SEMA5A | ENSG00000112902 | NCBI 9037

Details for: SEMA5A

Gene ID: 9037

Symbol: SEMA5A

Ensembl ID: ENSG00000112902

Description: semaphorin 5A

Associated with

Defective b3galtl causes pps
(R-HSA-5083635)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases associated with o-glycosylation of proteins
(R-HSA-3906995)
Diseases of glycosylation
(R-HSA-3781865)
Diseases of metabolism
(R-HSA-5668914)
Metabolism of proteins
(R-HSA-392499)
O-glycosylation of tsr domain-containing proteins
(R-HSA-5173214)
O-linked glycosylation
(R-HSA-5173105)
Other semaphorin interactions
(R-HSA-416700)
Post-translational protein modification
(R-HSA-597592)
Semaphorin interactions
(R-HSA-373755)
Axonal fasciculation
(GO:0007413)
Axon extension
(GO:0048675)
Axon guidance
(GO:0007411)
Blood vessel endothelial cell proliferation involved in sprouting angiogenesis
(GO:0002043)
Cell-cell signaling
(GO:0007267)
Cell adhesion
(GO:0007155)
Cell chemotaxis
(GO:0060326)
Chemorepellent activity
(GO:0045499)
Chondroitin sulfate proteoglycan binding
(GO:0035373)
Diencephalon development
(GO:0021536)
Extracellular exosome
(GO:0070062)
Heparan sulfate proteoglycan binding
(GO:0043395)
Membrane
(GO:0016020)
Negative chemotaxis
(GO:0050919)
Negative regulation of axon extension involved in axon guidance
(GO:0048843)
Negative regulation of cell adhesion
(GO:0007162)
Negative regulation of endothelial cell apoptotic process
(GO:2000352)
Nervous system development
(GO:0007399)
Neural crest cell migration
(GO:0001755)
Plasma membrane
(GO:0005886)
Positive chemotaxis
(GO:0050918)
Positive regulation of actin filament depolymerization
(GO:0030836)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of axon extension involved in axon guidance
(GO:0048842)
Positive regulation of canonical wnt signaling pathway
(GO:0090263)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of endothelial cell chemotaxis
(GO:2001028)
Positive regulation of endothelial cell proliferation
(GO:0001938)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Semaphorin-plexin signaling pathway
(GO:0071526)
Semaphorin receptor binding
(GO:0030215)
Signal clustering
(GO:1990256)
Syndecan binding
(GO:0045545)

Other Information

Proteins

Semaphorin-5A

Genular Protein ID: 2818616549

Symbol: SEM5A_HUMAN

Name: Semaphorin-5A

UniProtKB Accession Codes:

Q13591 D3DTC6 O60408 Q1RLL9

Database IDs:

Citations:

PubMed ID: 9464278

Title: Molecular cloning and mapping of human semaphorin F from the Cri-du-chat candidate interval.

PubMed ID: 9464278

DOI: 10.1006/bbrc.1997.8027

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15218527

Title: Plexin-B3 is a functional receptor for semaphorin 5A.

PubMed ID: 15218527

DOI: 10.1038/sj.embor.7400189

PubMed ID: 20696765

Title: Semaphorin 5A and plexin-B3 inhibit human glioma cell motility through RhoGDIalpha-mediated inactivation of Rac1 GTPase.

PubMed ID: 20696765

DOI: 10.1074/jbc.m110.120451

PubMed ID: 19850054

Title: Semaphorin 5A promotes angiogenesis by increasing endothelial cell proliferation, migration, and decreasing apoptosis.

PubMed ID: 19850054

DOI: 10.1016/j.mvr.2009.10.005

PubMed ID: 21706053

Title: Semaphorin 5A and plexin-B3 regulate human glioma cell motility and morphology through Rac1 and the actin cytoskeleton.

PubMed ID: 21706053

DOI: 10.1038/onc.2011.256

PubMed ID: 26637798

Title: Targeted DNA Sequencing from Autism Spectrum Disorder Brains Implicates Multiple Genetic Mechanisms.

PubMed ID: 26637798

DOI: 10.1016/j.neuron.2015.11.009

Sequence Information:

Length: 1074
Mass: 120615
Checksum: AE073413AC974CCC
Sequence:

MKGTCVIAWL FSSLGLWRLA HPEAQGTTQC QRTEHPVISY KEIGPWLREF RAKNAVDFSQ 
LTFDPGQKEL VVGARNYLFR LQLEDLSLIQ AVEWECDEAT KKACYSKGKS KEECQNYIRV 
LLVGGDRLFT CGTNAFTPVC TNRSLSNLTE IHDQISGMAR CPYSPQHNST ALLTAGGELY 
AATAMDFPGR DPAIYRSLGI LPPLRTAQYN SKWLNEPNFV SSYDIGNFTY FFFRENAVEH 
DCGKTVFSRA ARVCKNDIGG RFLLEDTWTT FMKARLNCSR PGEVPFYYNE LQSTFFLPEL 
DLIYGIFTTN VNSIAASAVC VFNLSAIAQA FSGPFKYQEN SRSAWLPYPN PNPHFQCGTV 
DQGLYVNLTE RNLQDAQKFI LMHEVVQPVT TVPSFMEDNS RFSHVAVDVV QGREALVHII 
YLATDYGTIK KVRVPLNQTS SSCLLEEIEL FPERRREPIR SLQILHSQSV LFVGLREHVV 
KIPLKRCQFY RTRSTCIGAQ DPYCGWDVVM KKCTSLEESL SMTQWEQSIS ACPTRNLTVD 
GHFGVWSPWT PCTHTDGSAV GSCLCRTRSC DSPAPQCGGW QCEGPGMEIA NCSRNGGWTP 
WTSWSPCSTT CGIGFQVRQR SCSNPTPRHG GRVCVGQNRE ERYCNEHLLC PPHMFWTGWG 
PWERCTAQCG GGIQARRRIC ENGPDCAGCN VEYQSCNTNP CPELKKTTPW TPWTPVNISD 
NGGHYEQRFR YTCKARLADP NLLEVGRQRI EMRYCSSDGT SGCSTDGLSG DFLRAGRYSA 
HTVNGAWSAW TSWSQCSRDC SRGIRNRKRV CNNPEPKYGG MPCLGPSLEY QECNILPCPV 
DGVWSCWSPW TKCSATCGGG HYMRTRSCSN PAPAYGGDIC LGLHTEEALC NTQPCPESWS 
EWSDWSECEA SGVQVRARQC ILLFPMGSQC SGNTTESRPC VFDSNFIPEV SVARSSSVEE 
KRCGEFNMFH MIAVGLSSSI LGCLLTLLVY TYCQRYQQQS HDATVIHPVS PAPLNTSITN 
HINKLDKYDS VEAIKAFNKN NLILEERNKY FNPHLTGKTY SNAYFTDLNN YDEY

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SEMA5A

Associated with

Other Information

Molecular cloning and mapping of human semaphorin F from the Cri-du-chat candidate interval. PubMed ID: 9464278

The DNA sequence and comparative analysis of human chromosome 5. PubMed ID: 15372022

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Plexin-B3 is a functional receptor for semaphorin 5A. PubMed ID: 15218527

Semaphorin 5A and plexin-B3 inhibit human glioma cell motility through RhoGDIalpha-mediated inactivation of Rac1 GTPase. PubMed ID: 20696765

Semaphorin 5A promotes angiogenesis by increasing endothelial cell proliferation, migration, and decreasing apoptosis. PubMed ID: 19850054

Semaphorin 5A and plexin-B3 regulate human glioma cell motility and morphology through Rac1 and the actin cytoskeleton. PubMed ID: 21706053

Targeted DNA Sequencing from Autism Spectrum Disorder Brains Implicates Multiple Genetic Mechanisms. PubMed ID: 26637798