Details for: NAT8

Gene ID: 9027

Symbol: NAT8

Ensembl ID: ENSG00000144035

Description: N-acetyltransferase 8 (putative)

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.76
    Marker Score: 6,843
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.01
    Marker Score: 10,673
  • Cell Name: T cell (CL0000084)
    Fold Change: 2.09
    Marker Score: 3,596
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.93
    Marker Score: 2,161
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.51
    Marker Score: 1,509
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 875
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 860
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 491
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7,674
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,820
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 801
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.02
    Marker Score: 1,939
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,831
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,056
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 513
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 466
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.96
    Marker Score: 253
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 378
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,349
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.92
    Marker Score: 330
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,744
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,291
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.78
    Marker Score: 455
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 401
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.77
    Marker Score: 1,567
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 505
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.75
    Marker Score: 710
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.74
    Marker Score: 1,194
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.74
    Marker Score: 466
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.73
    Marker Score: 11,455
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 466
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 182
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.62
    Marker Score: 497
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.61
    Marker Score: 370
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.57
    Marker Score: 208
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 151
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 177
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.52
    Marker Score: 376
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.51
    Marker Score: 789
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 479
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.49
    Marker Score: 1,148
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 281
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.44
    Marker Score: 447
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.44
    Marker Score: 232
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.43
    Marker Score: 181
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.43
    Marker Score: 457
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.43
    Marker Score: 435
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.42
    Marker Score: 240
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.42
    Marker Score: 237
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.42
    Marker Score: 250
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.42
    Marker Score: 2,495
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.41
    Marker Score: 411
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 376
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.37
    Marker Score: 456
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.33
    Marker Score: 151
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.32
    Marker Score: 120
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.32
    Marker Score: 74
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.32
    Marker Score: 160
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.3
    Marker Score: 794
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.28
    Marker Score: 133
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.25
    Marker Score: 1,224
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.25
    Marker Score: 65
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.25
    Marker Score: 358
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.25
    Marker Score: 815
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.25
    Marker Score: 113
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.24
    Marker Score: 464
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.24
    Marker Score: 498
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.23
    Marker Score: 210
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 76
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.21
    Marker Score: 46
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.21
    Marker Score: 142
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.19
    Marker Score: 185
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.19
    Marker Score: 109
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.19
    Marker Score: 129
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.18
    Marker Score: 44
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.17
    Marker Score: 77
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.17
    Marker Score: 47
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.17
    Marker Score: 348
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.17
    Marker Score: 111
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.17
    Marker Score: 92
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.16
    Marker Score: 172
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.16
    Marker Score: 84
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.16
    Marker Score: 107
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.16
    Marker Score: 150
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.15
    Marker Score: 388
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.15
    Marker Score: 42
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.14
    Marker Score: 229
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.14
    Marker Score: 44
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.14
    Marker Score: 37
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.12
    Marker Score: 36
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.12
    Marker Score: 33
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.1
    Marker Score: 105
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.1
    Marker Score: 70
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.1
    Marker Score: 19
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.09
    Marker Score: 155

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NAT8 is a member of the N-acetyltransferase family, which is known to catalyze the transfer of an acetyl group from acetyl phosphate to various substrates. This enzyme plays a crucial role in protein modification, including the acetylation of lysine residues, which is essential for various cellular processes. The expression of NAT8 is observed in multiple cell types, including microglial cells, epithelial cells, T cells, and plasma cells, highlighting its involvement in immune regulation and cellular homeostasis. **Pathways and Functions:** NAT8's involvement in amyloid fiber formation and fibril formation suggests its potential role in disease pathogenesis, such as amyloidosis. The enzyme's activity in cysteine-s-conjugate n-acetyltransferase also underscores its importance in maintaining cellular redox balance. Furthermore, NAT8's role in regulating gene expression through positive regulation of gene expression highlights its potential as a transcriptional regulator. Additionally, its association with the endoplasmic reticulum-golgi intermediate compartment and membrane suggests its involvement in protein metabolism and trafficking. **Clinical Significance:** The expression of NAT8 in various cell types and its involvement in immune regulation and cellular homeostasis imply its potential as a biomarker for immune-related disorders, such as multiple sclerosis, rheumatoid arthritis, and autoimmune diseases. Moreover, the enzyme's role in amyloid fiber formation and fibril formation suggests its potential as a therapeutic target for diseases characterized by amyloidosis, such as Alzheimer's disease and amyloidosis. Furthermore, NAT8's involvement in protein metabolism and trafficking highlights its potential as a therapeutic target for diseases characterized by protein misfolding and aggregation, such as Parkinson's disease and Huntington's disease. In conclusion, NAT8's involvement in immune regulation, cellular homeostasis, and disease pathogenesis underscores its potential as a therapeutic target and biomarker for various immune-related disorders. Further research is necessary to elucidate the intricacies of NAT8's role in the immune system and to explore its potential applications in disease prevention and treatment. **Recommendations:** 1. Further investigation into the molecular mechanisms underlying NAT8's role in immune regulation and cellular homeostasis. 2. Elucidation of NAT8's potential as a biomarker for immune-related disorders. 3. Exploration of NAT8 as a therapeutic target for diseases characterized by amyloidosis and protein misfolding and aggregation. 4. Investigation of NAT8's expression and activity in various disease models to better understand its role in disease pathogenesis. By addressing these recommendations, researchers can further unravel the enigmatic role of NAT8 in the immune system and unlock its potential as a therapeutic target and biomarker for various immune-related disorders.

Genular Protein ID: 3969197194

Symbol: NAT8_HUMAN

Name: N-acetyltransferase 8

UniProtKB Accession Codes:

Q9UHE5 O75839 Q6LEU4 Q96QI8 Q9UQ17

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 5 DMDM 1 DNASU 1 DisGeNET 1 EC 3 EMBL 9 Ensembl 2 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9852678

Title: Isolation and mapping of a novel human kidney- and liver-specific gene homologous to the bacterial acetyltransferases.

PubMed ID: 9852678

DOI: 10.1007/s100380050084

PubMed ID: 11397015

Title: Overexpression of camello, a member of a novel protein family, reduces blastomere adhesion and inhibits gastrulation in Xenopus laevis.

PubMed ID: 11397015

DOI: 10.1006/dbio.2001.0261

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19011241

Title: Two endoplasmic reticulum (ER)/ER Golgi intermediate compartment-based lysine acetyltransferases post-translationally regulate BACE1 levels.

PubMed ID: 19011241

DOI: 10.1074/jbc.m804901200

PubMed ID: 20392701

Title: Molecular identification of NAT8 as the enzyme that acetylates cysteine S-conjugates to mercapturic acids.

PubMed ID: 20392701

DOI: 10.1074/jbc.m110.110924

PubMed ID: 22267734

Title: Biochemical inhibition of the acetyltransferases ATase1 and ATase2 reduces beta-secretase (BACE1) levels and Abeta generation.

PubMed ID: 22267734

DOI: 10.1074/jbc.m111.310136

PubMed ID: 24556617

Title: Post-translational regulation of CD133 by ATase1/ATase2-mediated lysine acetylation.

PubMed ID: 24556617

DOI: 10.1016/j.jmb.2014.02.012

Sequence Information:

  • Length: 227
  • Mass: 25619
  • Checksum: B6CEAC98EFB0D6C8
  • Sequence:
    • MAPCHIRKYQ ESDRQWVVGL LSRGMAEHAP ATFRQLLKLP RTLILLLGGP LALLLVSGSW 
LLALVFSISL FPALWFLAKK PWTEYVDMTL CTDMSDITKS YLSERGSCFW VAESEEKVVG 
MVGALPVDDP TLREKRLQLF HLFVDSEHRR QGIAKALVRT VLQFARDQGY SEVILDTGTI 
QLSAMALYQS MGFKKTGQSF FCVWARLVAL HTVHFIYHLP SSKVGSL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.