UBE2M | ENSG00000130725 | NCBI 9040

Details for: UBE2M

Gene ID: 9040

Symbol: UBE2M

Ensembl ID: ENSG00000130725

Description: ubiquitin conjugating enzyme E2 M

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-HSA-983168)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Cytokine signaling in immune system
(R-HSA-1280215)
Dectin-1 mediated noncanonical nf-kb signaling
(R-HSA-5607761)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Metabolism of proteins
(R-HSA-392499)
Neddylation
(R-HSA-8951664)
Nik-->noncanonical nf-kb signaling
(R-HSA-5676590)
Signaling by tgf-beta receptor complex
(R-HSA-170834)
Signaling by tgfb family members
(R-HSA-9006936)
Signal transduction
(R-HSA-162582)
Tgf-beta receptor signaling activates smads
(R-HSA-2173789)
Tnfr2 non-canonical nf-kb pathway
(R-HSA-5668541)
Atp binding
(GO:0005524)
Cytosol
(GO:0005829)
Nedd8 conjugating enzyme activity
(GO:0061654)
Nedd8 transferase activity
(GO:0019788)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of neuron apoptotic process
(GO:0043525)
Post-translational protein modification
(GO:0043687)
Protein binding
(GO:0005515)
Protein modification process
(GO:0036211)
Protein neddylation
(GO:0045116)
Ubiquitin-protein transferase activity
(GO:0004842)

Other Information

Proteins

NEDD8-conjugating enzyme Ubc12

Genular Protein ID: 3369673565

Symbol: UBC12_HUMAN

Name: NEDD8-conjugating enzyme Ubc12

UniProtKB Accession Codes:

P61081 O76069 Q8VC50

Database IDs:

Citations:

PubMed ID: 9694792

Title: A new NEDD8-ligating system for cullin-4A.

PubMed ID: 9694792

DOI: 10.1101/gad.12.15.2263

PubMed ID: 10207026

Title: Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway.

PubMed ID: 10207026

DOI: 10.1074/jbc.274.17.12036

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10828074

Title: A dominant-negative UBC12 mutant sequesters NEDD8 and inhibits NEDD8 conjugation in vivo.

PubMed ID: 10828074

DOI: 10.1074/jbc.275.22.17008

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19250909

Title: E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification.

PubMed ID: 19250909

DOI: 10.1016/j.molcel.2009.01.011

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24192928

Title: Oncogenic function of SCCRO5/DCUN1D5 requires its Neddylation E3 activity and nuclear localization.

PubMed ID: 24192928

DOI: 10.1158/1078-0432.ccr-13-1252

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28581483

Title: Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.

PubMed ID: 28581483

DOI: 10.1038/nchembio.2386

PubMed ID: 15361859

Title: A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8.

PubMed ID: 15361859

DOI: 10.1038/nsmb826

PubMed ID: 15694336

Title: Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1.

PubMed ID: 15694336

DOI: 10.1016/j.molcel.2004.12.020

PubMed ID: 21940857

Title: N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex.

PubMed ID: 21940857

DOI: 10.1126/science.1209307

PubMed ID: 23201271

Title: Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes.

PubMed ID: 23201271

DOI: 10.1016/j.str.2012.10.013

Sequence Information:

Length: 183
Mass: 20900
Checksum: E3C288CA6A98BC5C
Sequence:

MIKLFSLKQQ KKEEESAGGT KGSSKKASAA QLRIQKDINE LNLPKTCDIS FSDPDDLLNF 
KLVICPDEGF YKSGKFVFSF KVGQGYPHDP PKVKCETMVY HPNIDLEGNV CLNILREDWK 
PVLTINSIIY GLQYLFLEPN PEDPLNKEAA EVLQNNRRLF EQNVQRSMRG GYIGSTYFER 
CLK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: UBE2M

Associated with

Other Information

A new NEDD8-ligating system for cullin-4A. PubMed ID: 9694792

Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway. PubMed ID: 10207026

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A dominant-negative UBC12 mutant sequesters NEDD8 and inhibits NEDD8 conjugation in vivo. PubMed ID: 10828074

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. PubMed ID: 19250909

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

Oncogenic function of SCCRO5/DCUN1D5 requires its Neddylation E3 activity and nuclear localization. PubMed ID: 24192928

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase. PubMed ID: 28581483

A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8. PubMed ID: 15361859

Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1. PubMed ID: 15694336

N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex. PubMed ID: 21940857

Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes. PubMed ID: 23201271