UBA3 | ENSG00000144744 | NCBI 9039

Details for: UBA3

Gene ID: 9039

Symbol: UBA3

Ensembl ID: ENSG00000144744

Description: ubiquitin like modifier activating enzyme 3

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-HSA-983168)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Cytokine signaling in immune system
(R-HSA-1280215)
Dectin-1 mediated noncanonical nf-kb signaling
(R-HSA-5607761)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Metabolism of proteins
(R-HSA-392499)
Neddylation
(R-HSA-8951664)
Nik-->noncanonical nf-kb signaling
(R-HSA-5676590)
Tnfr2 non-canonical nf-kb pathway
(R-HSA-5668541)
Atp binding
(GO:0005524)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Endomitotic cell cycle
(GO:0007113)
Identical protein binding
(GO:0042802)
Nedd8 activating enzyme activity
(GO:0019781)
Nedd8 transferase activity
(GO:0019788)
Nucleus
(GO:0005634)
Post-translational protein modification
(GO:0043687)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein modification process
(GO:0036211)
Protein neddylation
(GO:0045116)
Proteolysis
(GO:0006508)
Regulation of cell cycle
(GO:0051726)

Other Information

Proteins

NEDD8-activating enzyme E1 catalytic subunit

Genular Protein ID: 236527690

Symbol: UBA3_HUMAN

Name: NEDD8-activating enzyme E1 catalytic subunit

UniProtKB Accession Codes:

Q8TBC4 A6NLB5 A8K027 O76088 Q9NTU3

Database IDs:

Citations:

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10207026

Title: Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway.

PubMed ID: 10207026

DOI: 10.1074/jbc.274.17.12036

PubMed ID: 9694792

Title: A new NEDD8-ligating system for cullin-4A.

PubMed ID: 9694792

DOI: 10.1101/gad.12.15.2263

PubMed ID: 12740388

Title: Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer.

PubMed ID: 12740388

DOI: 10.1074/jbc.m303177200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 14690597

Title: The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1.

PubMed ID: 14690597

DOI: 10.1016/s1097-2765(03)00452-0

PubMed ID: 12646924

Title: Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8.

PubMed ID: 12646924

DOI: 10.1038/nature01456

PubMed ID: 15361859

Title: A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8.

PubMed ID: 15361859

DOI: 10.1038/nsmb826

PubMed ID: 15694336

Title: Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1.

PubMed ID: 15694336

DOI: 10.1016/j.molcel.2004.12.020

PubMed ID: 19250909

Title: E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification.

PubMed ID: 19250909

DOI: 10.1016/j.molcel.2009.01.011

Sequence Information:

Length: 463
Mass: 51852
Checksum: 4C16DC0EEDE31A76
Sequence:

MADGEEPEKK RRRIEELLAE KMAVDGGCGD TGDWEGRWNH VKKFLERSGP FTHPDFEPST 
ESLQFLLDTC KVLVIGAGGL GCELLKNLAL SGFRQIHVID MDTIDVSNLN RQFLFRPKDI 
GRPKAEVAAE FLNDRVPNCN VVPHFNKIQD FNDTFYRQFH IIVCGLDSII ARRWINGMLI 
SLLNYEDGVL DPSSIVPLID GGTEGFKGNA RVILPGMTAC IECTLELYPP QVNFPMCTIA 
SMPRLPEHCI EYVRMLQWPK EQPFGEGVPL DGDDPEHIQW IFQKSLERAS QYNIRGVTYR 
LTQGVVKRII PAVASTNAVI AAVCATEVFK IATSAYIPLN NYLVFNDVDG LYTYTFEAER 
KENCPACSQL PQNIQFSPSA KLQEVLDYLT NSASLQMKSP AITATLEGKN RTLYLQSVTS 
IEERTRPNLS KTLKELGLVD GQELAVADVT TPQTVLFKLH FTS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: UBA3

Associated with

Other Information

Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. PubMed ID: 11230166

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway. PubMed ID: 10207026

A new NEDD8-ligating system for cullin-4A. PubMed ID: 9694792

Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer. PubMed ID: 12740388

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1. PubMed ID: 14690597

Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8. PubMed ID: 12646924

A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8. PubMed ID: 15361859

Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1. PubMed ID: 15694336

E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. PubMed ID: 19250909