Details for: CCNH

Gene ID: 902

Symbol: CCNH

Ensembl ID: ENSG00000134480

Description: cyclin H

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 3
    Marker Score: 3,738
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.93
    Marker Score: 3,540
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.78
    Marker Score: 11,644
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.77
    Marker Score: 21,252
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.72
    Marker Score: 40,715
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.7
    Marker Score: 3,108
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.66
    Marker Score: 100,968
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.65
    Marker Score: 3,568
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.56
    Marker Score: 7,191
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.54
    Marker Score: 5,578
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.46
    Marker Score: 48,881
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.43
    Marker Score: 51,863
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.42
    Marker Score: 3,345
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.42
    Marker Score: 2,060
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.34
    Marker Score: 9,709
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.29
    Marker Score: 4,397
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 2.25
    Marker Score: 1,091
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.24
    Marker Score: 5,370
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.24
    Marker Score: 1,311
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.24
    Marker Score: 654
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.22
    Marker Score: 1,243
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.22
    Marker Score: 8,567
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 2.13
    Marker Score: 1,610
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.07
    Marker Score: 1,235
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.06
    Marker Score: 1,026
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.03
    Marker Score: 3,411
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.02
    Marker Score: 18,987
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.01
    Marker Score: 7,138
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 2
    Marker Score: 2,152
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.99
    Marker Score: 1,747
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.98
    Marker Score: 991
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.98
    Marker Score: 19,636
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.95
    Marker Score: 71,758
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.94
    Marker Score: 1,080
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.94
    Marker Score: 119,375
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.93
    Marker Score: 43,093
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.89
    Marker Score: 585
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.89
    Marker Score: 5,380
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.85
    Marker Score: 1,085
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.85
    Marker Score: 584
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.84
    Marker Score: 17,450
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.82
    Marker Score: 551
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.79
    Marker Score: 1,104
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.79
    Marker Score: 4,374
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.78
    Marker Score: 1,371
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.77
    Marker Score: 1,537
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.77
    Marker Score: 613
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.76
    Marker Score: 598
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.71
    Marker Score: 1,635
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.71
    Marker Score: 14,709
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.71
    Marker Score: 693
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.71
    Marker Score: 2,113
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.69
    Marker Score: 704
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.69
    Marker Score: 2,484
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.67
    Marker Score: 723
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.65
    Marker Score: 868
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.63
    Marker Score: 7,004
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.59
    Marker Score: 590
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.59
    Marker Score: 1,335
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.57
    Marker Score: 571
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.55
    Marker Score: 370
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 1.53
    Marker Score: 697
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.53
    Marker Score: 1,406
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.52
    Marker Score: 51,855
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.52
    Marker Score: 482
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.52
    Marker Score: 1,109
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.52
    Marker Score: 1,655
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.52
    Marker Score: 2,147
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.51
    Marker Score: 1,181
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.48
    Marker Score: 1,571
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.48
    Marker Score: 2,280
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.48
    Marker Score: 323
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.47
    Marker Score: 1,303
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.46
    Marker Score: 2,602
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.45
    Marker Score: 548
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 1.45
    Marker Score: 1,049
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.45
    Marker Score: 417
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.45
    Marker Score: 332
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.44
    Marker Score: 356
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.42
    Marker Score: 525
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.42
    Marker Score: 377
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.42
    Marker Score: 1,445
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.41
    Marker Score: 949
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.41
    Marker Score: 822
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.41
    Marker Score: 16,392
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.4
    Marker Score: 1,029
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.4
    Marker Score: 313
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 1.4
    Marker Score: 627
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 1.4
    Marker Score: 370
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.39
    Marker Score: 1,303
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.39
    Marker Score: 484
  • Cell Name: interneuron (CL0000099)
    Fold Change: 1.38
    Marker Score: 632
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.38
    Marker Score: 796
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.37
    Marker Score: 650
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 1.36
    Marker Score: 299
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 1.35
    Marker Score: 356
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.35
    Marker Score: 380
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.35
    Marker Score: 1,106
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.35
    Marker Score: 264
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 1.34
    Marker Score: 578

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** Cyclin H is a highly conserved protein that is found in all eukaryotic cells. It is a member of the cyclin family, which is characterized by the presence of a conserved cyclin box domain. Cyclin H is specifically associated with the CDKAP complex, which consists of Cyclin H, CDK5RAP2, and CDK5. This complex plays a crucial role in the activation of CDKs, which are essential for the progression of cells through the cell cycle. Cyclin H is also involved in the regulation of transcription by RNA polymerase II. It interacts with the transcription factor TFIH, which is responsible for the initiation of transcription by RNA polymerase II. Cyclin H has been shown to regulate the activity of TFIH, and its dysregulation has been implicated in various diseases, including cancer and viral infections. **Pathways and Functions** Cyclin H is involved in several key pathways, including: 1. **Cell Cycle Regulation**: Cyclin H is a key component of the CDKAP complex, which plays a crucial role in the activation of CDKs. CDKs are essential for the progression of cells through the cell cycle, and their dysregulation can lead to cancer and other diseases. 2. **DNA Repair**: Cyclin H is involved in the regulation of DNA repair processes, including nucleotide excision repair (NER) and global genome nucleotide excision repair (GG-NER). Its dysregulation has been implicated in various diseases, including cancer and viral infections. 3. **Transcriptional Regulation**: Cyclin H regulates the activity of RNA polymerase II, which is responsible for the transcription of genes. Its dysregulation has been implicated in various diseases, including cancer and viral infections. 4. **HIV Infection**: Cyclin H has been shown to play a role in the regulation of HIV transcription and replication. Its dysregulation has been implicated in the pathogenesis of HIV infection. **Clinical Significance** Cyclin H dysregulation has been implicated in various diseases, including: 1. **Cancer**: Cyclin H dysregulation has been implicated in the development and progression of various cancers, including breast, lung, and colon cancer. 2. **Viral Infections**: Cyclin H dysregulation has been implicated in the pathogenesis of HIV infection and other viral infections, including hepatitis B and C. 3. **Neurological Disorders**: Cyclin H dysregulation has been implicated in the development of various neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Cardiovascular Disease**: Cyclin H dysregulation has been implicated in the development of cardiovascular disease, including atherosclerosis and heart failure. In conclusion, Cyclin H is a critical protein that plays a key role in the regulation of the cell cycle, DNA repair, and transcriptional processes. Its dysregulation has been implicated in various diseases, including cancer, viral infections, and neurological disorders. Further research is needed to fully understand the role of Cyclin H in human disease and to develop effective therapeutic strategies for the treatment of these diseases.

Genular Protein ID: 2847686331

Symbol: CCNH_HUMAN

Name: Cyclin-H

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8078587

Title: A cyclin associated with the CDK-activating kinase MO15.

PubMed ID: 8078587

DOI: 10.1038/371254a0

PubMed ID: 8069918

Title: A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase.

PubMed ID: 8069918

DOI: 10.1016/0092-8674(94)90535-5

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7533895

Title: Cdk-activating kinase complex is a component of human transcription factor TFIIH.

PubMed ID: 7533895

DOI: 10.1038/374283a0

PubMed ID: 9852112

Title: Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes.

PubMed ID: 9852112

DOI: 10.1074/jbc.273.51.34444

PubMed ID: 10024882

Title: Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7.

PubMed ID: 10024882

DOI: 10.1016/s1097-2765(00)80177-x

PubMed ID: 10993082

Title: TFIIH is negatively regulated by cdk8-containing mediator complexes.

PubMed ID: 10993082

DOI: 10.1038/35024111

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 8836101

Title: Three-dimensional structure of human cyclin H, a positive regulator of the CDK-activating kinase.

PubMed ID: 8836101

DOI: 10.1038/nsb1096-849

PubMed ID: 9118957

Title: The structure of cyclin H: common mode of kinase activation and specific features.

PubMed ID: 9118957

DOI: 10.1093/emboj/16.5.958

Sequence Information:

  • Length: 323
  • Mass: 37643
  • Checksum: BB48D55DA397A0E4
  • Sequence:
  • MYHNSSQKRH WTFSSEEQLA RLRADANRKF RCKAVANGKV LPNDPVFLEP HEEMTLCKYY 
    EKRLLEFCSV FKPAMPRSVV GTACMYFKRF YLNNSVMEYH PRIIMLTCAF LACKVDEFNV 
    SSPQFVGNLR ESPLGQEKAL EQILEYELLL IQQLNFHLIV HNPYRPFEGF LIDLKTRYPI 
    LENPEILRKT ADDFLNRIAL TDAYLLYTPS QIALTAILSS ASRAGITMES YLSESLMLKE 
    NRTCLSQLLD IMKSMRNLVK KYEPPRSEEV AVLKQKLERC HSAELALNVI TKKRKGYEDD 
    DYVSKKSKHE EEEWTDDDLV ESL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.