Details for: LDB2

Gene ID: 9079

Symbol: LDB2

Ensembl ID: ENSG00000169744

Description: LIM domain binding 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 4.49
    Marker Score: 2,535
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 3.89
    Marker Score: 7,487
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 3.82
    Marker Score: 5,551
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 3.48
    Marker Score: 8,850
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.17
    Marker Score: 2,728
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.74
    Marker Score: 4,608
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2.73
    Marker Score: 2,927
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.69
    Marker Score: 5,382
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.33
    Marker Score: 20,465
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.25
    Marker Score: 6,409
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.2
    Marker Score: 20,663
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.16
    Marker Score: 79,739
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.15
    Marker Score: 4,727
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 2.14
    Marker Score: 519
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 2.11
    Marker Score: 580
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 2.09
    Marker Score: 654
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.08
    Marker Score: 127,824
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.97
    Marker Score: 2,269
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.96
    Marker Score: 2,832
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.93
    Marker Score: 18,310
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.91
    Marker Score: 28,587
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 1.89
    Marker Score: 479
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.88
    Marker Score: 399
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.85
    Marker Score: 15,863
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.8
    Marker Score: 1,073
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.75
    Marker Score: 1,571
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.74
    Marker Score: 13,366
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.7
    Marker Score: 17,580
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.7
    Marker Score: 1,598
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.66
    Marker Score: 63,038
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.65
    Marker Score: 2,545
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.61
    Marker Score: 21,248
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.6
    Marker Score: 372
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.53
    Marker Score: 1,536
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.5
    Marker Score: 50,737
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.47
    Marker Score: 556
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.47
    Marker Score: 322
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.47
    Marker Score: 1,328
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,814
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.45
    Marker Score: 2,457
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.44
    Marker Score: 1,550
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.43
    Marker Score: 1,364
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.42
    Marker Score: 5,481
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 1.42
    Marker Score: 884
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 1.36
    Marker Score: 317
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.36
    Marker Score: 327
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.36
    Marker Score: 5,532
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.22
    Marker Score: 615
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.22
    Marker Score: 731
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.2
    Marker Score: 1,445
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.2
    Marker Score: 665
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.19
    Marker Score: 646
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.16
    Marker Score: 773
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.16
    Marker Score: 481
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.14
    Marker Score: 2,153
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.09
    Marker Score: 539
  • Cell Name: dermis microvascular lymphatic vessel endothelial cell (CL2000041)
    Fold Change: 1.05
    Marker Score: 339
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.04
    Marker Score: 6,278
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,758
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.04
    Marker Score: 16,223
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.01
    Marker Score: 591
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.01
    Marker Score: 21,563
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,779
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,004
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.99
    Marker Score: 1,055
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.99
    Marker Score: 384
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.99
    Marker Score: 6,409
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.98
    Marker Score: 572
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,404
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.96
    Marker Score: 499
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.94
    Marker Score: 3,916
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5,259
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,738
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.91
    Marker Score: 3,790
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.9
    Marker Score: 1,116
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.88
    Marker Score: 9,942
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.88
    Marker Score: 420
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.85
    Marker Score: 16,963
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.85
    Marker Score: 650
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.85
    Marker Score: 1,999
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.84
    Marker Score: 1,010
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.84
    Marker Score: 221
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.82
    Marker Score: 773
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.82
    Marker Score: 275
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.82
    Marker Score: 297
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.81
    Marker Score: 280
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.8
    Marker Score: 1,040
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.78
    Marker Score: 252
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.78
    Marker Score: 180
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.78
    Marker Score: 220
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,252
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 694
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.76
    Marker Score: 1,022
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.75
    Marker Score: 1,524
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.74
    Marker Score: 488
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.74
    Marker Score: 3,170
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.73
    Marker Score: 256

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **LIM Domain:** The LDB2 protein contains a LIM domain, a conserved structural motif that mediates protein-protein interactions, enabling the protein to bind to specific transcription factors and co-regulators. 2. **Cellular Localization:** LDB2 is expressed in a wide range of cell types, including immune cells, endothelial cells, and somatic stem cells, highlighting its role in various cellular processes. 3. **Transcriptional Regulation:** LDB2 interacts with RNA polymerase II and other transcription factors to regulate gene expression, influencing the development and function of immune cells. 4. **Cell Migration and Adhesion:** LDB2 is involved in regulating cell migration and adhesion, essential processes in immune cell development and function. **Pathways and Functions:** 1. **Transcriptional Regulation:** LDB2 interacts with transcription factors, such as Nrf2, NF-κB, and STAT3, to regulate the expression of genes involved in immune cell development, function, and homeostasis. 2. **Cell Migration and Adhesion:** LDB2 regulates the expression of genes involved in cell migration and adhesion, such as integrins and cytoskeletal proteins, influencing the development and function of immune cells. 3. **Somatic Stem Cell Maintenance:** LDB2 is involved in maintaining the somatic stem cell population, a critical process in tissue homeostasis and immune function. 4. **Endothelial Function:** LDB2 regulates the expression of genes involved in endothelial function, including those involved in angiogenesis and vascular permeability. **Clinical Significance:** 1. **Immune-Related Disorders:** Alterations in LDB2 expression have been implicated in various immune-related disorders, including autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer:** LDB2 is involved in regulating cell migration and adhesion, processes that are often dysregulated in cancer. 3. **Infectious Diseases:** LDB2 plays a critical role in regulating the expression of genes involved in immune cell development and function, making it a potential target for the treatment of infectious diseases. 4. **Neurological Disorders:** LDB2 is expressed in the nervous system and is involved in regulating the expression of genes involved in neuronal development and function, making it a potential target for the treatment of neurological disorders, such as Alzheimer's disease. In conclusion, LDB2 is a critical regulator of cellular processes, including transcriptional regulation, cell migration, and somatic stem cell maintenance. Its dysregulation has been implicated in various immune-related disorders, cancer, and infectious diseases, highlighting the importance of further research into the mechanisms of LDB2 function and its potential as a therapeutic target.

Genular Protein ID: 702335955

Symbol: LDB2_HUMAN

Name: LIM domain-binding protein 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9799849

Title: Cloning and chromosomal localization of two novel human genes encoding LIM-domain binding factors CLIM1 and CLIM2/LDB1/NLI.

PubMed ID: 9799849

DOI: 10.1007/s003359900899

PubMed ID: 9853615

Title: Selection system for genes encoding nuclear-targeted proteins.

PubMed ID: 9853615

DOI: 10.1038/4315

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16815859

Title: Spliced isoforms of LIM-domain-binding protein (CLIM/NLI/Ldb) lacking the LIM-interaction domain.

PubMed ID: 16815859

DOI: 10.1093/jb/mvj134

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

Sequence Information:

  • Length: 373
  • Mass: 42793
  • Checksum: E86387BA027F383A
  • Sequence:
  • MSSTPHDPFY SSPFGPFYRR HTPYMVQPEY RIYEMNKRLQ SRTEDSDNLW WDAFATEFFE 
    DDATLTLSFC LEDGPKRYTI GRTLIPRYFS TVFEGGVTDL YYILKHSKES YHNSSITVDC 
    DQCTMVTQHG KPMFTKVCTE GRLILEFTFD DLMRIKTWHF TIRQYRELVP RSILAMHAQD 
    PQVLDQLSKN ITRMGLTNFT LNYLRLCVIL EPMQELMSRH KTYNLSPRDC LKTCLFQKWQ 
    RMVAPPAEPT RQPTTKRRKR KNSTSSTSNS SAGNNANSTG SKKKTTAANL SLSSQVPDVM 
    VVGEPTLMGG EFGDEDERLI TRLENTQYDA ANGMDDEEDF NNSPALGNNS PWNSKPPATQ 
    ETKSENPPPQ ASQ

Genular Protein ID: 4045777155

Symbol: B7Z6D0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 337
  • Mass: 38479
  • Checksum: 3F4926483798F659
  • Sequence:
  • MNKRLQSRTE DSDNLWWDAF ATEFFEDDAT LTLSFCLEDG PKRYTIGRTL IPRYFSTVFE 
    GGVTDLYYIL KHSKESYHNS SITVDCDQCT MVTQHGKPMF TKVCTEGRLI LEFTFDDLMR 
    IKTWHFTIRQ YRELVPRSIL AMHAQDPQVL DQLSKNITRM GLTNFTLNYL RLCVILEPMQ 
    ELMSRHKTYN LSPRDCLKTC LFQKWQRMVA PPAEPTRQPT TKRRKRKNST SSTSNSSAGN 
    NANSTGSKKK TTAANLSLSS QDVMVVGEPT LMGGEFGDED ERLITRLENT QYDAANGMDD 
    EEDFYNSPAL GNNSPWNSKP PATQETKSEN PPPQASQ

Genular Protein ID: 2265448197

Symbol: E9PFI4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

Sequence Information:

  • Length: 313
  • Mass: 36099
  • Checksum: 8CC3A93F28FA4A55
  • Sequence:
  • MSSTPHDPFY SSPFGPFYRR HTPYMVQPEY RIYEMNKRLQ SRTEDSDNLW WDAFATEFFE 
    DDATLTLSFC LEDGPKRYTI GRTLIPRYFS TVFEGGVTDL YYILKHSKES YHNSSITVDC 
    DQCTMVTQHG KPMFTKVCTE GRLILEFTFD DLMRIKTWHF TIRQYRELVP RSILAMHAQD 
    PQVLDQLSKN ITRMGLTNFT LNYLRLCVIL EPMQELMSRH KTYNLSPRDC LKTCLFQKWQ 
    RMVAPPAEPT RQPTTKRRKR KNSTSSTSNS SAGNNANSTG SKKKTTAANL SLSSQVPIAS 
    IARSPVSGCA LRT

Genular Protein ID: 4192811223

Symbol: G5E9Y7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

Sequence Information:

  • Length: 371
  • Mass: 42597
  • Checksum: 155DC904314517E6
  • Sequence:
  • MSSTPHDPFY SSPFGPFYRR HTPYMVQPEY RIYEMNKRLQ SRTEDSDNLW WDAFATEFFE 
    DDATLTLSFC LEDGPKRYTI GRTLIPRYFS TVFEGGVTDL YYILKHSKES YHNSSITVDC 
    DQCTMVTQHG KPMFTKVCTE GRLILEFTFD DLMRIKTWHF TIRQYRELVP RSILAMHAQD 
    PQVLDQLSKN ITRMGLTNFT LNYLRLCVIL EPMQELMSRH KTYNLSPRDC LKTCLFQKWQ 
    RMVAPPAEPT RQPTTKRRKR KNSTSSTSNS SAGNNANSTG SKKKTTAANL SLSSQDVMVV 
    GEPTLMGGEF GDEDERLITR LENTQYDAAN GMDDEEDFNN SPALGNNSPW NSKPPATQET 
    KSENPPPQAS Q

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.