Details for: SLC7A7
Associated with
Other Information
Genular Protein ID: 3989258463
Symbol: YLAT1_HUMAN
Name: Monocyte amino acid permease 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9829974
Title: Identification and characterization of a membrane protein (y+L amino acid transporter-1) that associates with 4F2hc to encode the amino acid transport activity y+L. A candidate gene for lysinuric protein intolerance.
PubMed ID: 9829974
PubMed ID: 9878049
Title: Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family.
PubMed ID: 9878049
PubMed ID: 10080183
Title: SLC7A7, encoding a putative permease-related protein, is mutated in patients with lysinuric protein intolerance.
PubMed ID: 10080183
DOI: 10.1038/6815
PubMed ID: 10737982
Title: SLC7A7 genomic structure and novel variants in three Japanese lysinuric protein intolerance families.
PubMed ID: 10737982
DOI: 10.1002/(sici)1098-1004(200004)15:4<367::aid-humu9>3.0.co;2-c
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11078698
Title: Arginine transport through system y(+)L in cultured human fibroblasts: normal phenotype of cells from LPI subjects.
PubMed ID: 11078698
PubMed ID: 11742806
Title: Two-way arginine transport in human endothelial cells: TNF-alpha stimulation is restricted to system y(+).
PubMed ID: 11742806
PubMed ID: 14603368
Title: Nitric oxide synthesis requires activity of the cationic and neutral amino acid transport system y+L in human umbilical vein endothelium.
PubMed ID: 14603368
DOI: 10.1113/eph8802647
PubMed ID: 15280038
Title: INFgamma stimulates arginine transport through system y+L in human monocytes.
PubMed ID: 15280038
PubMed ID: 17329401
Title: Activation of classical protein kinase C decreases transport via systems y+ and y+L.
PubMed ID: 17329401
PubMed ID: 17197568
Title: Ornithine transport via cationic amino acid transporter-1 is involved in ornithine cytotoxicity in retinal pigment epithelial cells.
PubMed ID: 17197568
DOI: 10.1167/iovs.06-0398
PubMed ID: 31705628
Title: y+LAT1 and y+LAT2 contribution to arginine uptake in different human cell models: Implications in the pathophysiology of Lysinuric Protein Intolerance.
PubMed ID: 31705628
DOI: 10.1111/jcmm.14801
PubMed ID: 10080182
Title: Identification of SLC7A7, encoding y+LAT-1, as the lysinuric protein intolerance gene.
PubMed ID: 10080182
DOI: 10.1038/6809
PubMed ID: 10631139
Title: Structure of the SLC7A7 gene and mutational analysis of patients affected by lysinuric protein intolerance.
PubMed ID: 10631139
DOI: 10.1086/302700
PubMed ID: 10655553
Title: Functional analysis of novel mutations in y+LAT-1 amino acid transporter gene causing lysinuric protein intolerance (LPI).
PubMed ID: 10655553
DOI: 10.1093/hmg/9.3.431
PubMed ID: 12402335
Title: Five novel SLC7A7 variants and y+L gene-expression pattern in cultured lymphoblasts from Japanese patients with lysinuric protein intolerance.
PubMed ID: 12402335
DOI: 10.1002/humu.10140
PubMed ID: 15756301
Title: A y(+)LAT-1 mutant protein interferes with y(+)LAT-2 activity: implications for the molecular pathogenesis of lysinuric protein intolerance.
PubMed ID: 15756301
PubMed ID: 15776427
Title: Lysinuric protein intolerance: identification and functional analysis of mutations of the SLC7A7 gene.
PubMed ID: 15776427
DOI: 10.1002/humu.9323
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
PubMed ID: 17764084
Title: Lysinuric protein intolerance: update and extended mutation analysis of the SLC7A7 gene.
PubMed ID: 17764084
DOI: 10.1002/humu.20589
PubMed ID: 23940088
Title: Interactions of y+LAT1 and 4F2hc in the y+l amino acid transporter complex: consequences of lysinuric protein intolerance-causing mutations.
PubMed ID: 23940088
DOI: 10.4149/gpb_2013050
Sequence Information:
- Length: 511
- Mass: 55991
- Checksum: A71D677B6B075894
- Sequence:
MVDSTEYEVA SQPEVETSPL GDGASPGPEQ VKLKKEISLL NGVCLIVGNM IGSGIFVSPK GVLIYSASFG LSLVIWAVGG LFSVFGALCY AELGTTIKKS GASYAYILEA FGGFLAFIRL WTSLLIIEPT SQAIIAITFA NYMVQPLFPS CFAPYAASRL LAAACICLLT FINCAYVKWG TLVQDIFTYA KVLALIAVIV AGIVRLGQGA STHFENSFEG SSFAVGDIAL ALYSALFSYS GWDTLNYVTE EIKNPERNLP LSIGISMPIV TIIYILTNVA YYTVLDMRDI LASDAVAVTF ADQIFGIFNW IIPLSVALSC FGGLNASIVA ASRLFFVGSR EGHLPDAICM IHVERFTPVP SLLFNGIMAL IYLCVEDIFQ LINYYSFSYW FFVGLSIVGQ LYLRWKEPDR PRPLKLSVFF PIVFCLCTIF LVAVPLYSDT INSLIGIAIA LSGLPFYFLI IRVPEHKRPL YLRRIVGSAT RYLQVLCMSV AAEMDLEDGG EMPKQRDPKS N
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.