PSTPIP1 | ENSG00000140368 | NCBI 9051

Details for: PSTPIP1

Gene ID: 9051

Symbol: PSTPIP1

Ensembl ID: ENSG00000140368

Description: proline-serine-threonine phosphatase interacting protein 1

Associated with

Cell recruitment (pro-inflammatory response)
(R-HSA-9664424)
Disease
(R-HSA-1643685)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Inflammasomes
(R-HSA-622312)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-HSA-168643)
Parasitic infection pathways
(R-HSA-9824443)
Purinergic signaling in leishmaniasis infection
(R-HSA-9660826)
The nlrp3 inflammasome
(R-HSA-844456)
Actin filament
(GO:0005884)
Actin filament binding
(GO:0051015)
Actin filament polymerization
(GO:0030041)
Cell adhesion
(GO:0007155)
Cleavage furrow
(GO:0032154)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Endocytosis
(GO:0006897)
Identical protein binding
(GO:0042802)
Inflammatory response
(GO:0006954)
Innate immune response
(GO:0045087)
Lamellipodium
(GO:0030027)
Membrane
(GO:0016020)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Signal transduction
(GO:0007165)
Uropod
(GO:0001931)

Other Information

Proteins

Proline-serine-threonine phosphatase-interacting protein 1

Genular Protein ID: 1631987272

Symbol: PPIP1_HUMAN

Name: Proline-serine-threonine phosphatase-interacting protein 1

UniProtKB Accession Codes:

O43586 B5BU74 B5BUK4 O43585 O95657

Database IDs:

Citations:

PubMed ID: 9857189

Title: A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion.

PubMed ID: 9857189

DOI: 10.1093/emboj/17.24.7320

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14595024

Title: Pyrin binds the PSTPIP1/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway.

PubMed ID: 14595024

DOI: 10.1073/pnas.2135380100

PubMed ID: 17964261

Title: Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants.

PubMed ID: 17964261

DOI: 10.1016/j.molcel.2007.08.029

PubMed ID: 18480402

Title: The PCH family member proline-serine-threonine phosphatase-interacting protein 1 targets to the leukocyte uropod and regulates directed cell migration.

PubMed ID: 18480402

DOI: 10.1091/mbc.e08-02-0225

PubMed ID: 19807924

Title: Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.

PubMed ID: 19807924

DOI: 10.1186/1471-2172-10-53

PubMed ID: 19109554

Title: Pyrin and ASC co-localize to cellular sites that are rich in polymerizing actin.

PubMed ID: 19109554

DOI: 10.3181/0806-rm-184

PubMed ID: 19584923

Title: Pyrin Modulates the Intracellular Distribution of PSTPIP1.

PubMed ID: 19584923

DOI: 10.1371/journal.pone.0006147

PubMed ID: 11971877

Title: Mutations in CD2BP1 disrupt binding to PTP PEST and are responsible for PAPA syndrome, an autoinflammatory disorder.

PubMed ID: 11971877

DOI: 10.1093/hmg/11.8.961

PubMed ID: 22161697

Title: Brief report: genotype, phenotype, and clinical course in five patients with PAPA syndrome (pyogenic sterile arthritis, pyoderma gangrenosum, and acne).

PubMed ID: 22161697

DOI: 10.1002/art.34332

Sequence Information:

Length: 416
Mass: 47591
Checksum: 97818150B3D5D600
Sequence:

MMPQLQFKDA FWCRDFTAHT GYEVLLQRLL DGRKMCKDME ELLRQRAQAE ERYGKELVQI 
ARKAGGQTEI NSLRASFDSL KQQMENVGSS HIQLALTLRE ELRSLEEFRE RQKEQRKKYE 
AVMDRVQKSK LSLYKKAMES KKTYEQKCRD ADDAEQAFER ISANGHQKQV EKSQNKARQC 
KDSATEAERV YRQSIAQLEK VRAEWEQEHR TTCEAFQLQE FDRLTILRNA LWVHSNQLSM 
QCVKDDELYE EVRLTLEGCS IDADIDSFIQ AKSTGTEPPA PVPYQNYYDR EVTPLTSSPG 
IQPSCGMIKR FSGLLHGSPK TTSLAASAAS TETLTPTPER NEGVYTAIAV QEIQGNPASP 
AQEYRALYDY TAQNPDELDL SAGDILEVIL EGEDGWWTVE RNGQRGFVPG SYLEKL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PSTPIP1

Associated with

Other Information

A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion. PubMed ID: 9857189

Human protein factory for converting the transcriptome into an in vitro-expressed proteome. PubMed ID: 19054851

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Pyrin binds the PSTPIP1/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway. PubMed ID: 14595024

Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants. PubMed ID: 17964261

The PCH family member proline-serine-threonine phosphatase-interacting protein 1 targets to the leukocyte uropod and regulates directed cell migration. PubMed ID: 18480402

Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. PubMed ID: 19807924

Pyrin and ASC co-localize to cellular sites that are rich in polymerizing actin. PubMed ID: 19109554

Pyrin Modulates the Intracellular Distribution of PSTPIP1. PubMed ID: 19584923

Mutations in CD2BP1 disrupt binding to PTP PEST and are responsible for PAPA syndrome, an autoinflammatory disorder. PubMed ID: 11971877

Brief report: genotype, phenotype, and clinical course in five patients with PAPA syndrome (pyogenic sterile arthritis, pyoderma gangrenosum, and acne). PubMed ID: 22161697