CCNT1 | ENSG00000129315 | NCBI 904

Details for: CCNT1

Gene ID: 904

Symbol: CCNT1

Ensembl ID: ENSG00000129315

Description: cyclin T1

Associated with

Disease
(R-HSA-1643685)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Formation of hiv-1 elongation complex containing hiv-1 tat
(R-HSA-167200)
Formation of hiv elongation complex in the absence of hiv tat
(R-HSA-167152)
Formation of rna pol ii elongation complex
(R-HSA-112382)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Hiv elongation arrest and recovery
(R-HSA-167287)
Hiv infection
(R-HSA-162906)
Hiv life cycle
(R-HSA-162587)
Hiv transcription elongation
(R-HSA-167169)
Host interactions of hiv factors
(R-HSA-162909)
Infectious disease
(R-HSA-5663205)
Interactions of tat with host cellular proteins
(R-HSA-176034)
Late phase of hiv life cycle
(R-HSA-162599)
Pausing and recovery of hiv elongation
(R-HSA-167290)
Pausing and recovery of tat-mediated hiv elongation
(R-HSA-167238)
Rna polymerase ii pre-transcription events
(R-HSA-674695)
Rna polymerase ii transcribes snrna genes
(R-HSA-6807505)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase ii transcription elongation
(R-HSA-75955)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by tgf-beta receptor complex
(R-HSA-170834)
Signaling by tgfb family members
(R-HSA-9006936)
Signal transduction
(R-HSA-162582)
Smad2/smad3:smad4 heterotrimer regulates transcription
(R-HSA-2173796)
Tat-mediated elongation of the hiv-1 transcript
(R-HSA-167246)
Tat-mediated hiv elongation arrest and recovery
(R-HSA-167243)
Tp53 regulates transcription of dna repair genes
(R-HSA-6796648)
Transcriptional activity of smad2/smad3:smad4 heterotrimer
(R-HSA-2173793)
Transcriptional regulation by tp53
(R-HSA-3700989)
Transcription of the hiv genome
(R-HSA-167172)
Viral infection pathways
(R-HSA-9824446)
7sk snrna binding
(GO:0097322)
Cell cycle
(GO:0007049)
Cell division
(GO:0051301)
Chromatin binding
(GO:0003682)
Cyclin-dependent protein serine/threonine kinase activator activity
(GO:0061575)
Cyclin/cdk positive transcription elongation factor complex
(GO:0008024)
Cytosol
(GO:0005829)
Dna-binding transcription factor binding
(GO:0140297)
Dna binding
(GO:0003677)
Molecular condensate scaffold activity
(GO:0140693)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
P-tefb complex
(GO:0070691)
Positive regulation by host of viral transcription
(GO:0043923)
Positive regulation of dna-templated transcription, elongation
(GO:0032786)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of transcription elongation by rna polymerase ii
(GO:0032968)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0000079)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to xenobiotic stimulus
(GO:0009410)
Rna polymerase binding
(GO:0070063)
Transcription by rna polymerase ii
(GO:0006366)
Transcription cis-regulatory region binding
(GO:0000976)

Other Information

Proteins

CCNT1_HUMAN
A8K4M5_HUMAN

Genular Protein ID: 1113320453

Symbol: CCNT1_HUMAN

Name: N/A

UniProtKB Accession Codes:

O60563 A9XU13 E7EX76 O60581

Database IDs:

Citations:

PubMed ID: 9491887

Title: A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA.

PubMed ID: 9491887

DOI: 10.1016/s0092-8674(00)80939-3

PubMed ID: 9499409

Title: Identification of multiple cyclin subunits of human P-TEFb.

PubMed ID: 9499409

DOI: 10.1101/gad.12.5.755

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 10393184

Title: A novel RNA polymerase II-containing complex potentiates Tat-enhanced HIV-1 transcription.

PubMed ID: 10393184

DOI: 10.1093/emboj/18.13.3688

PubMed ID: 10329125

Title: Cyclin T1 domains involved in complex formation with Tat and TAR RNA are critical for tat-activation.

PubMed ID: 10329125

DOI: 10.1006/jmbi.1999.2663

PubMed ID: 10329126

Title: Role of the human and murine cyclin T proteins in regulating HIV-1 Tat-activation.

PubMed ID: 10329126

DOI: 10.1006/jmbi.1999.2664

PubMed ID: 9832504

Title: The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein.

PubMed ID: 9832504

DOI: 10.1101/gad.12.22.3512

PubMed ID: 10364329

Title: Analysis of the effect of natural sequence variation in Tat and in cyclin T on the formation and RNA binding properties of Tat-cyclin T complexes.

PubMed ID: 10364329

DOI: 10.1128/jvi.73.7.5777-5786.1999

PubMed ID: 10913173

Title: Relief of two built-In autoinhibitory mechanisms in P-TEFb is required for assembly of a multicomponent transcription elongation complex at the human immunodeficiency virus type 1 promoter.

PubMed ID: 10913173

DOI: 10.1128/mcb.20.16.5897-5907.2000

PubMed ID: 12065898

Title: MCEF, the newest member of the AF4 family of transcription factors involved in leukemia, is a positive transcription elongation factor-b-associated protein.

PubMed ID: 12065898

DOI: 10.1007/bf02256070

PubMed ID: 12944466

Title: The human I-mfa domain-containing protein, HIC, interacts with cyclin T1 and modulates P-TEFb-dependent transcription.

PubMed ID: 12944466

DOI: 10.1128/mcb.23.18.6373-6384.2003

PubMed ID: 14972556

Title: Evidence for conformational flexibility in the Tat-TAR recognition motif of cyclin T1.

PubMed ID: 14972556

DOI: 10.1016/j.virol.2003.10.003

PubMed ID: 16109376

Title: The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription.

PubMed ID: 16109376

DOI: 10.1016/j.molcel.2005.06.027

PubMed ID: 16109377

Title: Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4.

PubMed ID: 16109377

DOI: 10.1016/j.molcel.2005.06.029

PubMed ID: 17643375

Title: Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.

PubMed ID: 17643375

DOI: 10.1016/j.molcel.2007.06.027

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24360279

Title: Brd4 and JMJD6-associated anti-pause enhancers in regulation of transcriptional pause release.

PubMed ID: 24360279

DOI: 10.1016/j.cell.2013.10.056

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 27292648

Title: T-bet activates Th1 genes through mediator and the super elongation complex.

PubMed ID: 27292648

DOI: 10.1016/j.celrep.2016.05.054

PubMed ID: 27189267

Title: Heat shock factor 1 mediates latent HIV reactivation.

PubMed ID: 27189267

DOI: 10.1038/srep26294

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 30134174

Title: Positive Regulation of Transcription by Human ZMYND8 through Its Association with P-TEFb Complex.

PubMed ID: 30134174

DOI: 10.1016/j.celrep.2018.07.064

PubMed ID: 29849146

Title: Phase-separation mechanism for C-terminal hyperphosphorylation of RNA polymerase II.

PubMed ID: 29849146

DOI: 10.1038/s41586-018-0174-3

PubMed ID: 34696162

Title: HSV-1 ICP22 Is a Selective Viral Repressor of Cellular RNA Polymerase II-Mediated Transcription Elongation.

PubMed ID: 34696162

DOI: 10.3390/vaccines9101054

PubMed ID: 35393539

Title: Poly(ADP-ribosylation) of P-TEFb by PARP1 disrupts phase separation to inhibit global transcription after DNA damage.

PubMed ID: 35393539

DOI: 10.1038/s41556-022-00872-5

PubMed ID: 23033978

Title: Diagnostic exome sequencing in persons with severe intellectual disability.

PubMed ID: 23033978

DOI: 10.1056/nejmoa1206524

Sequence Information:

Length: 726
Mass: 80685
Checksum: 4637EFB2DDEDFE13
Sequence:

MEGERKNNNK RWYFTREQLE NSPSRRFGVD PDKELSYRQQ AANLLQDMGQ RLNVSQLTIN 
TAIVYMHRFY MIQSFTQFPG NSVAPAALFL AAKVEEQPKK LEHVIKVAHT CLHPQESLPD 
TRSEAYLQQV QDLVILESII LQTLGFELTI DHPHTHVVKC TQLVRASKDL AQTSYFMATN 
SLHLTTFSLQ YTPPVVACVC IHLACKWSNW EIPVSTDGKH WWEYVDATVT LELLDELTHE 
FLQILEKTPN RLKRIWNWRA CEAAKKTKAD DRGTDEKTSE QTILNMISQS SSDTTIAGLM 
SMSTSTTSAV PSLPVSEESS SNLTSVEMLP GKRWLSSQPS FKLEPTQGHR TSENLALTGV 
DHSLPQDGSN AFISQKQNSK SVPSAKVSLK EYRAKHAEEL AAQKRQLENM EANVKSQYAY 
AAQNLLSHHD SHSSVILKMP IEGSENPERP FLEKADKTAL KMRIPVAGGD KAASSKPEEI 
KMRIKVHAAA DKHNSVEDSV TKSREHKEKH KTHPSNHHHH HNHHSHKHSH SQLPVGTGNK 
RPGDPKHSSQ TSNLAHKTYS LSSSFSSSSS TRKRGPSEET GGAVFDHPAK IAKSTKSSSL 
NFSFPSLPTM GQMPGHSSDT SGLSFSQPSC KTRVPHSKLD KGPTGANGHN TTQTIDYQDT 
VNMLHSLLSA QGVQPTQPTA FEFVRPYSDY LNPRSGGISS RSGNTDKPRP PPLPSEPPPP 
LPPLPK

Genular Protein ID: 1439126333

Symbol: A8K4M5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K4M5

Database IDs:

Sequence Information:

Length: 726
Mass: 80585
Checksum: 062A44C4849C2D4A
Sequence:

MEGERKNNNK RWYFTREQLE NSPSRRFGVD PDKELSYRQQ AANLLQDMGQ RLNVSQLTIN 
TAIVYMHRFY MIQSFTQFPG NSVAPAALFL AAKVEEQPKK LEHVIKVAHT CLHPQESLPD 
TRSEAYLQQV QDLVILESII LQTLGFELTI DHPHTHVVKC TQLVRASKDL AQTSYFMATN 
SLHLTTFSLQ YTPPVVACVC IHLACKWSNW EIPVSTDGKH WWEYVDATVT LELLDELTHE 
FLQILEKTPN GLKRIWNWRA CEAAKKTKAD DRGTDEKTSE QTILNMISQS SSDTTIAGLM 
SMSTSTTSAV PSLPVSEESS SNLTSVEMLP GKRWLSSQPS FKLEPTQGHR TSENLALTGV 
DHSLPQDGSN AFISQKQNSK SVPSAKVSLK EYRAKHAEEL AAQKRQLENM EANVKSQYAY 
AAQNLLSHHD SHSSVILKMP IEGSENPERP FLEKADKTAL KMRIPVAGGD KAASSKPEEI 
KMRIKVHAAA DKHNSVEDSV TKSREHKEKH KTHPSNHHHH HNHHSHKHSH SQLPVGTGNK 
RPGDPKHSSQ TSNLAHKTYS LSSSFSSSSS TRKRGPSEET GGAVFDHPAK IAKSTKSSSL 
NFSFPSLPTM GQMPGHSSDT SGLSFSQPSC KTRVPHSKLD KGPTGANGHN TTQTIDYQDT 
VNMLHSLLSA QGVQPTQPTA FEFVRPYSDY LNPRSGGISS RSGNTDKPRP PPLPSEPPPP 
LPPLPK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CCNT1

Associated with

Other Information

A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA. PubMed ID: 9491887

Identification of multiple cyclin subunits of human P-TEFb. PubMed ID: 9499409

The finished DNA sequence of human chromosome 12. PubMed ID: 16541075

A novel RNA polymerase II-containing complex potentiates Tat-enhanced HIV-1 transcription. PubMed ID: 10393184

Cyclin T1 domains involved in complex formation with Tat and TAR RNA are critical for tat-activation. PubMed ID: 10329125

Role of the human and murine cyclin T proteins in regulating HIV-1 Tat-activation. PubMed ID: 10329126

The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein. PubMed ID: 9832504

Analysis of the effect of natural sequence variation in Tat and in cyclin T on the formation and RNA binding properties of Tat-cyclin T complexes. PubMed ID: 10364329

Relief of two built-In autoinhibitory mechanisms in P-TEFb is required for assembly of a multicomponent transcription elongation complex at the human immunodeficiency virus type 1 promoter. PubMed ID: 10913173

MCEF, the newest member of the AF4 family of transcription factors involved in leukemia, is a positive transcription elongation factor-b-associated protein. PubMed ID: 12065898

The human I-mfa domain-containing protein, HIC, interacts with cyclin T1 and modulates P-TEFb-dependent transcription. PubMed ID: 12944466

Evidence for conformational flexibility in the Tat-TAR recognition motif of cyclin T1. PubMed ID: 14972556

The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription. PubMed ID: 16109376

Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4. PubMed ID: 16109377

Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. PubMed ID: 17643375

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Brd4 and JMJD6-associated anti-pause enhancers in regulation of transcriptional pause release. PubMed ID: 24360279

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

T-bet activates Th1 genes through mediator and the super elongation complex. PubMed ID: 27292648

Heat shock factor 1 mediates latent HIV reactivation. PubMed ID: 27189267

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Positive Regulation of Transcription by Human ZMYND8 through Its Association with P-TEFb Complex. PubMed ID: 30134174

Phase-separation mechanism for C-terminal hyperphosphorylation of RNA polymerase II. PubMed ID: 29849146

HSV-1 ICP22 Is a Selective Viral Repressor of Cellular RNA Polymerase II-Mediated Transcription Elongation. PubMed ID: 34696162

Poly(ADP-ribosylation) of P-TEFb by PARP1 disrupts phase separation to inhibit global transcription after DNA damage. PubMed ID: 35393539

Diagnostic exome sequencing in persons with severe intellectual disability. PubMed ID: 23033978