Details for: CCNT1

Gene ID: 904

Symbol: CCNT1

Ensembl ID: ENSG00000129315

Description: cyclin T1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.45
    Marker Score: 1545
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.13
    Marker Score: 1188
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1.08
    Marker Score: 1066
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.04
    Marker Score: 16350
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71654
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.99
    Marker Score: 429
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47876
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30384
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.95
    Marker Score: 8192
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.95
    Marker Score: 58382.5
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.95
    Marker Score: 8987
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.94
    Marker Score: 472
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2387
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.94
    Marker Score: 31941
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.94
    Marker Score: 1444
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 478
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.92
    Marker Score: 3764
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.92
    Marker Score: 48860
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 436
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.92
    Marker Score: 9522
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.91
    Marker Score: 616
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.91
    Marker Score: 9180
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2689
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.89
    Marker Score: 834
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.89
    Marker Score: 439
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.88
    Marker Score: 2074
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.86
    Marker Score: 852
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.86
    Marker Score: 654
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.86
    Marker Score: 299
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.85
    Marker Score: 2679
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.85
    Marker Score: 618
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.84
    Marker Score: 3518
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.84
    Marker Score: 1010
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.83
    Marker Score: 2320.5
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.82
    Marker Score: 399
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.82
    Marker Score: 4685
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.82
    Marker Score: 468
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.82
    Marker Score: 254
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.81
    Marker Score: 288
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 324
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.81
    Marker Score: 329
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.8
    Marker Score: 483
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.8
    Marker Score: 1759.5
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.8
    Marker Score: 2206.5
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.8
    Marker Score: 848
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.8
    Marker Score: 732
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.8
    Marker Score: 1943
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.79
    Marker Score: 381
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.79
    Marker Score: 492.5
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.79
    Marker Score: 272
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.79
    Marker Score: 1016
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.79
    Marker Score: 189
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.79
    Marker Score: 905
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.78
    Marker Score: 186
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.78
    Marker Score: 7315.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1259
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.77
    Marker Score: 834
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.77
    Marker Score: 223
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 590
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.77
    Marker Score: 966.5
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.77
    Marker Score: 851
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.77
    Marker Score: 233.5
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.77
    Marker Score: 830
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.77
    Marker Score: 224.5
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.77
    Marker Score: 522
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.77
    Marker Score: 460
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.76
    Marker Score: 1869
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.76
    Marker Score: 187
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.76
    Marker Score: 307
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.76
    Marker Score: 824
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.75
    Marker Score: 2908.5
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.75
    Marker Score: 1108
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.75
    Marker Score: 27705.5
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.75
    Marker Score: 511
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.75
    Marker Score: 612
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.74
    Marker Score: 4389.5
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.74
    Marker Score: 7440.5
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.74
    Marker Score: 255
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.73
    Marker Score: 615
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.73
    Marker Score: 15510
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.72
    Marker Score: 999.5
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.72
    Marker Score: 27466
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.72
    Marker Score: 266
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 372
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.72
    Marker Score: 189
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.72
    Marker Score: 455
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.72
    Marker Score: 164
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.71
    Marker Score: 470
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2975
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.71
    Marker Score: 163
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.71
    Marker Score: 12558
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.71
    Marker Score: 1027
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.71
    Marker Score: 434
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.71
    Marker Score: 708
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.7
    Marker Score: 760
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.7
    Marker Score: 265
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.7
    Marker Score: 551
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.7
    Marker Score: 13963

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Other Information

**Key characteristics:** * CCNT1 is a protein of the CCNT family of cyclin-dependent kinases. * It is expressed in a variety of cell types, including skeletal muscle satellite stem cells, conjunctival epithelial cells, type B pancreatic cells, cardiac muscle myoblasts, cerebral cortex GABAergic interneurons, CD8-positive, alpha-beta cytokine secreting effector T cells, forebrain radial glial cells, absorptive cells, and L6b glutamatergic cortical neurons. * CCNT1 is a key regulator of cell cycle progression, and its expression is often altered in cancer. **Pathways and functions:** * CCNT1 is involved in the regulation of cell cycle progression and proliferation. * It is a key regulator of the cell cycle, and its expression is often altered in cancer. * CCNT1 is involved in the regulation of cell cycle progression by binding to the Cyclin-dependent kinase inhibitor protein CDK4 and inhibiting its activity. * It also binds to the p53 tumor suppressor protein and inhibits its activity, which leads to cell cycle progression. * CCNT1 is also involved in the regulation of cell cycle progression by promoting the formation of the transcription complex required for the initiation of transcription. * It is involved in the regulation of cell cycle progression by promoting the formation of the transcription complex required for the initiation of transcription. * CCNT1 is also involved in the regulation of cell cycle progression by promoting the degradation of the E2F transcription factor, which is a key repressor of cell cycle progression. **Clinical significance:** CCNT1 is a promising target for cancer therapy. Mutations in CCNT1 have been linked to the development of a number of human cancers, including breast cancer, lung cancer, and colon cancer. Inhibition of CCNT1 has been shown to inhibit cell growth and proliferation, and it is a promising treatment for cancer.

Genular Protein ID: 1113320453

Symbol: CCNT1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9491887

Title: A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA.

PubMed ID: 9491887

DOI: 10.1016/s0092-8674(00)80939-3

PubMed ID: 9499409

Title: Identification of multiple cyclin subunits of human P-TEFb.

PubMed ID: 9499409

DOI: 10.1101/gad.12.5.755

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 10393184

Title: A novel RNA polymerase II-containing complex potentiates Tat-enhanced HIV-1 transcription.

PubMed ID: 10393184

DOI: 10.1093/emboj/18.13.3688

PubMed ID: 10329125

Title: Cyclin T1 domains involved in complex formation with Tat and TAR RNA are critical for tat-activation.

PubMed ID: 10329125

DOI: 10.1006/jmbi.1999.2663

PubMed ID: 10329126

Title: Role of the human and murine cyclin T proteins in regulating HIV-1 Tat-activation.

PubMed ID: 10329126

DOI: 10.1006/jmbi.1999.2664

PubMed ID: 9832504

Title: The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein.

PubMed ID: 9832504

DOI: 10.1101/gad.12.22.3512

PubMed ID: 10364329

Title: Analysis of the effect of natural sequence variation in Tat and in cyclin T on the formation and RNA binding properties of Tat-cyclin T complexes.

PubMed ID: 10364329

DOI: 10.1128/jvi.73.7.5777-5786.1999

PubMed ID: 10913173

Title: Relief of two built-In autoinhibitory mechanisms in P-TEFb is required for assembly of a multicomponent transcription elongation complex at the human immunodeficiency virus type 1 promoter.

PubMed ID: 10913173

DOI: 10.1128/mcb.20.16.5897-5907.2000

PubMed ID: 12065898

Title: MCEF, the newest member of the AF4 family of transcription factors involved in leukemia, is a positive transcription elongation factor-b-associated protein.

PubMed ID: 12065898

DOI: 10.1007/bf02256070

PubMed ID: 12944466

Title: The human I-mfa domain-containing protein, HIC, interacts with cyclin T1 and modulates P-TEFb-dependent transcription.

PubMed ID: 12944466

DOI: 10.1128/mcb.23.18.6373-6384.2003

PubMed ID: 14972556

Title: Evidence for conformational flexibility in the Tat-TAR recognition motif of cyclin T1.

PubMed ID: 14972556

DOI: 10.1016/j.virol.2003.10.003

PubMed ID: 16109376

Title: The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription.

PubMed ID: 16109376

DOI: 10.1016/j.molcel.2005.06.027

PubMed ID: 16109377

Title: Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4.

PubMed ID: 16109377

DOI: 10.1016/j.molcel.2005.06.029

PubMed ID: 17643375

Title: Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.

PubMed ID: 17643375

DOI: 10.1016/j.molcel.2007.06.027

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24360279

Title: Brd4 and JMJD6-associated anti-pause enhancers in regulation of transcriptional pause release.

PubMed ID: 24360279

DOI: 10.1016/j.cell.2013.10.056

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 27292648

Title: T-bet activates Th1 genes through mediator and the super elongation complex.

PubMed ID: 27292648

DOI: 10.1016/j.celrep.2016.05.054

PubMed ID: 27189267

Title: Heat shock factor 1 mediates latent HIV reactivation.

PubMed ID: 27189267

DOI: 10.1038/srep26294

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 30134174

Title: Positive Regulation of Transcription by Human ZMYND8 through Its Association with P-TEFb Complex.

PubMed ID: 30134174

DOI: 10.1016/j.celrep.2018.07.064

PubMed ID: 29849146

Title: Phase-separation mechanism for C-terminal hyperphosphorylation of RNA polymerase II.

PubMed ID: 29849146

DOI: 10.1038/s41586-018-0174-3

PubMed ID: 34696162

Title: HSV-1 ICP22 Is a Selective Viral Repressor of Cellular RNA Polymerase II-Mediated Transcription Elongation.

PubMed ID: 34696162

DOI: 10.3390/vaccines9101054

PubMed ID: 35393539

Title: Poly(ADP-ribosylation) of P-TEFb by PARP1 disrupts phase separation to inhibit global transcription after DNA damage.

PubMed ID: 35393539

DOI: 10.1038/s41556-022-00872-5

PubMed ID: 23033978

Title: Diagnostic exome sequencing in persons with severe intellectual disability.

PubMed ID: 23033978

DOI: 10.1056/nejmoa1206524

Sequence Information:

  • Length: 726
  • Mass: 80685
  • Checksum: 4637EFB2DDEDFE13
  • Sequence:
  • MEGERKNNNK RWYFTREQLE NSPSRRFGVD PDKELSYRQQ AANLLQDMGQ RLNVSQLTIN 
    TAIVYMHRFY MIQSFTQFPG NSVAPAALFL AAKVEEQPKK LEHVIKVAHT CLHPQESLPD 
    TRSEAYLQQV QDLVILESII LQTLGFELTI DHPHTHVVKC TQLVRASKDL AQTSYFMATN 
    SLHLTTFSLQ YTPPVVACVC IHLACKWSNW EIPVSTDGKH WWEYVDATVT LELLDELTHE 
    FLQILEKTPN RLKRIWNWRA CEAAKKTKAD DRGTDEKTSE QTILNMISQS SSDTTIAGLM 
    SMSTSTTSAV PSLPVSEESS SNLTSVEMLP GKRWLSSQPS FKLEPTQGHR TSENLALTGV 
    DHSLPQDGSN AFISQKQNSK SVPSAKVSLK EYRAKHAEEL AAQKRQLENM EANVKSQYAY 
    AAQNLLSHHD SHSSVILKMP IEGSENPERP FLEKADKTAL KMRIPVAGGD KAASSKPEEI 
    KMRIKVHAAA DKHNSVEDSV TKSREHKEKH KTHPSNHHHH HNHHSHKHSH SQLPVGTGNK 
    RPGDPKHSSQ TSNLAHKTYS LSSSFSSSSS TRKRGPSEET GGAVFDHPAK IAKSTKSSSL 
    NFSFPSLPTM GQMPGHSSDT SGLSFSQPSC KTRVPHSKLD KGPTGANGHN TTQTIDYQDT 
    VNMLHSLLSA QGVQPTQPTA FEFVRPYSDY LNPRSGGISS RSGNTDKPRP PPLPSEPPPP 
    LPPLPK

Genular Protein ID: 1439126333

Symbol: A8K4M5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 726
  • Mass: 80585
  • Checksum: 062A44C4849C2D4A
  • Sequence:
  • MEGERKNNNK RWYFTREQLE NSPSRRFGVD PDKELSYRQQ AANLLQDMGQ RLNVSQLTIN 
    TAIVYMHRFY MIQSFTQFPG NSVAPAALFL AAKVEEQPKK LEHVIKVAHT CLHPQESLPD 
    TRSEAYLQQV QDLVILESII LQTLGFELTI DHPHTHVVKC TQLVRASKDL AQTSYFMATN 
    SLHLTTFSLQ YTPPVVACVC IHLACKWSNW EIPVSTDGKH WWEYVDATVT LELLDELTHE 
    FLQILEKTPN GLKRIWNWRA CEAAKKTKAD DRGTDEKTSE QTILNMISQS SSDTTIAGLM 
    SMSTSTTSAV PSLPVSEESS SNLTSVEMLP GKRWLSSQPS FKLEPTQGHR TSENLALTGV 
    DHSLPQDGSN AFISQKQNSK SVPSAKVSLK EYRAKHAEEL AAQKRQLENM EANVKSQYAY 
    AAQNLLSHHD SHSSVILKMP IEGSENPERP FLEKADKTAL KMRIPVAGGD KAASSKPEEI 
    KMRIKVHAAA DKHNSVEDSV TKSREHKEKH KTHPSNHHHH HNHHSHKHSH SQLPVGTGNK 
    RPGDPKHSSQ TSNLAHKTYS LSSSFSSSSS TRKRGPSEET GGAVFDHPAK IAKSTKSSSL 
    NFSFPSLPTM GQMPGHSSDT SGLSFSQPSC KTRVPHSKLD KGPTGANGHN TTQTIDYQDT 
    VNMLHSLLSA QGVQPTQPTA FEFVRPYSDY LNPRSGGISS RSGNTDKPRP PPLPSEPPPP 
    LPPLPK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.