Details for: CLDN1

Gene ID: 9076

Symbol: CLDN1

Ensembl ID: ENSG00000163347

Description: claudin 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.74
    Marker Score: 2,155
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.68
    Marker Score: 4,137
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.45
    Marker Score: 8,034
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.34
    Marker Score: 2,461
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.2
    Marker Score: 3,244
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.16
    Marker Score: 732
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.14
    Marker Score: 15,956
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 2.05
    Marker Score: 895
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.85
    Marker Score: 2,047
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.75
    Marker Score: 1,814
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.65
    Marker Score: 4,060
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.51
    Marker Score: 20,227
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.5
    Marker Score: 1,935
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.5
    Marker Score: 1,251
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.49
    Marker Score: 3,643
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.47
    Marker Score: 1,301
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.4
    Marker Score: 14,460
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.38
    Marker Score: 492
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.37
    Marker Score: 2,503
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.36
    Marker Score: 5,864
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.35
    Marker Score: 859
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.25
    Marker Score: 43,261
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.23
    Marker Score: 448
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.17
    Marker Score: 7,525
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.16
    Marker Score: 787
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.14
    Marker Score: 276
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.14
    Marker Score: 1,160
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.14
    Marker Score: 760
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.11
    Marker Score: 5,945
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.1
    Marker Score: 2,839
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.03
    Marker Score: 1,199
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 1.01
    Marker Score: 405
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,792
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,017
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.99
    Marker Score: 8,608
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.98
    Marker Score: 8,412
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.97
    Marker Score: 677
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 501
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.97
    Marker Score: 658
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.95
    Marker Score: 1,932
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.95
    Marker Score: 274
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.92
    Marker Score: 7,179
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.92
    Marker Score: 1,504
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,732
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.91
    Marker Score: 183
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5,058
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.85
    Marker Score: 1,498
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.82
    Marker Score: 1,559
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.82
    Marker Score: 381
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.81
    Marker Score: 876
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 613
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 318
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.79
    Marker Score: 540
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,269
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 391
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.74
    Marker Score: 3,101
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 657
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.71
    Marker Score: 267
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.71
    Marker Score: 229
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.71
    Marker Score: 1,940
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.68
    Marker Score: 190
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.65
    Marker Score: 433
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.65
    Marker Score: 1,229
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.65
    Marker Score: 2,295
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.65
    Marker Score: 10,107
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.63
    Marker Score: 894
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.62
    Marker Score: 382
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.62
    Marker Score: 2,122
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.59
    Marker Score: 3,119
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.58
    Marker Score: 1,330
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.57
    Marker Score: 283
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.57
    Marker Score: 216
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.57
    Marker Score: 239
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.57
    Marker Score: 690
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.56
    Marker Score: 1,189
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.56
    Marker Score: 360
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.55
    Marker Score: 346
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.54
    Marker Score: 360
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.54
    Marker Score: 382
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.54
    Marker Score: 1,664
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.52
    Marker Score: 166
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.52
    Marker Score: 556
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.48
    Marker Score: 467
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.48
    Marker Score: 122
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.48
    Marker Score: 348
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.47
    Marker Score: 3,085
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.47
    Marker Score: 280
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.46
    Marker Score: 426
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.46
    Marker Score: 115
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.46
    Marker Score: 499
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.46
    Marker Score: 170
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.46
    Marker Score: 189

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CLDN1 is a small, transmembrane protein with four transmembrane domains and two extracellular loops. It is a calcium-independent cell-adhesion molecule, meaning that it does not require calcium ions to facilitate cell-cell adhesion. CLDN1 is also a component of bicellular tight junctions, which are essential for maintaining the integrity of epithelial and endothelial barriers. Its expression is often regulated by various signaling pathways, including those involved in inflammation, cell proliferation, and differentiation. **Pathways and Functions** CLDN1 plays a critical role in various cellular processes, including: 1. **Cell-cell adhesion**: CLDN1 facilitates the formation and maintenance of tight junctions, which are essential for maintaining the integrity of epithelial and endothelial barriers. 2. **Barrier function**: CLDN1 helps to regulate the transport of ions and molecules across epithelial and endothelial layers, maintaining the homeostasis of the extracellular environment. 3. **Cell migration**: CLDN1 is involved in the regulation of cell migration, particularly in the context of wound healing and tissue repair. 4. **Cell proliferation**: CLDN1 is also involved in regulating cell proliferation, particularly in the context of epithelial cell proliferation involved in wound healing. 5. **Inflammation**: CLDN1 is regulated by various inflammatory signaling pathways, including those involved in the response to lipopolysaccharide and dexamethasone. 6. **Transport**: CLDN1 is involved in the transport of xenobiotics across the blood-brain barrier and the establishment of the blood-nerve barrier. **Clinical Significance** Dysregulation of CLDN1 has been implicated in various diseases, including: 1. **Inflammatory bowel disease**: CLDN1 has been shown to play a critical role in maintaining the integrity of the intestinal barrier, and its dysregulation is thought to contribute to the development of inflammatory bowel disease. 2. **Cancer**: CLDN1 has been implicated in the regulation of cell proliferation and migration in various types of cancer, including colorectal cancer and pancreatic cancer. 3. **Neurological disorders**: CLDN1 has been shown to play a critical role in maintaining the integrity of the blood-brain barrier, and its dysregulation is thought to contribute to the development of neurological disorders, including multiple sclerosis and Alzheimer's disease. 4. **Skin disorders**: CLDN1 has been implicated in the regulation of skin barrier function, and its dysregulation is thought to contribute to the development of skin disorders, including psoriasis and atopic dermatitis. In conclusion, CLDN1 is a critical component of tight junctions, playing a crucial role in maintaining the structural and functional integrity of epithelial and endothelial cells. Its dysregulation has been implicated in various diseases, highlighting the importance of CLDN1 in maintaining tissue homeostasis and preventing disease.

Genular Protein ID: 439738300

Symbol: CLD1_HUMAN

Name: Claudin-1

UniProtKB Accession Codes:

O95832

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 10 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 37 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9931503

Title: SEMP1, a senescence-associated cDNA isolated from human mammary epithelial cells, is a member of an epithelial membrane protein superfamily.

PubMed ID: 9931503

DOI: 10.1016/s0378-1119(98)00553-8

PubMed ID: 10828592

Title: Assignment of claudin-1 (CLDN1) to human chromosome 3q28-->q29 with somatic cell hybrids.

PubMed ID: 10828592

DOI: 10.1159/000015553

PubMed ID: 11071387

Title: Genomic organization of claudin-1 and its assessment in hereditary and sporadic breast cancer.

PubMed ID: 11071387

DOI: 10.1007/s004390000375

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15521008

Title: Claudin-1 gene mutations in neonatal sclerosing cholangitis associated with ichthyosis: a tight junction disease.

PubMed ID: 15521008

DOI: 10.1053/j.gastro.2004.07.022

PubMed ID: 16619213

Title: Confirmation of the origin of NISCH syndrome.

PubMed ID: 16619213

DOI: 10.1002/humu.20333

PubMed ID: 17325668

Title: Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry.

PubMed ID: 17325668

DOI: 10.1038/nature05654

PubMed ID: 20375010

Title: Claudin association with CD81 defines hepatitis C virus entry.

PubMed ID: 20375010

DOI: 10.1074/jbc.m110.104836

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21516087

Title: EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy.

PubMed ID: 21516087

DOI: 10.1038/nm.2341

PubMed ID: 23407391

Title: Contribution of tight junction proteins to ion, macromolecule, and water barrier in keratinocytes.

PubMed ID: 23407391

DOI: 10.1038/jid.2012.507

PubMed ID: 24074594

Title: The interaction between claudin-1 and dengue viral prM/M protein for its entry.

PubMed ID: 24074594

DOI: 10.1016/j.virol.2013.08.009

PubMed ID: 23704991

Title: Production, purification and characterization of recombinant, full-length human claudin-1.

PubMed ID: 23704991

DOI: 10.1371/journal.pone.0064517

PubMed ID: 24038151

Title: Critical interaction between E1 and E2 glycoproteins determines binding and fusion properties of hepatitis C virus during cell entry.

PubMed ID: 24038151

DOI: 10.1002/hep.26733

Sequence Information:

  • Length: 211
  • Mass: 22744
  • Checksum: 07269000E6C214F0
  • Sequence:
    • MANAGLQLLG FILAFLGWIG AIVSTALPQW RIYSYAGDNI VTAQAMYEGL WMSCVSQSTG 
QIQCKVFDSL LNLSSTLQAT RALMVVGILL GVIAIFVATV GMKCMKCLED DEVQKMRMAV 
IGGAIFLLAG LAILVATAWY GNRIVQEFYD PMTPVNARYE FGQALFTGWA AASLCLLGGA 
LLCCSCPRKT TSYPTPRPYP KPAPSSGKDY V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.