Details for: CH25H

Gene ID: 9023

Symbol: CH25H

Ensembl ID: ENSG00000138135

Description: cholesterol 25-hydroxylase

Associated with

Other Information

Genular Protein ID: 3460628022

Symbol: CH25H_HUMAN

Name: Cholesterol 25-monooxygenase

UniProtKB Accession Codes:

O95992 B2RBY3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 14 DNASU 1 DisGeNET 1 EC 1 EMBL 7 Ensembl 1 GO 13 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 4 STRING 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 9852097

Title: cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism.

PubMed ID: 9852097

DOI: 10.1074/jbc.273.51.34316

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15465627

Title: Association analysis of genes involved in cholesterol metabolism located within the linkage region on chromosome 10 and Alzheimer's disease.

PubMed ID: 15465627

DOI: 10.1016/j.neurobiolaging.2004.01.001

PubMed ID: 16157450

Title: Association studies of cholesterol metabolism genes (CH25H, ABCA1 and CH24H) in Alzheimer's disease.

PubMed ID: 16157450

DOI: 10.1016/j.neulet.2005.08.048

PubMed ID: 32944968

Title: Cholesterol 25-Hydroxylase inhibits SARS-CoV-2 and other coronaviruses by depleting membrane cholesterol.

PubMed ID: 32944968

DOI: 10.15252/embj.2020106057

PubMed ID: 33239446

Title: Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion.

PubMed ID: 33239446

DOI: 10.1073/pnas.2012197117

Sequence Information:

  • Length: 272
  • Mass: 31745
  • Checksum: 0DF46BC21802008B
  • Sequence:
    • MSCHNCSDPQ VLCSSGQLFL QPLWDHLRSW EALLQSPFFP VIFSITTYVG FCLPFVVLDI 
LCSWVPALRR YKIHPDFSPS AQQLLPCLGQ TLYQHVMFVF PVTLLHWARS PALLPHEAPE 
LLLLLHHILF CLLLFDMEFF VWHLLHHKVP WLYRTFHKVH HQNSSSFALA TQYMSVWELF 
SLGFFDMMNV TLLGCHPLTT LTFHVVNIWL SVEDHSGYNF PWSTHRLVPF GWYGGVVHHD 
LHHSHFNCNF APYFTHWDKI LGTLRTASVP AR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.