BAZ1B | ENSG00000009954 | NCBI 9031

Details for: BAZ1B

Gene ID: 9031

Symbol: BAZ1B

Ensembl ID: ENSG00000009954

Description: bromodomain adjacent to zinc finger domain 1B

Associated with

B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Dna double-strand break repair
(R-HSA-5693532)
Dna double strand break response
(R-HSA-5693606)
Dna repair
(R-HSA-73894)
Epigenetic regulation of gene expression
(R-HSA-212165)
Gene expression (transcription)
(R-HSA-74160)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-HSA-5693565)
Atp binding
(GO:0005524)
B-wich complex
(GO:0110016)
Chromatin remodeling
(GO:0006338)
Condensed chromosome
(GO:0000793)
Dna damage response
(GO:0006974)
Histone binding
(GO:0042393)
Histone h2axy142 kinase activity
(GO:0140801)
Histone kinase activity
(GO:0035173)
Negative regulation of mitotic chromosome condensation
(GO:1905213)
Non-membrane spanning protein tyrosine kinase activity
(GO:0004715)
Nuclear replication fork
(GO:0043596)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Pericentric heterochromatin
(GO:0005721)
Phosphorylation
(GO:0016310)
Positive regulation of transcription by rna polymerase i
(GO:0045943)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of transcription by rna polymerase iii
(GO:0045945)
Post-translational protein modification
(GO:0043687)
Protein binding
(GO:0005515)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Wich complex
(GO:0090535)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Tyrosine-protein kinase BAZ1B

Genular Protein ID: 1288322588

Symbol: BAZ1B_HUMAN

Name: Tyrosine-protein kinase BAZ1B

UniProtKB Accession Codes:

Q9UIG0 B9EGK3 D3DXE9 O95039 O95247 O95277 Q6P1K4 Q86UJ6

Database IDs:

Citations:

PubMed ID: 9858827

Title: Identification of the WBSCR9 gene, encoding a novel transcriptional regulator, in the Williams-Beuren syndrome deletion at 7q11.23.

PubMed ID: 9858827

DOI: 10.1159/000015110

PubMed ID: 9828126

Title: A novel human gene, WSTF, is deleted in Williams Syndrome.

PubMed ID: 9828126

DOI: 10.1006/geno.1998.5578

PubMed ID: 10662543

Title: A novel family of bromodomain genes.

PubMed ID: 10662543

DOI: 10.1006/geno.1999.6071

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11980720

Title: WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci.

PubMed ID: 11980720

DOI: 10.1093/emboj/21.9.2231

PubMed ID: 15543136

Title: The Williams syndrome transcription factor interacts with PCNA to target chromatin remodelling by ISWI to replication foci.

PubMed ID: 15543136

DOI: 10.1038/ncb1196

PubMed ID: 16252006

Title: Ligand-induced transrepression by VDR through association of WSTF with acetylated histones.

PubMed ID: 16252006

DOI: 10.1038/sj.emboj.7600853

PubMed ID: 25452584

Title: Retraction: 'Ligand-induced transrepression by VDR through association of WSTF with acetylated histones'.

PubMed ID: 25452584

DOI: 10.15252/embj.201470110

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16603771

Title: The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription.

PubMed ID: 16603771

DOI: 10.1074/jbc.m600233200

PubMed ID: 18162579

Title: Identification of novel human Cdt1-binding proteins by a proteomics approach: proteolytic regulation by APC/CCdh1.

PubMed ID: 18162579

DOI: 10.1091/mbc.e07-09-0859

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19092802

Title: WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity.

PubMed ID: 19092802

DOI: 10.1038/nature07668

PubMed ID: 19234442

Title: Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions.

PubMed ID: 19234442

DOI: 10.1038/nature07849

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25593309

Title: Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.

PubMed ID: 25593309

DOI: 10.1101/gad.252189.114

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28801535

Title: Expansion of the ISWI chromatin remodeler family with new active complexes.

PubMed ID: 28801535

DOI: 10.15252/embr.201744011

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 11124022

Title: Structure of the PHD zinc finger from human Williams-Beuren syndrome transcription factor.

PubMed ID: 11124022

DOI: 10.1006/jmbi.2000.4308

Sequence Information:

Length: 1483
Mass: 170903
Checksum: 0CC146FEBB954261
Sequence:

MAPLLGRKPF PLVKPLPGEE PLFTIPHTQE AFRTREEYEA RLERYSERIW TCKSTGSSQL 
THKEAWEEEQ EVAELLKEEF PAWYEKLVLE MVHHNTASLE KLVDTAWLEI MTKYAVGEEC 
DFEVGKEKML KVKIVKIHPL EKVDEEATEK KSDGACDSPS SDKENSSQIA QDHQKKETVV 
KEDEGRRESI NDRARRSPRK LPTSLKKGER KWAPPKFLPH KYDVKLQNED KIISNVPADS 
LIRTERPPNK EIVRYFIRHN ALRAGTGENA PWVVEDELVK KYSLPSKFSD FLLDPYKYMT 
LNPSTKRKNT GSPDRKPSKK SKTDNSSLSS PLNPKLWCHV HLKKSLSGSP LKVKNSKNSK 
SPEEHLEEMM KMMSPNKLHT NFHIPKKGPP AKKPGKHSDK PLKAKGRSKG ILNGQKSTGN 
SKSPKKGLKT PKTKMKQMTL LDMAKGTQKM TRAPRNSGGT PRTSSKPHKH LPPAALHLIA 
YYKENKDRED KRSALSCVIS KTARLLSSED RARLPEELRS LVQKRYELLE HKKRWASMSE 
EQRKEYLKKK REELKKKLKE KAKERREKEM LERLEKQKRY EDQELTGKNL PAFRLVDTPE 
GLPNTLFGDV AMVVEFLSCY SGLLLPDAQY PITAVSLMEA LSADKGGFLY LNRVLVILLQ 
TLLQDEIAED YGELGMKLSE IPLTLHSVSE LVRLCLRRSD VQEESEGSDT DDNKDSAAFE 
DNEVQDEFLE KLETSEFFEL TSEEKLQILT ALCHRILMTY SVQDHMETRQ QMSAELWKER 
LAVLKEENDK KRAEKQKRKE MEAKNKENGK VENGLGKTDR KKEIVKFEPQ VDTEAEDMIS 
AVKSRRLLAI QAKKEREIQE REMKVKLERQ AEEERIRKHK AAAEKAFQEG IAKAKLVMRR 
TPIGTDRNHN RYWLFSDEVP GLFIEKGWVH DSIDYRFNHH CKDHTVSGDE DYCPRSKKAN 
LGKNASMNTQ HGTATEVAVE TTTPKQGQNL WFLCDSQKEL DELLNCLHPQ GIRESQLKER 
LEKRYQDIIH SIHLARKPNL GLKSCDGNQE LLNFLRSDLI EVATRLQKGG LGYVEETSEF 
EARVISLEKL KDFGECVIAL QASVIKKFLQ GFMAPKQKRR KLQSEDSAKT EEVDEEKKMV 
EEAKVASALE KWKTAIREAQ TFSRMHVLLG MLDACIKWDM SAENARCKVC RKKGEDDKLI 
LCDECNKAFH LFCLRPALYE VPDGEWQCPA CQPATARRNS RGRNYTEESA SEDSEDDESD 
EEEEEEEEEE EEEDYEVAGL RLRPRKTIRG KHSVIPPAAR SGRRPGKKPH STRRSQPKAP 
PVDDAEVDEL VLQTKRSSRR QSLELQKCEE ILHKIVKYRF SWPFREPVTR DEAEDYYDVI 
THPMDFQTVQ NKCSCGSYRS VQEFLTDMKQ VFTNAEVYNC RGSHVLSCMV KTEQCLVALL 
HKHLPGHPYV RRKRKKFPDR LAEDEGDSEP EAVGQSRGRR QKK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: BAZ1B

Associated with

Other Information

Identification of the WBSCR9 gene, encoding a novel transcriptional regulator, in the Williams-Beuren syndrome deletion at 7q11.23. PubMed ID: 9858827

A novel human gene, WSTF, is deleted in Williams Syndrome. PubMed ID: 9828126

A novel family of bromodomain genes. PubMed ID: 10662543

The DNA sequence of human chromosome 7. PubMed ID: 12853948

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci. PubMed ID: 11980720

The Williams syndrome transcription factor interacts with PCNA to target chromatin remodelling by ISWI to replication foci. PubMed ID: 15543136

Ligand-induced transrepression by VDR through association of WSTF with acetylated histones. PubMed ID: 16252006

Retraction: 'Ligand-induced transrepression by VDR through association of WSTF with acetylated histones'. PubMed ID: 25452584

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription. PubMed ID: 16603771

Identification of novel human Cdt1-binding proteins by a proteomics approach: proteolytic regulation by APC/CCdh1. PubMed ID: 18162579

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity. PubMed ID: 19092802

Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions. PubMed ID: 19234442

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Uncovering global SUMOylation signaling networks in a site-specific manner. PubMed ID: 25218447

Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. PubMed ID: 25114211

Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination. PubMed ID: 25593309

System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability. PubMed ID: 25755297

Expansion of the ISWI chromatin remodeler family with new active complexes. PubMed ID: 28801535

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Structure of the PHD zinc finger from human Williams-Beuren syndrome transcription factor. PubMed ID: 11124022