CLDN1 | ENSG00000163347 | NCBI 9076

Details for: CLDN1

Gene ID: 9076

Symbol: CLDN1

Ensembl ID: ENSG00000163347

Description: claudin 1

Associated with

Cell-cell communication
(R-HSA-1500931)
Cell junction organization
(R-HSA-446728)
Tight junction interactions
(R-HSA-420029)
Apical plasma membrane
(GO:0016324)
Basolateral plasma membrane
(GO:0016323)
Bicellular tight junction
(GO:0005923)
Bicellular tight junction assembly
(GO:0070830)
Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
(GO:0016338)
Cell-cell junction organization
(GO:0045216)
Cell adhesion
(GO:0007155)
Cell junction maintenance
(GO:0034331)
Cellular response to butyrate
(GO:1903545)
Cellular response to lead ion
(GO:0071284)
Cellular response to transforming growth factor beta stimulus
(GO:0071560)
Cellular response to tumor necrosis factor
(GO:0071356)
Cellular response to type ii interferon
(GO:0071346)
Establishment of blood-nerve barrier
(GO:0008065)
Establishment of endothelial intestinal barrier
(GO:0090557)
Establishment of skin barrier
(GO:0061436)
Identical protein binding
(GO:0042802)
Lateral plasma membrane
(GO:0016328)
Liver regeneration
(GO:0097421)
Maintenance of blood-brain barrier
(GO:0035633)
Membrane
(GO:0016020)
Plasma membrane
(GO:0005886)
Positive regulation of bicellular tight junction assembly
(GO:1903348)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of epithelial cell proliferation involved in wound healing
(GO:0060054)
Positive regulation of wound healing
(GO:0090303)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein complex oligomerization
(GO:0051259)
Response to dexamethasone
(GO:0071548)
Response to ethanol
(GO:0045471)
Response to interleukin-18
(GO:0070673)
Response to lipopolysaccharide
(GO:0032496)
Response to toxic substance
(GO:0009636)
Structural molecule activity
(GO:0005198)
Symbiont entry into host cell
(GO:0046718)
Tight junction
(GO:0070160)
Virus receptor activity
(GO:0001618)
Xenobiotic transport across blood-nerve barrier
(GO:0061772)

Other Information

Proteins

Claudin-1

Genular Protein ID: 439738300

Symbol: CLD1_HUMAN

Name: Claudin-1

UniProtKB Accession Codes:

O95832

Database IDs:

Citations:

PubMed ID: 9931503

Title: SEMP1, a senescence-associated cDNA isolated from human mammary epithelial cells, is a member of an epithelial membrane protein superfamily.

PubMed ID: 9931503

DOI: 10.1016/s0378-1119(98)00553-8

PubMed ID: 10828592

Title: Assignment of claudin-1 (CLDN1) to human chromosome 3q28-->q29 with somatic cell hybrids.

PubMed ID: 10828592

DOI: 10.1159/000015553

PubMed ID: 11071387

Title: Genomic organization of claudin-1 and its assessment in hereditary and sporadic breast cancer.

PubMed ID: 11071387

DOI: 10.1007/s004390000375

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15521008

Title: Claudin-1 gene mutations in neonatal sclerosing cholangitis associated with ichthyosis: a tight junction disease.

PubMed ID: 15521008

DOI: 10.1053/j.gastro.2004.07.022

PubMed ID: 16619213

Title: Confirmation of the origin of NISCH syndrome.

PubMed ID: 16619213

DOI: 10.1002/humu.20333

PubMed ID: 17325668

Title: Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry.

PubMed ID: 17325668

DOI: 10.1038/nature05654

PubMed ID: 20375010

Title: Claudin association with CD81 defines hepatitis C virus entry.

PubMed ID: 20375010

DOI: 10.1074/jbc.m110.104836

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21516087

Title: EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy.

PubMed ID: 21516087

DOI: 10.1038/nm.2341

PubMed ID: 23407391

Title: Contribution of tight junction proteins to ion, macromolecule, and water barrier in keratinocytes.

PubMed ID: 23407391

DOI: 10.1038/jid.2012.507

PubMed ID: 24074594

Title: The interaction between claudin-1 and dengue viral prM/M protein for its entry.

PubMed ID: 24074594

DOI: 10.1016/j.virol.2013.08.009

PubMed ID: 23704991

Title: Production, purification and characterization of recombinant, full-length human claudin-1.

PubMed ID: 23704991

DOI: 10.1371/journal.pone.0064517

PubMed ID: 24038151

Title: Critical interaction between E1 and E2 glycoproteins determines binding and fusion properties of hepatitis C virus during cell entry.

PubMed ID: 24038151

DOI: 10.1002/hep.26733

Sequence Information:

Length: 211
Mass: 22744
Checksum: 07269000E6C214F0
Sequence:

MANAGLQLLG FILAFLGWIG AIVSTALPQW RIYSYAGDNI VTAQAMYEGL WMSCVSQSTG 
QIQCKVFDSL LNLSSTLQAT RALMVVGILL GVIAIFVATV GMKCMKCLED DEVQKMRMAV 
IGGAIFLLAG LAILVATAWY GNRIVQEFYD PMTPVNARYE FGQALFTGWA AASLCLLGGA 
LLCCSCPRKT TSYPTPRPYP KPAPSSGKDY V

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CLDN1

Associated with

Other Information

SEMP1, a senescence-associated cDNA isolated from human mammary epithelial cells, is a member of an epithelial membrane protein superfamily. PubMed ID: 9931503

Assignment of claudin-1 (CLDN1) to human chromosome 3q28--&gt;q29 with somatic cell hybrids. PubMed ID: 10828592

Genomic organization of claudin-1 and its assessment in hereditary and sporadic breast cancer. PubMed ID: 11071387

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. PubMed ID: 12975309

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Claudin-1 gene mutations in neonatal sclerosing cholangitis associated with ichthyosis: a tight junction disease. PubMed ID: 15521008

Confirmation of the origin of NISCH syndrome. PubMed ID: 16619213

Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry. PubMed ID: 17325668

Claudin association with CD81 defines hepatitis C virus entry. PubMed ID: 20375010

Initial characterization of the human central proteome. PubMed ID: 21269460

EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy. PubMed ID: 21516087

Contribution of tight junction proteins to ion, macromolecule, and water barrier in keratinocytes. PubMed ID: 23407391

The interaction between claudin-1 and dengue viral prM/M protein for its entry. PubMed ID: 24074594

Production, purification and characterization of recombinant, full-length human claudin-1. PubMed ID: 23704991

Critical interaction between E1 and E2 glycoproteins determines binding and fusion properties of hepatitis C virus during cell entry. PubMed ID: 24038151