Details for: CCNT1

Gene ID: 904

Symbol: CCNT1

Ensembl ID: ENSG00000129315

Description: cyclin T1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 176.1546
    Cell Significance Index: -27.4000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 107.8877
    Cell Significance Index: -27.3700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 65.0450
    Cell Significance Index: -26.4300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 57.7388
    Cell Significance Index: -29.7000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 27.6881
    Cell Significance Index: -26.4400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.7559
    Cell Significance Index: -29.2900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.2585
    Cell Significance Index: -30.1600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.5088
    Cell Significance Index: -29.6300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.1204
    Cell Significance Index: -21.8700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 4.7031
    Cell Significance Index: 77.5000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.4092
    Cell Significance Index: -9.6500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.7823
    Cell Significance Index: 207.7100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1412
    Cell Significance Index: 15.5700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1043
    Cell Significance Index: 219.1500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7217
    Cell Significance Index: 117.3800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7078
    Cell Significance Index: 18.9700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6793
    Cell Significance Index: 136.2700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6528
    Cell Significance Index: 42.1200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5573
    Cell Significance Index: 15.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4832
    Cell Significance Index: 87.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4686
    Cell Significance Index: 57.6200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4413
    Cell Significance Index: 30.5200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3985
    Cell Significance Index: 22.3600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3700
    Cell Significance Index: 10.3400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3667
    Cell Significance Index: 36.2700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3287
    Cell Significance Index: 117.9200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2976
    Cell Significance Index: 162.5200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2964
    Cell Significance Index: 40.7100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2915
    Cell Significance Index: 128.8700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2817
    Cell Significance Index: 194.8100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2704
    Cell Significance Index: 7.7500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2485
    Cell Significance Index: 7.1600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1948
    Cell Significance Index: 8.8300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1880
    Cell Significance Index: 5.0200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1880
    Cell Significance Index: 14.4300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1715
    Cell Significance Index: 32.6400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1685
    Cell Significance Index: 19.8700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1539
    Cell Significance Index: 10.8900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1168
    Cell Significance Index: 2.9200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1144
    Cell Significance Index: 103.2800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0957
    Cell Significance Index: 6.0300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0866
    Cell Significance Index: 4.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0641
    Cell Significance Index: 10.9500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0629
    Cell Significance Index: 3.2700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0615
    Cell Significance Index: 2.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0576
    Cell Significance Index: 108.4100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0328
    Cell Significance Index: 20.8600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0262
    Cell Significance Index: 1.2300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0185
    Cell Significance Index: 2.3700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0119
    Cell Significance Index: 18.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0104
    Cell Significance Index: 4.7300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0093
    Cell Significance Index: 17.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0069
    Cell Significance Index: -9.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0081
    Cell Significance Index: -5.9700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0196
    Cell Significance Index: -14.3400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0206
    Cell Significance Index: -0.5300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0221
    Cell Significance Index: -13.7800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0258
    Cell Significance Index: -3.7500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0300
    Cell Significance Index: -22.7100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0332
    Cell Significance Index: -2.0400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0377
    Cell Significance Index: -21.2500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0633
    Cell Significance Index: -6.4700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0708
    Cell Significance Index: -14.9100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0900
    Cell Significance Index: -25.9000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1024
    Cell Significance Index: -2.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1208
    Cell Significance Index: -13.8400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1255
    Cell Significance Index: -9.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1255
    Cell Significance Index: -3.3000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1269
    Cell Significance Index: -14.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1344
    Cell Significance Index: -17.3700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1490
    Cell Significance Index: -10.0200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1745
    Cell Significance Index: -2.9200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1867
    Cell Significance Index: -3.2000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1901
    Cell Significance Index: -3.7100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1943
    Cell Significance Index: -4.0300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2184
    Cell Significance Index: -9.6600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2475
    Cell Significance Index: -25.7700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2503
    Cell Significance Index: -5.3500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2815
    Cell Significance Index: -10.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2948
    Cell Significance Index: -15.4800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3292
    Cell Significance Index: -8.8100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3442
    Cell Significance Index: -27.2600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3443
    Cell Significance Index: -2.0800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3490
    Cell Significance Index: -10.2500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3867
    Cell Significance Index: -11.3900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4023
    Cell Significance Index: -20.3300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4133
    Cell Significance Index: -9.0500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4235
    Cell Significance Index: -22.0600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4549
    Cell Significance Index: -6.5400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4633
    Cell Significance Index: -16.1000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4662
    Cell Significance Index: -10.1000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4685
    Cell Significance Index: -5.5900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5071
    Cell Significance Index: -31.0900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5112
    Cell Significance Index: -11.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5327
    Cell Significance Index: -17.0600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5712
    Cell Significance Index: -16.3000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.5806
    Cell Significance Index: -8.5700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.5806
    Cell Significance Index: -9.7800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5953
    Cell Significance Index: -12.4600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.6160
    Cell Significance Index: -15.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CCNT1 is a phosphoprotein that belongs to the cyclin family of proteins, which are essential regulators of the cell cycle. The protein is characterized by its ability to bind to the 7sk snRNA, a small nuclear RNA that is involved in the regulation of gene expression and cell cycle progression. CCNT1 is also capable of interacting with various transcription factors, including the estrogen receptor (ER), which suggests its involvement in estrogen-dependent gene expression. Additionally, CCNT1 has been shown to regulate the formation of the HIV-1 elongation complex, which is essential for the replication of the human immunodeficiency virus (HIV). **Pathways and Functions** CCNT1 is involved in several key pathways, including: 1. **Cell Cycle Regulation**: CCNT1 plays a crucial role in regulating the cell cycle by phosphorylating and activating CDK9, which in turn regulates the transcription of RNAPII target genes. 2. **Transcription Elongation**: CCNT1 is involved in the regulation of transcription elongation by RNAPII, which is essential for the expression of genes involved in cell growth, differentiation, and survival. 3. **HIV Replication**: CCNT1 regulates the formation of the HIV-1 elongation complex, which is essential for the replication of the virus. 4. **Estrogen-Dependent Gene Expression**: CCNT1 interacts with the estrogen receptor (ER) to regulate estrogen-dependent gene expression, which is involved in various physiological processes, including cell growth and differentiation. 5. **Smad Signaling**: CCNT1 regulates the activity of the Smad2/Smad3:Smad4 heterotrimer, which is involved in the signaling of TGF-β receptors and plays a crucial role in regulating cell growth, differentiation, and survival. **Clinical Significance** CCNT1 has been implicated in various diseases, including: 1. **Cancer**: CCNT1 is overexpressed in various types of cancer, including breast, lung, and colon cancer, suggesting its involvement in tumorigenesis. 2. **HIV Infection**: CCNT1 is essential for the replication of HIV, and its dysregulation can lead to impaired immune function and increased susceptibility to infection. 3. **Endocrine Disorders**: CCNT1 interacts with the estrogen receptor (ER) to regulate estrogen-dependent gene expression, which is involved in various endocrine disorders, including breast cancer and osteoporosis. 4. **Neurological Disorders**: CCNT1 has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease, suggesting its involvement in the regulation of gene expression and cell survival. In conclusion, CCNT1 is a critical protein involved in the regulation of gene expression and cell cycle progression. Its dysregulation can lead to various diseases, including cancer, HIV infection, and endocrine disorders. Further research is needed to fully understand the role of CCNT1 in human disease and to identify potential therapeutic targets for the treatment of these diseases.

Genular Protein ID: 1113320453

Symbol: CCNT1_HUMAN

Name: N/A

UniProtKB Accession Codes:

O60563 A9XU13 E7EX76 O60581

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CPTAC 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 29 PDBsum 29 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 15 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9491887

Title: A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA.

PubMed ID: 9491887

DOI: 10.1016/s0092-8674(00)80939-3

PubMed ID: 9499409

Title: Identification of multiple cyclin subunits of human P-TEFb.

PubMed ID: 9499409

DOI: 10.1101/gad.12.5.755

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 10393184

Title: A novel RNA polymerase II-containing complex potentiates Tat-enhanced HIV-1 transcription.

PubMed ID: 10393184

DOI: 10.1093/emboj/18.13.3688

PubMed ID: 10329125

Title: Cyclin T1 domains involved in complex formation with Tat and TAR RNA are critical for tat-activation.

PubMed ID: 10329125

DOI: 10.1006/jmbi.1999.2663

PubMed ID: 10329126

Title: Role of the human and murine cyclin T proteins in regulating HIV-1 Tat-activation.

PubMed ID: 10329126

DOI: 10.1006/jmbi.1999.2664

PubMed ID: 9832504

Title: The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein.

PubMed ID: 9832504

DOI: 10.1101/gad.12.22.3512

PubMed ID: 10364329

Title: Analysis of the effect of natural sequence variation in Tat and in cyclin T on the formation and RNA binding properties of Tat-cyclin T complexes.

PubMed ID: 10364329

DOI: 10.1128/jvi.73.7.5777-5786.1999

PubMed ID: 10913173

Title: Relief of two built-In autoinhibitory mechanisms in P-TEFb is required for assembly of a multicomponent transcription elongation complex at the human immunodeficiency virus type 1 promoter.

PubMed ID: 10913173

DOI: 10.1128/mcb.20.16.5897-5907.2000

PubMed ID: 12065898

Title: MCEF, the newest member of the AF4 family of transcription factors involved in leukemia, is a positive transcription elongation factor-b-associated protein.

PubMed ID: 12065898

DOI: 10.1007/bf02256070

PubMed ID: 12944466

Title: The human I-mfa domain-containing protein, HIC, interacts with cyclin T1 and modulates P-TEFb-dependent transcription.

PubMed ID: 12944466

DOI: 10.1128/mcb.23.18.6373-6384.2003

PubMed ID: 14972556

Title: Evidence for conformational flexibility in the Tat-TAR recognition motif of cyclin T1.

PubMed ID: 14972556

DOI: 10.1016/j.virol.2003.10.003

PubMed ID: 16109376

Title: The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription.

PubMed ID: 16109376

DOI: 10.1016/j.molcel.2005.06.027

PubMed ID: 16109377

Title: Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4.

PubMed ID: 16109377

DOI: 10.1016/j.molcel.2005.06.029

PubMed ID: 17643375

Title: Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.

PubMed ID: 17643375

DOI: 10.1016/j.molcel.2007.06.027

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24360279

Title: Brd4 and JMJD6-associated anti-pause enhancers in regulation of transcriptional pause release.

PubMed ID: 24360279

DOI: 10.1016/j.cell.2013.10.056

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 27292648

Title: T-bet activates Th1 genes through mediator and the super elongation complex.

PubMed ID: 27292648

DOI: 10.1016/j.celrep.2016.05.054

PubMed ID: 27189267

Title: Heat shock factor 1 mediates latent HIV reactivation.

PubMed ID: 27189267

DOI: 10.1038/srep26294

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 30134174

Title: Positive Regulation of Transcription by Human ZMYND8 through Its Association with P-TEFb Complex.

PubMed ID: 30134174

DOI: 10.1016/j.celrep.2018.07.064

PubMed ID: 29849146

Title: Phase-separation mechanism for C-terminal hyperphosphorylation of RNA polymerase II.

PubMed ID: 29849146

DOI: 10.1038/s41586-018-0174-3

PubMed ID: 34696162

Title: HSV-1 ICP22 Is a Selective Viral Repressor of Cellular RNA Polymerase II-Mediated Transcription Elongation.

PubMed ID: 34696162

DOI: 10.3390/vaccines9101054

PubMed ID: 35393539

Title: Poly(ADP-ribosylation) of P-TEFb by PARP1 disrupts phase separation to inhibit global transcription after DNA damage.

PubMed ID: 35393539

DOI: 10.1038/s41556-022-00872-5

PubMed ID: 23033978

Title: Diagnostic exome sequencing in persons with severe intellectual disability.

PubMed ID: 23033978

DOI: 10.1056/nejmoa1206524

Sequence Information:

  • Length: 726
  • Mass: 80685
  • Checksum: 4637EFB2DDEDFE13
  • Sequence:
    • MEGERKNNNK RWYFTREQLE NSPSRRFGVD PDKELSYRQQ AANLLQDMGQ RLNVSQLTIN 
TAIVYMHRFY MIQSFTQFPG NSVAPAALFL AAKVEEQPKK LEHVIKVAHT CLHPQESLPD 
TRSEAYLQQV QDLVILESII LQTLGFELTI DHPHTHVVKC TQLVRASKDL AQTSYFMATN 
SLHLTTFSLQ YTPPVVACVC IHLACKWSNW EIPVSTDGKH WWEYVDATVT LELLDELTHE 
FLQILEKTPN RLKRIWNWRA CEAAKKTKAD DRGTDEKTSE QTILNMISQS SSDTTIAGLM 
SMSTSTTSAV PSLPVSEESS SNLTSVEMLP GKRWLSSQPS FKLEPTQGHR TSENLALTGV 
DHSLPQDGSN AFISQKQNSK SVPSAKVSLK EYRAKHAEEL AAQKRQLENM EANVKSQYAY 
AAQNLLSHHD SHSSVILKMP IEGSENPERP FLEKADKTAL KMRIPVAGGD KAASSKPEEI 
KMRIKVHAAA DKHNSVEDSV TKSREHKEKH KTHPSNHHHH HNHHSHKHSH SQLPVGTGNK 
RPGDPKHSSQ TSNLAHKTYS LSSSFSSSSS TRKRGPSEET GGAVFDHPAK IAKSTKSSSL 
NFSFPSLPTM GQMPGHSSDT SGLSFSQPSC KTRVPHSKLD KGPTGANGHN TTQTIDYQDT 
VNMLHSLLSA QGVQPTQPTA FEFVRPYSDY LNPRSGGISS RSGNTDKPRP PPLPSEPPPP 
LPPLPK

Genular Protein ID: 1439126333

Symbol: A8K4M5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K4M5

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 1 IntAct 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 726
  • Mass: 80585
  • Checksum: 062A44C4849C2D4A
  • Sequence:
    • MEGERKNNNK RWYFTREQLE NSPSRRFGVD PDKELSYRQQ AANLLQDMGQ RLNVSQLTIN 
TAIVYMHRFY MIQSFTQFPG NSVAPAALFL AAKVEEQPKK LEHVIKVAHT CLHPQESLPD 
TRSEAYLQQV QDLVILESII LQTLGFELTI DHPHTHVVKC TQLVRASKDL AQTSYFMATN 
SLHLTTFSLQ YTPPVVACVC IHLACKWSNW EIPVSTDGKH WWEYVDATVT LELLDELTHE 
FLQILEKTPN GLKRIWNWRA CEAAKKTKAD DRGTDEKTSE QTILNMISQS SSDTTIAGLM 
SMSTSTTSAV PSLPVSEESS SNLTSVEMLP GKRWLSSQPS FKLEPTQGHR TSENLALTGV 
DHSLPQDGSN AFISQKQNSK SVPSAKVSLK EYRAKHAEEL AAQKRQLENM EANVKSQYAY 
AAQNLLSHHD SHSSVILKMP IEGSENPERP FLEKADKTAL KMRIPVAGGD KAASSKPEEI 
KMRIKVHAAA DKHNSVEDSV TKSREHKEKH KTHPSNHHHH HNHHSHKHSH SQLPVGTGNK 
RPGDPKHSSQ TSNLAHKTYS LSSSFSSSSS TRKRGPSEET GGAVFDHPAK IAKSTKSSSL 
NFSFPSLPTM GQMPGHSSDT SGLSFSQPSC KTRVPHSKLD KGPTGANGHN TTQTIDYQDT 
VNMLHSLLSA QGVQPTQPTA FEFVRPYSDY LNPRSGGISS RSGNTDKPRP PPLPSEPPPP 
LPPLPK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.