Details for: BAZ1B
Gene ID: 9031
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: BAZ1B
Ensembl ID: ENSG00000009954
Description: bromodomain adjacent to zinc finger domain 1B
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 21.56rCSI 26.24%PRS 28.05
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CSI 11.15rCSI 35.69%PRS 18.35
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CSI 11.04rCSI 7.34%PRS 26.91
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CSI 10.49rCSI 10.47%PRS 19.19
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CSI 9.92rCSI 14.03%PRS 31.52
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CSI 7.48rCSI 42.29%PRS 13.12
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CSI 7.06rCSI 6.8%PRS 23.23
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CSI 6.59rCSI 8.97%PRS 33.8
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CSI 6.56rCSI 17.41%PRS 34.76
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CSI 5.81rCSI 14.76%PRS 22.37
-
CSI 5.8rCSI 5.09%PRS 26
-
CSI 5.69rCSI 7.16%PRS 34.31
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CSI 5.56rCSI 10.61%PRS 35.07
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CSI 5.49rCSI 7.48%PRS 19.67
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CSI 5.41rCSI 15.22%PRS 29.3
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CSI 5.37rCSI 7.18%PRS 42.14
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CSI 4.98rCSI 14.21%PRS 37.34
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CSI 4.91rCSI 12.96%PRS 26.77
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CSI 4.85rCSI 18.9%PRS 36.78
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CSI 4.85rCSI 7.8%PRS 17.1
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CSI 4.7rCSI 16.93%PRS 12.51
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CSI 4.7rCSI 6.4%PRS 50.75
-
CSI 4.43rCSI 6.42%PRS 34.17
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CSI 4.24rCSI 16.13%PRS 21.58
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CSI 4.01rCSI 4.63%PRS 19.46
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CSI 3.91rCSI 21.11%PRS 37.61
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CSI 3.87rCSI 6.03%PRS 49.8
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CSI 3.66rCSI 2.74%PRS 35.42
-
CSI 3.5rCSI 30.81%PRS 16.34
-
CSI 3.21rCSI 6.02%PRS 16.16
-
CSI 3.21rCSI 4%PRS 31.71
-
CSI 3.18rCSI 7.25%PRS 23.06
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CSI 3.12rCSI 15.64%PRS 29.79
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CSI 3.08rCSI 3.95%PRS 21.49
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CSI 3.08rCSI 2.14%PRS 27.17
-
CSI 3.06rCSI 2.68%PRS 29.91
-
CSI 2.99rCSI 11.19%PRS 18.82
-
CSI 2.97rCSI 2.92%PRS 34.96
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CSI 2.96rCSI 2.39%PRS 34.52
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CSI 2.95rCSI 31.28%PRS 28.72
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CSI 2.87rCSI 2.13%PRS 33.11
-
CSI 2.86rCSI 4.55%PRS 18.94
-
CSI 2.86rCSI 3.35%PRS 25.69
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CSI 2.82rCSI 3.85%PRS 24.96
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CSI 2.8rCSI 66.99%PRS 11.84
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CSI 2.71rCSI 65.28%PRS 12.76
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CSI 2.62rCSI 2.1%PRS 39.86
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CSI 2.57rCSI 4.87%PRS 57.48
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CSI 2.5rCSI 1.94%PRS 21.62
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CSI 2.49rCSI 2.35%PRS 23.58
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CSI 2.42rCSI 3.43%PRS 20.79
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CSI 2.32rCSI 2.06%PRS 22.63
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CSI 2.3rCSI 10.12%PRS 20.72
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CSI 2.26rCSI 10.85%PRS 18.27
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CSI 2.22rCSI 2.27%PRS 32.1
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CSI 2.18rCSI 5.83%PRS 18.69
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CSI 2.16rCSI 2.96%PRS 25.33
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CSI 2.14rCSI 2.93%PRS 34.16
-
CSI 2.11rCSI 1.78%PRS 35.5
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CSI 2.09rCSI 10.3%PRS 30.21
-
CSI 2.08rCSI 4.94%PRS 27.77
-
CSI 2.08rCSI 6.67%PRS 31.27
-
CSI 2.07rCSI 4.63%PRS 26.38
-
CSI 2.07rCSI 2.56%PRS 19.67
-
CSI 2.07rCSI 4.72%PRS 21.93
-
CSI 2.05rCSI 1.6%PRS 33.07
-
CSI 2.05rCSI 8.26%PRS 20.5
-
CSI 2.05rCSI 1.63%PRS 40.08
-
CSI 2.03rCSI 3.55%PRS 17.17
-
CSI 2.03rCSI 11.68%PRS 28.26
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CSI 2.02rCSI 1.6%PRS 15.4
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CSI 2.02rCSI 5.99%PRS 31.32
-
CSI 2.01rCSI 10.36%PRS 43.13
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CSI 2rCSI 5.92%PRS 26.38
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CSI 1.96rCSI 3.57%PRS 34.1
-
CSI 1.95rCSI 1.61%PRS 22.87
-
CSI 1.94rCSI 1.57%PRS 23.58
-
CSI 1.92rCSI 1.38%PRS 31.14
-
CSI 1.89rCSI 1.97%PRS 23
-
CSI 1.85rCSI 2.17%PRS 31.38
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CSI 1.83rCSI 2%PRS 25.19
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CSI 1.83rCSI 10.76%PRS 13.92
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CSI 1.82rCSI 4.16%PRS 19.22
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CSI 1.82rCSI 3.11%PRS 44.9
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CSI 1.82rCSI 4.27%PRS 32
-
CSI 1.82rCSI 2.9%PRS 19.07
-
CSI 1.81rCSI 2.97%PRS 17.18
-
CSI 1.8rCSI 2.3%PRS 25.98
-
CSI 1.78rCSI 2.73%PRS 30.16
-
CSI 1.75rCSI 1.38%PRS 27.29
-
CSI 1.73rCSI 8.88%PRS 24.27
-
CSI 1.73rCSI 1.81%PRS 23.81
-
CSI 1.73rCSI 2.31%PRS 28.84
-
CSI 1.67rCSI 4.35%PRS 20.98
-
CSI 1.66rCSI 1.27%PRS 29.84
-
CSI 1.66rCSI 1.6%PRS 16.36
-
CSI 1.65rCSI 2.39%PRS 31.31
-
CSI 1.64rCSI 1.5%PRS 34.32
-
CSI 1.63rCSI 2.59%PRS 28.79
-
CSI 1.62rCSI 1.13%PRS 31.85
-
CSI 0.0rCSI 0.1%PRS 42.4%
-
CSI 0.1rCSI 1.0%PRS 39.0%
-
CSI 0.1rCSI 2.0%PRS 60.0%
-
CSI 0.1rCSI 0.7%PRS 33.2%
-
CSI 0.1rCSI 1.7%PRS 61.0%
-
CSI 0.2rCSI 1.8%PRS 42.1%
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CSI 0.2rCSI 4.4%PRS 41.4%
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CSI 0.2rCSI 1.0%PRS 65.8%
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CSI 0.2rCSI 0.4%PRS 28.5%
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CSI 0.2rCSI 3.9%PRS 19.6%
-
CSI 0.2rCSI 4.0%PRS 18.5%
-
CSI 0.2rCSI 0.8%PRS 36.1%
-
CSI 0.3rCSI 3.8%PRS 51.8%
-
CSI 0.3rCSI 1.5%PRS 49.7%
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CSI 0.3rCSI 4.6%PRS 21.8%
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CSI 0.3rCSI 1.3%PRS 37.9%
-
CSI 0.3rCSI 1.9%PRS 33.0%
-
CSI 0.3rCSI 4.8%PRS 17.7%
-
CSI 0.3rCSI 0.3%PRS 26.6%
-
CSI 0.4rCSI 2.0%PRS 33.1%
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CSI 0.4rCSI 2.6%PRS 13.7%
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CSI 0.4rCSI 1.9%PRS 24.4%
-
CSI 0.4rCSI 1.7%PRS 38.5%
-
CSI 0.4rCSI 1.9%PRS 47.4%
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CSI 0.4rCSI 0.7%PRS 13.2%
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CSI 0.5rCSI 1.3%PRS 34.6%
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CSI 0.5rCSI 2.0%PRS 40.7%
-
CSI 0.5rCSI 0.6%PRS 38.9%
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CSI 0.5rCSI 3.1%PRS 54.3%
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CSI 0.5rCSI 3.0%PRS 17.5%
-
CSI 0.5rCSI 3.1%PRS 34.2%
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CSI 0.5rCSI 1.5%PRS 25.2%
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CSI 0.5rCSI 2.0%PRS 13.8%
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CSI 0.5rCSI 1.3%PRS 35.5%
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CSI 0.5rCSI 1.2%PRS 16.0%
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CSI 0.5rCSI 0.4%PRS 37.7%
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CSI 0.6rCSI 1.1%PRS 23.1%
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CSI 0.6rCSI 2.5%PRS 15.5%
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CSI 0.6rCSI 1.5%PRS 43.2%
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CSI 0.6rCSI 0.8%PRS 30.1%
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CSI 0.6rCSI 2.0%PRS 38.4%
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CSI 0.6rCSI 2.0%PRS 62.7%
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CSI 0.6rCSI 1.4%PRS 32.8%
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CSI 0.6rCSI 2.6%PRS 65.4%
-
CSI 0.6rCSI 1.9%PRS 15.1%
-
CSI 0.6rCSI 2.1%PRS 19.6%
-
CSI 0.6rCSI 3.4%PRS 67.9%
-
CSI 0.6rCSI 1.5%PRS 15.1%
-
CSI 0.7rCSI 3.9%PRS 38.6%
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CSI 0.7rCSI 1.8%PRS 29.1%
-
CSI 0.7rCSI 1.1%PRS 30.4%
-
CSI 0.7rCSI 1.6%PRS 20.8%
-
CSI 0.7rCSI 3.1%PRS 43.7%
-
CSI 0.7rCSI 3.2%PRS 53.0%
-
CSI 0.7rCSI 2.3%PRS 23.3%
-
CSI 0.7rCSI 2.5%PRS 38.6%
-
CSI 0.7rCSI 2.1%PRS 49.1%
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CSI 0.7rCSI 0.9%PRS 25.9%
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CSI 0.7rCSI 1.2%PRS 14.5%
-
CSI 0.8rCSI 1.1%PRS 17.4%
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CSI 0.8rCSI 0.9%PRS 21.8%
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CSI 0.8rCSI 1.4%PRS 20.8%
-
CSI 0.8rCSI 0.8%PRS 26.5%
-
CSI 0.8rCSI 1.2%PRS 25.6%
-
CSI 0.8rCSI 2.0%PRS 22.8%
-
CSI 0.8rCSI 1.2%PRS 20.7%
-
CSI 0.8rCSI 1.0%PRS 16.6%
-
CSI 0.8rCSI 1.5%PRS 21.9%
-
CSI 0.8rCSI 0.9%PRS 20.7%
-
CSI 0.8rCSI 1.3%PRS 27.1%
-
CSI 0.8rCSI 1.3%PRS 23.0%
-
CSI 0.9rCSI 2.2%PRS 55.4%
-
CSI 0.9rCSI 0.6%PRS 27.9%
-
CSI 0.9rCSI 1.5%PRS 13.3%
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CSI 0.9rCSI 1.8%PRS 37.6%
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CSI 0.9rCSI 2.7%PRS 33.3%
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CSI 0.9rCSI 0.7%PRS 21.0%
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CSI 0.9rCSI 1.4%PRS 21.0%
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CSI 0.9rCSI 2.2%PRS 33.2%
-
CSI 0.9rCSI 1.1%PRS 27.2%
-
CSI 0.9rCSI 15.4%PRS 66.2%
-
CSI 0.9rCSI 1.3%PRS 23.8%
-
CSI 0.9rCSI 2.4%PRS 53.7%
-
CSI 0.9rCSI 8.0%PRS 12.1%
-
CSI 0.9rCSI 2.2%PRS 33.5%
-
CSI 0.9rCSI 1.8%PRS 42.9%
-
CSI 1.0rCSI 1.3%PRS 24.6%
-
CSI 1.0rCSI 2.8%PRS 17.3%
-
CSI 1.0rCSI 2.1%PRS 25.8%
-
CSI 1.0rCSI 1.7%PRS 17.1%
-
CSI 1.0rCSI 1.5%PRS 29.3%
-
CSI 1.0rCSI 1.5%PRS 36.0%
-
CSI 1.0rCSI 2.7%PRS 36.5%
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CSI 1.0rCSI 1.9%PRS 49.9%
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CSI 1.0rCSI 0.9%PRS 25.4%
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CSI 1.0rCSI 1.5%PRS 20.7%
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CSI 1.0rCSI 0.9%PRS 16.3%
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CSI 1.0rCSI 1.1%PRS 21.0%
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CSI 1.0rCSI 2.3%PRS 13.9%
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CSI 1.0rCSI 2.4%PRS 50.0%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1288322588
Symbol: BAZ1B_HUMAN
Name: Tyrosine-protein kinase BAZ1B
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9858827
Title: Identification of the WBSCR9 gene, encoding a novel transcriptional regulator, in the Williams-Beuren syndrome deletion at 7q11.23.
PubMed ID: 9858827
DOI: 10.1159/000015110
PubMed ID: 9828126
Title: A novel human gene, WSTF, is deleted in Williams Syndrome.
PubMed ID: 9828126
PubMed ID: 10662543
PubMed ID: 12853948
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11980720
Title: WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci.
PubMed ID: 11980720
PubMed ID: 15543136
Title: The Williams syndrome transcription factor interacts with PCNA to target chromatin remodelling by ISWI to replication foci.
PubMed ID: 15543136
DOI: 10.1038/ncb1196
PubMed ID: 16252006
Title: Ligand-induced transrepression by VDR through association of WSTF with acetylated histones.
PubMed ID: 16252006
PubMed ID: 25452584
Title: Retraction: 'Ligand-induced transrepression by VDR through association of WSTF with acetylated histones'.
PubMed ID: 25452584
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16603771
Title: The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription.
PubMed ID: 16603771
PubMed ID: 18162579
Title: Identification of novel human Cdt1-binding proteins by a proteomics approach: proteolytic regulation by APC/CCdh1.
PubMed ID: 18162579
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19092802
Title: WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity.
PubMed ID: 19092802
DOI: 10.1038/nature07668
PubMed ID: 19234442
Title: Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions.
PubMed ID: 19234442
DOI: 10.1038/nature07849
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25218447
Title: Uncovering global SUMOylation signaling networks in a site-specific manner.
PubMed ID: 25218447
DOI: 10.1038/nsmb.2890
PubMed ID: 25114211
Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.
PubMed ID: 25114211
PubMed ID: 25593309
Title: Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.
PubMed ID: 25593309
PubMed ID: 25755297
Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.
PubMed ID: 25755297
PubMed ID: 28801535
Title: Expansion of the ISWI chromatin remodeler family with new active complexes.
PubMed ID: 28801535
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 11124022
Title: Structure of the PHD zinc finger from human Williams-Beuren syndrome transcription factor.
PubMed ID: 11124022
Sequence Information:
- Length: 1483
- Mass: 170903
- Checksum: 0CC146FEBB954261
- Sequence:
MAPLLGRKPF PLVKPLPGEE PLFTIPHTQE AFRTREEYEA RLERYSERIW TCKSTGSSQL THKEAWEEEQ EVAELLKEEF PAWYEKLVLE MVHHNTASLE KLVDTAWLEI MTKYAVGEEC DFEVGKEKML KVKIVKIHPL EKVDEEATEK KSDGACDSPS SDKENSSQIA QDHQKKETVV KEDEGRRESI NDRARRSPRK LPTSLKKGER KWAPPKFLPH KYDVKLQNED KIISNVPADS LIRTERPPNK EIVRYFIRHN ALRAGTGENA PWVVEDELVK KYSLPSKFSD FLLDPYKYMT LNPSTKRKNT GSPDRKPSKK SKTDNSSLSS PLNPKLWCHV HLKKSLSGSP LKVKNSKNSK SPEEHLEEMM KMMSPNKLHT NFHIPKKGPP AKKPGKHSDK PLKAKGRSKG ILNGQKSTGN SKSPKKGLKT PKTKMKQMTL LDMAKGTQKM TRAPRNSGGT PRTSSKPHKH LPPAALHLIA YYKENKDRED KRSALSCVIS KTARLLSSED RARLPEELRS LVQKRYELLE HKKRWASMSE EQRKEYLKKK REELKKKLKE KAKERREKEM LERLEKQKRY EDQELTGKNL PAFRLVDTPE GLPNTLFGDV AMVVEFLSCY SGLLLPDAQY PITAVSLMEA LSADKGGFLY LNRVLVILLQ TLLQDEIAED YGELGMKLSE IPLTLHSVSE LVRLCLRRSD VQEESEGSDT DDNKDSAAFE DNEVQDEFLE KLETSEFFEL TSEEKLQILT ALCHRILMTY SVQDHMETRQ QMSAELWKER LAVLKEENDK KRAEKQKRKE MEAKNKENGK VENGLGKTDR KKEIVKFEPQ VDTEAEDMIS AVKSRRLLAI QAKKEREIQE REMKVKLERQ AEEERIRKHK AAAEKAFQEG IAKAKLVMRR TPIGTDRNHN RYWLFSDEVP GLFIEKGWVH DSIDYRFNHH CKDHTVSGDE DYCPRSKKAN LGKNASMNTQ HGTATEVAVE TTTPKQGQNL WFLCDSQKEL DELLNCLHPQ GIRESQLKER LEKRYQDIIH SIHLARKPNL GLKSCDGNQE LLNFLRSDLI EVATRLQKGG LGYVEETSEF EARVISLEKL KDFGECVIAL QASVIKKFLQ GFMAPKQKRR KLQSEDSAKT EEVDEEKKMV EEAKVASALE KWKTAIREAQ TFSRMHVLLG MLDACIKWDM SAENARCKVC RKKGEDDKLI LCDECNKAFH LFCLRPALYE VPDGEWQCPA CQPATARRNS RGRNYTEESA SEDSEDDESD EEEEEEEEEE EEEDYEVAGL RLRPRKTIRG KHSVIPPAAR SGRRPGKKPH STRRSQPKAP PVDDAEVDEL VLQTKRSSRR QSLELQKCEE ILHKIVKYRF SWPFREPVTR DEAEDYYDVI THPMDFQTVQ NKCSCGSYRS VQEFLTDMKQ VFTNAEVYNC RGSHVLSCMV KTEQCLVALL HKHLPGHPYV RRKRKKFPDR LAEDEGDSEP EAVGQSRGRR QKK