0006367)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 475.1030
Cell Significance Index: -73.9000
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 272.0355
Cell Significance Index: -69.0000
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 170.6309
Cell Significance Index: -69.3200
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 168.5155
Cell Significance Index: -79.5600
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 147.5548
Cell Significance Index: -75.9000
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 118.7442
Cell Significance Index: -79.6800
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 72.8625
Cell Significance Index: -69.5700
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 62.8530
Cell Significance Index: -77.5000
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 26.0671
Cell Significance Index: -69.8300
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 22.3510
Cell Significance Index: -68.6500
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 19.9035
Cell Significance Index: -78.5400
Cell Name: cortical interneuron (CL0008031)
Fold Change: 5.9731
Cell Significance Index: 143.2500
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 5.0621
Cell Significance Index: 311.1400
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 3.8855
Cell Significance Index: 1393.6700
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 3.0174
Cell Significance Index: 169.3200
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 2.0736
Cell Significance Index: 91.7200
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 1.9893
Cell Significance Index: 75.3300
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 1.8633
Cell Significance Index: 125.2900
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.6163
Cell Significance Index: 320.7700
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.5692
Cell Significance Index: 1085.3300
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.4319
Cell Significance Index: 109.8900
Cell Name: hippocampal interneuron (CL1001569)
Fold Change: 1.0626
Cell Significance Index: 13.7800
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.0429
Cell Significance Index: 1963.6200
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.0361
Cell Significance Index: 207.8400
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.9447
Cell Significance Index: 599.9700
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.8776
Cell Significance Index: 95.4600
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.6775
Cell Significance Index: 110.1900
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.5637
Cell Significance Index: 33.8400
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.5055
Cell Significance Index: 62.1600
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.4400
Cell Significance Index: 677.4100
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.3262
Cell Significance Index: 9.3100
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.3254
Cell Significance Index: 143.8700
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.3191
Cell Significance Index: 144.8500
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.3162
Cell Significance Index: 57.0100
Cell Name: adipocyte of breast (CL0002617)
Fold Change: 0.3002
Cell Significance Index: 3.7800
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.2964
Cell Significance Index: 546.7000
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.2941
Cell Significance Index: 18.9800
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2841
Cell Significance Index: 54.0600
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2815
Cell Significance Index: 153.7400
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.2705
Cell Significance Index: 13.6700
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2341
Cell Significance Index: 211.3800
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2078
Cell Significance Index: 14.3700
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.1979
Cell Significance Index: 5.2900
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.1962
Cell Significance Index: 266.8200
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1837
Cell Significance Index: 18.1700
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.1174
Cell Significance Index: 13.8400
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0768
Cell Significance Index: 10.5500
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0150
Cell Significance Index: -0.3300
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0689
Cell Significance Index: -3.2400
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0726
Cell Significance Index: -53.2000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0760
Cell Significance Index: -57.4900
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0805
Cell Significance Index: -8.2200
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0924
Cell Significance Index: -11.8400
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0950
Cell Significance Index: -70.4000
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1375
Cell Significance Index: -77.5400
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1480
Cell Significance Index: -92.4000
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1525
Cell Significance Index: -5.3600
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.1763
Cell Significance Index: -5.0800
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1814
Cell Significance Index: -13.5200
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1830
Cell Significance Index: -23.6500
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2292
Cell Significance Index: -33.3200
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2491
Cell Significance Index: -71.6800
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.2995
Cell Significance Index: -13.5800
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.3303
Cell Significance Index: -38.4900
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.3375
Cell Significance Index: -23.8700
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.3801
Cell Significance Index: -64.9100
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3916
Cell Significance Index: -40.7700
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.4166
Cell Significance Index: -87.7400
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.4204
Cell Significance Index: -12.0500
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.5536
Cell Significance Index: -7.9500
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.6310
Cell Significance Index: -72.2900
Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.6746
Cell Significance Index: -16.4600
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.7022
Cell Significance Index: -36.8700
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.7352
Cell Significance Index: -46.3400
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.7656
Cell Significance Index: -35.7000
Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: -0.8446
Cell Significance Index: -11.8100
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.8685
Cell Significance Index: -7.0800
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.8844
Cell Significance Index: -18.9100
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.8966
Cell Significance Index: -71.0100
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.9194
Cell Significance Index: -47.7600
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -1.0023
Cell Significance Index: -52.2100
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -1.2403
Cell Significance Index: -24.9000
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -1.2421
Cell Significance Index: -33.8100
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.2881
Cell Significance Index: -78.9700
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -1.2918
Cell Significance Index: -36.1000
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.3802
Cell Significance Index: -44.2100
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -1.4142
Cell Significance Index: -46.3000
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: -1.4143
Cell Significance Index: -19.0700
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -1.4382
Cell Significance Index: -38.4700
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -1.4988
Cell Significance Index: -25.6900
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -1.5260
Cell Significance Index: -48.6000
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -1.5394
Cell Significance Index: -45.2100
Cell Name: granulosa cell (CL0000501)
Fold Change: -1.5725
Cell Significance Index: -41.3500
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -1.5853
Cell Significance Index: -55.0900
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -1.6514
Cell Significance Index: -24.3800
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -1.6699
Cell Significance Index: -33.0200
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -1.6957
Cell Significance Index: -10.2500
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -1.6989
Cell Significance Index: -43.6700
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -1.7056
Cell Significance Index: -23.2700
Cell Name: pro-T cell (CL0000827)
Fold Change: -1.7231
Cell Significance Index: -44.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** Cyclin H is a highly conserved protein that is found in all eukaryotic cells. It is a member of the cyclin family, which is characterized by the presence of a conserved cyclin box domain. Cyclin H is specifically associated with the CDKAP complex, which consists of Cyclin H, CDK5RAP2, and CDK5. This complex plays a crucial role in the activation of CDKs, which are essential for the progression of cells through the cell cycle. Cyclin H is also involved in the regulation of transcription by RNA polymerase II. It interacts with the transcription factor TFIH, which is responsible for the initiation of transcription by RNA polymerase II. Cyclin H has been shown to regulate the activity of TFIH, and its dysregulation has been implicated in various diseases, including cancer and viral infections. **Pathways and Functions** Cyclin H is involved in several key pathways, including: 1. **Cell Cycle Regulation**: Cyclin H is a key component of the CDKAP complex, which plays a crucial role in the activation of CDKs. CDKs are essential for the progression of cells through the cell cycle, and their dysregulation can lead to cancer and other diseases. 2. **DNA Repair**: Cyclin H is involved in the regulation of DNA repair processes, including nucleotide excision repair (NER) and global genome nucleotide excision repair (GG-NER). Its dysregulation has been implicated in various diseases, including cancer and viral infections. 3. **Transcriptional Regulation**: Cyclin H regulates the activity of RNA polymerase II, which is responsible for the transcription of genes. Its dysregulation has been implicated in various diseases, including cancer and viral infections. 4. **HIV Infection**: Cyclin H has been shown to play a role in the regulation of HIV transcription and replication. Its dysregulation has been implicated in the pathogenesis of HIV infection. **Clinical Significance** Cyclin H dysregulation has been implicated in various diseases, including: 1. **Cancer**: Cyclin H dysregulation has been implicated in the development and progression of various cancers, including breast, lung, and colon cancer. 2. **Viral Infections**: Cyclin H dysregulation has been implicated in the pathogenesis of HIV infection and other viral infections, including hepatitis B and C. 3. **Neurological Disorders**: Cyclin H dysregulation has been implicated in the development of various neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Cardiovascular Disease**: Cyclin H dysregulation has been implicated in the development of cardiovascular disease, including atherosclerosis and heart failure. In conclusion, Cyclin H is a critical protein that plays a key role in the regulation of the cell cycle, DNA repair, and transcriptional processes. Its dysregulation has been implicated in various diseases, including cancer, viral infections, and neurological disorders. Further research is needed to fully understand the role of Cyclin H in human disease and to develop effective therapeutic strategies for the treatment of these diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Cyclin-H

Genular Protein ID: 2847686331

Symbol: CCNH_HUMAN

Name: Cyclin-H

UniProtKB Accession Codes:

P51946 Q53X72 Q8TBL9

Database IDs:

Citations:

PubMed ID: 8078587

Title: A cyclin associated with the CDK-activating kinase MO15.

PubMed ID: 8078587

DOI: 10.1038/371254a0

PubMed ID: 8069918

Title: A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase.

PubMed ID: 8069918

DOI: 10.1016/0092-8674(94)90535-5

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7533895

Title: Cdk-activating kinase complex is a component of human transcription factor TFIIH.

PubMed ID: 7533895

DOI: 10.1038/374283a0

PubMed ID: 9852112

Title: Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes.

PubMed ID: 9852112

DOI: 10.1074/jbc.273.51.34444

PubMed ID: 10024882

Title: Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7.

PubMed ID: 10024882

DOI: 10.1016/s1097-2765(00)80177-x

PubMed ID: 10993082

Title: TFIIH is negatively regulated by cdk8-containing mediator complexes.

PubMed ID: 10993082

DOI: 10.1038/35024111

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 8836101

Title: Three-dimensional structure of human cyclin H, a positive regulator of the CDK-activating kinase.

PubMed ID: 8836101

DOI: 10.1038/nsb1096-849

PubMed ID: 9118957

Title: The structure of cyclin H: common mode of kinase activation and specific features.

PubMed ID: 9118957

DOI: 10.1093/emboj/16.5.958

Sequence Information:

Length: 323
Mass: 37643
Checksum: BB48D55DA397A0E4
Sequence:

MYHNSSQKRH WTFSSEEQLA RLRADANRKF RCKAVANGKV LPNDPVFLEP HEEMTLCKYY 
EKRLLEFCSV FKPAMPRSVV GTACMYFKRF YLNNSVMEYH PRIIMLTCAF LACKVDEFNV 
SSPQFVGNLR ESPLGQEKAL EQILEYELLL IQQLNFHLIV HNPYRPFEGF LIDLKTRYPI 
LENPEILRKT ADDFLNRIAL TDAYLLYTPS QIALTAILSS ASRAGITMES YLSESLMLKE 
NRTCLSQLLD IMKSMRNLVK KYEPPRSEEV AVLKQKLERC HSAELALNVI TKKRKGYEDD 
DYVSKKSKHE EEEWTDDDLV ESL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CCNH

Associated with

Cells (max top 100)

Other Information

A cyclin associated with the CDK-activating kinase MO15. PubMed ID: 8078587

A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase. PubMed ID: 8069918

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cdk-activating kinase complex is a component of human transcription factor TFIIH. PubMed ID: 7533895

Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. PubMed ID: 9852112

Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7. PubMed ID: 10024882

TFIIH is negatively regulated by cdk8-containing mediator complexes. PubMed ID: 10993082

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Three-dimensional structure of human cyclin H, a positive regulator of the CDK-activating kinase. PubMed ID: 8836101

The structure of cyclin H: common mode of kinase activation and specific features. PubMed ID: 9118957