CCNH | ENSG00000134480 | NCBI 902

Details for: CCNH

Gene ID: 902

Symbol: CCNH

Ensembl ID: ENSG00000134480

Description: cyclin H

Associated with

Cell cycle, mitotic
(R-HSA-69278)
Cyclin a/b1/b2 associated events during g2/m transition
(R-HSA-69273)
Cyclin a:cdk2-associated events at s phase entry
(R-HSA-69656)
Cyclin d associated events in g1
(R-HSA-69231)
Cyclin e associated events during g1/s transition
(R-HSA-69202)
Disease
(R-HSA-1643685)
Dna repair
(R-HSA-73894)
Dual incision in tc-ner
(R-HSA-6782135)
Epigenetic regulation of gene expression
(R-HSA-212165)
Formation of hiv-1 elongation complex containing hiv-1 tat
(R-HSA-167200)
Formation of hiv elongation complex in the absence of hiv tat
(R-HSA-167152)
Formation of incision complex in gg-ner
(R-HSA-5696395)
Formation of rna pol ii elongation complex
(R-HSA-112382)
Formation of tc-ner pre-incision complex
(R-HSA-6781823)
Formation of the early elongation complex
(R-HSA-113418)
Formation of the hiv-1 early elongation complex
(R-HSA-167158)
G1 phase
(R-HSA-69236)
G1/s transition
(R-HSA-69206)
G2/m transition
(R-HSA-69275)
Gap-filling dna repair synthesis and ligation in tc-ner
(R-HSA-6782210)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Global genome nucleotide excision repair (gg-ner)
(R-HSA-5696399)
Hiv infection
(R-HSA-162906)
Hiv life cycle
(R-HSA-162587)
Hiv transcription elongation
(R-HSA-167169)
Hiv transcription initiation
(R-HSA-167161)
Infectious disease
(R-HSA-5663205)
Late phase of hiv life cycle
(R-HSA-162599)
Metabolism of rna
(R-HSA-8953854)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mrna capping
(R-HSA-72086)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleotide excision repair
(R-HSA-5696398)
Rna pol ii ctd phosphorylation and interaction with ce
(R-HSA-77075)
Rna pol ii ctd phosphorylation and interaction with ce during hiv infection
(R-HSA-167160)
Rna polymerase ii hiv promoter escape
(R-HSA-167162)
Rna polymerase ii pre-transcription events
(R-HSA-674695)
Rna polymerase ii promoter escape
(R-HSA-73776)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase ii transcription elongation
(R-HSA-75955)
Rna polymerase ii transcription initiation
(R-HSA-75953)
Rna polymerase ii transcription initiation and promoter clearance
(R-HSA-76042)
Rna polymerase ii transcription pre-initiation and promoter opening
(R-HSA-73779)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i transcription
(R-HSA-73864)
Rna polymerase i transcription initiation
(R-HSA-73762)
Rna polymerase i transcription termination
(R-HSA-73863)
Runx1 regulates transcription of genes involved in differentiation of hscs
(R-HSA-8939236)
S phase
(R-HSA-69242)
Tat-mediated elongation of the hiv-1 transcript
(R-HSA-167246)
Tp53 regulates transcription of dna repair genes
(R-HSA-6796648)
Transcription-coupled nucleotide excision repair (tc-ner)
(R-HSA-6781827)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by tp53
(R-HSA-3700989)
Transcription of the hiv genome
(R-HSA-167172)
Viral infection pathways
(R-HSA-9824446)
Cak-ercc2 complex
(GO:0070516)
Cell cycle
(GO:0007049)
Cyclin-dependent protein kinase activating kinase holoenzyme complex
(GO:0019907)
Cyclin-dependent protein serine/threonine kinase regulator activity
(GO:0016538)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Protein stabilization
(GO:0050821)
Regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0000079)
Regulation of g1/s transition of mitotic cell cycle
(GO:2000045)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii general transcription initiation factor activity
(GO:0016251)
Transcription by rna polymerase ii
(GO:0006366)
Transcription factor tfiih core complex
(GO:0000439)
Transcription factor tfiih holo complex
(GO:0005675)
Transcription factor tfiik complex
(GO:0070985)
Transcription initiation at rna polymerase ii promoter
(GO:0006367)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: cardiac neuron (CL0010022)
Fold Change: 3
Marker Score: 3,738
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 2.93
Marker Score: 3,540
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 2.78
Marker Score: 11,644
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 2.77
Marker Score: 21,252
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 2.72
Marker Score: 40,715
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 2.7
Marker Score: 3,108
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 2.66
Marker Score: 100,968
Cell Name: anterior lens cell (CL0002223)
Fold Change: 2.65
Marker Score: 3,568
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 2.56
Marker Score: 7,191
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 2.54
Marker Score: 5,578
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 2.46
Marker Score: 48,881
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 2.43
Marker Score: 51,863
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 2.42
Marker Score: 3,345
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 2.42
Marker Score: 2,060
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 2.34
Marker Score: 9,709
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 2.29
Marker Score: 4,397
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 2.25
Marker Score: 1,091
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 2.24
Marker Score: 5,370
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 2.24
Marker Score: 1,311
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 2.24
Marker Score: 654
Cell Name: fat cell (CL0000136)
Fold Change: 2.22
Marker Score: 1,243
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.22
Marker Score: 8,567
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 2.13
Marker Score: 1,610
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 2.07
Marker Score: 1,235
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 2.06
Marker Score: 1,026
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 2.03
Marker Score: 3,411
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 2.02
Marker Score: 18,987
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 2.01
Marker Score: 7,138
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 2
Marker Score: 2,152
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 1.99
Marker Score: 1,747
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 1.98
Marker Score: 991
Cell Name: mature T cell (CL0002419)
Fold Change: 1.98
Marker Score: 19,636
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.95
Marker Score: 71,758
Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 1.94
Marker Score: 1,080
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.94
Marker Score: 119,375
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 1.93
Marker Score: 43,093
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 1.89
Marker Score: 585
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 1.89
Marker Score: 5,380
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 1.85
Marker Score: 1,085
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 1.85
Marker Score: 584
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.84
Marker Score: 17,450
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 1.82
Marker Score: 551
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 1.79
Marker Score: 1,104
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 1.79
Marker Score: 4,374
Cell Name: renal principal cell (CL0005009)
Fold Change: 1.78
Marker Score: 1,371
Cell Name: astrocyte (CL0000127)
Fold Change: 1.77
Marker Score: 1,537
Cell Name: Schwann cell (CL0002573)
Fold Change: 1.77
Marker Score: 613
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 1.76
Marker Score: 598
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 1.71
Marker Score: 1,635
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.71
Marker Score: 14,709
Cell Name: melanocyte (CL0000148)
Fold Change: 1.71
Marker Score: 693
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 1.71
Marker Score: 2,113
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 1.69
Marker Score: 704
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 1.69
Marker Score: 2,484
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 1.67
Marker Score: 723
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 1.65
Marker Score: 868
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 1.63
Marker Score: 7,004
Cell Name: podocyte (CL0000653)
Fold Change: 1.59
Marker Score: 590
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 1.59
Marker Score: 1,335
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 1.57
Marker Score: 571
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.55
Marker Score: 370
Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
Fold Change: 1.53
Marker Score: 697
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 1.53
Marker Score: 1,406
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.52
Marker Score: 51,855
Cell Name: lens fiber cell (CL0011004)
Fold Change: 1.52
Marker Score: 482
Cell Name: Unknown (CL0000548)
Fold Change: 1.52
Marker Score: 1,109
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 1.52
Marker Score: 1,655
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.52
Marker Score: 2,147
Cell Name: type I NK T cell (CL0000921)
Fold Change: 1.51
Marker Score: 1,181
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 1.48
Marker Score: 1,571
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.48
Marker Score: 2,280
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 1.48
Marker Score: 323
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 1.47
Marker Score: 1,303
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 1.46
Marker Score: 2,602
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.45
Marker Score: 548
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 1.45
Marker Score: 1,049
Cell Name: lung goblet cell (CL1000143)
Fold Change: 1.45
Marker Score: 417
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 1.45
Marker Score: 332
Cell Name: cardiac mesenchymal cell (CL0000569)
Fold Change: 1.44
Marker Score: 356
Cell Name: radial glial cell (CL0000681)
Fold Change: 1.42
Marker Score: 525
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 1.42
Marker Score: 377
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 1.42
Marker Score: 1,445
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 1.41
Marker Score: 949
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1.41
Marker Score: 822
Cell Name: blood cell (CL0000081)
Fold Change: 1.41
Marker Score: 16,392
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 1.4
Marker Score: 1,029
Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 1.4
Marker Score: 313
Cell Name: granulocyte (CL0000094)
Fold Change: 1.4
Marker Score: 627
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 1.4
Marker Score: 370
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 1.39
Marker Score: 1,303
Cell Name: ependymal cell (CL0000065)
Fold Change: 1.39
Marker Score: 484
Cell Name: interneuron (CL0000099)
Fold Change: 1.38
Marker Score: 632
Cell Name: exhausted T cell (CL0011025)
Fold Change: 1.38
Marker Score: 796
Cell Name: basophil (CL0000767)
Fold Change: 1.37
Marker Score: 650
Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
Fold Change: 1.36
Marker Score: 299
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 1.35
Marker Score: 356
Cell Name: epidermal cell (CL0000362)
Fold Change: 1.35
Marker Score: 380
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 1.35
Marker Score: 1,106
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 1.35
Marker Score: 264
Cell Name: memory T cell (CL0000813)
Fold Change: 1.34
Marker Score: 578

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

**Key Characteristics** Cyclin H is a highly conserved protein that is found in all eukaryotic cells. It is a member of the cyclin family, which is characterized by the presence of a conserved cyclin box domain. Cyclin H is specifically associated with the CDKAP complex, which consists of Cyclin H, CDK5RAP2, and CDK5. This complex plays a crucial role in the activation of CDKs, which are essential for the progression of cells through the cell cycle. Cyclin H is also involved in the regulation of transcription by RNA polymerase II. It interacts with the transcription factor TFIH, which is responsible for the initiation of transcription by RNA polymerase II. Cyclin H has been shown to regulate the activity of TFIH, and its dysregulation has been implicated in various diseases, including cancer and viral infections. **Pathways and Functions** Cyclin H is involved in several key pathways, including: 1. **Cell Cycle Regulation**: Cyclin H is a key component of the CDKAP complex, which plays a crucial role in the activation of CDKs. CDKs are essential for the progression of cells through the cell cycle, and their dysregulation can lead to cancer and other diseases. 2. **DNA Repair**: Cyclin H is involved in the regulation of DNA repair processes, including nucleotide excision repair (NER) and global genome nucleotide excision repair (GG-NER). Its dysregulation has been implicated in various diseases, including cancer and viral infections. 3. **Transcriptional Regulation**: Cyclin H regulates the activity of RNA polymerase II, which is responsible for the transcription of genes. Its dysregulation has been implicated in various diseases, including cancer and viral infections. 4. **HIV Infection**: Cyclin H has been shown to play a role in the regulation of HIV transcription and replication. Its dysregulation has been implicated in the pathogenesis of HIV infection. **Clinical Significance** Cyclin H dysregulation has been implicated in various diseases, including: 1. **Cancer**: Cyclin H dysregulation has been implicated in the development and progression of various cancers, including breast, lung, and colon cancer. 2. **Viral Infections**: Cyclin H dysregulation has been implicated in the pathogenesis of HIV infection and other viral infections, including hepatitis B and C. 3. **Neurological Disorders**: Cyclin H dysregulation has been implicated in the development of various neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Cardiovascular Disease**: Cyclin H dysregulation has been implicated in the development of cardiovascular disease, including atherosclerosis and heart failure. In conclusion, Cyclin H is a critical protein that plays a key role in the regulation of the cell cycle, DNA repair, and transcriptional processes. Its dysregulation has been implicated in various diseases, including cancer, viral infections, and neurological disorders. Further research is needed to fully understand the role of Cyclin H in human disease and to develop effective therapeutic strategies for the treatment of these diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Cyclin-H

Genular Protein ID: 2847686331

Symbol: CCNH_HUMAN

Name: Cyclin-H

UniProtKB Accession Codes:

P51946 Q53X72 Q8TBL9

Database IDs:

Citations:

PubMed ID: 8078587

Title: A cyclin associated with the CDK-activating kinase MO15.

PubMed ID: 8078587

DOI: 10.1038/371254a0

PubMed ID: 8069918

Title: A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase.

PubMed ID: 8069918

DOI: 10.1016/0092-8674(94)90535-5

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7533895

Title: Cdk-activating kinase complex is a component of human transcription factor TFIIH.

PubMed ID: 7533895

DOI: 10.1038/374283a0

PubMed ID: 9852112

Title: Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes.

PubMed ID: 9852112

DOI: 10.1074/jbc.273.51.34444

PubMed ID: 10024882

Title: Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7.

PubMed ID: 10024882

DOI: 10.1016/s1097-2765(00)80177-x

PubMed ID: 10993082

Title: TFIIH is negatively regulated by cdk8-containing mediator complexes.

PubMed ID: 10993082

DOI: 10.1038/35024111

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 8836101

Title: Three-dimensional structure of human cyclin H, a positive regulator of the CDK-activating kinase.

PubMed ID: 8836101

DOI: 10.1038/nsb1096-849

PubMed ID: 9118957

Title: The structure of cyclin H: common mode of kinase activation and specific features.

PubMed ID: 9118957

DOI: 10.1093/emboj/16.5.958

Sequence Information:

Length: 323
Mass: 37643
Checksum: BB48D55DA397A0E4
Sequence:

MYHNSSQKRH WTFSSEEQLA RLRADANRKF RCKAVANGKV LPNDPVFLEP HEEMTLCKYY 
EKRLLEFCSV FKPAMPRSVV GTACMYFKRF YLNNSVMEYH PRIIMLTCAF LACKVDEFNV 
SSPQFVGNLR ESPLGQEKAL EQILEYELLL IQQLNFHLIV HNPYRPFEGF LIDLKTRYPI 
LENPEILRKT ADDFLNRIAL TDAYLLYTPS QIALTAILSS ASRAGITMES YLSESLMLKE 
NRTCLSQLLD IMKSMRNLVK KYEPPRSEEV AVLKQKLERC HSAELALNVI TKKRKGYEDD 
DYVSKKSKHE EEEWTDDDLV ESL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CCNH

Associated with

Cells (max top 100)

Other Information

A cyclin associated with the CDK-activating kinase MO15. PubMed ID: 8078587

A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase. PubMed ID: 8069918

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cdk-activating kinase complex is a component of human transcription factor TFIIH. PubMed ID: 7533895

Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. PubMed ID: 9852112

Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7. PubMed ID: 10024882

TFIIH is negatively regulated by cdk8-containing mediator complexes. PubMed ID: 10993082

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Three-dimensional structure of human cyclin H, a positive regulator of the CDK-activating kinase. PubMed ID: 8836101

The structure of cyclin H: common mode of kinase activation and specific features. PubMed ID: 9118957