Details for: PKD2L1
Associated with
Other Information
Genular Protein ID: 3679054659
Symbol: PK2L1_HUMAN
Name: Polycystin-2-like protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9748274
Title: Identification of PKDL, a novel polycystic kidney disease 2-like gene whose murine homologue is deleted in mice with kidney and retinal defects.
PubMed ID: 9748274
PubMed ID: 10602992
Title: The human polycystic kidney disease 2-like (PKDL) gene: exon/intron structure and evidence for a novel splicing mechanism.
PubMed ID: 10602992
PubMed ID: 15164054
Title: The DNA sequence and comparative analysis of human chromosome 10.
PubMed ID: 15164054
DOI: 10.1038/nature02462
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9878261
Title: Identification of PKD2L, a human PKD2-related gene: tissue-specific expression and mapping to chromosome 10q25.
PubMed ID: 9878261
PubMed ID: 10602361
Title: Genes homologous to the autosomal dominant polycystic kidney disease genes (PKD1 and PKD2).
PubMed ID: 10602361
PubMed ID: 10517637
Title: Polycystin-L is a calcium-regulated cation channel permeable to calcium ions.
PubMed ID: 10517637
DOI: 10.1038/43907
PubMed ID: 11959145
Title: The calcium-binding EF-hand in polycystin-L is not a domain for channel activation and ensuing inactivation.
PubMed ID: 11959145
PubMed ID: 19812697
Title: Sour ageusia in two individuals implicates ion channels of the ASIC and PKD families in human sour taste perception at the anterior tongue.
PubMed ID: 19812697
PubMed ID: 20408813
Title: Identification of the structural motif responsible for trimeric assembly of the C-terminal regulatory domains of polycystin channels PKD2L1 and PKD2.
PubMed ID: 20408813
DOI: 10.1042/bj20091843
PubMed ID: 22174419
Title: Receptor for activated C kinase 1 (RACK1) inhibits function of transient receptor potential (TRP)-type channel Pkd2L1 through physical interaction.
PubMed ID: 22174419
PubMed ID: 24336289
Title: Direct recording and molecular identification of the calcium channel of primary cilia.
PubMed ID: 24336289
DOI: 10.1038/nature12832
PubMed ID: 25820328
Title: A novel PKD2L1 C-terminal domain critical for trimerization and channel function.
PubMed ID: 25820328
DOI: 10.1038/srep09460
PubMed ID: 27754867
Title: Regulation of TRPP3 Channel Function by N-terminal Domain Palmitoylation and Phosphorylation.
PubMed ID: 27754867
PubMed ID: 29425510
Title: Direct Binding between Pre-S1 and TRP-like Domains in TRPP Channels Mediates Gating and Functional Regulation by PIP2.
PubMed ID: 29425510
PubMed ID: 22193359
Title: Crystal structure and characterization of coiled-coil domain of the transient receptor potential channel PKD2L1.
PubMed ID: 22193359
PubMed ID: 23212381
Title: Molecular mechanism of the assembly of an acid-sensing receptor ion channel complex.
PubMed ID: 23212381
DOI: 10.1038/ncomms2257
PubMed ID: 30004384
Title: Cryo-EM structure of the polycystin 2-l1 ion channel.
PubMed ID: 30004384
DOI: 10.7554/elife.36931
Sequence Information:
- Length: 805
- Mass: 91982
- Checksum: 3714C07F4B71F9C6
- Sequence:
MNAVGSPEGQ ELQKLGSGAW DNPAYSGPPS PHGTLRVCTI SSTGPLQPQP KKPEDEPQET AYRTQVSSCC LHICQGIRGL WGTTLTENTA ENRELYIKTT LRELLVYIVF LVDICLLTYG MTSSSAYYYT KVMSELFLHT PSDTGVSFQA ISSMADFWDF AQGPLLDSLY WTKWYNNQSL GHGSHSFIYY ENMLLGVPRL RQLKVRNDSC VVHEDFREDI LSCYDVYSPD KEEQLPFGPF NGTAWTYHSQ DELGGFSHWG RLTSYSGGGY YLDLPGSRQG SAEALRALQE GLWLDRGTRV VFIDFSVYNA NINLFCVLRL VVEFPATGGA IPSWQIRTVK LIRYVSNWDF FIVGCEVIFC VFIFYYVVEE ILELHIHRLR YLSSIWNILD LVVILLSIVA VGFHIFRTLE VNRLMGKLLQ QPNTYADFEF LAFWQTQYNN MNAVNLFFAW IKIFKYISFN KTMTQLSSTL ARCAKDILGF AVMFFIVFFA YAQLGYLLFG TQVENFSTFI KCIFTQFRII LGDFDYNAID NANRILGPAY FVTYVFFVFF VLLNMFLAII NDTYSEVKEE LAGQKDELQL SDLLKQGYNK TLLRLRLRKE RVSDVQKVLQ GGEQEIQFED FTNTLRELGH AEHEITELTA TFTKFDRDGN RILDEKEQEK MRQDLEEERV ALNTEIEKLG RSIVSSPQGK SGPEAARAGG WVSGEEFYML TRRVLQLETV LEGVVSQIDA VGSKLKMLER KGWLAPSPGV KEQAIWKHPQ PAPAVTPDPW GVQGGQESEV PYKREEEALE ERRLSRGEIP TLQRS
Genular Protein ID: 226492941
Symbol: Q1L4F0_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 16537653
Title: Polycystin-2 traffics to cilia independently of polycystin-1 by using an N-terminal RVxP motif.
PubMed ID: 16537653
DOI: 10.1242/jcs.02818
Sequence Information:
- Length: 758
- Mass: 86972
- Checksum: CFD8837B8227088D
- Sequence:
MNPRRRHTGP RCPAAASISV KASEASLPCP LGLWGTTLTE NTAENRELYI KTTLRELLVY IVFLVDICLL TYGMTSSSAY YYTKVMSELF FHTPSDTGVS FQAISSMADF WDFAQGPLLD SLYWTKWYNN QSLGHGSHSF IYYENMLLGV PRLRQLKVRN DSCVVHEDFR EDILSCYDVY SPDKEEQLPF GPFNGTAWTY HSQDELGGFS HWGRLTSYSG GGYYLDLPGS RQGSAEALRA LQEGLWLDRG TRVVFIDFSV YNANINLFCV LRLVVEFPAT GGAIPSWQIR TVKLIRYVSN WDFFIVGCEV IFCVFIFYYV VEEILELHIH RLRYLSSIWN ILDLVVILLS IVAVGFHIFR TLEVNRLMGK LLQQPNTYAD FEFLAFWQTQ YNNMNAVNLF FAWIKIFKYI SFNKTMTQLS STLARCAKDI LGFAVMFFIV FFAYAQLGYL LFGTQVENFS TFIKCIFTQF RIILGDFDYN AIDNANRILG PAYFVTYVFF VFFVLLNMFL AIINDTYSEV KEELAGQKDE LQLSDLLKQG YNKTLLRLRL RKERVSDVQK VLQGGEQEIQ FEDFTNTLRE LGHAEHEITE LTATFTKFDR DGNRILDEKE QEKMRQDLEE ERVALNTEIE KLGRSIVSSP QGKSGPEAAR AGGWVSGEEF YMLTRRVLQL ETVLEGVVSQ IDAVGSKLKM LERKGWLAPS PGVKEQAIWK HPQPAPAVTP DPWGVQGGQE SEVPYKREEE ALEERRLSRG EIPTLQRS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.